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| 1 | An XA21-Associated Kinase (OsSERK2) Regulates Immunity Mediated by the XA21 and XA3 Immune Receptors显示文摘米饭 XA21 有免疫力的受体 kinase 和在结构上联系了 XA3 受体授与免疫到 Xanthomonas oryzae pv。oryzae (Xoo ) ,细菌的叶老家的原因的代理人。这里,我们报导 OsSERK2 的隔离(米饭体的 embryogenesis receptorkinase 2 ) 并且证明 OsSERK2 断然调整免疫由 XA21 和 XA3 以及米饭免疫者 receptorFLS2 (OsFLS2 ) 调停了。为 OsSerk2 显示的瑞斯植物 silenced 改变了形态学并且把敏感归结为荷尔蒙 brassinolide。OsSERK2 在酵母与每有免疫力的受体的 intracellulardomains 交往以一种 kinase 活动依赖者方式的二混血儿的系统。OsSERK2 在 vitro 与 XA21 经历 bidirectionaltransphosphorylation 并且在 vivo 与 XA21 形成组成的建筑群。这些结果在三米饭免疫者受体的功能为 OsSERK2 表明一个必要角色并且建议和米饭免疫者受体的 thatdirect 相互作用为他们的功能是批评的。一起拿,我们的调查结果建议米饭 XA21, XA3,和 FLS2 的反省 OsSERK2 的规定的 thatthe 机制不同于 AtSERK3/BAK1-mediated regulationof Arabidopsis FLS2 和 EFR.Key 词的: | Xuewei Chena Shimin Zuo Benjamin Schwessinger Mawsheng Chern Patrick E. Canlas Deling Ruan Xiaogang Zhou Jing Wang Arsalan Daudi Christopher J. Petzold Joshua L. Heazlewood Pamela C. Ronald | 2014 | Molecular Plant2014，7，5： | 17 |
| 2 | OsSERK1 regulates rice development but not immunity to Xanthomonas oryzae pv. oryzae or Magnaporthe oryzae显示文摘Somatic embryogenesis receptor kinase(SERK)proteins play pivotal roles in regulation of plant development and immunity. The rice genome contains two SERK genes,OsSerk1 and OsSerk2. We previously demonstrated that OsSerk2 is required for rice Xa21-mediated resistance to Xanthomonas oryzae pv. oryzae(Xoo) and for normal development. Here we report the molecular characterization of OsSerk1. Overexpression of OsSerk1 results in a semi-dwarf phenotype whereas silencing of OsSerk1 results in a reduced angle of the lamina joint. OsSerk1 is not required for rice resistance to Xoo or Magnaporthe oryzae. Overexpression of Os Serk1 in OsSerk2-silenced lines complements phenotypes associated with brassinosteroid(BR) signaling defects, but not the disease resistance phenotype mediated by Xa21. In yeast, OsSERK1 interacts with itself forming homodimers, and also interacts with the kinase domains of OsSERK2 and BRI1, respectively.OsSERK1 is a functional protein kinase capable of auto-phosphorylation in vitro. We conclude that, whereas OsSERK2 regulates both rice development and immunity, OsSERK1 functions in rice development but not immunity to Xoo and M. oryzae. | Shimin Zuo Xiaogang Zhou Mawsheng Chen Shilu Zhang Benjamin Schwessinger Deling Ruan Can Yuan Jing Wang Xuewei Chen Pamela C.Ronald | 2014 | Journal of Integrative Plant Biology2014，56，12： | 4 |
| 3 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 4 | A chaos genetic algorithm for optimizing an artificial neural network of predicting silicon content in hot metal显示文摘A genetic algorithm based on the nested intervals chaos search (NICGA) has been given. Because the nested intervalschaos search is introduced into the NICGA to initialize the population and to lead the evolution of the population, the NICGA has theadvantages of decreasing the population size, enhancing the local search ability, and improving the computational efficiency and op-timization precision. In a multi-layer feed forward neural network model for predicting the silicon content in hot metal, the NICGAwas used to optimize the connection weights and threshold values of the neural network to improve the prediction precision. The ap-plication results show that the precision of predicting the silicon content has been increased. | Deling Zheng, Ruixin Liang, Ying Zhou, and Ying WangInformation Engineering School, University of Science and Technology Beijing, Beijing 100083, China | 2003 | Journal of University of Science and Technology Beijing2003，10，2： | 3 |
| 5 | The “1-3-7” Approach to Malaria Surveillance and Response--Henan Province, China, 2012−2018显示文摘What is already known about this topic?The“1-3-7”approach to malaria surveillance and response was a key measure for malaria elimination in China and was first introduced into the World Health Organization(WHO)as an international guideline for malaria surveillance and response in 2018.What is added by this report?The“1-3-7”approach was well implemented in Henan Province from 2012−2018.Over this study period,a total of 1,294 malaria cases were detected and reported,and all cases were diagnosed and reported within 1 day with 99.23%(1,284/1,294)of cases were investigated within 3 days.In addition,93.7%(1,212/1,294)of foci were investigated and vector control was implemented within 7 days at all residual non-active foci to prevent further spread.What are the implications for public health practice?The“1-3-7”controlling pattern would be an effective and approachable method for implementation especially in malaria-eliminating countries and regions,but the interval from symptom onset to diagnosis cannot be ignored.Thus,the roles and responsibilities that all actors involved in the health sector must be specified too. | Qunqun Zhang Ying Liu Yabo Hu Yuling Zhao Chengyun Yang Dan Qian Ruimin Zhou Suhua Li Zhou Guan Deling Lu Hongwei Zhang Wanshen Guo | 2020 | China CDC weekly2020，2，17： | 3 |
| 6 | Self-assembled PEG-b-PDPA-b-PGEM copolymer nanoparticles as protein antigen delivery vehicles to dendritic cells:preparation,characterization and cellular uptake显示文摘Antigen uptake by dendritic cells(DCs)is a key step for initiating antigen-specific T cell immunity.In the present study,novel synthetic polymeric nanoparticles were prepared as antigen delivery vehicles to improve the antigen uptake by DCs.Well-defined cationic and acid-responsive copolymers,monomethoxy poly(ethylene glycol)-block-poly(2-(diisopropyl amino)ethyl methacrylate)-block-poly(2-(guanidyl)ethyl methacrylate)(mPEG-b-PDPA-b-PGEM,PEDG)were synthesized by reversible addition-fragmentation chain transfer polymerization of 2-(diisopropylamino)ethyl methacrylate and N-(tert-butoxycarbonyl)amino ethyl methacrylate monomers,followed by deprotection of tert-butyl protective groups and guanidinylation of obtained primary amines.1H NMR,13C NMR and GPC results indicated the successful synthesis of well-defined PEDG copolymers.PEDG copolymers could self-assemble into nanoparticles in aqueous solution,which were of cationic surface charges and showed acid-triggered disassembly contributed by PGEM and PDPA moieties,respectively.Significantly,PEDG nanoparticles could effectively condense with negatively charged model antigen ovalbumin(OVA)to form OVA/PEDG nanoparticle formulations with no influence on its secondary and tertiary structures demonstrating by far-UV circular dichroism and UV-vis spectra.In vitro antigen cellular uptake by bone marrow DCs(BMDCs)indicated using PEDG nanoparticles as antigen delivery vehicles could significantly improve the antigen uptake efficiency of OVA compared with free OVA or the commercialized Alum adjuvant.Moreover,as the surface cationic charges of OVA/PEDG nanoparticle formulations reduced,the uptake efficiency decreased correspondingly.Collectively,our work suggests that guanidinylated,cationic and acid-responsive PEDG nanoparticles represent a new kind of promising antigen delivery vehicle to DCs and hold great potential to serve as immunoadjuvants in the development of vaccines. | Pan Li Junhui Zhou Pingsheng Huang Chuangnian Zhang Weiwei Wang Chen Lia Deling Kong | 2017 | Regenerative Biomaterials2017，4，1： | 2 |
| 7 | Stabilization of Chaotic Time Series by Proportional Pulse in the System Variable Based on Genetic Algorithm显示文摘The PPSV (Proportional Pulse in the System Variable) algorithm is a convenient method for the stabilization of the chaotic time series. It does not require any previous knowledge of the system. The PPSV method also has a shortcoming, that is, the determination off. is a procedure by trial and error, since it lacks of optimization. In order to overcome the blindness, GA (Genetic Algorithm), a search algorithm based on the mechanics of natural selection and natural genetics, is used to optimize the λi The new method is named as GAPPSV algorithm. The simulation results show that GAPPSV algorithm is very efficient because the control process is short and the steady-state error is small. | Qing Li Deling Zheng Jianlong Zhou(Information Engineering School, University of Science and Technology Beijing, Beijing 100083, China)(Handan iron and Steel Co., Handan 056015, China) | 1999 | International Journal of Minerals,Metallurgy and Materials1999，13，3： | 1 |
| 8 | A calorimetric investigation of thermodynamic and molecular mobility contributions to the physical stability of two pharmaceutical glasses显示文摘 | Zhou Deling Grant David J W Zhang Geoff G Z | 2007 | Pharm Sci2007，96，： | 1 |
| 9 | Operational Methods for Ships in Waves From Perspectives of Structure Health and Maneuvering Convenience显示文摘 | ZHOU Feng ZHOU Junwei CHEN Yuli WANG Deling | 2017 | Journal of Shipping and Ocean Engineering2017，7，3： | 0 |
| 10 | Charnockite Formation and Early Precambrian Crust Evolution in Yishui Area, Shandong Province, China显示文摘Charnockite and granulite in Yishui area, Shandong Province are located in the middle part of the Tancheng Lujiang fault zone, eastern China. Field studies have shown that the charnockites, derived from the adjacent granulites, are classified as three types: enderbite, garnet enderbite and hypersthene trondhjemite. In addition, two generations of minerals are present in the charnockites: the relic minerals such as garnet, hypersthene and clinopyroxene, and the neocrystallized minerals such as plagioclase and K feldspar. The relic minerals occurring in the granulite facies stage were affected by the later partial melting. The relic minerals, irregular and usually ragged in shape, occupy the interstitial positions in the neocrystalline minerals. The neocrystalline minerals are usually euhedral subhedral crystals. The study of petrology, mineralogy and geochemistry of charnokites concludes that the enderbite was formed by the anatexis of the two pyroxene plagioclase granulite, that the garnet enderbite was formed by the anatexis of sillimanite garnet gneiss, and that the hypersthene trondhjemite was formed by the anatexis of the leucocratic two pyroxene plagioclase granulite. The U Pb dating of the zircon indicates that the formation of the charnockite and granulite was related to the Archean Proterozoic upwelling of a mantle plume (hot spot) around 2 500 Ma, in Yishui area, Shandong Province. | Su Shangguo Zhou Xunruo Gu Deling Hu Ling Faculty of Earth Sciences and Mineral Resources, China University of Geosciences, Beijing 100083, China | 2000 | Journal of Earth Science2000，19，3： | 0 |
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