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| 1 | SARS-CoV-2 nsp12 attenuates type Ⅰ interferon production by inhibiting IRF3 nuclear translocation显示文摘SARS-CoV-2 is the pathogenic agent of COVID-19,which has evolved into a global pandemic.Compared with some other respiratory RNA viruses,SARS-CoV-2 is a poor inducer of type Ⅰ interferon(IFN).Here,we report that SARS-CoV-2 nsp12,the viral RNA-dependent RNA polymerase(RdRp),suppresses host antiviral responses.SARS-CoV-2 nsp12 attenuated Sendai virus(SeV)-or poly(I:C)-induced IFN-β promoter activation in a dose-dependent manner.It also inhibited IFN promoter activation triggered by RIG-I,MDA5,MAVS,and IRF3 overexpression.Nsp12 did not impair IRF3 phosphorylation but suppressed the nuclear translocation of IRF3.Mutational analyses suggested that this suppression was not dependent on the polymerase activity of nsp12.Given these findings,our study reveals that SARS-CoV-2 RdRp can antagonize host antiviral innate immunity and thus provides insights into viral pathogenesis. | Wenjing Wang Zhuo Zhou Xia Xiao Zhongqin Tian Xiaojing Dong Conghui Wang Li Li Lili Ren Xiaobo Lei Zichun Xiang Jianwei Wang | 2021 | Cellular & Molecular Immunology2021，18，4： | 4 |
| 2 | High population and dispersion of pentacoordinated Al~Ⅴ species on the surface of ?ame-made amorphous silica-alumina显示文摘Pentacoordinated Al(Al~Ⅴ)species in silica-alumina are promising to promote the formation of acid sites or act as surface defects for tailoring single-atom catalysts.However,pentahedral coordination(Al~Ⅴ)is rarely observed in conventionally prepared silica-alumina.Here,we show that high population and dispersion of Al~Ⅴ species on the surface of amorphous silica-alumina(ASA)can be achieved by means of flame spray pyrolysis.High resolution TEM/EDX,high magnetic-field NMR and DFT calculations are employed to characterize the structure of as-prepared ASAs.Solid-state ^(27)Al multi-quantum MAS NMR experiments show that most of the Al~Ⅴspecies are formed independently from the alumina phase and are accessible for guest molecules on the surface.Upon water adsorption,these Al~Ⅴ species are transformed to Al~Ⅵ species,structurally similar to surface Al~Ⅳ species,as confirmed by DFT calculations.The outstanding catalytic activity of as-synthesized ASA is demonstrated using the in situ H/D exchange reaction with deuterated benzene as an example.The Al~Ⅴ-rich ASA provides a much lower activation energy(~30 kJ/mol)than that reported for zeolite H-ZSM-5(~60 kJ/mol).The superior catalytic performance is attributed to the high Al~Ⅴcontent promoting the surface active sites in ASA.The knowledge gained on the synthesis of Al~Ⅴ-rich ASAs and the nature of aluminum coordination in these materials could pave the way to more efficient silica-alumina based catalysts. | Zichun Wang Yijiao Jiang Xianfeng Yi Cuifeng Zhou Aditya Rawal James Hook Zongwen Liu Feng Deng Anmin Zheng Michael Hunger Alfons Baiker Jun Huang | 2019 | Science Bulletin2019，64，8： | 2 |
| 3 | Anti-gravity loop-shaped heat pipe with graded pore-size wick 显示文摘 | Tang Yong Zhou Rui Lu Longsheng Xie Zichun | 2012 | Applied Thermal Engineering2012，36，： | 1 |
| 4 | Stochastic Finite Element Method Baved on Laguerre Integrate显示文摘 | Zhou Zonghe Yang Zichun | 2010 | International Conference on Information Technology and Industrial Engineering2010，，： | 1 |
| 5 | Pijx confers broad-spectrum seedling and panicle blast resistance by promoting the degradation of ATP β subunit and OsRbohC-mediated ROS burst in rice显示文摘Rice blast,caused by the fungal pathogen Magnaporthe oryzae,is one of the most important diseases of rice.Utilization of blast-resistance genes is the most economical,effective,and environmentally friendly way to control the disease.However,genetic resources with broad-spectrum resistance(BSR)that is effective throughout the rice growth period are rare.In this work,using a genome-wide association study,we identify a new blast-resistance gene,Pijx,which encodes a typical CC-NBS-LRR protein.Pijx is derived from a wild rice species and confers BSR to M.oryzae at both the seedling and panicle stages.The functions of the resistant haplotypes of Pijx are confirmed by gene knockout and overexpression experiments.Mechanistically,the LRR domain in Pijx interacts with and promotes the degradation of the ATP synthase β subunit(ATPb)via the 26S proteasome pathway.ATPb acts as a negative regulator of Pijx-mediated panicle blast resistance,and interacts with OsRbohC to promote its degradation.Consistently,loss of ATPb function causes an increase in NAPDH content and ROS burst.Remarkably,when Pijx is introgressed into two japonica rice varieties,the introgression lines show BSR and increased yields that are approximately 51.59%and 79.31%higher compared with those of their parents in a natural blast disease nursery.In addition,we generate PPL^(Pijx Pigm) and PPL^(Pijx Piz-t) pyramided lines and these lines also have higher BSR to panicle blast compared with Pigm-or Piz-t-containing rice plants.Collectively,this study demonstrates that Pijx not only confers BSR to M.oryzae but also maintains high and stable rice yield,providing new genetic resources and molecular targets for breeding rice varieties with broad-spectrum blast resistance. | Ning Xiao Yunyu Wu Xiaoxiang Zhang Zeyun Hao Zichun Chen Zefeng Yang Yue Cai Ruyi Wang Ling Yu Zhiping Wang Yue Lu Wei Shi Cunhong Pan Yuhong Li Changhai Zhou Jianju Liu Niansheng Huang Guangqing Liu Hongjuan Ji Shuhao Zhu Shuai Fang Yuese Ning Aihong Li | 2023 | Molecular Plant2023，16，11： | 0 |
| 6 | CRISPR-Cas9-mediated editing of the OsHPPD 30 UTR confers enhanced resistance to HPPDinhibiting herbicides in rice显示文摘Dear Editor,Loss of yield because of competition from weeds restricts the production of rice(Oryza sativa L.)(Maeda et al.,2019).Application of chemical herbicides is currently the most effective method for controlling weeds during rice production,especially in modern simplified cultivation systems.However,long-term and extensive use of herbicides,such as inhibitors of the enzymes 5-enolpyruvylshikimate-3-phosphate synthase,acetolactate synthase,and acetyl-coenzyme A carboxylase,has resulted in the emergence of herbicide-resistant weed species as well as soils with high levels of herbicide residues,which limit crop rotation.Therefore,there is an urgent need for alternative herbicides and breeding of corresponding herbicideresistant rice varieties. | Yunyu Wu Ning Xiao Yue Cai Qian Yang Ling Yu Zichun Chen Wei Shi Jianju Liu Cunhong Pan Yuhong Li Xiaoxiang Zhang Changhai Zhou Niansheng Huang Hongjuan Ji Shuhao Zhu Aihong Li | 2023 | Plant Communications2023，4，5： | 0 |
| 7 | Probiotics and Their Metabolites Ameliorate Inflammatory Bowel Disease:A Critical Review显示文摘Crohn disease and ulcerative colitis are the two main manifestations of inflammatory bowel disease(IBD),and both are highly morbid.However,the precise etiology of IBD is still unknown and effective therapeutics are yet to be discovered.It is becoming increasingly clear that a combination of factors,including genetic background,host immune response,and microbial reduced diversity status are related to IBD.The cardinal symptom of IBD patients is the imbalance of the intestinal microflora.According to previous studies,both probiotics and symbiotic microbiota can play a protective role through intestinal micro-ecosystem regulation,epithelial barrier integrity enhancement,and inflammation reduction.Therefore,probiotics can provide an alternative or auxiliary method to traditional IBD treatment.Here,we reviewed the possible pathogenesis of IBD,summarized the possible mechanisms of probiotics modulation of IBD,and emphasized the prevention and treatment targets of probiotics-mediated IBD,with the aim to provide theoretical support for the treatment of IBD patients by probiotics in clinical trials. | Ying Liang Manman Liu Jiaqian Pu Zichun Zhu Zining Gao Qingqing Zhou Qing Gu Ping Li | 2021 | Infectious Microbes & Diseases2021，3，1： | 0 |
| 8 | Design Rules of the Mixing Phase and Impacts on Device Performance in High-Efficiency Organic Photovoltaics显示文摘In nonfullerene acceptor-(NFA-)based solar cells,the exciton splitting takes place at both domain interface and donor/acceptor mixture,which brings in the state of mixing phase into focus.The energetics and morphology are key parameters dictating the charge generation,diffusion,and recombination.It is revealed that tailoringthe electronic properties of the mixing region by doping with larger-bandgap components could reduce the density of state but elevate the filling state level,leading to improved open-circuit voltage(V_(OC))and reduced recombination.The monomolecular and bimolecular recombinations are shown to be intercorrelated,which show a Gaussian-like relationship with V_(OC) and linear relationship with short-circuit current density(JSC)and fill factor(FF).The kinetics of hole transfer and exciton diffusion scale with JSC similarly,indicating the carrier generation in mixing region and crystalline domain are equally important.From the morphology perspective,the crystalline order could contribute to V_(OC) improvement,and the fibrillar structure strongly affects the FF.These observations highlight the importance of the mixing region and its connection with crystalline domains and point out the design rules to optimize the mixing phase structure,which is an effective approach to further improve device performance. | Jingnan Song Ming Zhang Tianyu Hao Jun Yan Lei Zhu Guanqing Zhou Rui Zeng Wenkai Zhong Jinqiu Xu Zichun Zhou Xiaonan Xue Chun-Chao Chen Weihua Tang Haiming Zhu Zaifei Ma Zheng Tang Yongming Zhang Feng Liu | 2022 | Research2022，，4： | 0 |
| 9 | Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection显示文摘The global coronavirus disease 2019(COVID-19)pandemic is caused by severe acute respiratory syndrome coronavirus 2(SARSCoV-2),a positive-sense RNA virus.How the host immune system senses and responds to SARS-CoV-2 infection remain largely unresolved.Here,we report that SARS-CoV-2 infection activates the innate immune response through the cytosolic DNA sensing cGAS-STING pathway.SARS-CoV-2 infection induces the cellular level of 2′3′-cGAMP associated with STING activation.cGAS recognizes chromatin DNA shuttled from the nucleus as a result of cell-to-cell fusion upon SARS-CoV-2 infection.We further demonstrate that the expression of spike protein from SARS-CoV-2 and ACE2 from host cells is sufficient to trigger cytoplasmic chromatin upon cell fusion.Furthermore,cytoplasmic chromatin-cGAS-STING pathway,but not MAVS-mediated viral RNA sensing pathway,contributes to interferon and pro-inflammatory gene expression upon cell fusion.Finally,we show that cGAS is required for host antiviral responses against SARS-CoV-2,and a STING-activating compound potently inhibits viral replication.Together,our study reported a previously unappreciated mechanism by which the host innate immune system responds to SARS-CoV-2 infection,mediated by cytoplasmic chromatin from the infected cells.Targeting the cytoplasmic chromatin-cGAS-STING pathway may offer novel therapeutic opportunities in treating COVID-19.In addition,these findings extend our knowledge in host defense against viral infection by showing that host cells’self-nucleic acids can be employed as a“danger signal”to alarm the immune system. | Zhuo Zhou Xinyi Zhang Xiaobo Lei Xia Xiao Tao Jiao Ruiyi Ma Xiaojing Dong Qi Jiang Wenjing Wang Yujin Shi Tian Zheng Jian Rao Zichun Xiang Lili Ren Tao Deng Zhengfan Jiang Zhixun Dou Wensheng Wei Jianwei Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 0 |
| 10 | A bacteria-based system expressing anti-TNF-αnanobody for enhanced cancer immunotherapy显示文摘Dear Editor,As a successful drug for inflammatory diseases,the application of TNF-αinhibitor on cancer therapy is limited by repeated administration and off-target effects.1 A body of evidence indicated that the anti-tumor efficacy of TNF-αinhibitor is unsatisfactory,though repeated administration was used to improve its efficacy in tumor-treating fields,it will also lead to severe side effects and high cost.2,3,4 Hence,an efficient and highly targeted TNF-αantibody delivery system is worth developing. | Lina Liu Xing Liu Wenjie Xin Lulu Zhou Baolian Huang Chao Han Zhiting Cao Zichun Hua | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 0 |
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