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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | 通过监测乙型肝炎患者耐药突变株比例的变化推测cccDNA的快速更新周期显示文摘【据Hepatology 2021年1月报道】题:通过监测乙型肝炎患者耐药突变株比例的变化推测ccc DNA的快速更新周期(作者Huang Q等)来自南方医科大学南方医院的孙剑教授课题组利用两项已结束的随机对照临床研究样本,以拉米夫定耐药(LAMR)突变位点—rt M204I/V作为标记,以rt M204I/V耐药株相对于野毒株的比例变化,推测ccc DNA池的更新周期。 | 陆星宇 周彬孙 HUANG Q ZHOU B CAI D | 2021 | 临床肝胆病杂志2021，37，4： | 16 |
| 3 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 4 | Magnetic texture in Fe nanowire array显示文摘 | Wang J B Zhou X Z Liu Q F | 2004 | Nanotecnology2004，15，： | 2 |
| 5 | Prospect of application of wetlands plant and root-zone in non-pointpollution treatment显示文摘 | Li G B Zhou H D Yin C Q | 2003 | China Water Resources2003，，： | 1 |
| 6 | Butyltin accumulation in the marine clam Mya arenaria: An evaluation of its suitability for monitoring butyltin pollutin 显示文摘 | YANG R Q ZHOU Q F JIANG G B | 2006 | Chemosphere2006，63，： | 1 |
| 7 | Optimization of pulse-field gel electrophoresis for subtyping of Legionella pneumophila 显示文摘 | ZHOU H J REN H Y ZHU B Q | 2010 | Appl Environ Microbiol2010，76，5： | 1 |
| 8 | Robust exponential stability for uncertain stochastic neural networks with discrete and distributed time varying delays 显示文摘 | Li H Chen B Zhou Q | 2008 | Physics Letters A2008，372，19： | 1 |
| 9 | Synthesis of Thiosemicarbazone Derivatives of Benzo-15-crown-5 and Their Anion Recognition Properties 显示文摘 | Y Q Zhou T B Wei Y M Zhang | 2008 | Phosphorus Sulfur and Silicon2008，183，6： | 1 |
| 10 | Quantitative evaluation of precipitates in an A1-Zn-Mg-Cu alloy after isothermal aging 显示文摘 | DU Z W SUN Z M SHAO B L ZHOU T T CHEN C Q | 2006 | Materials Characterization2006，56，： | 1 |
| 11 | Effect of dietary lipid level on growth performance,feed utilization and digestive enzyme of juvenile ivory shell,Babylonia areolate显示文摘 | ZHOU Q C ZHOU J B CHI S Y | 2007 | Aquaculture2007，272，1234： | 1 |
| 12 | Comparative study of photodynamic therapy with 5%,10% and 20% aminolevulinic acid in the treatment of generalized recalcitrant facial verruca plana:a randomized clinical trial显示文摘 | Li Q Jiao B Zhou F | 2013 | J Eur Acad Dermatol Venereol2013，25，： | 1 |
| 13 | IrrE, a global regulator of extreme radiation resistance inDeinococcus radiodurans, enhances salt tolerance in Escherichia coli and Brassica napus显示文摘 | Pan J Wang J Zhou Z Yan Y Zhang W Lu W Ping S Dai Q Yuan M Feng B Hou X Zhang Y Ma R Liu T Feng L Wang L Chen M Lin M | 2009 | PloS One2009，4，2： | 1 |
| 14 | High resolution and precisely dated record of weathering and hydrological dynamics recorded by manganese and rare earth elements in a stalagmite from central China 显示文摘 | Zhou H Y Chi B Q Lawrence M | 2008 | Quaternary Research2008，68，3： | 1 |
| 15 | Chelator-enhanced pH ytoextrac-tion of heavy metals from contaminated soil irrigated by industrialwastewater with the hyperaccumulator plant ( Sedum alfredii Hance )显示文摘 | SUN Y B ZHOU Q X AN J | 2009 | Geoderma2009，150，12： | 1 |
| 16 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 17 | Synthesis and Volume Phase Transition of Poly ( methacrylic and Acid - co - N - isopropylacrylamide) Microgel Particles in Water显示文摘 | Zhou S Q Chu B | 1998 | J phys chem B1998，102，： | 1 |
| 18 | Influence of the coexisting contaminants on bisphenol A sorption and desorption in soil 显示文摘 | Li J H Zhou B X Liu Y Q Yang Q F Cai W M | 2008 | Journal of Hazardous Materials2008，151，23： | 1 |
| 19 | Color removal from dye-containing wastewater by magnesium chloride显示文摘 | Gao B Y Yue Q Y Zhou W Z | 2007 | Journal of Environmental Management2007，82，2： | 1 |
| 20 | Energy and emission scenarios for China in the 21st century exploration of baseline development and mitigation options 显示文摘 | Vuuren D Zhou F Q Vries B | 2003 | Energy Policy2003，31，4： | 1 |
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