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| 1 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 2 | MODELING, VALIDATION AND OPTIMAL DESIGN OF THE CLAMPING FORCE CONTROL VALVE USED IN CONTINUOUSLY VARIABLE TRANSMISSION显示文摘Associated dynamic performance of the clamping force control valve used in continuously variable transmission (CVT) is optimized. Firstly, the structure and working principle of the valve are analyzed, and then a dynamic model is set up by means of mechanism analysis. For the purpose of checking the validity of the modeling method, a prototype workpiece of the valve is manufactured for comparison test, and its simulation result follows the experimental result quite well. An associated performance index is founded considering the response time, overshoot and saving energy, and five structural parameters are selected to adjust for deriving the optimal associated performance index. The optimization problem is solved by the genetic algorithm (GA) with necessary constraints. Finally, the properties of the optimized valve are compared with those of the prototype workpiece, and the results prove that the dynamic performance indexes of the optimized valve are much better than those of the prototype workpiece. | ZHOU Yunshan LIU Jin'gang CAIYuanchun ZOU Naiwei | 2008 | Chinese Journal of Mechanical Engineering2008，21，4： | 4 |
| 3 | Integrative analysis of DNA methylation and gene expression identified cervical cancer-specific diagnostic biomarkers显示文摘Cervical cancer is the leading cause of death among women with cancer worldwide.Here,we performed an integrative analysis of Illumina HumanMethylation450K and RNA-seq data from TCGA to identify cervical cancer-specific DNA methylation markers.We first identified differentially methylated and expressed genes and examined the correlation between DNA methylation and gene expression.The DNA methylation profiles of 12 types of cancers,including cervical cancer,were used to generate a candidate set,and machine-learning techniques were adopted to define the final cervical cancer-specific markers in the candidate set.Then,we assessed the protein levels of marker genes by immunohistochemistry by using tissue arrays containing 93 human cervical squamous cell carcinoma samples and cancer-adjacent normal tissues.Promoter methylation was negatively correlated with the local regulation of gene expression.In the distant regulation of gene expression,the methylation of hypermethylated genes was more likely to be negatively correlated with gene expression,while the methylation of hypomethylated genes was more likely to be positively correlated with gene expression.Moreover,we identified four cervical cancer-specific methylation markers,cg07211381(RAB3C),cg12205729(GABRA2),cg20708961(ZNF257),and cg26490054(SLC5A8),with 96.2%sensitivity and 95.2%specificity by using the tenfold cross-validation of TCGA data.The four markers could distinguish tumors from normal tissues with a 94.2,100,100,and 100%AUC in four independent validation sets from the GEO database.Overall,our study demonstrates the potential use of methylation markers in cervical cancer diagnosis and may boost the development of new epigenetic therapies. | Wanxue Xu Mengyao Xu Longlong Wang Wei Zhou Rong Xiang Yi Shi Yunshan Zhang Yongjun Piao | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 4 | Space charge phenomena in oil-paper insulation materials under high voltage direct current显示文摘 | Zhou Yuanxiang Wang Yunshan Li Guangfan | 2009 | Journal of Electrostatics2009，67，23： | 1 |
| 5 | The COVID‐19 vaccine: Attitudes and vaccination in patients with autoimmune inflammatory rheumatic diseases显示文摘Background:We examined attitudes toward the COVID‐19 vaccine,potential factors underlying these attitudes,and ways to increase vaccination willingness in autoimmune inflammatory rheumatic diseases(AIIRD)patients.Methods:A multicenter,web‐based,observational survey using an online questionnaire was conducted among AIIRD patients aged≥18 years from May 24,2021,to June 3,2021.Participants were 3104 AIIRD patients(2921 unvaccinated and 183 vaccinated).Results:Of the unvaccinated patients,32.9%were willing to receive the COVID‐19 vaccine,45.0%were uncertain,and 14.8%were unwilling.When vaccination was recommended by physicians,patients'willingness increased to 93.8%.Participants'main concerns were that the vaccine may aggravate AIIRD disease(63.0%)and may cause vaccine‐related adverse events(19.9%).Female patients were less likely to be vaccinated.However,patients who had children aged≤18 years were more willing to be vaccinated.In addition,vaccination willingness was higher in patients with trust in the safety and efficacy of the COVID‐19 vaccine.Notably,183(5.9%)patients were vaccinated.The major vaccination side effects were injection reaction,myalgia,and fatigue.At a median follow‐up of 88(38,131)days,patients'disease activities were stable.Conclusions:The findings show that AIIRD patients were unwilling to receive the COVID‐19 vaccine because of fears of potential disease exacerbation and additional adverse events.Sociodemographic characteristics and concerns about COVID‐19 disease and vaccines had a significant effect on vaccination willingness. | Jiali Chen Wenxin Cai Tian Liu Yunshan Zhou Yuebo Jin Yue Yang Shi Chen Kun Tang Chun Li | 2022 | Rheumatology & Autoimmunity2022，2，2： | 1 |
| 6 | ,Novel Optical Charge-Transfer Complex between an Organic Substrate and a Polyoxometalate,α-H6P2W18O62 · 6phen· 10H2O显示文摘 | Zhou Yunshan Peng Jun Wang Enbo | 1998 | Transition Metal Chemistry1998，23，2： | 1 |
| 7 | Research on spray, combustion and emission characteristic for DI diesel engine显示文摘 | Ge Yunshan Zhang Shiying Zhou Lei | 2006 | Journal of Beijing Institute of Technology2006，15，1： | 1 |
| 8 | Simulation of space charge dynamics in low-density polyethylene under exter- nal electric field and injection harrier heights using discontinuous galerkin method显示文摘 | Tian Jihuan Zhou Yuanxiang Wang Yunshan | 2011 | IEEE Transactions on Dielectrics and Elec- trical Insulation2011，18，5： | 1 |
| 9 | Synthesis and antiinfluenza virus activities of heteropoly compounds containing rare earth elements显示文摘 | Liu Jie Wang Enbo Zhou Yunshan | 2002 | Yao Xue Xue Bdo2002，33，7： | 1 |
| 10 | A novel optical charge-transfer complex between an organic substrate and a polyoxometalate, alpha-H6P2W18O62middot phen middot10H2O显示文摘 | Yunshan Zhou Jun Peng Enbo Wang Lijuan Zhang | 1998 | Transition Metal Chemistry1998，，2： | 1 |
| 11 | Space charge phenomena in oil-paper insulation materials under high voltage direct current显示文摘 | Zhou Yuanxiang Wang Yunshan Li Guangfan | 2009 | Journal of Electrostatics2009，67，： | 1 |
| 12 | Space charge phenomena in oil-paper insulation materials under high voltage direct current显示文摘 | Yuanxiang Zhou Yunshan Wang Guangfan Li | 2009 | Journal of Electrostatics2009，67，23： | 1 |
| 13 | Space charge phenomena in oil-paper insulation materials under high voltage direct current显示文摘 | Zhou Yuanxiang Wang Yunshan Li Guangfan | 2009 | Journal ofElactrostatics2009，67，23： | 1 |
| 14 | CVT start clutch Control Algorithm显示文摘 | ZHANG Feitie ZHOU Yunshan XUE Dianlun | 2006 | Journal of Hunan Universi- ty: Natural Science Edition2006，33，6： | 1 |
| 15 | Space charge phenomena in oil-paper insulation materials under high voltage direct current显示文摘 | Zhou Yuanxiang Wang Yunshan Li Guangfan | 2009 | Journal of Electrostatics2009，67，23： | 1 |
| 16 | Historic and future trends of vehicle emissions in Beijing, 1998–2020: A policy assessment for the most stringent vehicle emission control program in China显示文摘 | Shaojun Zhang Ye Wu Xiaomeng Wu Mengliang Li Yunshan Ge Bin Liang Yueyun Xu Yu Zhou Huan Liu Lixin Fu Jiming Hao | 2013 | Atmospheric Environment2013，，： | 1 |
| 17 | Space charge phenomena in oil-paper insulation materials under high voltage direct current显示文摘 | Zhou Yuanxiang Wang Yunshan Li Guangfan | 2009 | Journal of Electrostatics2009，67，23： | 1 |
| 18 | Effects of M-nisoldipine on Contraction and 45Ca Influx in Isolated rat Aorta显示文摘 | Zhou Baojun Li Yunshan Fu Shaoxuan | 1994 | ACTA Pharmacological Sinica1994，15，4： | 1 |
| 19 | Effects of M-nisoldipine on contraction and 45Ca influx in isolated rat aorta显示文摘 | ZHOU Baojun LI Yunshan FU Shaoxuan | 1992 | Biochem1992，156，2： | 1 |
| 20 | Space charge phenomena in oil-paper insulation material under high voltage direct current显示文摘 | Zhou Yuanxiang Wang Yunshan Li Guangfan | 2009 | Journal of Electrostatics2009，67，23： | 1 |
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