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| 1 | The mechanism of dentine hypersensitivity:Stimuli-induced directional cation transport through dentinal tubules显示文摘Dentine hypersensitivity is an annoying worldwide disease,yet its mechanism remains unclear.The long-used hydrodynamic theory,a stimuli-induced fluid-flow process,describes the pain processes.However,no experimental evidence supports the statements.Here,we demonstrate that stimuli-induced directional cation transport,rather than fluid-flow,through dentinal tubules actually leads to dentine hypersensitivity.The in vitro/in vivo electro-chemical and electro-neurophysiological approaches reveal the cation current through the nanoconfined negatively charged dentinal tubules coming from external stimuli(pressure,pH,and temperature)on dentin surface and further triggering the nerve impulses causing the dentine hypersensitivity.Furthermore,the cationic-hydrogels blocked dentinal tubules could significantly reduce the stimuli-triggered nerve action potentials and the anionhydrogels counterpart enhances those,supporting the cation-flow transducing dentine hypersensitivity.Therefore,the inspired ion-blocking desensitizing therapies have achieved remarkable pain relief in clinical applications.The proposed mechanism would enrich the basic knowledge of dentistry and further foster breakthrough initiatives in hypersensitivity mitigation and cure. | Nuo Chen Jingjing Deng Shengjie Jiang Xiang-Yu Kong Teng Zhou Kai Zhao Zuohui Xiao Huimin Zheng Weipeng Chen Congcong Zhu Xinyu Liu Liping Wen Yan Wei Xuliang Deng Lei Jiang | 2023 | Nano Research2023，16，1： | 2 |
| 2 | Grape seed proanthocyanidin extract attenuates oxidant injury in cardiomyocytes显示文摘 | SHAO Zuohui BECKER L B VANDEN HOEK T L | 2003 | Pharmacological Research2003，47，6： | 1 |
| 3 | Hydroxy-safflor yellow A inhibits neuroinflammation mediated by Aβ 1–42 in BV-2 cells显示文摘 | Zuohui Zhang Zhengzheng Wu Xiaolei Zhu Xinchen Hui Jie Pan Yun Xu | 2014 | Neuroscience Letters2014，，： | 1 |
| 4 | Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes显示文摘 | CHANG Weitien SHAO Zuohui YIN Junjie | 2007 | Eur J Pharmacol2007，566，3： | 1 |
| 5 | MicroRNAs target gene and signaling pathway by bioinformatics analysis in the cardiac hypertrophy显示文摘 | E. Shen Xuehong Diao Cong Wei Zuohui Wu Ling Zhang Bing Hu | 2010 | Biochemical and Biophysical Research Communications2010，，3： | 1 |
| 6 | Hydroxysafflor yellow A inhibits neuroinflammation mediated by Aβ1-42in BV-2 cell显示文摘 | Zhang Zuohui Wu Zhengzheng Zhu Xiaolei | 2014 | Neuroscience Letters2014，562，6： | 1 |
| 7 | Synergistic effect of scutellaria baicalensis and grape seed proanthocyanidins on scavenging reactive oxygen species in vitro 显示文摘 | SHAO Zuohui TERRY L VANDEN H | 2004 | Am J Chin Med2004，32，： | 1 |
| 8 | NUMERICAL MODELLING OF GOLD-ROLLBONDING OF CLAD METAL SHEETS显示文摘An analytical model based on the rigid-plastic finite-element formulation for slightly compressible materials is newly proposed to examine the bonding behavior at the roll gap during clad metal sheets rolling. The interfacial elements inserted between the two metals, which are characteristic of the shear-susceptible deformation with the help of the shear factor in the expression of effective strain rate,are used to model the relative slidding at the interface. It is found that the proposed method is applicable to the simulation of clad metal sheets rolling. | Luo Chunhui Peng Dashu Xu Zuohui (Department of Materials Science and Engineering, Central South University of Technology, Changsha 410083, China) | 1997 | Journal of Central South University1997，9，2： | 0 |
| 9 | MDR1/P-Glycoprotein Overexpression in Bladder Transitional Cell Carcinoma and its Correlation with Expression of Survivin and Fas显示文摘OBJECTIVE To explore the expression of the MDR1/P-glycoprotein, Fas and survivin and to examine their correlation with the biologic behavior of bladder transitional cell carcinoma (BTCC). METHODS Immunohistochemistry was used to examine the expression of P-gp, survivin and Fas in BTCC (n=64) and normal bladder mucosa (n=12). RESULTS The expression level of P-gp and survivin in BTCC was higher compared to normal bladder mucosa (P<0.01) and their expression was strongly correlated with clinical grading (P<0.01). In BTCC and normal bladder mucosa Fas expression was 50% and 100%, respectively (P< 0.01). Recurrent BTCC showed higher expression than primary BTCC (P< 0.01) and the expression of P-gp in BTCC had a reverse correlation with Fas expression but no correlation with survivin expression. CONCLUSUON The MDR of BTCC was strongly correlated with the ex- pression of P-gp and Fas, but was not correlated with survivin expres- sion. Thus, enhancing cancer sensitivity to chemotherapy by reversing multidrug resistance with reversal agents or up-regulating Fas expres- sion by apoptotic enhancing agents, might be a potential therapy to pre- vent tumor recurrence and invasiveness. | Changli Wu Wenlan Zhang Jiwu Chang Zuohui Zhao Guang Sun Ruifa Han | 2006 | Chinese Journal of Clinical Oncology2006，3，3： | 0 |
| 10 | 6-31 Progress of Cryogenic System in 2014显示文摘During the year of 2014, the work of cryogenic group was mainly focused on operation of refrigerator system,test of TCM1, design and machining of HCM6. At the end of 2014 refrigerator system has achieved closed-loopoperation and recycle of helium gas, which did great contribution to superconducting cavity and superconductingmagnet test. Since the refrigerator was put into use(Fig. 1), it has operated continuously and reliably for more than5 110 h, reached helium lique ed capacity 270 L/h at 850 W. | Zhang Junhui Guo Xiaohong Jin Tao Zhao Yugang Niu Xiaofei Wan Yuqin Su Hailin Han Yanning Yang Yonghui Bai Feng Jiang Ziyun Hu Chuanfei Zhang Peng Guo Wanhong Yin Yukui Liu Zuohui Hu Yongping Wang Xianjin | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 11 | 6-32 Design and Operation of Cryogenic Vertical Testing System for Superconducting Cavity显示文摘The superconducting accelerating segment in injectorⅡof Accelerator Driven Sub-critical System(ADS) uses superconductingcavities whose frequency are 162.5 MHz. The vertical performance of superconducting cavity devicesmust be tested at liquid helium temperature(2, 4.2 K) before being assembled in cryostat. To meet the runninggoal of the 0 25 MeV linac system, it is necessary to build a set of cryogenic testing system for superconductingcavity, which is used to test the performance of the superconducting cavity and whether cavity meet the designgoal. | Bai Feng Su Hailin Zhang Junhui Guo Xiaohong Hu Chuanfei Niu Xiaofei Zhang Peng Zhao Yugang Yin Yukui Guo Wanhong Liu Zuohui Wang Xianjin Hu Yongping | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 12 | Experimental Study on the Influence Mechanism of Carbon Fiber/Epoxy Composite Reinforcement and Matrix on Its Fire Performance显示文摘The effects of the number of layers,the arrangement of carbon fiber(CF)tow and the epoxy resin(ER)matrix on the fire performance of carbon fiber/epoxy composites(CFEC)were studied by a variety of experimental methods.The results show that the number of layers of CF tow has influence on the combustion characteristics and fire propagation of the composites.The arrangement of CF tow has influence on flame propagation rate and high temperature mechanicalproperties.The mechanism of the influence of the number of layers of CF tow on the composite is mainly due to the different thermal capacity of ER matrix.The effect of the arrangement of CF tow on the fire performance of the composite is mainly due to the inhibition and obstruction of the tow on the combustion of ER matrix.The influence on the high temperature mechanicalproperties is mainly due to the different arrangement direction of CF tow.The fitting equation of the mechanicalproperties of the samples was obtained.This equation could be used to predict the samples’tensile strength from 25°C to 150℃by comparing with the experimental results.Taking the carbon fiber woven cloth(C)applied in the fuselage material as an example,combining the influencing factors of various parameters in the fire field,some suggestions are put forward combined with the research conclusion. | Lei Zhang Haiyan Wang Junpeng Zhang Zhi Wang Zuohui Xu Xinyu Gao | 2020 | Journal of Renewable Materials2020，8，3： | 0 |
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