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| 1 | ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy显示文摘响应滋养的应力,房间开始能导致改编或死亡的一个 autophagy 节目。位于从饥饿发信号到 autophagy 的开始下面的机制充分没被理解。在当前的学习,我们证明 PARP-1 的缺席或 inactivation 强烈推迟导致饥饿的 autophagy。我们发现了那 DNA 损坏是由 γ 测量了的导致饥饿的 autophagy 的一个早事件; -H2AX 累积和彗星试金,与在两个参数显示减小的 PARP-1 猛烈房间。在饥饿期间,导致 ROS 的 DNA 损坏激活 PARP-1,导致 ATP 弄空(在滋养的剥夺以后的一个早事件) 。PARP-1 的缺席弄钝 AMPK 激活并且阻止了 mTOR 活动的完全的损失,导致在 autophagy 的延期。PARP-1 弄空在饥饿的房间赞成 apoptosis,建议在滋养的剥夺以后的 autophagy 和 PARP-1 激活的一个支持幸存的角色。在 PARP-1 变异的老鼠的出生不满一月的婴儿使遭到了到尖锐饥饿的 vivo 结果表演,也显示缺乏的肝 autophagy,暗示为在导致饥饿的 autophagy 的 PARP-1 的一个生理的角色。因此,表明小径的 PARP 是 autophagy 承诺追随者饥饿的起始的步骤的一个关键管理者。 | Jose Manuel Rodriguez-Vargas Maria Jose Ruiz-Magana Carmen Ruiz-Ruiz Jara Majuelos-Melguizo Andreina Peralta-Lea Maria Isabel Rodriguez Jose Antonio Munoz-Gaimez Mariano Ruiz de Almodovar Eva Siles Abelardo Lopez Rivas Marja Jaattela F Javier Oliver | 2012 | Cell Research2012，22，7： | 8 |
| 2 | 永磁导轨上组合与单块YBCO的悬浮力关系研究显示文摘受现有块材尺寸与性能的限制 ,实际应用中总是将许多超导块组合以满足实际需求 .因此 ,研究组合样品与单个样品悬浮力之间的关系对设计磁悬浮系统具有实际意义 .本文研究了永磁导轨上组合样品与单块样品悬浮力之间的关系 .组合样品由 3块矩形融熔织构YBCO块材组成 ,实验分两种方式进行 ,即组合样品平行于永磁导轨和垂直于永磁导轨两种情况 .两种情况的实验结果均表明 ,组合样品的悬浮力与单个样品悬浮力的总和相当 ,平行时的最大悬浮力偏差为 1 4 .0N ,垂直时的最大悬浮力偏差为 4.9N .30mm悬浮间距内的最大悬浮力偏差百分比不超过 6% .因此 ,我们可以根据单个样品的悬浮力来估算各种组合情况时的悬浮力 . | 任仲友 Oliver de Hass 王晓融 宋宏海 王兴志 郑珺 王素玉 王家素 | 2003 | 低温物理学报2003，25，A01： | 7 |
| 3 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 4 | 应用改良的枕下乙状窦后入路显微外科手术切除大型岩斜区脑膜瘤显示文摘目的介绍应用改良的枕下乙状窦后入路显微外科手术切除大型岩斜区脑膜瘤的方法和经验。方法枕下乙状窦后骨窗形成后,注意将横窦、乙状窦轮廓。切开硬膜后充分向外侧和向上牵开。通过颅神经间隙完成肿瘤的内减压后,分离肿瘤与颅神经及脑干的粘连并分块切除。如果肿瘤向中颅凹延伸,可切开部分天幕后向上切除肿瘤。如果肿瘤向枕骨大孔延伸,可将乙状窦后入路与枕下远外侧入路结合起来加以切除。对于MRI显示具有侵袭性特征,侵犯海绵窦或脑干的肿瘤,不应追求肿瘤的全切除,“脑干减压”成为手术的主要目标。结果肿瘤全切除9例(60%)。手术后新增颅神经损害6例(40%)。半年随访恢复良好者13例(86.6%)。结论应用简单的枕下乙状窦后入路,结合一些新的技术改良处理大型岩斜区脑膜瘤,可获得满意的手术疗效。 | 冯东侠 Oliver De Witte | 2004 | 中华神经外科杂志2004，20，4： | 3 |
| 5 | Model uncertainty and systematic risk in US banking 显示文摘 | Lieven Baele Valerie De Bruyckere Oliver De Jonghe Rudi Vander Ve- nnert | 2015 | Journal of Banking and Financial2015，，53： | 1 |
| 6 | Measles elimination in the Americas 显示文摘 | De Quadros CA Olive JM Hersh BC | 1996 | J Am Med Assoc1996，275，3： | 1 |
| 7 | Biofeedback therapy for urinary incontinence in children 显示文摘 | Blanco JL Oliver FJ de Celis R | 2006 | Cir Pediatr2006，19，2： | 1 |
| 8 | D -Dimer is an early diagnostic marker of coronary ischemia in patients with chest pain显示文摘 | Antoni Bayes-Genis Jose Mateo Miquel Santaló Artur Oliver Josep Guindo Lina Badimon Antoni Mart??nez-Rubio Jordi Fontcuberta Robert S. Schwartz Antoni Bayés de Luna | 2000 | American Heart Journal2000，，3： | 1 |
| 9 | Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)显示文摘 | Bentley SD Chater KF Cerdeno-Tarraga AM Challis GL Thomson NR James KD Harris DE Quail MA Kieser H Harper D Bateman A Brown S Chandra G Chen CW Collins M Cronin A Fraser A Goble A Hidalgo J Hornsby T Howarth S Huang CH Kieser T Larke L Murphy L Oliver K O | | 0，，： | 1 |
| 10 | Staging of carcinoid tumours with 18 F-DOPA PET: a prospective, diagnostic accuracy study显示文摘 | Klaas P Koopmans Elisabeth GE de Vries Ido P Kema Philip H Elsinga Oliver C Neels Wim J Sluiter Anouk NA van der Horst-Schrivers Pieter L Jager | 2006 | Lancet Oncology2006，，9： | 1 |
| 11 | Efficacy of Re-treatment With TMC435 as Combination Therapy in Hepatitis C Virus–Infected Patients Following TMC435 Monotherapy显示文摘 | Oliver Lenz Joep de Bruijne Leen Vijgen Thierry Verbinnen Christine Weegink Herwig Van Marck Ina Vandenbroucke Monika Peeters Kenneth Simmen Greg Fanning Rene Verloes Gaston Picchio Hendrik Reesink | 2012 | Gastroenterology2012，，5： | 1 |
| 12 | Treatment of suhtrochanteric nonunions 显示文摘 | Jasper S de Vries PK Oliver Borens | 2006 | Injury Int J Care Injured2006，37，2： | 1 |
| 13 | Choose your partners: dimerization in eukaryotic transcription factors显示文摘 | Grigoris D. Amoutzias David L. Robertson Yves Van de Peer Stephen G. Oliver | 2008 | Trends in Biochemical Sciences2008，，5： | 1 |
| 14 | Techniques and Training with GreenLight HPS 120-W Laser Therapy of the Prostate: Position Paper显示文摘 | Gordon Muir Fernando Gómez Sancha Alexander Bachmann Benjamin Choi Edward Collins Jean de la Rosette Oliver Reich Shahin Tabatabaei Henry Woo | 2007 | European Urology Supplements2007，，： | 1 |
| 15 | Radiofrequency ablation of spinal tumors: temperature distribution in the spinal canal 显示文摘 | Dupuy DE Hong R Oliver B | 2000 | AJR2000，175，： | 1 |
| 16 | Measles elimination in the Americas 显示文摘 | De Qnadros CA Olive JM Hersh BC | 1996 | J AM MED ASSOC1996，275，3： | 1 |
| 17 | Irreversible telomereshortening by3′-Azido-2′,3′-dideoxythmidine(AZT)treatment显示文摘 | Gomez DE Tejera AM Olive OA | 1998 | Biochem Biophy Res Commun1998，246，1： | 1 |
| 18 | The effect of RRA on the strength and SCC resistance on AA7050 and AA7150 alu-minium alloys 显示文摘 | Oliver A F Jr de Barros M C | 2004 | Materials Science and Engineering A2004，379，： | 1 |
| 19 | Congenital hyperinsulinism显示文摘 | Jean-Baptiste Arnoux Pascale de Lonlay Maria-Joao Ribeiro Khalid Hussain Oliver Blankenstein Klaus Mohnike Vassili Valayannopoulos Jean-Jacques Robert Jacques Rahier Christine Sempoux Christine Bellanné Virginie Verkarre Yves Aigrain Francis Jaubert Franc | 2010 | Early Human Development2010，，5： | 1 |
| 20 | The effect of RRA on the strength and SCC resistance on AA7050 and AA7150 aluminium alloys显示文摘 | OLIVE|RA J A F de BARROS M C CARDOSO K R TRAVESSA D N | 2004 | Materials Science and Engineering A2004，379，12： | 1 |
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