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| 1 | Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics显示文摘Background and purpose Stroke is the second leading cause of death worldwide and the leading cause of mortality and long-term disability in China,but its underlying risk genes and pathways are far from being comprehensively understood.We here describe the design and methods of whole genome sequencing(WGS)for 10914 patients with acute ischaemic stroke or transient ischaemic attack from the Third China National Stroke Registry(CNSR-III).Methods Baseline clinical characteristics of the included patients in this study were reported.DNA was extracted from white blood cells of participants.Libraries are constructed using qualified DNA,and WGS is conducted on BGISEQ-500 platform.The average depth is intended to be greater than 30×for each subject.Afterwards,Sentieon software is applied to process the sequencing data under the Genome Analysis Toolkit best practice guidance to call genotypes of single nucleotide variants(SNVs)and insertion-deletions.For each included subject,21 fingerprint SNVs are genotyped by MassARRAY assays to verify that DNA sample and sequencing data originate from the same individual.The copy number variations and structural variations are also called for each patient.All of the genetic variants are annotated and predicted by bioinformatics software or by reviewing public databases.Results The average age of the included 10914 patients was 62.2±11.3 years,and 31.4%patients were women.Most of the baseline clinical characteristics of the 10914 and the excluded patients were balanced.Conclusions The WGS data together with abundant clinical and imaging data of CNSR-III could provide opportunity to elucidate the molecular mechanisms and discover novel therapeutic targets for stroke. | Si Cheng Zhe Xu Yang Liu Jinxi Lin Yong Jiang Yilong Wang Xia Meng Anxin Wang Xinying Huang Zhimin Wang Guohua Chen Songdi Wu Zhengchang Jia Yongming Chen Xuerong Qiu Jun Wu Binbin Song Weizhong Ji Zhongping An Wenjun Xue Lili Zhao Yu Geng Hongyan Li Hao Li Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 8 |
| 2 | 3-year Treatment of Tenofovir Alafenamide vs.Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China显示文摘Background and Aims:Tenofovir alafenamide(TAF)has similar efficacy to tenofovir disoproxil fumarate(TDF)but with improved renal and bone safety in chronic hepatitis B patients studied outside of China.We report 3-year results from two phase 3 studies with TAF in China(Clinicaltrials.gov:NCT02836249 and NCT02836236).Methods:Chinese hepatitis B e antigen(HBeAg)-positive and-negative chronic hepatitis B patients with viremia and elevated alanine aminotransferase were randomized 2:1 to TAF or TDF treatment groups and treated in a double-blind fashion for 144 weeks(3 years).Efficacy responses were assessed by individual study while safety was assessed by a pooled analysis.Results:Of the 334 patients(180 HBeAg-positive and 154 HBeAg-negative)randomized and treated,baseline characteristics were similar between groups.The overall mean age was 38 years and 73%were male.The mean HBV DNA was 6.4 log10 IU/mL.The median alanine aminotransferase was 88 U/L,and 37%had a history of antiviral use.At week 144,the proportion with HBV DNA<29 IU/mL was similar among the two groups,with TAF at 83%vs.TDF at 79%,and TAF at 93%vs.TDF at 92%for the HBeAg-positive and-negative patients,respectively.In each study,higher proportions of TAF than TDF patients showed normalized alanine aminotransferase(via the American Association for the Study of Liver Diseases and the China criteria)and showed loss of HBsAg;meanwhile,the HBeAg seroconversion rates were similar.Treatment was well-tolerated among the TAF patients,who showed a smaller median decline in creatinine clearance(−0.4 vs.−3.2 mL/min;p=0.014)and less percentage change in bone mineral density vs.TDF at hip(−0.95%vs.−1.93%)and spine(+0.35%vs.−1.40%).Conclusions:In chronic hepatitis B patients from China,TAF treatment provided efficacy similar to TDF but with better renal and bone safety at 3 years. | Jinlin Hou Qin Ning Zhongping Duan You Chen Qing Xie Fu-Sheng Wang Lunli Zhang Shanming Wu Hong Tang Jun Li Feng Lin Yongfeng Yang Guozhong Gong John FFlaherty Anuj Gaggar Shuyuan Mo Cong Cheng Gregory Camus Chengwei Chen Yan Huang Jidong Jia Mingxiang Zhang GS-US-320-0110 and GS-US-320-0108 China Investigators | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 7 |
| 3 | 北斗导航系统卫星激光测距综述显示文摘Satellite laser ranging(SLR)is an unambiguous measurement technique and generates high accuracy satellite orbit data.All satellites in the BeiDou navigation satellite system(BDS)carried laser retro-reflector arrays(LRAs),so they can be tracked by ground SLR stations in order to provide the accurate observation data.The Shanghai astronomical observatory(SHAO)designed the LRAs,and also developed the dedicated SLR systems using a 1 m-aperture telescope and a transportable cabin-based SLR system with a telescopes of 60 cm aperture.These enable BDS satellite ranging during daytime and nighttime with centimeter-level precision,allowing highly accurate estimations of satellite orbits.Moreover,some of the BDS satellites are also equipped with laser time transfer(LTT)payloads,which were developed by the SHAO and China Academy of Space Technology(CAST),providing a highly accurate time comparison between the satellites and ground clocks.This paper describes the dedicated SLR system and the design of the LRAs for BDS satellites,as well as global SLR measurements.The SLR tracking data is used for evaluating the orbit accuracy of BDS satellites and broadcast ephemeris,with an accuracy of less than 1 m.The LTT measurements to BDS satellites for a single shot have a precision of approximately 300 picoseconds,with a time stability of 20 picoseconds in 500 s. | ZHANG Haifeng LONG Mingliang YANG Huafeng MENG Wendong CHENG Zhi’en DENG Huarong ZHANG Zhongping ZHANG A’li | 2020 | Aerospace China2020，21，4： | 4 |
| 4 | The progress of laser ranging technology at Shanghai Astronomical Observatory显示文摘As an important station of International Laser Ranging Service(ILRS),Shanghai Astronomical Observatory(SHAO)has upgraded Satellite Laser Ranging(SLR)system with high repetition rate and achieved some technological progress,There are a lot of improvements for overall system performance,such as annual observation passes,measurement precision and quality of observation data.SLR technology with repetition rate of 10 kHz is accomplished firstly in China,and space debris laser ranging technology with200 Hz laser is promoted and proved to be more detective for weak echo,which lead to successful measurement for 40,000 km satellites and space debris within 3000 km.At the same time,SLR based on multi-telescopes and 1064 nm wavelength are planned to make a breakthrough of detection capabilities,and also to expand its application fields.These progresses will be introduced in this paper in detail. | Zhibo Wu Haifeng Zhang Huarong Deng Mingliang Long Zhien Cheng Zhongping Zhang Wendong Meng | 2019 | Geodesy and Geodynamics2019，10，6： | 1 |
| 5 | Bilevel newsvendor models considering retailer with CVaR objective显示文摘 | Cheng Lu Wan Zhongping Wang Guangmin | 2009 | Computers & Industrial Engineering2009，57，1： | 1 |
| 6 | Prospective comparison of laparoscopic uterine artery occlusion plus myomectomy with classic intrafascial supracervical hysterectomy for symptomatic fibroid treatment:differences in post-operative quality-of-life measures显示文摘 | Mingmin Liu Zhongping Cheng Yu Zhu | 2010 | European Journal of Obstetrics and Gynecology2010，155，1： | 1 |
| 7 | cAMP-PGC1α途径诱导的抗Warburg效应驱动胶质母细胞瘤细胞分化为星形胶质细胞显示文摘文章简介多形性胶质母细胞瘤(GBM)是人类最具侵袭性的肿瘤之一。虽然分化治疗已被提出作为治疗GBM的潜在方法,但诱导分化的机制仍然很不清楚。在此,课题组利用c AMP激活剂建立了GBM诱导分化模型,该模型特异性地指导GBM分化为星形胶质细胞。 | Fan Xing Yizhao Luan Jing Cai Sihan Wu Jialuo Mai Jiayu Gu Haipeng Zhang Kai Li Yuan Lin Xiao Xiao Jiankai Liang Yuan Li Wenli Chen Yaqian Tan Longxiang Sheng Bingzheng Lu Wanjun Lu Mingshi Gao Pengxin Qiu Xingwen Su Wei Yin Jun Hu Zhongping Chen Ke Sai Jing Wang Furong Chen Yinsheng Chen Shida Zhu Dongbing Liu Shiyuan Cheng 谢志 朱文博 颜光美 | 2018 | 科学新闻2018，0，4： | 1 |
| 8 | A Rat Surgical Model of Esophageal Metaplasia and Adenocarcinoma-Induced by Mixed Reflux of Gastric Acid and Duodenal Contents显示文摘 | Tao Zhang Feng Zhang Yong Han Zhongping Gu Yong’an Zhou Qingshu Cheng Yifang Zhu Chuanshan Zhang Yunjie Wang | 2007 | Digestive Diseases and Sciences2007，，11： | 1 |
| 9 | An in vitro cellular system modelling progressive human adipose-derived stem cell aging显示文摘Adipose-derived stem cells (ADSCs) assume essential roles intissue homeostasis and aging and have been explored as regenera-tive therapies for a broad range of diseases including physiologicaland pathological aging [1 ]. These multipotent cells are plastic, cap-able to differentiate and transdifferentiate to a range of cell types[2]. With aging, diseases and inundergo cellular senescence [3].vitro passing, ADSCs decline andFor therapies, typically cells fromyoung adults before 5-8 passages should be used, posing majorobstacles for conditions requiring much more cells [4]. | Yanghua Shi Lian Wang Yichang Li Congdi Xu Xiaowen Shao Zhongping Cheng Mei Jiang Jiajing Cheng Jun Xu Jianxing Song Xiuli Wang Zhengliang Gao | 2018 | Science Bulletin2018，63，5： | 0 |
| 10 | Design and analysis of the Macao Science Satellite-1's laser retro-reflector array显示文摘The origin and spatial-temporal variation of the Earth’s magnetic field(EMF)is one of the important scientific problems that has long been unsolved.The Macao Science Satellite-1(MSS-1)under construction is China’s first high-precision EMF measurement satellite.To satisfy the highly precise requirements of the MSS-1 orbit measurement,a light,high-precision,four-prism laser retroreflector array was designed.It weighs approximately 285 g,its effective reflection area is greater than 1.77 cm^(2),and its size is 100×100×41 mm.The laser retro-reflector array has excellent performance,and it can achieve a ranging precision at the subcentimeter level for satellite laser ranging.It will be developed and installed on the MSS-1 as a power-free load for high-precision orbit measurement and accurate orbit calibration.The MSS-1 is planned to be brought into the International Laser Ranging Service observations.More than 31satellite laser ranging stations in the International Laser Ranging Service around the world will be able to measure the MSS-1 with long arcs,which will support the scientific mission of high-precision EMF exploration. | ZhiEn Cheng Kai Tang ZhongPing Zhang HaiFeng Zhang Pu Li MingLiang Long | 2023 | Earth and Planetary Physics2023，7，1： | 0 |
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