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| 1 | Innovation on Distant Hybridization of Saline-tolerant Mud Flat Spartina and Rice Germplasm显示文摘To explore saline-tolerant high yield Spartina and rice germplasm resources,innovate upon distant hybridization technology,and develop new saline-tolerant mud flat Spartina germplasm,autonomous patent for invention was used to study distant hybridization of Spartina and rice in 2005- 2016. The study adopted tidal flat planting screening,phenotypic screening,molecular marker assisted selection,to find biological evidences of new germplasm,and also applied crossbreeding,conventional breeding,and molecular breeding,to select new saline-tolerant Spartina and rice varieties. With 12 years of efforts,the team developed 1498 crossbreeding combinations and established pedigree file and seed bank,tested 307 crossbreeding materials(57 hybrid seeds showed parental genetic components of Spartina and Rice); obtained Spartina/ Rice distant hybridization and seed setting,transplanting,hybridization material economic traits,and molecular biological experimental evidences; Rice♀× Spartina ♂ hybridization success rate of 1. 04- 1. 39%; obtained authorization of patent for invention of Distant Hybridization Methods for Spartina and Rice; formulated procedures for high yield cultivation of Spartina-Rice,planted 33. 33 hm2Spartina-Rice in coastal saline and alkaline land,cultivated 10 new saline-tolerant Spartina-Rice varieties,and the rice yield up to 5. 925- 8. 28 t / hm2. Results indicate that Spartina-Rice is saline-tolerant high yield rice germplasm,developed through sexual hybridization,conventional breeding,and molecular breeding technologies,and is optimal crop for saline and alkaline land. Success of Spartina-Rice solves the problem of saline-tolerant crop badly for transformation of saline and alkaline land,the problem of feeds for herbivores,as well as problem of environmental pollution resulted from straw burning. Besides,it is of essential scientific significance for resource utilization,increase of agricultural efficiency,grain security,and farmland strategy,so it has broad application prospect. | Qikang CHEN Bo CHEN Huilan LU Hui ZHOU Zhiping MEI | 2016 | Asian Agricultural Research2016，8，11： | 2 |
| 2 | High-Speed EMU TCMS Design and LCC Technology Research显示文摘本文介绍了高速动车组的生命周期——设计、制造、测试、运营和维护阶段,以及各种平台,包括列车控制与监视系统(TCMS)开发平台、测试和验证平台、动车组(EMU)驾驶仿真平台及远程数据传输和维护平台。所有平台构成了EMU全寿命周期系统并绑定在一起。每个平台都有利于EMU全寿命周期管理且成为EMU全寿命周期管理的重要组成部分。 | Hongwei Zhao Zhiping Huang Ying Mei | 2017 | Engineering2017，3，1： | 1 |
| 3 | Effects of Various Light-Emitting Diode(LED)Wavelengths on the Growth of Scenedesmus Obliquus Fachb-12 and Accumulation of Astaxanthin显示文摘Given the central role of light in the algal photosynthesis,respiration,cell division,growth and the accumulation of value products,the effects of light-emitting diodes(LEDs)light wavelengths(blue,white,red and green)were studied in Scenedesmus obliquus.Biomass,residual nutrient amount,soluble protein,astaxanthin and reactive oxygen species,superoxide dismutase(SOD),catalase(CAT)and peroxidase(POD)activity were analyzed to determine the effects of different monochromatic light wavelengths via biochemical methods.The results showed that blue light wavelength is the optimal light wavelength for phosphorus removal efficiency and the accumulation of biomass and astaxanthin in S.obliquus.Meanwhile,high reactive oxygen species content under the blue light might induce the accumulation of astaxanthin.The high activity of SOD,CAT and POD might participate in clearing the reactive oxygen species to facilitate the growth of microalgae.Furthermore,we found mixed blue/green lights treatment is the most appropriate mixture for the nitrogen removal.Under the blue light treatment,high light intensity and 18L:6D light cycle is the best condition for biomass and astaxanthin accumulation.Optimal nitrogen/phosphorus removal efficiency was observed under a 24L:0D light cycle.These results might provide a foundational data for the optimizing the productivity of high-value metabolites and treatment of wastewater. | Huabing Xu Xiaojuan Liu Zhiping Mei Jinchun Lin Stephan Aaron Hong Du | 2019 | Phyton-International Journal of Experimental Botany2019，88，3： | 1 |
| 4 | The Characteristics of Seismic Activity Before the Devastating Earthquake with M_W9.0 Off the West Coast of Northern Sumatra显示文摘The characteristics of seismic activity in different time-spatial domain before the M_W9.0 earthquake were studied. The results are as follows:The activity of the deep earthquakes in the north boundary zone of the Australian plate had been evidently strengthened since 1994, showing an increased frequency, magnitude and depth, especially in regards to the heterogeneous distribution of the earthquake depth (namely between 500km and 689km). Meanwhile the shallow earthquakes of M≥7.0 in the Sumatra island and its vicinity had been obviously strengthened too, and formed a strengthening area with a length of about 1000 km and width 300 km. ②The time distribution of global strong earthquakes with M≥7.0 shows that the character of anomalous seismic quiescence-activity one year before the M_W9.0 earthquake and during its active period, the strong earthquakes formed a seismic belt striking in NWW direction. At the same time, there is a seismic gap formed by earthquakes of M≥5.0 in the epicenter and its neighboring region. ③Two deep earthquakes of M≥7.0 occurred in the west and in the east of the north boundary zone of the Australian plate half year ago. It is notable that one of them occurred in the Sumatra island where no deep earthquake with M≥6.0 has occurred in the past thirty years. ④The space distribution of moderate shocks occurring three days ago exhibited a NWW-strike seismic belt along the north boundary zone of the Australian plate. ⑤The activity of volcanoes distributed in the north boundary zone of the Australian plate had been strengthened in the past 4 years, especially several months before the occurrence of the M_W9.0 earthquake. | Xue Yan Song Zhiping Mei Shirong Liu Jie | 2006 | Earthquake Research in China2006，20，2： | 1 |
| 5 | Characteristics of seismic activity before the M_S8.0 Wenchuan earthquake显示文摘The characteristics of spatio-temporal seismicity evolution before the Wenchuan earthquake are studied.The results mainly involve in the trend abnormal features and its relation to the Wenchuan earthquake.The western Chinese mainland and its adjacent area has been in the seismically active period since 2001,while the seismic activity shows the obvious quiescence of M≥7.0,M≥6.0 and M≥5.0 earthquakes in Chinese mainland.A quiescence area with M≥7.0 has been formed in the middle of the North-South seismic zone since 1988,and the Wenchuan earthquake occurred just within this area.There are a background seismicity gap of M≥5.0 earthquakes and a seismogenic gap of ML≥4.0 earthquakes in the area of Longmenshan fault zone and its vicinity prior to the Wenchuan earthquake.The seismic activity obviously strengthened and a doughnut-shape pattern of M≥4.6 earthquakes is formed in the middle and southern part of the North-South seismic zone after the 2003 Dayao,Yunnan,earthquake.Sichuan and its vicinity in the middle of the doughnut-shape pattern show abnormal quiescence.At the same time,the seismicity of earthquake swarms is significant and shows heterogeneity in the temporal and spatial process.A swarm gap appears in the M4.6 seismically quiet area,and the Wenchuan earthquake occurred just on the margin of the gap.In addition,in the short term before the Wenchuan earthquake,the quiescence of earthquake with ML≥4.0 appears in Qinghai-Tibet block and a seismic belt of ML≥3.0 earthquakes,with NW striking and oblique with Longmenshan fault zone,is formed. | Yan Xue Jie Liu Shirong Mei Zhiping Song | 2009 | Earthquake Science2009，22，5： | 0 |
| 6 | SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism显示文摘The SARS-CoV-2 infection causes severe immune disruption.However,it is unclear if disrupted immune regulation still exists and pertains in recovered COVID-19 patients.In our study,we have characterized the immunephe no type of B cells from 15 recovered COVID-19 patients,and found that healthy controls and recovered patients had similar B-cell populations before and after BCR stimulation,but the frequencies of PBC in patients were significantly increased when compared to healthy controls before stimulation.However,the percentage of unswitched memory B cells was decreased in recovered patients but not changed in healthy controls upon BCR stimulation.Interestingly,we found that CD19 expression was significantly reduced in almost all the B-cell subsets in recovered patients.Moreover,the BCR signaling and early B-cell response were disrupted upon BCR stimulation.Mechanistically,we found that the reduced CD19 expression was caused by the dysregulation of cell metabolism.In conclusion,we found that SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhandng B-cell metabolism,which may provide a new intervention target to cure COVID-19. | Yukai Jing Li Luo Ying Chen Lisa S.Westerberg Peng Zhou Zhiping Xu Andres A.Herrada Chan-Sik Park Masato Kubo Heng Mei Yu Hu Pamela Pui-Wah Lee Bing Zheng Zhiwei Sui Wei Xiao Quan Gong Zhongxin Lu Chaohong Liu | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 0 |
| 7 | Investigation on the short-term outcome and prognostic impact of predisposition,and precipitants in inpatients with chronic liver disease from Chinese AcuTe on CHronic LIver FailurE(CATCH-LIFE)cohorts显示文摘Aim:The study aimed to investigate the short-term outcomes of hospitalized patients with chronic liver disease(CLDs)and assess the prognostic impact of predisposition and precipitants,which currently remains unclear.Methods:The study included 3970 hospitalized patients with CLDs from two prospective longitudinal multicenter studies(NCT02457637 and NCT03641872)conducted in highly endemic hepatitis B virus(HBV)areas.Competing risk analysis was used to evaluate the effect of predispositions,including the etiology and severity of CLDs and precipitants;on sequential 28,90,and 365-day liver transplantation(LT)-free mortality.Results:Among all enrolled patients,76.8%of adverse outcomes(including death and LT)within one year occurred within 90 days.Compared with alcoholic etiology,the association of HBV etiology with poorer outcomes was remarkably on the 28th day(hazard ratio[HR],1.81;95%confidence interval[CI],1.07-3.06;p=0.026);however,and dimin-ished or became insignificant at 90 days and 365 days.Cirrhosis increased the adjusted risk for 365-day(HR,1.50;CI,1.13-1.99;p=0.004)LT-free mortality when compared with noncirrhosis.In patients with cirrhosis,prior decompensation(PD)independently increased the adjusted risk of 365-day LT-free mortality by 1.25-fold(p=0.021);however,it did not increase the risk for 90-day mortality.Neither the category nor the number of precipitants influenced the adjusted risk of 28 or 90-day LT-free mortality.Conclusions:The 90-day outcome should be considered a significant endpoint for evaluating the short-term prognosis of hospitalized patients with CLD.Predisposing factors,other than etiology,mainly affected the delayed(365-day)outcome.Timely effective therapy for CLD etiology,especially antiviral treatments for HBV,and post-discharge long-term surveillance monitoring in cirrhotic patients undergoing PD are suggested to enhance disease management and reduce mortality. | Yan Zhang Wenting Tan Xiaobo Wang Xin Zheng Yan Huang Beiling Li Zhongji Meng Yanhang Gao Zhiping Qian Feng Liu Xiaobo Lu Jia Shang Yubao Zheng Weituo Zhang Shan Yin Wenyi Gu Tongyu Wang Jianyi Wei Zixuan Shen Guohong Deng Yi Zhou Yixin Hou Qun Zhang Shue Xiong Jing Liu Liyuan Long Ruochan Chen Jinjun Chen Xiuhua Jiang Sen Luo Yuanyuan Chen Chang Jiang Jinming Zhao Liujuan Ji Xue Mei Jing Li Tao Li Rongjiong Zheng Xinyi Zhou Haotang Ren Yu Shi Hai Li for the CATCH‐LIFE Study Investigators of Chinese(Acute‐on)Chronic Liver Failure(CLIF)Consortium(Ch‐CLIFC) | 2023 | Portal Hypertension & Cirrhosis2023，2，3： | 0 |
| 8 | Enhancing cancer chemo-immunotherapy by biomimetic nanogel with tumor targeting capacity and rapid drug-releasing in tumor microenvironment显示文摘In the development of chemo-immunotherapy, many efforts have been focusing on designing suitable carriers to realize the co-delivery of chemotherapeutic and immunotherapeutic with different physicochemical properties and mechanisms of action. Besides, rapid drug release at the tumor site with minimal drug degradation is also essential to facilitate the antitumor effect in a short time. Here, we reported a cancer cell membrane-coated pH-responsive nanogel(NG@M) to co-deliver chemotherapeutic paclitaxel(PTX) and immunotherapeutic agent interleukin-2(IL-2) under mild conditions for combinational treatment of triple-negative breast cancer. In the designed nanogels, the synthetic copolymer PDEA-co-HP-β-cyclodextrin-co-Pluronic F127 and charge reversible polymer dimethylmaleic anhydride-modified polyethyleneimine endowed nanogels with excellent drug-loading capacity and rapid responsive drug-releasing behavior under acidic tumor microenvironment. Benefited from tumor homologous targeting capacity, NG@M exhibited 4.59-fold higher accumulation at the homologous tumor site than heterologous cancer cell membrane-coated NG. Rapidly released PTX and IL-2 enhanced the maturation of dendritic cells and quickly activated the antitumor immune response in situ, followed by prompted infiltration of immune effector cells. By the combined chemo-immunotherapy, enhanced antitumor effect and efficient pulmonary metastasis inhibition were achieved with a prolonged median survival rate(39 days). | Lihuan Shang Xue Jiang Ting Yang Hongbo Xu Qi Xie Mei Hu Conglian Yang Li Kong Zhiping Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 0 |
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