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| 1 | Communicative Language Teaching显示文摘Since its appearance in the late 1960s,Communicative Language Teaching (CLT) has gained anincomparable popularity and a present-day worldwide application.Through tuacing back the origin and thedevelopment of CIT,and presenting its proponents’ various versions,we see it is common to all thatcommunicative approach in language teaching starts from a theory of communication and has the aim to developprocedures for the teaching of the four language skills that acknowledge the interdependence of language andcommunication.The purpose of this paper is to make a general study of CLT.It gives a historical background ofCLT,reveals the theoretical basis of CLT and gives description of some basic features of CLT in the classroom. | Li wei (Department of English , Zunyi Teacher’s College) | 2000 | 遵义师范高等专科学校学报2000，2，3： | 17 |
| 2 | Metal-Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications显示文摘Investigation of metal–organic frameworks(MOFs)for biomedical applications has attracted much attention in recent years.MOFs are regarded as a promising class of nanocarriers for drug delivery owing to well-defined structure,ultrahigh surface area and porosity,tunable pore size,and easy chemical functionalization.In this review,the unique properties of MOFs and their advantages as nanocarriers for drug delivery in biomedical applications were discussed in the first section.Then,state-ofthe-art strategies to functionalize MOFs with therapeutic agents were summarized,including surface adsorption,pore encapsulation,covalent binding,and functional molecules as building blocks.In the third section,the most recent biological applications of MOFs for intracellular delivery of drugs,proteins,and nucleic acids,especially aptamers,were presented.Finally,challenges and prospects were comprehensively discussed to provide context for future development of MOFs as efficient drug delivery systems. | Yujia Sun Liwei Zheng Yu Yang Xu Qian Ting Fu Xiaowei Li Zunyi Yang He Yan Cheng Cui Weihong Tan | 2020 | Nano-Micro Letters2020，12，8： | 10 |
| 3 | Tissue and host tropism of influenza viruses:Importance of quantitative analysis显示文摘It is generally accepted that human influenza viruses preferentially bind to cell-surface glycoproteins/ glycolipids containing sialic acids in α2,6-linkage; while avian and equine influenza viruses preferentially bind to those containing sialic acids in α2,3-linkage. Even though this generalized view is accurate for H3 subtype isolates, it may not be accurate and absolute for all subtypes of influenza A viruses and, therefore, needs to be reevaluated carefully and realistically. Some of the studies published in major scientific journals on the subject of tissue tropism of influenza viruses are inconsistent and caused confusion in the scientific community. One of the reasons for the inconsistency is that most studies were quantitative descriptions of sialic acid receptor distributions based on lectin or influenza virus immunohistochemistry results with limited numbers of stained cells. In addition, recent studies indicate that α2,3- and α2,6-linked sialic acids are not the sole receptors determining tissue and host tropism of influenza viruses. In fact, determinants for tissue and host tropism of human, avian and animal influenza viruses are more complex than what has been generally accepted. Other factors, such as glycan topology, concentration of invading viruses, local density of receptors, lipid raft microdomains, coreceptors or sialic acid-independent receptors, may also be important. To more efficiently control the global spread of pandemic influenza such as the current circulating influenza A H1N1, it is crucial to clarify the determinants for tissue and host tropism of influenza viruses through quantitative analysis of experimental results. In this review, I will comment on some conflicting issues related to tissue and host tropism of influenza viruses, discuss the importance of quantitative analysis of lectin and influenza virus immunohistochemistry results and point out directions for future studies in this area, which should lead to a better understanding of tissue and host tropism of influenza viruses. | ZHANG Hong1,2 1 Z-BioMed, Inc., Rockville, MD 20855, USA 2 Department of Respiratory Medicine, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China | 2009 | Science China(Life Sciences)2009，52，12： | 7 |
| 4 | 创建服务型党组织显示文摘遵义市创建服务型党组织,以服务基层、服务群众、服务发展为创建主题,以提升服务功能、提升服务能力、提升民主水平、提升工作水平、提升满意程度为目标,着力构建上级党组织服务下级党组织的工作体系、党组织服务党员的工作体系、党组织和党员共同服务群众的工作体系、城乡党建一体化的工作体系、党组织和广大党员干部共同服务科学发展的工作体系。 | Zunyi Municipal Organization Department of CPC (Communist Party Organization Department of Zunyi,Zunyi 563000,Guizhou,China) | 2011 | 中国浦东干部学院学报2011，5，1： | 5 |
| 5 | Construction of human eukaryotic expression plasmid vascular endothelial growth factor 165 and its expression in transfected vascular smooth muscles显示文摘BACKGROUND: The highly specific vascular endothelialgrowth factor (VEGF) induces the growth of vascular en-dothelial cell. This study was to construct the eukaryoticexpression plasmid of vascular endothelial growth factorl65(VEGF165) and observe its expression in vascular smoothmuscles (VSMCs).METHODS: The primers were designed and synthesizedaccording to the gene sequences of human VEGF165. TheVEGF165 gene was obtained from umbilic artery tissue bythe method of RT-PCR, then it was cloned to eukaryoticexpression plasmid pBudCE4.1 by recombination strategy.The eukaryotic expression plasmid named pBudCE4.1/VEGF165 was identified by restriction enzyme digestion,and was sequenced. The pBudCE4.1/VEGF165 was trans-fected into VSMCs by using lipofection. The VEGF165 ex-pression of mRNA and protein was detected by RT-PCRand Western blot respectively.RESULTS: VEGF165 was shown about 576bp by RT-PCR.Sequencing revealed the amplified VEGF165 gene was iden-tical with that in the GeneBank. Restrictive enzyme (HindBam HI) digestion analysis showed that recombinantexpression plasmid pBudCE4. l/tVEGF165 had been con-structed successfully. The expression of VEGF165 at mRNAand protein levels in the transformed VSMCs had beendemonstrated by RT-PCR and Western blot.CONCLUSIONS: The recombinant eukaryotic expressionplasmid pBudCE4.1/VEGF165 has been successfully con-structed and expressed in transformed VSMCs. The presentstudy has laid a foundation for VEGF165 gene therapy ofvascular stenosis in the transplant organ. | Zhong-Jun Wu, Xiao-Hong Yang, Shu-Sen Zheng, Su-Fen Yang and De Shi Organ Transplant Center, First Affiliated Hospital,Zhejiang University School of Medicine, Hangzhou 310003, China Department of General Surgery, Affiliated Hospital of ZunyiMedical College, Zunyi 563003 , China and Department ofVascular Surgery, Chongqing Medical University, Chongqing 400016 , Chi-na | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，3： | 5 |
| 6 | Concurrent multi-scale design optimization of composite frame structures using the Heaviside penalization of discrete material model显示文摘This paper deals with the concurrent multi-scale optimization design of frame structure composed of glass or carbon fiber reinforced polymer laminates. In the composite frame structure, the fiber winding angle at the micro-material scale and the geometrical parameter of components of the frame in the macro-structural scale are introduced as the independent variables on the two geometrical scales. Considering manufacturing requirements, discrete fiber winding angles are specified for the micro design variable. The improved Heaviside penalization discrete material optimization interpolation scheme has been applied to achieve the discrete optimization design of the fiber winding angle. An optimization model based on the minimum structural compliance and the specified fiber material volume constraint has been established. The sensitivity information about the two geometrical scales design variables are also deduced considering the characteristics of discrete fiber winding angles. The optimization results of the fiber winding angle or the macro structural topology on the two single geometrical scales, together with the concurrent two-scale optimization, is separately studied and compared in the paper. Numerical examples in the paper show that the concurrent multi-scale optimization can further explore the coupling effect between the macro-structure and micro-material of the composite to achieve an ultralight design of the composite frame structure. The novel two geometrical scales optimization model provides a new opportunity for the design of composite structure in aerospace and other industries. | Jun Yan Zunyi Duan Erik Lund Guozhong Zhao | 2016 | Acta Mechanica Sinica2016，32，3： | 4 |
| 7 | Essential role of Msx1 in regulating anterior-posterior patterning of the secondary palate in mice显示文摘Development of the secondary palate displays molecular heterogeneity along the anterior-posterior axis;however, the underlying molecular mechanism remains largely unknown. MSX1 is an anteriorly expressed transcription repressor required for palate development. Here, we investigate the role of Msx1 in regional patterning of the secondary palate. The Wnt1-Cre-mediated expression of Msx1(Rosa Msx1^(Wnt1-Cre))throughout the palatal mesenchyme leads to cleft palate in mice, associated with aberrant cell proliferation and cell death. Osteogenic patterning of the hard palate in Rosa Msx1^(Wnt1-Cre)mice is severely impaired, as revealed by a marked reduction in palatine bone formation and decreased expression of the osteogenic regulator Sp7. Overexpression and knockout of Msx1 in mice show that the transcription repressor promotes the expression of the anterior palate-specific Alx1 but represses the expression of the medialposterior palate genes Barx1, Meox2, and Tbx22. Furthermore, Tbx22 constitutes a direct Msx1 target gene in the secondary palate, suggesting that Msx1 can directly repress the expression of medial-posterior specific genes. Finally, we determine that Sp7 is downstream of Tbx22 in palatal mesenchymal cells,suggesting that a Msx1/Tbx22/Sp7 axis participates in the regulation of palate development. Our findings unveil a novel role for Msx1 in regulating the anterior-posterior growth and patterning of the secondary palate. | Shicheng Zhu Hanjing Song Liangjun Zhong Suman Huo Yukun Fang Wanxin Zhao Xueqin Yang Zhong-Min Dai Rui He Mengsheng Qiu Zunyi Zhang Xiao-Jing Zhu | 2022 | Journal of Genetics and Genomics2022，49，1： | 2 |
| 8 | 显示文摘 | Qing-song JIANG~2 Xie-nan HUANG Gui-zhong YANG~4 Xiao-yan JIANG~5 Qi-xin ZHOU~(2 6) ~2Department of Pharmacology Chongqing Medical University Chongqing 400016 China ~3Department of Pharmacology Zunyi Medical College Zunyi 563003 China ~4Department of Bioc | 2007 | Acta Pharmacologica Sinica2007，，08： | 1 |
| 9 | Treatment of acute abdominal diseases by combined traditional chinese and western medicine显示文摘 | Nan Kai Hospital Tientsin Zunyi Medical College | 1979 | World J Surg1979，，3： | 1 |
| 10 | Sulfur Isotopes Geochemistry of the Nage Cu-Pb Polymetallic Deposit,Southeast Guizhou Province,China显示文摘The Nage Cu-Pb polymetallic deposit is located in the transitional zone of the Yangtze craton and cathaysia,that is the southwest of Jiangnan orogenic belt. The mainly strata are Wentong formation of Mesoproterozoic Sibo group and the Jialu formation(Qbj) ,Wuye formation(Qbw) ,Fanzhao formation(Qbf) and Gongdong formation(Qbg) of the Neoproterozoic Qingbaikou System Xiajiang group. | LONG Xuan-lin1,ZHOU Jia-xi2,HUANG Zhi-long2,WANG Jing-song1,YANG De-zhi1,3,FAN Liang-wu2,BAO Guang-ping2,LIU Yong-kun1(1. The 102 Geological Team,Guizhou Bureau of Exploration and Development of Geology and Mineral Resources,Zunyi 563003,China 2. State key Laboratory of Ore Deposits Geochemistry,Institute of Geochemistry,Chinese Academy of Science,Guiyang 550002,China 3. China University of Geosciences(Wuhan) ,Wuhan 430074,China) evidence. | 2009 | 矿物学报2009，29，S1： | 1 |
| 11 | Jurassic Brachiopods and Paleogeography of North Qinghai-Tibetan Plateau显示文摘This paper deals with Jurassic brachiopods from North Tibet and SouthQinghai and the stratigraphical subdivision there.Based on faunas andstrata,a general outline of the palaeogeographical evolution has been traced outalong the line of plate-tectonic movements.In this paper,10 species of 8 gen-era are described,among which the species Lacunosella rhombica,Pentithyrisvulgaris,Tanyothyris appositus,Apatecosia navicularis and Flabellothyris sp.nov.have been recognized as new. | Yang Zunyi Shi XiaoyingDepartment of Geology , China University of Geosciences , Beijing 100083 | 1990 | Journal of Earth Science1990，9，1： | 1 |
| 12 | Roles of estrogen receptor α and β in modulating urothelial cell proliferation显示文摘 | Teng Jian Wang Zunyi Jarrard DF | 2008 | Endocr Relat Cancer2008，15，1： | 1 |
| 13 | UAV-assisted data gathering in wireless sensor networks显示文摘 | Mianxiong Dong Kaoru Ota Man Lin Zunyi Tang Suguo Du Haojin Zhu | 2014 | The Journal of Supercomputing2014，，3： | 1 |
| 14 | Carbon-doped anatase TiO 2 obtained from TiC for photocatalysis under visible light irradiation显示文摘 | Ming Shen Zunyi Wu Hui Huang Yukou Du Zhigang Zou Ping Yang | 2005 | Materials Letters2005，，5： | 1 |
| 15 | Dose-dependent regulation of oligodendrocyte specification by β-catenin signaling显示文摘Dear Editor,Although various components of the Wnt/β-catenin pathway have been investigated,there are conflicting reports on the roles of Wnt/β-catenin signaling in oligodendrogenesis and differentiation.For instance,theΔExon3 mutation ofβ-catenin[1-4],which stabilizesβ-catenin by deletion of the phosphorylation site for the destruction complex,signifi cantly inhibits the differentiation of oligodendrocytes, | Shuhui Sun Wei Guo Zunyi Zhang Mengsheng Qiu Zhong-Min Dai | 2015 | Neuroscience Bulletin2015，31，2： | 1 |
| 16 | TAPP1 inhibits the differentiation of oligodendrocyte precursor cells via suppressing the Mek/Erk pathway显示文摘Oligodendrocytes(OLs) are glial cells that form myelin sheaths around axons in the central nervous system(CNS).Loss of the myelin sheath in demyelinating and neurodegenerative diseases can lead to severe impairment of movement.Understanding the extracellular signals and intracellular factors that regulate OL differentiation and myelination during development can help to develop novel strategies for enhancing myelin repair in neurological disorders.Here,we report that TAPP1 was selectively expressed in differentiating OL precursor cells(OPCs).TAPP1 knockdown promoted OL differentiation and myelin gene expression in culture.Conversely,over-expression of TAPP1 in immature OPCs suppressed their differentiation.Moreover,TAPP1 inhibition in OPCs altered the expression of Erk1/2 but not AKT.Taken together,our results identify TAPP1 as an important negative regulator of OPC differentiation through the Mek/Erk signaling pathway. | Yidan Chen Ruyi Mei Peng Teng Aifen Yang Xuemei Hu Zunyi Zhang Mengsheng Qiu Xiaofeng Zhao | 2015 | Neuroscience Bulletin2015，31，5： | 1 |
| 17 | Agricultural Eco-efficiency Evaluation in Anhui Province: An Empirical Analysis Based on DEA Method显示文摘According to the eco-efficiency theory, combined with agricultural production characteristics, I point out the environmental impact and substance energy consumption characteristics of agricultural production. Based on this, I establish the eco-efficiency evaluation indicator system for agricultural production, and conduct a comprehensive analysis on the agricultural eco-efficiency of 17 prefecture-level cities in Anhui Province, using data envelopment analysis method. | Zunyi CHEN | 2013 | Asian Agricultural Research2013，5，4： | 1 |
| 18 | Index for hazard of glacier lake outburst flood of Lake Merzbacher by satellite-based monitoring of lake area and ice cover显示文摘 | Xie Zunyi Shangguan Donghui Zhang Shiqiang | 2013 | Global and Planetary Change2013，107，： | 1 |
| 19 | Lead Isotope and Rock Geochemistry of Zaibian Mafic-Ultramafic Rock,Southeast Guizhou Province,China显示文摘The Zaibian mafic-ultramafic rock is located in the transitional zone of the Yangtze craton and south China fold system,where is the southwest of Jiangnan orogenic belt(Zeng et al.,2003;Wang et al.,in press). | LIU Yong-kun1,ZHOU Jia-xi2,HUANG Zhi-long2,WANG Jing-song1,YANG De-zhi1,3,DING wei2,CHEN Yuan-xing1,BAO Guang-ping2(1. The 102 Geological Team,Guizhou Bureau of Exploration and Development of Geology and Mineral Resources,Zunyi 563003,China 2. State key Laboratory of Ore Deposits Geochemistry,Institute of Geochemistry,Chinese Academy of Science,Guiyang 550002,China 3. China University of Geosciences(Wuhan) ,Wuhan 430074,China) | 2009 | 矿物学报2009，29，S1： | 1 |
| 20 | Rescue of cleft palate in Msx1 - deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis 显示文摘 | Zunyi Zhang Yiqiang Song Xiang Zhao Xiaoyun Zhang Cesar Fermin YiPing Chen | 2002 | Development2002，129，17： | 1 |
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