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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | 柑桔黄龙病的鉴定和柯赫氏定理(英文)显示文摘黄龙(梢)病被认为是世界柑橘生产上的毁灭性病害已超过一个世纪,但该病害的病原学至今还没有清晰地建立起来。根据16S rRNA基因序列分析,一组被称为'Candidatus Liberibacter species'的难培养细菌被认为与黄龙病相关。然而,要确定'Ca.Liberibacter spp.'是黄龙病病原的柯赫氏定理并没有真正完成。令我们担忧的是,近年来有些文献频频指出'Ca.Liberibacter spp.'是黄龙病的病原,其实该细菌与柑橘寄主的直接病理反应还没有完全确定。我们建议,在黄龙病病原学清楚之前,文献报道在这方面需要有准确的阐述。 | Chen J Deng X Civerolo E L Lee R F Jones J B Zhou C Hartung J S Manjunath K L Brlansky R H | 2011 | 植物病理学报2011，41，2： | 10 |
| 4 | A Quartz Crystal Embedded Split Hopkinson Pressure Bar for Soft Materials 显示文摘 | Chen W Lu F Zhou B | 2000 | Experimental Mechanics2000，40，1： | 2 |
| 5 | Magnetic texture in Fe nanowire array显示文摘 | Wang J B Zhou X Z Liu Q F | 2004 | Nanotecnology2004，15，： | 2 |
| 6 | Butyltin accumulation in the marine clam Mya arenaria: An evaluation of its suitability for monitoring butyltin pollutin 显示文摘 | YANG R Q ZHOU Q F JIANG G B | 2006 | Chemosphere2006，63，： | 1 |
| 7 | Electrodeposition of metallic nanowire thin films using, mesoporous silica templates显示文摘 | Wano D H Zhou W L McCaughv B F | 2003 | Adv Mater2003，15，2： | 1 |
| 8 | Anodic dissolution of spongy titanium in ethanol solution for preparation of nano-sized Tio2 powder显示文摘 | Zhou X F Chu D B Lin C J | 2002 | Electrochim Acta2002，47，： | 1 |
| 9 | A Study of the Ce3+/Ce4+ Redox Couple in Sulfamic Acid for Redox Battery Application 显示文摘 | Xiong F J Zhou D B Xie Z P | 2012 | Appl Energy2012，99，： | 1 |
| 10 | Comparative study of photodynamic therapy with 5%,10% and 20% aminolevulinic acid in the treatment of generalized recalcitrant facial verruca plana:a randomized clinical trial显示文摘 | Li Q Jiao B Zhou F | 2013 | J Eur Acad Dermatol Venereol2013，25，： | 1 |
| 11 | 2013, Antigenic and genetic characterization of a European avian-like H1N1 swine influenza virus from a boy in China in 2011显示文摘 | Qi x Cui L Jiao Y Pan Y Li X Zu R Huo X Wu B Tang F Song Y Zhou M Wang H Cardona C J Xing Z | 2013 | Archives of Virology2013，158，1： | 1 |
| 12 | Preparation and properties of novel inherent flame-retardant cyclotriphosphazene-containing epoxy resins 显示文摘 | Liu F F Wei H Huang X B Zhang J W Zhou Y B Tang X Z | 2010 | Journal of Macromolecular Science Part B: Physics2010，49，5： | 1 |
| 13 | Amyloid-显示文摘 | ZHANG Y ZHOU B ZHANG F | 2012 | Diabetes2012，61，6： | 1 |
| 14 | Atom-bond connectivity index of graphs显示文摘 | Xing R Zhou B Dong F | 2011 | Discrete Appl Math2011，159，： | 1 |
| 15 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 16 | Influence of the coexisting contaminants on bisphenol A sorption and desorption in soil 显示文摘 | Li J H Zhou B X Liu Y Q Yang Q F Cai W M | 2008 | Journal of Hazardous Materials2008，151，23： | 1 |
| 17 | Comtraints on the depth,geometry and kinematics of blind detachment faults provided by fault propagation folds:an example from the Mesozoic fold belt of South China显示文摘 | Yan D P Zhang B Zhou M F | 2009 | journal of Structural Geology2009，31，： | 1 |
| 18 | Improved stability of OLEDs with mild oxygen plasma treated PEDOT: PSS 显示文摘 | Zhou Y F Yuan Y B Cao L F | 2007 | Luminescence2007，122，123： | 1 |
| 19 | Risk factors for cervical canaer in China: a case-control study显示文摘 | Cai H B Ding X H Zhou Y F | 2008 | Eur J Gynaecol Oncol2008，29，1： | 1 |
| 20 | Energy and emission scenarios for China in the 21st century exploration of baseline development and mitigation options 显示文摘 | Vuuren D Zhou F Q Vries B | 2003 | Energy Policy2003，31，4： | 1 |
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