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| 1 | Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis显示文摘Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients. | Ruonan Zhang Ting Pan Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui | 2022 | Bioactive Materials2022，7，7： | 8 |
| 2 | Bioactive thionic compounds and aromatic glycosides from Ligusticum chuanxiong显示文摘Three new thionic compounds,(S)-2-(2-carboxyl-2-hydroxyethylthio)-ferulic acid(1),(E)-2-methoxy-4-(3-(methylsulfonyl)prop-1-en-1-yl)phenol(2), and thiosenkyunolide C(3), together with two new aromatic glycosides(4 and 5) were isolated from the rhizome of Ligusticum chuanxiong Hort. Two known compounds(6 and 7) were also obtained. Their structures were elucidated based on extensive spectroscopic data(UV, IR, 1D and 2D NMR, and HR-ESI-MS). Furthermore the absolute configurations were established by comparison of their calculated and experimental circular dichroism spectra and by a dimolybdenum tetraacetate [Mo_2(AcO)_4]-induced circular dichroism procedure. All compounds were evaluated against lipopolysaccharide(LPS)-induced NO production in BV2 cells, and compounds 4 and 5 showed strong inhibitory activities with IC_(50) values of 2.03 and 3.09 μmol/L, respectively(positive control curcumin, IC_(50)=6.17 μmol/L). In addition, compound 1 showed weak proteintyrosine phosphatase-1 B(PTP1B) inhibitory activity. | Xu Zhang Bing Han Ziming Feng Jianshuang Jiang Yanan Yang Peicheng Zhang | 2018 | Acta Pharmaceutica Sinica B2018，8，5： | 5 |
| 3 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 4 | Expression of EphA2 receptor in ovarian cancer tissue 显示文摘 | HAN LIPING DONG ZIMING QIAO YUHUAN | 2005 | Journal of Zhengzhou University(Medical Sciences )2005，40，2： | 1 |
| 5 | Constitutive Modeling and Dynamic Recrystallization Mechanisms of an Ultralow-carbon Microalloyed Steel During Hot Compression Tests显示文摘The hot deformation behavior of an ultralow-carbon microalloyed steel was investigated using an MMS-200 thermal simulation test machine in a temperature range of 1073-1373 K and strain rate range of 0.01-10 s-1.The results show that the flow stress decreases with increasing deformation temperature or decreasing strain rate.The strain-compensated constitutive model based on the Arrhenius equation for this steel was established using the true stress-strain data obtained from a hot compression test.Furthermore,a new constitutive model based on the Z-parameter was proposed for this steel.The predictive ability of two constitutive models was compared with statistical measures.The results indicate the new constitutive model based on the Z-parameter can more accurately predict the flow stress of an ultralow-carbon microalloyed steel during hot deformation.The dynamic recrystallization(DRX)nucleation mechanism at different deformation temperatures was observed and analyzed by transmission electron microscopy(TEM),and strain-induced grain boundary migration was observed at 1373 K/0.01 s^-1. | 李宁 HUANG Yao HAN Renheng BAO Ziming ZHU Yanqing ZHANG Hexin 赵成志 | 2020 | Journal of Wuhan University of Technology(Materials Science)2020，35，5： | 1 |
| 6 | Three-Year Consecutive Field Application of Erythromycin Fermentation Residue Following Hydrothermal Treatment:Cumulative Effect on Soil Antibiotic Resistance Genes显示文摘Fermentation-based antibiotic production results in abundant nutrient-rich fermentation residue with high potential for recycling,but the high antibiotic residual concentration restricts its usefulness(e.g.,in land application as organic fertilizer).In this study,an industrial-scale hydrothermal facility for the treatment of erythromycin fermentation residue(EFR)was investigated,and the potential risk of the long-term soil application of treated EFR promoting environmental antibiotic resistance development was evaluated.The treatment effectively removed bacteria and their DNA,and an erythromycin removal ratio of up to approximately 98%was achieved.The treated EFR was utilized as organic fertilizer for consecutive field applications from 2018 to 2020,with dosages ranging from 3750 to 15000 kg·hm^(-2),resulting in subinhibitory levels of erythromycin(ranging from 0.83-76.00μg·kg^(-1))in soils.Metagenomic shotgun sequencing was then used to characterize the antibiotic resistance genes(ARGs),mobile genetic elements(MGEs),and bacterial community composition of the soils.The soil ARG abundance and diversity did not respond to the treated EFR application in the first year,but gradually changed in the second and third year of application.The highest fold change in relative abundance of macrolide-lincosamide-streptogramin(MLS)and total ARGs were 12.59 and 2.75 times,compared with the control(CK;without application),respectively.The soil MGEs and taxonomic composition showed similar temporal trends to those of the ARGs,and appeared to assist in driving increasing ARG proliferation,as revealed by correlation analysis and structural equation models(SEMs).The relative abundance of particular erm resistance genes(RNA methyltransferase genes)increased significantly in the third year of treated EFR application.The close association of erm with MGEs suggested that horizontal gene transfer played a critical role in the observed erm gene enrichment.Metagenomic binning results demonstrated that the proliferation of mac genecarrying hosts was responsible for the increased abundance of mac genes(efflux pump genes).This study shows that sub-inhibitory levels of erythromycin in soils had a cumulative effect on soil ARGs over time and emphasizes the importance of long-term monitoring for assessing the risk of soil amendment with treated industrial waste. | Ziming Han Haodi Feng Xiao Luan Yunpeng Shen Liren Ren Liujie Deng D.G.Joakim Larsson Michael Gillings Yu Zhang Min Yang | 2022 | Engineering2022，8，8： | 1 |
| 7 | Influence of circulation types on temporal and spatial variations of ozone in Beijing显示文摘This study analyzes the impact of circulation types(CTs)on ozone(O_(3))pollution in Beijing.The easterly high-pressure(SWW)circulation occurred most frequently(30%;276 day),followed by northwesterly high-pressure(AN)circulation(24.3%;224 day).The SWW type had the highest O_(3) anomaly of+17.28μg/m^(3),which was caused by excellent photochemical reactions,poor diffusion ability and regional transport.Due to the higher humidity and precipitation in the low-pressure type(C),the O_(3) increase(+8.02μg/m^(3))was less than that in the SWW type.Good diffusion/wet deposition and weak formation ability contributed to O_(3) decrease in AN(-12.54μg/m^(3))and northerly high-pressure(ESN)CTs(-12.26μg/m^(3)).The intra-area transport of O_(3) was significant in polluted circulations(SWW-and C-CTs).In addition,higher temperature,radiation and less rainfall also contributed to higher O_(3) in northern Beijing under the SWW type.For the clean CTs(AN and ESN CTs),precursor amount and intra-area transport played a dominant role in O_(3) distribution.Under the northeasterly low-pressure CT,better formation conditions and higher precursor amount combined with the intra-area southerly transport to cause higher O_(3) values in the south than in the north.The higher O_(3) in the northwestern area under the northeasterly high-pressure type was influenced by weaker titration loss and high O_(3) concentration in previous day.Annual variation in the CTs contributed up to 86.1%of the annual variation in O_(3).About 78%-83%of the diurnal variation in O_(3) resulted from local meteorological factors. | Xiaowan Zhu JinWu Guiqian Tang Lin Qiao Tingting Han Xiaomei Yin Xiangxue Liu Ziming Li Yajun Xiong Di He Zhiqiang Ma | 2023 | Journal of Environmental Sciences2023，，8： | 1 |
| 8 | Field-based evidence for the enrichment of intrinsic antibiotic resistome stimulated by plant-derived fertilizer in agricultural soil显示文摘Animal manures have been demonstrated to enhance antibiotic resistance in agricultural soils.However,little is known about the effects of plant-derived fertilizer on soil antibiotic resistome.Herein,metagenomic sequencing was used to investigate the effects of a plantderived fertilizer processed from sugarcane and beet on soil antibiotic resistance genes(ARGs)in a soybean field along crop growth stages.ARG profiles in the soils amended by plant-derived fertilizer were compared with those in the soils amended by chicken manure.The abundance and diversity of total ARGs in the soils amended by plant-derived fertilizer were significantly(P<0.05)elevated at the sprout stage,to a level comparable to that in the manured soils.Whereas,unlike chicken manure mainly introducing manure-borne ARGs to soil,the plant-derived fertilizer was indicated to mainly enrich multidrug resistance genes in soil by nourishing indigenous bacteria.ARGs with abundances in amended soils significantly(P<0.05)higher than in unamended soils at the sprout stage of soybean were considered as enriched ARGs.Decrease in the abundance of the enriched ARGs was observed in both the amended soils from the sprout to the harvest.Network analysis further identified Proteobacteria and Bacteroidetes as the primary bacterial taxa involved in the temporal variation of the enriched ARGs in the soils amended by plant-derived fertilizer,while in manured soils were Firmicutes and Actinobacteria.As revealed by multivariate statistical analyses,variation of the enriched ARGs in the soils amended by plant-derived fertilizer was majorly attributed to the response of co-occurred bacteria to depleting nutrients,which was different from the failed establishment of manure-borne bacteria in the manured soils.Our study provided field-based evidence that plant-derived fertilizer stimulated the intrinsic antibiotic resistome,and proposed attention to the un-perceived risk since some clinically relevant ARGs originate and evolve from natural resistome. | Shihai Liu Ziming Han Dong Zhu Xiao Luan Liujie Deng Liping Dong Min Yang Yu Zhang | 2024 | Journal of Environmental Sciences2024，，1： | 1 |
| 9 | NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation显示文摘NDFIP1 has been previously reported as a tumor suppressor in multiple solid tumors,but the function of NDFIP1 in NSCLC and the underlying mechanism are still unknown.Besides,the WW domain containing proteins can be recognized by NDFIP1,resulted in the loading of the target proteins into exosomes.However,whether WW domain-containing transcription regulator 1(WWTR1,also known as TAZ)can be packaged into exosomes by NDFIP1 and if so,whether the release of this oncogenic protein via exosomes has an effect on tumor development has not been investigated to any extent.Here,we first found that NDFIP1 was low expressed in NSCLC samples and cell lines,which is associated with shorter OS.Then,we confirmed the interaction between TAZ and NDFIP1,and the existence of TAZ in exosomes,which requires NDFIP1.Critically,knockout of NDFIP1 led to TAZ accumulation with no change in its mRNA level and degradation rate.And the cellular TAZ level could be altered by exosome secretion.Furthermore,NDFIP1 inhibited proliferation in vitro and in vivo,and silencing TAZ eliminated the increase of proliferation caused by NDFIP1 knockout.Moreover,TAZ was negatively correlated with NDFIP1 in subcutaneous xenograft model and clinical samples,and the serum exosomal TAZ level was lower in NSCLC patients.In summary,our data uncover a new tumor suppressor,NDFIP1 in NSCLC,and a new exosome-related regulatory mechanism of TAZ. | Yirui Cheng Xin Lu Fan Li Zhuo Chen Yanshuang Zhang Qing Han Qingyu Zeng Tingyu Wu Ziming Li Shun Lu Cecilia Williams Weiliang Xia | 2023 | Protein & Cell2023，14，2： | 0 |
| 10 | CD301b^(+) macrophages mediate angiogenesis of calcium phosphate bioceramics by CaN/NFATc1/VEGF axis显示文摘Calcium phosphate(CaP)bioceramics are important for tissue regeneration and immune response,yet how CaP bioceramics influence these biological processes remains unclear.Recently,the role of immune cells in biomaterial-mediated regeneration,especially macrophages,has been well concerned.CD301b^(+)macrophages were a new subset of macrophages we have discovered,which were required for bioceramics-mediated bone regeneration.Nevertheless,the impact of CD301b^(+)macrophages on angiogenesis,which is a vital prerequisite to bone formation is yet indistinct.Herein,we found that CD301b^(+)macrophages were closely correlated to angiogenesis of CaP bioceramics.Additionally,depletion of CD301b^(+)macrophages led to the failure of angiogenesis.We showed that store-operated Ca^(2+)entry and calcineurin signals regulated the VEGF expression of CD301b^(+)macrophages via the NFATc1/VEGF axis.Inhibition of calcineurin effectively impaired angiogenesis via decreasing the infiltration of CD301b^(+)macrophages.These findings provided a potential immunomodulatory strategy to optimize the integration of angiogenesis and bone tissue engineering scaffold materials. | Jiaolong Wang Qin Zhao Liangliang Fu Shihang Zheng Can Wang Litian Han Zijian Gong Ziming Wang Hua Tang Yufeng Zhang | 2022 | Bioactive Materials2022，7，9： | 0 |
| 11 | Symmetric-threshold ReLU for Fast and Nearly Lossless ANN-SNN Conversion显示文摘The artificial neural network-spiking neural network(ANN-SNN)conversion,as an efficient algorithm for deep SNNs training,promotes the performance of shallow SNNs,and expands the application in various tasks.However,the existing conversion methods still face the problem of large conversion error within low conversion time steps.In this paper,a heuristic symmetric-threshold rectified linear unit(stReLU)activation function for ANNs is proposed,based on the intrinsically different responses between the integrate-and-fire(IF)neurons in SNNs and the activation functions in ANNs.The negative threshold in stReLU can guarantee the conversion of negative activations,and the symmetric thresholds enable positive error to offset negative error between activation value and spike firing rate,thus reducing the conversion error from ANNs to SNNs.The lossless conversion from ANNs with stReLU to SNNs is demonstrated by theoretical formulation.By contrasting stReLU with asymmetric-threshold LeakyReLU and threshold ReLU,the effectiveness of symmetric thresholds is further explored.The results show that ANNs with stReLU can decrease the conversion error and achieve nearly lossless conversion based on the MNIST,Fashion-MNIST,and CIFAR10 datasets,with 6×to 250 speedup compared with other methods.Moreover,the comparison of energy consumption between ANNs and SNNs indicates that this novel conversion algorithm can also significantly reduce energy consumption. | Jianing Han Ziming Wang Jiangrong Shen Huajin Tang | 2023 | Machine Intelligence Research2023，20，3： | 0 |
| 12 | Metagenomic insights into microorganisms and antibiotic resistance genes of waste antibiotic fermentation residues along production,storage and treatment processes显示文摘Antibiotic fermentation residue(AFR)is nutrient-rich solid waste generated from fermentative antibiotic production process.It is demonstrated that AFR contains high-concentration of remaining antibiotics,and thus may promote antibiotic resistance development in receiving environment or feeding farmed animals.However,the dominate microorganisms and antibiotic resistance genes(ARGs)in AFRs have not been adequately explored,hampering understanding on the potential antibiotic resistance risk development caused by AFRs.Herein,seven kinds of representative AFRs along their production,storage,and treatment processes were collected,and multiple methods including amplicon sequencing,metagenomic sequencing,and bioinformatic approaches were adopted to explore the biological characteristics of AFRs.As expected,antibiotic fermentation producer was found as the predominant species in raw AFRs,which were collected at the outlet of fermentation tanks.However,except for producer species,more environment-derived species persisted in stored AFRs,which were temporarily stored at a semi-open space.Lactobacillus genus,classified as Firmicutes phylum and Bacilli class,became predominant bacterial taxa in stored AFRs,which might attribute to its tolerance to high concentration of antibiotics.Results from metagenomic sequencing together with assembly and binning approaches showed that these newly-colonizing species(e.g.,Lactobacillus genus)tended to carry ARGs conferring resistance to the remaining antibiotic.However,after thermal treatment,remaining antibiotic could be efficiently removed from AFRs,and microorganisms together with DNA could be strongly destroyed.In sum,the main risk from the AFRs was the remaining antibiotic,while environment-derived bacteria which tolerate extreme environment,survived in ARFs with high content antibiotics,and may carry ARGs.Thus,hydrothermal or other harmless treatment technologies are recommended to remove antibiotic content and inactivate bacteria before recycling of AFRs in pharmaceutical industry. | Ziming Han Xiao Luan Haodi Feng Yanqin Deng Min Yang Yu Zhang | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 13 | Elimination of the yellow pigment gene PSY-E2 tightly linked to the Fusarium head blight resistance gene Fhb7 from Thinopyrum ponticum显示文摘Fhb7 is a major gene that was transferred from Thinopyrum ponticum to chromosome 7D of wheat(Triticum aestivum)and confers resistance to both Fusarium head blight(FHB)and Fusarium crown rot(FCR).However,Fhb7 is tightly linked to the PSY-E2 gene,which causes yellow flour,limiting its application in breeding.To break this linkage,marker K-PSY was developed for tagging PSY-E2 and used with Fhb7 markers to identify recombination between the two genes.Screening 21,000 BC1F2 backcross progeny(Chinese Spring ph1bph1b*2/SDAU 2028)revealed two Fhb7^(+)wheat-Tp7el_(2)L lines,Shannong 2–16and Shannong 16–1,that carry a desired truncated Fhb7^(+)translocation segment without PSY-E2.The two lines show levels of resistance to FHB and FCR similar to those of the original translocation line SDAU 2028,but have white flour.To facilitate Fhb7 use in wheat breeding,STS markers were developed and used to isolate Fhb7 on a truncated Tp7el_(2) translocation segment.Near-isogenic lines carrying the Fhb7^(+)segment were generated in the backgrounds of three commercial cultivars,and Fhb7^(+)lines showed increased FHB and FCR resistance without yield penalty.The breakage of the tight linkage between Fhb7 and PSY-E2 via homoeologous recombination provides genetic resources for improvement of wheat resistance to FHB and FCR and permit the large-scale deployment of Fhb7 in breeding using marker-assisted selection. | Xuefeng Li Dong Li Yu Xuan Ziming He Lanfei Zhao Yongchao Hao Wenyang Ge Shoushen Xu Bingqian Hou Biao Wang Jun Guo Wenwen Liu Mingzhu Li Yi Han Cunyao Bo Yinguang Bao Zengjun Qi Steven S.Xu Guihua Bai Hongwei Wang Lingrang Kong | 2023 | The Crop Journal2023，11，3： | 0 |
| 14 | Mitigating Antibiotic Resistance Emissions in the Pharmaceutical Industry: Global Governance and Available Techniques显示文摘We highlight the paramount importance of pretreatment processes preceding the biological treatment of antibiotic manufacturing wastewater as a strategy to curb the escalation of antibiotic resistance.In an effort to curtail the advancement of antimicrobial resistance(AMR)in antibiotic production in China,a comprehensive array of technical and regulatory initiatives have been implemented.These measures offer valuable insights that could inform and enhance global AMR containment strategies.Looking ahead,there is a pressing need to form an interdisciplinary team tasked with refining antibiotic emission standards and tailoring environmental engineering practices for the pharmaceutical sector. | Ziming Han Haodi Feng Chen Wang Xuegong Wang Min Yang Yu Zhang | 2023 | China CDC weekly2023，5，46： | 0 |
| 15 | 利用微孔板测序技术绘制小鼠细胞图谱显示文摘文章简介长久以来,生命科学的研究主要基于群体细胞水平的分析,近几年所涌现的单细胞组学技术,使我们能够从单个细胞的水平上更为精确的解析细胞的分化、再生、衰老以及病变。在本研究中,科研团队自主开发了一套完全国产化的Microwell-seq高通量单细胞测序平台. | Xiaoping Han Renying Wang Yincong Zhou Lijiang Fei Huiyu Sun Shujing Lai Assieh Saadatpour Ziming Zhou Haide Chen Fang Ye Daosheng Huang Yang Xu Wentao Huang Mengmeng Jiang Xinyi Jiang Jie Mao Yao Chen Chenyu Lu Jin Xie Qun Fang Yibin Wang Rui Yue Tiefeng Li He Huang Stuart H.Orkin Guo-Cheng Yuan Ming Chen 郭国骥 | 2019 | 科学新闻2019，0，2： | 0 |
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