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| 1 | Biodegradation and origin of oil sands in the Western Canada Sedimentary Basin显示文摘The oil sands deposits in the Western Canada Sedimentary Basin (WCSB) comprise of at least 85% of the total immobile bitumen in place in the world and are so concentrated as to be virtually the only such deposits that are economically recoverable for conversion to oil. The major deposits are in three geographic and geologic regions of Alberta: Athabasca, Cold Lake and Peace River. The bitumen reserves have oil gravities ranging from 8 to 12° API, and are hosted in the reservoirs of varying age, ranging from Devonian (Grosmont Formation) to Early Cretaceous (Mannville Group). They were derived from light oils in the southern Alberta and migrated to the north and east for over 100 km during the Laramide Orogeny, which was responsible for the uplift of the Rocky Mountains. Biodegradation is the only process that transforms light oil into bitumen in such a dramatic way that overshadowed other alterations with minor contributions. The levels of biodegradation in the basin increasing from west (non-biodegraded) to east (extremely biodegraded) can be attributed to decreasing reservoir temperature, which played the primary role in controlling the biodegradation regime. Once the reservoir was heated to approximately 80 °C, it was pasteurized and no biodegradation would further occur. However, reservoir temperature could not alone predict the variations of the oil composition and physical properties. Compositional gradients and a wide range of biodegradation degree at single reservoir column indicate that the water-leg size or the volume ratio of oil to water is one of the critical local controls for the vertical variations of biodegradation degree and oil physical properties. Late charging and mixing of the fresh and degraded oils ultimately dictate the final distribution of compositions and physical properties found in the heavy oil and oil sand fields. Oil geochemistry can reveal precisely the processes and levels that control these variations in a given field, which opens the possibility of model-driven prediction of oil properties and sweet spots in reservoirs. | Zhou Shuqing Huang Haiping Liu Yuming | 2008 | Petroleum Science2008，5，2： | 6 |
| 2 | A thermosensitive gel formulation of an empirical traditional Chinese prescription for treating cervical erosion显示文摘Cervical eropion,a pathological change associated with chronic cervicitis,is a common condition that is difficult to cure.M any pa tients particularly those with mild or medium infection and those preparing for pregnancy require a simple but effective medication.In this study,extracts of an empirical herbal prescription composed of six Chinese traditional drugs viz Cortex Phellodendri,Rhizoma Coptidis,Olibanum,Myrrha,borneol and catechu were formulated to facilitate intravaginal administration and improve efficacy.An extract of the first four components was formulated with borneol as a thermosensitive gel(TG)while an extract of catechu used to prepare a regular gel(CG)because of a chemical incompatibility.The optimized TG was prepared using poloxamer 407 and poloxamer 188.The CG was prepared using glycerin,carbopol and triethanolamine.The gels were characterized in vitro in terms of release of berberine(TG)and total catechins(CG)and in vivo in a rat model of cervical erosion.Trea tment by once daily application of the TG for 7 days followed by once daily application of the CG for 3 days produced a restoration of normal tissues.Gel formulation of the empirical Chinese traditional remedy appears to provide a promising treatment for cervical erosion. | Shuqing Zhou Xiaoling Zheng Caihong Zheng Fan Qu Xuefen Cai Juanhua Xu | 2012 | Acta Pharmaceutica Sinica B2012，2，5： | 6 |
| 3 | Fragment Propagation and Colonization Ability Enhanced and Varied at Node Level after Escaping from Apical Dominance in Submerged Macrophytes显示文摘Aquatic plants develop strong fragment propagation and colonization ability to endure the natural disturbances. However,detailed research of ability to endure the natural disturbances has been lacking to date. Therefore,reproduction(shoot) and colonization(root) of shoot fragments of Potamogeton crispus L. with or without apices were investigated for the effect of apical dominance,and the growth of decapitated shoot fragments at three lengths(2,4,6 cm) was compared. Meanwhile,fragment propagation at levels of bud position was studied for bud position effect after escaping from apical dominance. The results showed significant increases occurred in the outgrowth of lateral branches on fragments decapitated compared with the fragments with apices,implying that apical dominance exists. Different lengths of fragments showed little difference in biomass allocations,but significant differences were noted in their propagation. Meanwhile,the effect of bud position was verified,due to the significant difference of average reproduction per node among the three length groups. Thus,the present study has made progress in the current understanding of aquatic plant dispersion among natural systems and contributes to improve methods of in vitro propagation for re-implantation purposes. | Jinhui Jiang Shuqing An Changfang Zhou Baohua Guan Zhiyi Sun Ying Cai Fude Liu | 2009 | Journal of Integrative Plant Biology2009，51，3： | 4 |
| 4 | A novel mosquito-borne reassortant orbivirus isolated from Xishuangbanna,China显示文摘Dear Editor,The genus Orbivirus,within the family Reoviridae,includes 22 virus species(King et al.,2011).They are distributed globally,but are particularly prevalent in Europe,Asia,and Africa.In addition,they can be transmitted by ticks or other hematophagous insect vectors,including Culicoides,mosquitoes,and sandflies(Belaga- | Shaozhen Xing Xiaofang Guo Xianglilan Zhang Qiumin Zhao Lingli Li Shuqing Zuo Xiaoping An Guangqian Pei Qiang Sun Shi Cheng Yunfei Wang Hang Fan Zhiqiang Mi Yong Huang Zhiyi Zhang Hongning Zhou Jiusong Zhang Yigang Tong | 2017 | Virologica Sinica2017，32，2： | 4 |
| 5 | Biomechanical analysis of the computer-assisted internal fixation of a femoral neck fracture显示文摘The number and spatial configuration of the screws will affect the stability and prognosis of the fractures.In our study,we assessed the biomechanical effects of the double-head cannulated compression screw(DhCCS)and ordinary cannulated compression screw(OCCS)for the treatment of femoral neck fractures by using computer finite element analysis.The original digital imaging and communications in medicine(DICOM)data of a proximal femur were imported into Materialise’s interactive medical image control system(MIMICS)software for modeling.Both DhCCS and OCCS 3D-models were obtained by using the 3D scan technique.Using the fracture model and internal fixation assembly model with an inverted triangle,two horizontal and vertical distribution were established in UG software.Next,the displacement and stress distribution were calculated in ANSYS software.The displacement value of the femoral head in the DhCCS group was smaller than that in the OCCS group,and the displacement value in the two horizontal groups was smaller than that in the vertical group.The stress distribution in the DhCCS group was concentrated on the screw rod at the fracture block and thread end,while only at the fracture block in the OCCS group.The stress in the horizontal group was more dispersed on the screws than that in the vertical group.DhCCS has reliable stability for the fixation of femoral neck fractures and applied in the clinical work and 2 horizontal fixation can be used when two screws are selected. | Hui Lu Hongquan Shen Shuqing Zhou Weidong Ni Dianming Jiang | 2020 | Genes & Diseases2020，7，3： | 3 |
| 6 | High-resolution azimuth estimation algorithm based on data fusion method for the vector hydrophone vertical array显示文摘To aim at the problem that the horizontal directivity index of the vector hydrophone vertical array is not higher than that of a vector hydrophone,the high-resolution azimuth estimation algorithm based on the data fusion method was presented.The proposed algorithm first employs MUSIC algorithm to estimate the azimuth of each divided sub-band signal,and then the estimated azimuths of multiple hydrophones are processed by using the data fusion technique.The high-resolution estimated result is achieved finally by adopting the weighted histogram statistics method.The results of the simulation and sea trials indicated that the proposed algorithm has better azimuth estimation performance than MUSIC algorithm of a single vector hydrophone and the data fusion technique based on the acoustic energy flux method.The better performance is reflected in the aspects of the estimation precision,the probability of correct estimation,the capability to distinguish multi-objects and the inhibition of the noise sub-bands. | CHEN Yu MENG Zhou MA Shuqing BAO Changchun | 2015 | Chinese Journal of Acoustics2015，34，3： | 3 |
| 7 | Using Geochemical Method to Distinguish Lateral Migration and Vertical Migration in Rifted Basin:A Case Study from Eastern Lujiapu Depression in the Kailu Basin,NE China显示文摘摘要:迁居分别诊断在迁居距离通常是在沙的床上的短、侧面的移植的 rifted 盆是复杂的,沿着差错的垂直移植被共存。从 GCMS 分析的量的数据使区分侧面、垂直的移植效果可能。从 Jiaolige 油矿发现的油,东方 Lujiapu 消沉与类似的成熟从单身的来源岩石被导出,它是一个理想的盒子学习迁居分别效果。在油之中的组合差别被迁居分别任何一个大部分沿着差错在沙床上或垂直地旁边地引起。微妙的成熟差别被在氮混合物上有某些影响的经典的浸透的烃参数估计。在某个成熟范围,到 alkylcarbazoles 的暴露的异构体的盾和半盾异构体的比率与迁居分别在一个相反的方向随着成熟变化,它可以隐藏迁居影响。然而,移植和成熟在 alkylated carbazoles 和 benzocarbazole 的绝对集中上有一样的效果[一]/([ 一]+[c ]) 比率,它为迁居方向评价提供一个理想的工具。在不同样品之中的连续变化在沙的床上反映增加的移植距离,当突然的变化可以显示移植水管系统的变化时。综合两 geochemical 解释并且地质抑制,不是仅仅迁居方向能被决定,而且通过沙的床的水管系统或差错能被认出。 | ZHOU Shuqing HUANG Haiping LIU Yuming | 2008 | Acta Geologica Sinica(English Edition)2008，82，3： | 3 |
| 8 | Controllable photonic spin Hall effect with phase function construction显示文摘Photonic spin Hall efect(SHE)provides new opportunities for achieving spin-based photonics applications.However,flexibly manipulating the spin-dependent sltting(SDS)of photonic SHE and imposing extra phase modulation on the two spin components are always a challenge.Here,a controllable SHE mechanism based on phase function construction is reported.It is conduded that the phases with specific functional structures performing a coordinate translation are equivalent to integrating a gradient phase to the original phases.Hence,the original phase can be used for independent phase modulation,and the gradient phase originating from the co-ordinate translation is capable of manipulating the SDS.A metasurface with Pancharatnam-Berry phase that can impose conjugate phases to the two spin components of light is fabricated to verify this mechanism.By shifing the light position,the SDS is continuously manipulated in the visible region,which is successfully used for detecting the polarization llipticity.The extra phase modulation is also performed with the original phase and thus enables measuring singular beams.It is anticipated that the controllable SHE manipulation method may open new avenues in the fields of spin photonics,optical sensing,optical communications,etc. | YANLIANG HE ZHIQIANG XIE BO YANG XUEYU CHEN JUNMIN LIU HUAPENG YE XINXING ZHOU YING LI SHUQING CHEN DIANYUAN FAN | 2020 | Photonics Research2020，8，6： | 3 |
| 9 | Methylesterification of cell-wall pectin controls the diurnal flower-opening times in rice显示文摘Flowers are the core reproductive organ of plants, and flowering is essential for cross-pollination. Diurnal flower-opening time is thus a key trait influencing reproductive isolation, hybrid breeding, and thermostability in plants. However, the molecular mechanisms controlling this trait remain unknown. Here, we report that rice Diurnal Flower Opening Time 1 (DFOT1) modulates pectin methylesterase (PME) activity to regulate pectin methylesterification levels of the lodicule cell walls, which affect lodicule swelling to control diurnal flower-opening time. DFOT1 is specifically expressed in the lodicules, and its expression gradually increases with the approach to flowering but decreases with flowering. Importantly, a knockout of DFOT1 showed earlier diurnal flower opening. We demonstrate that DFOT1 interacts directly with multiple PMEs to promote their activity. Knockout of PME40 also resulted in early diurnal flower opening, whereas overexpression of PME42 delayed diurnal flower opening. Lower PME activity was observed to be associated with higher levels of pectin methylesterification and the softening of cell walls in lodicules, which contribute to the absorption of water by lodicules and cause them to swell, thus promoting early diurnal flower opening. Higher PME activity had the opposite effect. Collectively, our work uncovers a molecular mechanism underlying the regulation of diurnal flower-opening time in rice, which would help reduce the costs of hybrid breeding and improve the heat tolerance of flowering plants by avoiding higher temperatures at anthesis. | Mumei Wang Xiaopei Zhu Guoqing Peng Minglong Liu Shuqing Zhang Minghao Chen Shitang Liao Xiaoying Wei Peng Xu Xiyu Tan Fangping Li Zhichuan Li Li Deng Ziliang Luo Liya Zhu Shuai Zhao Dagang Jiang Jing Li Zhenlan Liu Xianrong Xie Shaokui Wang Aimin Wu Chuxiong Zhuang Hai Zhou | 2022 | Molecular Plant2022，15，6： | 2 |
| 10 | A ubiquitous knowledgeable data representation model(UKRM) for three-dimensional geographic information systems(3D GIS)显示文摘In the face of complicated, diversified three-dimensional world, the existing 3D GIS data models suffer from certain issues such as data incompatibility, insufficiency in data representation and representation types, among others. It is often hard to meet the requirements of multiple application purposes(users) related to GIS spatial data management and data query and analysis, especially in the case of massive spatial objects. In this study, according to the habits of human thinking and recognition, discrete expressions(such as discrete curved surface(DCS), and discrete body(DB)) were integrated and two novel representation types(including function structure and mapping structure) were put forward. A flexible and extensible ubiquitous knowledgeable data representation model(UKRM) was then constructed, in which structurally heterogeneous multiple expressions(including boundary representation(B-rep), constructive solid geometry(CSG), functional/parameter representation, etc.) were normalized. GIS's ability in representing the massive, complicated and diversified 3D world was thus greatly enhanced. In addition, data reuse was realized, and the bridge linking static GIS to dynamic GIS was built up. Primary experimental results illustrated that UKRM was overwhelmingly superior to the current data models(e.g. IFC, City GML) in describing both regular and irregular spatial objects. | ZHANG ShuQing ZHOU ChengHu ZHANG JunYan CHEN XiangCong | 2016 | Science China Earth Sciences2016，59，4： | 2 |
| 11 | TSNAdb: A Database for Tumor-specific Neoantigens from Immunogenomics Data Analysis显示文摘Tumor-specific neoantigens have attracted much attention since they can be used as biomarkers to predict therapeutic effects of immune checkpoint blockade therapy and as potential targets for cancer immunotherapy. In this study, we developed a comprehensive tumor-specific neoantigen database(TSNAdb v1.0), based on pan-cancer immunogenomic analyses of somatic mutation data and human leukocyte antigen(HLA) allele information for 16 tumor types with 7748 tumor samples from The Cancer Genome Atlas(TCGA) and The Cancer Immunome Atlas(TCIA). We predicted binding affinities between mutant/wild-type peptides and HLA class I molecules by NetMHCpan v2.8/v4.0, and presented detailed information of 3,707,562/1,146,961 potential neoantigens generated by somatic mutations of all tumor samples. Moreover, we employed recurrent mutations in combination with highly frequent HLA alleles to predict potential shared neoantigens across tumor patients,which would facilitate the discovery of putative targets for neoantigen-based cancer immunotherapy.TSNAdb is freely available at http://gffzz7fc4ad2a729e4c47hknkfo66b5q5b6qkn.ffgz.tsg.suse.edu.cn/tsnadb. | Jingcheng Wu Wenyi Zhao Binbin Zhou Zhixi Su Xun Gu Zhan Zhou Shuqing Chen | 2018 | Genomics, Proteomics & Bioinformatics2018，16，4： | 2 |
| 12 | The grain for green pro- ject induced land cover change in the Loess Plateau:A case study with Ansai county, Shanxi province, China 显示文摘 | Zhou Decheng Zhao Shuqing Zhu Chao | 2012 | Ecological Indica- tors2012，23，： | 1 |
| 13 | The grain for green project induced land cover chang in the Loess Plateau: a case study with Ansai County, Shanxi Province, China显示文摘 | ZHOU Decheng ZHAO Shuqing ZHU Chao | 2012 | Ecological Indicators2012，23，： | 1 |
| 14 | Engineering nanointerface of molybdenum-based heterostructures to boost the electrocatalytic hydrogen evolution reaction显示文摘Rational heterostructure-design in electrocatalysts represents a promising approach toward high performance in the electrocatalytic hydrogen evolution reaction(HER).In specific,optimizing the H adsorption behavior at the surface/interface of heterostructure is of key importance to improve the catalytic performance.Herein,we demonstrate the construction of a heterostructure from a well-defined oxygenbridged Co/Mo heterometallic zeolitic imidazolate framework(MOZ) as an efficient electrocatalyst for HER.The optimized hybrid exhibits high catalytic activity and stability in electrolytes with a wide pH range.Detailed XPS,XAS and theoretical studies reveal that the regulation of metal species can tailor the lattice of Mo_(2)C within the hybrid and induce the formation of defect sites,which could not only induce surface charge transfer between the atoms and provide an additional active site,but also affect the H adsorption behavior at the interface of a heterostructure.This work provides an effective strategy to design a heterostructure with tailored active sites for energy conversion. | Tong Liu Shuqing Zhou Jing Qi Kaiwen Wang Lirong Zheng Qingming Huang Tianhua Zhou Jian Zhang | 2021 | Journal of Energy Chemistry2021，30，7： | 1 |
| 15 | The grain for green project induced land cover change in the Loess Plat- eau: a ease study with Ansai County, Shaanxi Province, China显示文摘 | Zhou Decheng Zhao Shuqing Zhu Chao | 2012 | Ecological Indicators2012，23，4： | 1 |
| 16 | Pt- based anode catalysts for direct ethanol fuel cells 显示文摘 | Zhou Weijiang Song Shuqing Li Wenzhen | 2004 | Solid State Ionics2004，175，： | 1 |
| 17 | Sediment type, population density and their combined effect greatly charge the short-time growth of two common submerged macrophytes显示文摘 | JIANG Jirthui ZHOU Changfang AN Shuqing | 2008 | Ecological Engineering2008，34，2： | 1 |
| 18 | A multivalent biparatopic EGFR-targeting nanobody drug conjugate displays potent anticancer activity in solid tumor models显示文摘Dear Editor,The epidermal growth factor receptor(EGFR),one member of the ErbB family of receptor tyrosine kinases,has been implicated in various epithelial malignancies.As a clinically validated target,both small-molecule tyrosine kinase inhibitors and antibody-based drugs have been approved by regulatory agencies.Anti-EGFR antibodyci rug conjugates(ADCs)could kill target tumor cells irrespective of EGFR signaling.However,cancer patients treated with EGFR-targeted antibody therapy eventually develop acquired epitope substitutions such as S492R,G465R,G465E,and 1491M. | Jian sheng Fan Xinlei Zhuang Xiaoyue Yang Yingchun Xu Zhan Zhou Liqiang Pan Shuqing Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 1 |
| 19 | Characteristics and origins of heavy metals in sediments from Ximen Co Lake during summer monsoon season, a deep lake on the eastern Tibetan Plateau显示文摘 | Hezhong Yuan Enfeng Liu Ji Shen Hengjie Zhou Qifang Geng Shuqing An | 2014 | Journal of Geochemical Exploration2014，，： | 1 |
| 20 | Coordinated regulation for nature products discovery and overproduction in Streptomyces显示文摘Streptomyces is an important treasure trove for natural products discovery.In recent years,many scientists focused on the genetic modification and metabolic regulation of Streptomyces to obtain diverse bioactive compounds with high yields.This review summarized the commonly used regulatory strategies for natural products discovery and overproduction in Streptomyces from three main aspects,including regulator-related strategies,promoter engineering,as well as other strategies employing transposons,signal factors,or feedback regulations.It is expected that the metabolic regulation network of Streptomyces will be elucidated more comprehensively to shed light on natural products research in the future. | Qun Zhou Shuqing Ning Yunzi Luo | 2020 | Synthetic and Systems Biotechnology2020，5，2： | 1 |
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