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| 1 | BZR1 Family Transcription Factors Function Redundantly and Indispensably in BR Signaling but Exhibit BRI1-Independent Function in Regulating Anther Development in Arabidopsis显示文摘BRASSINAZOLE-RESISTANT 1 family proteins(BZRs)are central transcription factors that govern brassinosteroid(BR)-regulated gene expression and plant growth.However,it is unclear whether there exists a BZR-independent pathway that mediates BR signaling.In this study,we found that disruption of all BZRs in Arabidopsis generated a hextuple mutant(bzr-h)displaying vegetative growth phenotypes that were almost identical to those of the null mutant of three BR receptors,bri1brl1brl3(bri-t).By RNA sequencing,we found that global gene expression in bzr-h was unaffected by 2 h of BR treatment.The anthers of bzr-h plants were loculeless,but a similar phenotype was not observed in bri-t,suggesting that BZRs have a BR signaling-independent regulatory role in anther development.By real-time PCR and in situ hybridization,we found that the expression of SPOROCYTELESS(SPL),which encodes a transcription factor essential for anther locule development,was barely detectable in bzr-h,suggesting that BZRs regulate locule development by affecting SPL expression.Our findings reveal that BZRs are indispensable transcription factors required for both BR signaling and anther locule development,providing new insight into the molecular mechanisms underlying the microsporogenesis in Arabidopsis. | Lian-Ge Chen Zhihua Gao Zhiying Zhao Xinye Liu Yongpeng Li Yuxiang Zhang Xigang Liu Yu Sun Wenqiang Tang | 2019 | Molecular Plant2019，12，10： | 11 |
| 2 | IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity显示文摘Obesity and associated metabolic diseases are characterized by a chronic low-grade inflammatory state with the infiltration of many inflammatory cells,especially macrophages.Immune molecules,including some cytokines,have a close relationship with metabolism.Interleukin(IL)-25 is a member of the IL-17 cytokine family that can regulate macrophages and alleviate some metabolic dysfunction;however,its role and mechanisms in lipid metabolism remain to be extensively clarified.Human serum and liver biopsy specimens,high-fat diet-induced obesity mice and DB/DB(Lepr−/−)animal models were used to examine IL-25 expression in obesity and nonalcoholic fatty liver diseases(NAFLD).To observe the role of IL-25 in lipid metabolism,model mice were administered with IL-25 or adoptively transferred with IL-25-educated macrophages in vivo,whereas bone marrow-derived macrophages,the macrophage cell line RAW264.7 and adipocytes differentiated from 3T3-L1 were used in vitro.IL-25 was decreased in NAFLD patients and obese mice.In addition,IL-25 reduced body weight gain and lipid accumulation,enhanced lipid uptake by macrophages and increased the expression of lipolysis andβ-oxidation enzymes via alternatively activating macrophages.IL-25 also promoted lipolysis and suppressed lipogenesis in adipocytes co-cultured with the IL-25-educated macrophages.Furthermore,IL-25 improved the mitochondrial respiratory capacity and oxygen consumption rate of macrophages and produced more NAD+/NADH and ATP.In conclusion,IL-25 can stimulate M2 macrophage polarization and thereby promote lipolysis and mitochondrial respiratory capacity,highlighting the potential for IL-25 to be used as a therapeutic agent against obesity and associated metabolic syndromes. | Juan Feng Lingyi Li Zhiying Ou Qiao Li Baoyong Gong Zhenxian Zhao Weiwei Qi Ti Zhou Jun Zhong Weibin Cai Xia Yang Aiping Zhao Guoquan Gao Zhonghan Yang | 2018 | Cellular & Molecular Immunology2018，15，5： | 10 |
| 3 | Application of Improved Multi-Objective Ant Colony Optimization Algorithm in Ship Weather Routing显示文摘This paper presents a novel intelligent and effective method based on an improved ant colony optimization(ACO)algorithm to solve the multi-objective ship weather routing optimization problem,considering the navigation safety,fuel consumption,and sailing time.Here the improvement of the ACO algorithm is mainly reflected in two aspects.First,to make the classical ACO algorithm more suitable for long-distance ship weather routing and plan a smoother route,the basic parameters of the algorithm are improved,and new control factors are introduced.Second,to improve the situation of too few Pareto non-dominated solutions generated by the algorithm for solving multi-objective problems,the related operations of crossover,recombination,and mutation in the genetic algorithm are introduced in the improved ACO algorithm.The final simulation results prove the effectiveness of the improved algorithm in solving multi-objective weather routing optimization problems.In addition,the black-box model method was used to study the ship fuel consumption during a voyage;the model was constructed based on an artificial neural network.The parameters of the neural network model were refined repeatedly through the historical navigation data of the test ship,and then the trained black-box model was used to predict the future fuel consumption of the test ship.Compared with other fuel consumption calculation methods,the black-box model method showed higher accuracy and applicability. | ZHANG Guangyu WANG Hongbo ZHAO Wei GUAN Zhiying LI Pengfei | 2021 | Journal of Ocean University of China2021，20，1： | 7 |
| 4 | Clinical diagnosis and treatment of alpha-fetoprotein-negative small hepatic lesions显示文摘Objective: We examined 103 cases over the last five years and discussed diagnosis and treatment of alpha- fetoprotein (AFP)-negative small hepatic lesions. Background: Small hepatic lesions (less than 2 cm in diameter) usually have no typical imaging characteristics and therefore are difficult to diagnose, especially when AFP tests provide a negative result. Methods: A total of 103 patients with AFP-negative small hepatic lesions from January 2003 to December 2008 were retrospectively reviewed. Differential diagnosis was performed by digital subtraction angiography (DSA), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), contrast-enhanced ultrasound (CEUS), or positron emission tomography-computed tomography (PET-CT) based on the multiplicity of lesions. Ninety-four patients with suspected cancers underwent partial hepatectomy. Clinical data were collected from hospital records and follow-up questionnaires. Results: Hepatocellular carcinoma (HCC) diagnostic sensitivity of DSA, DCE-MRI, CEUS and PET-CT was 88.2%, 93.9%, 88.9% and 88.9%, respectively. The surgery-related complication rate was 6.4%. Prognosis was good, with 1- and 3-year survival rates of 98.8% and 76.1%, respectively. Conclusions: DSA, DCE-MRI, CEUS and PET-CT are valuable for diagnosis of small hepatic lesions. Partial hepatectomy is a preferred surgical procedure. Surgery for small liver cancers usually has little risk and good prognosis, therefore it can be actively applied in suspected HCC cases. | Yiyao Xu Xin Lu Yilei Mao Xinting Sang Haitao Zhao Shunda Du Haifeng Xu Yongliang Sun Huayu Yang Tianyi Chi Zhiying Yang Shouxian Zhong Jiefu Huang | 2013 | Chinese Journal of Cancer Research2013，25，4： | 6 |
| 5 | Experimental and modeling study of NO emission under high CO_2 concentration显示文摘An experimental and numerical study of the NOx formation and reduction process in a designed coal combustion furnace under both traditional air atmosphere and O2/CO2 atmosphere was conducted, in an attempt to explore the chemistry mechanism of the experimentally observed NOx suppression under high CO2 concentration atmospheres. A simplified ‘chemically oriented’ approach, computational fluid dynamics (CFD)-chemical kinetics modeling method, was validated and used to model the experimental process. The high CO2 concentration’s chemical effect on NO reduction has been studied, and the differences in NOx reaction behaviors between O2/CO2 atmosphere and air atmosphere were analyzed by detailed chemical kinetic model. On the basis of investigations through elementary chemical reactions, it can be concluded that high CO2 concentration plays an important role on NOx conversion process during oxy-fuel combustion. Moreover, the dominant reaction steps and the most important reactions for NO conversion under different atmospheres were discussed. Under O2/CO2 atmosphere, the main active sequence for NO reaction includes: NO→N→N2, and the main active path for NO reaction under air atmosphere is through N2→N→NO. | ZHAO Ran, LIU Hao, HU Han, ZHONG XiaoJiao, WANG ZiJian, XU ZhiYing & QIU JianRong State Key Laboratory of Coal Combustion, Huazhong University of Science and Technology, Wuhan, 430074, China | 2010 | Science China(Technological Sciences)2010，53，12： | 4 |
| 6 | Analysis of three echo-trainings of a rainstorm in the South China warm region显示文摘 | Zhiying DING Lei QIAN Xiangjun ZHAO Fan XIA | 2018 | Frontiers of Earth Science2018，12，2： | 3 |
| 7 | Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases显示文摘 | Tan Jiping Li Nan Gao Jing Guo Yuhe Hu Wei Yang Jinsheng Yu Baocheng Yu Jianmin Du Wei Zhang Wenjun Cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan Deng Ruixiang Dai Wenguang Yi Fang Chen Wenjun Zhang Yongqing Xue Shenwu Cui Bo Zhao Yiming Wang Luning | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 8 | Capacitive micromachined ultrasonic transducer as a resonant temperature sensor显示文摘Resonant temperature sensors have drawn considerable attention for their advantages such as high sensitivity,digitized signal output and high precision.This paper presents a new type of resonant temperature sensor,which uses capacitive micromachined ultrasonic transducer(CMUT)as the sensing element.A lumped electro-mechanical-thermal model was established to show its working principle for temperature measurement.The theoretical model explicitly explains the thermally induced changes in the resonant frequency of the CMUT.Then,the finite element method was used to further investigate the sensing performance.The numerical results agree well with the established analytical model qualitatively.The numerical results show that the resonant frequency varies linearly with the temperature over the range of 20℃to 140℃ at the first four vibrating modes.However,the first order vibrating mode shows a higher sensitivity than the other three higher modes.When working at the first order vibrating mode,the temperature coefficient of the resonance frequency(TCf)can reach as high as-1114.3 ppm/℃ at a bias voltage equal to 90%of the collapse voltage of the MCUT.The corresponding nonlinear error was as low as 1.18%.It is discovered that the sensing sensitivity is dependent on the applied bias voltages.A higher sensitivity can be achieved by increasing the bias voltages. | LI Zhikang Rahman hebibul ZHAO Libo YE Zhiying ZHAO Yulong JIANG Zhuangde | 2014 | Instrumentation2014，1，3： | 3 |
| 9 | Variation of the Vaginal Microbiome During and After Pregnancy in Chinese Women显示文摘A comprehensive profiling of the vaginal microbial communities and their variability enables an accurate description of the microbiome in women.However,there is a lack of studies available on Chinese women.In the present study,the composition of the vaginal microbiota during pregnancy and the 6-week postpartum period of 454 Chinese women was characterized by sequencing the V3-V4 region of the 16S ribosomal RNA(rRNA)gene.The vaginal microbiome showed variations during pregnancy and the postpartum period based on the abortion history,hypertensive disorders,delivery mode,and maternal age.Co-variation of 22 bacterial taxa,including the Lactobacillus genus and two of its species,may account for the common characteristics of the vaginal microbiome under scenarios of different medical histories and pregnancy outcomes.In contrast,discriminant bacterial species were significantly different between women who had preterm birth(PTB)with and without premature rupture of membranes(PROM),and the community state type(CST)IV-A without any predominant Lactobacillus species in the microbiota was more prevalent during pregnancy in the PROM-PTB cases,suggesting that specific bacterial species could be considered to distinguish between different types of PTB.By providing data on Chinese women,this study will enrich the knowledge of the human microbiome and contribute to a better understanding of the association between the vaginal microbiome and reproductive health. | Xiaoai Zhang Qingzhi Zhai Jinfeng Wang Xiuling Ma Bo Xing Hang Fan Zhiying Gao Fangqing Zhao Wei Liu | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 2 |
| 10 | A point-based rendering approach for real-time interaction on mobile devices显示文摘Mobile device is an important interactive platform. Due to the limitation of computation, memory, display area and energy, how to realize the efficient and real-time interaction of 3D models based on mobile devices is an important research topic. Considering features of mobile devices, this paper adopts remote rendering mode and point models, and then, proposes a transmission and rendering approach that could interact in real time. First, improved simplification algorithm based on MLS and display resolution of mobile devices is proposed. Then, a hierarchy selection of point models and a QoS transmission control strategy are given based on interest area of operator, interest degree of object in the virtual environment and rendering error. They can save the energy consumption. Finally, the rendering and interaction of point models are completed on mobile devices. The experiments show that our method is efficient. | LIANG XiaoHui ZHAO QinPing HE ZhiYing XIE Ke LIU YuBo | 2009 | Science in China(Series F)2009，52，8： | 2 |
| 11 | Establishment of Real-time Fluorescent RT-LAMP Detection Method for Grouper Nervous Necrosis Virus显示文摘Nervous necrosis virus( NNV) is the causative agent of fulminant infectious diseases in marine fishes such as grouper. Specific primers were designed based on the conserved sequence of capsid protein( CP) gene of red-spotted grouper nervous necrosis virus( NNV). By optimizing the reaction conditions,a rapid and simple reverse transcription loop-mediated isothermal amplification( RT-LAMP) method was established for NNV detection. After adding SYTO-9 fluorescent dye in the reaction system,the amplification curve was monitored in real time using a fluorescence detector,and the result was obviously easy to assess. Moreover,the specificity and sensitivity of the established method was analyzed. The results showed that the established RT-LAMP method has good specificity with a detection limit of 1. 3 pg/μl. The detection sensitivity of the established RT-LAMP method is 100 times that of the conventional RT-PCR method,and the detection duration is only 40 min. The established RT-LAMP method is suitable for quarantine and rapid detection of grouper nervous necrosis virus. | Zhiying ZHAO Lirong BAI | 2018 | Agricultural Biotechnology2018，7，4： | 2 |
| 12 | Starch digestibility and the estimated glycemic score of different types of rice differing in amylose contents显示文摘 | Peisong Hu Haijun Zhao Zhiying Duan Zhang Linlin Dianxing Wu | 2004 | Journal of Cereal Science2004，，3： | 1 |
| 13 | A novel C-type lectin from the shrimp Litopenaeus vannamei possesses anti white spot syndrome virus activity显示文摘 | Zhao Zhiying Yin Zhixin Xu Xiaopeng | 2009 | J ViroI2009，83，1： | 1 |
| 14 | Thiophene and naphthalene-based double helix:Synthesis,structures and chirality显示文摘Both racemate and enantiomer of a novel double helix,binaphthylcyclooctaterthiophene(BN-COTh),which is a DNA-like molecule constructed by two single helices intertwined with each other via covalent bonds,have been synthesized with two building blocks,cycloocta-tetrathiophene(COTh) and cyclooctadinaphthyldithiophene(CONT) fused together via Negishi coupling reaction.Another homologue,dinaphthylcyclooctaterthiophene(DN-COTh) has been employed together as a model compound.Besides the synthetic work,BN-COTh and DN-COTh have been investigated by studying their crystal structures,spectroscopic behaviors,chiral resolution and chiral characteristics,including circular dichroism(CD) spectra and optical rotations.In addition,the novel crystal of enantiomer of(R,R,R)-BN-COTh has been explored.The enantiomer molecules packing along b-axis to form a larger and extended assembly packing due to intermolecular interactions between the enantiomer molecules and chloroform molecules in crystal. | Chunmei Zhao Zhiying Ma Chunli Li Li Xu Hua Wang | 2021 | Chinese Chemical Letters2021，32，1： | 1 |
| 15 | Effects of Temperature and pH on Embryonic Development and Survival Rate of Newly Hatched Larvae of Epinephelus fuscoguttatus显示文摘The effects of temperature and pH on embryonic development and survival rate of newly hatched larvae of Epinephelus fuscoguttatus were discussed by single factor experiment method.Under a salinity of 31‰,fertilized eggs were incubated at different temperatures( 17,20,23,26,29( control),32,35 ℃) and different pH values( 5.5,6.0,6.5,7.0,7.5,8.0,8.4( control),8.5,9.0,9.5 and 10.0),the development rate of fertilized eggs,hatching rate,deformity rate,survival rate of newly hatched larvae,and optimum temperature and pH ranges for embryonic development were recorded and analyzed.The results showed that the incubation period y required by fertilized eggs was in remarkably negative correlation with temperature x,y = 4 017.3x^(-1.527 7),R^2= 0.971 3.At 29 ℃,the hatching rate was the highest,up to 92.00%; this temperature was corresponding to the lowest deformity rate of newly hatched larvae( 1.09%); corresponding effective accumulative temperature was also the lowest( 437.410 ℃·h),and significantly different from other experimental groups( P < 0.05); but on the contrary,corresponding survival rates at 24 and 48 h reached,respectively,88.03% and 82.97% which were significantly different from other experimental groups( P <0.05).At the pH of 8.4 in the CK group and the pH of 8.5 of one experimental group,the embryonic development rates were the highest; corresponding hatching rates of fertilized eggs were the highest,respectively,of 88.33% and 83.33% which were significantly different from other groups( P < 0.05); and corresponding survival rates at 24 and 48 h were the highest,and reached 90.84% and 85.03%,respectively.In the pH range of 8.0- 8.5,the deformity rate of newly hatched larvae was 0.It was indicating that for embryonic development of E.fuscoguttatus,the suitable water temperature value was in the range of 17- 29 ℃,the optimum value was in the range of 23- 29℃; and the suitable pH value was in the range of 6.5- 9.5,and the optimum value was in the range of 8.0- 8.5. | Lirong BAI Zhiying ZHAO | 2016 | Agricultural Biotechnology2016，5，5： | 1 |
| 16 | Evaluation of the antioxidant activity of blueberry ethanol extracts under microwave extraction显示文摘Blueberry extract contains diversiform monomers of anthocyanins, whose antioxidant activity determines the functionality of anthocyanidins and the efficacy of extraction technology. The evaluation of the antioxidant activity of anthocyanidins of blueberry ethanol extracts (BEE) was investigated by considering the monomers' identification and thermal degradation in microwave-assisted extraction (MAE). Thirteen monomers of anthocyanins were identified from the extracts of blueberry under MAE, where the highest content was for cyanidin glycosides, and the lowest content was for the malvidin glycosides. The onset temperatures of degradation for anthocyanidins monomers in BEE were 41.07°C-48.50°C, and the glycoside contents of delphinidin, cyanidin, petunidin, peonidin, peonidin, and malvidin, in turn, decreased obviously. The degradation of anthocyanidins with extraction temperature improved, other than weakened, its antioxidant activities in BEE under MAE. The research results may provide valuable guidance for the antioxidant application of extracts from blueberries. | Chenghai Liu Xinglong Zhao Zhen Wang Xianzhe Zheng Liangliang Xue Chai Liu Zhiying Chen Bingfang Zhang | 2022 | International Journal of Agricultural and Biological Engineering2022，15，4： | 1 |
| 17 | Recommendations for the diagnosis and treatment of paroxysmal kinesigemc dyskinesia: an expert consensus in China显示文摘Paroxysmal dyskinesias are a group of neurological diseases characterized by intermittent episodes of involuntary movements with different causes.Paroxysmal kinesigenic dyskinesia(PKD)is the most common type of paroxysmal dyskinesia and can be divided into primary and secondary types based on the etiology.Clinically,PKD is characterized by recurrent and transient attacks of involuntary movements precipitated by a sudden voluntary action.The major cause of primary PKD is genetic abnormalities,and the inheritance pattern of PKD is mainly autosomal-dominant with incomplete penetrance.The proline-rich transmembrane protein 2(PRRT2)was the first identified causative gene of PKD,accounting for the majority of PKD cases worldwide.An increasing number of studies has revealed the clinical and genetic characteristics,as well as the underlying mechanisms of PKD.By seeking the views of domestic experts,we propose an expert consensus regarding the diagnosis and treatment of PKD to help establish standardized clinical evaluation and therapies for PKD.In this consensus,we review the clinical manifestations,etiology,clinical diagnostic criteria and therapeutic recommendations for PKD,and results of genetic analyses in PKD patients performed in domestic hospitals. | Li Cao Xiaojun Huang Ning Wang Zhiying Wu Cheng Zhang Weihong Gu Shuyan Cong Jianhua Ma Ling Wei Yanchun Deng Qi Fang Qi Niu Jin Wang Zhaoxia Wang You Yin Jinyong Tian Shufen Tian Hongyan Bi Hong Jiang Xiaorong Liu Yang Lu Meizhen Sun Jianjun Wu Erhe Xu Tao Chen Tao Chen Xu Chen Wei Li Shujian Li Qinghua Li Xiaonan Song Ying Tang Ping Yang Yun Yang Min Zhang Xiong Zhang Yuhu Zhang Ruxu Zhang Yi Ouyang Jintai Yu Quanzhong Hu Qing Ke Yuanrong Yao Zhe Zhao Xiuhe Zhao Guohua Zhao Furu Liang Nan Cheng Jianhong Han Rong Peng Shengdi Chen Beisha Tang | 2021 | Translational Neurodegeneration2021，10，1： | 1 |
| 18 | Effect of Female Reproduction and Mate Choice on Sexual Size Dimorphism in the Northeast Treefrog Hyla ussuriensis (Anura:Hylidae) in China显示文摘Sexual size dimorphism(SSD) plays a significant role in understanding the evolution of life history and mating behavior. In this study,we analyzed the morphological data from a treefrog,Hyla ussuriensis,in northeastern China and found that there are significant differences between males and females. Females that are larger in body size increase fecundity as the total number of eggs is positively correlated to female body size. Males are smaller in body size due to the mate choice by females based on the size dimorphism index(SVL mean of female divided by that of male) for the population,which may be an evolutionary stable strategy(ESS). SSD can be influenced not only through mate choice,but also reproductive behavior by analyzing the female reproduction output in the field. Our data are consistent with many previous studies,indicating that fecundity selection and sexual selection may be the common cause for sexual dimorphism in this species. Furthermore,there are no significant morphological differences between mated and unmated frogs of both sexes,which suggests that any frog can obtain a breeding chance when it matures. It further indicates that males may not affect female choice except by their snout-vent length(SVL) and body mass. It is,of course,possible that females adopt a mating strategy to mate with males whose SVL and body mass are smaller than paired females. Our research provides unequivocal evidence for effective female choice and information on the evolution of SSD in the production of anuran pairing patterns. | Peng LIU Zhiying ZHANG Shuai ZHAO Wenge ZHAO | 2012 | Asian Herpetological Research2012，3，4： | 1 |
| 19 | The SACT Template:A Human Brain Diffusion Tensor Template for School-age Children显示文摘School-age children are in a specific development stage corresponding to juvenility,when the white matter of the brain experiences ongoing maturation.Dffusion-weighted magnetic resonance imaging(DWI),especially diffusion tensor imaging(DTI),is extensively used to characterize the maturation by assessing white matter properties in vivo.In the analysis of DWI data,spatial normalization is crucial for conducting inter-subject analyses or linking the individual space with the reference space.Using tensor-based registration with an appropriate diffusion tensor template presents high accuracy regarding spatial normalization.However,there is a lack of a standardized diffusion tensor template dedicated to school-age children with ongoing brain development.Here,we established the school-age children diffusion tensor(SACT)template by optimizing tensor reorientation on high-quality DTI data from a large sample of cognitively normal participants aged 6-12 years.With an age-balanced design,the SACT template represented the entire age range well by showing high similarity to the age-specific templates.Compared with the tensor template of adults,the SACT template revealed significantly higher spatial normalization accuracy and inter-subject coherence upon evaluation of subjects in two different datasets of schoolage children.A practical application regarding the age associations with the normalized DTI-derived data was conducted to further compare the SACT template and the adult template.Although similar spatial patterns were found,the SACT template showed significant effects on the distributions of the statistical results,which may be related to the performance of spatial normalization.Looking forward,the SACT template could contribute to future studies of white matter development in both healthy and clinical populations.The SACT template is publicly available now(tp://igshare com/aricles/dataseu'SACT_.template/14071283). | Congying Chu Haoran Guan Sangma Xie Yanpei Wang Jie Luo Gai Zhao Zhiying Pan Mingming Hu Weiwei Men Shuping Tan Jia-Hong Gao Shaozheng Qin Yong He Lingzhong Fan Qi Dong Sha Tao | 2022 | Neuroscience Bulletin2022，38，6： | 1 |
| 20 | Mobileterminal-oriented real-time interaction point model drawingmethod 显示文摘 | LIANG Xiaohui ZHAO Qinping HE Zhiying | 2009 | Science China Press2009，39，8： | 1 |
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