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| 1 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 2 | Factors affecting phosphate adsorption equilibria in lake sediments显示文摘 | Ku W C Digiano F A Feng T H | 1978 | Water Res1978，12，： | 2 |
| 3 | EEG default mode network in the human brain:spectral regional field powers显示文摘 | Chen A C Feng W Zhao H | | 0，，02： | 1 |
| 4 | Evidence for osteocyte regulation of bone homeostasis through RANKL expression显示文摘 | Nakashima T Hayashi M Fukunaga T Kurata K Oh-Hora M Feng J Q B onewald L F K odama T W utz A W agner E F Penninger JM Takayanagi H | | 0，，： | 1 |
| 5 | YM155induces caspase-8dependent apoptosis through downregulation of survivin and Mcl-1in human leukemia cells显示文摘 | Feng W Yoshida A Ueda T | 2013 | Biochem Biophys Res Commun2013，435，： | 1 |
| 6 | Berberine amelio- rates COX--2 expression in rat small intestinal mucosa partially through PPARgamma pathway during acute endotoxemia显示文摘 | feng A W Gao W Zhou G R | 2012 | Int Immunopharmacol2012，12，1： | 1 |
| 7 | Algorithms for integrated routing and scheduling for aggregating data from distributed resources on a Lambda Grid 显示文摘 | BANERJEE A FENG W GHOSAL D | 2008 | IEEE Transactions on parallel and distributed systems2008，19，1： | 1 |
| 8 | Stochastic construction timecost tradeoff analysis 显示文摘 | Feng C W Liu L Burns S A | 2000 | Journal of Computing in Civil Engineering2000，14，2： | 1 |
| 9 | Altered microbial community structure and organic matter composition under elevated CO2 and N fertilization in the duke forest显示文摘 | Feng X J Simpson A J Schlesinger W H | 2010 | Global Change Biology2010，16，： | 1 |
| 10 | Estrogen modulates TNF-α-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-β activation显示文摘 | Xing D Feng W Miller A | 2007 | Am J Physiol Heart Circ Physiol2007，292，6： | 1 |
| 11 | A group of Esche- richia coli and Salmonella enterica () antigens sharing a com- mon backbone structure显示文摘 | Wang W Perepelov A V Feng L | 2007 | Microbiology2007，153，7： | 1 |
| 12 | Microstructure and stress development in magnetron sputtered TiAlCr(N) films 显示文摘 | Feng H Guohua W John A | 2001 | Surface and Coatings Technology2001，，： | 1 |
| 13 | Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm 显示文摘 | Huang X Zhao Y Wei X Li C Wang A Zhao Q Li W Guo Y Deng L Zhu C Fan D Lu Y Weng Q Liu K Zhou T Jing Y SiL DongG Huang T Lu T Feng Q Qian Q Li J Han B | 2011 | Nature Genetics2011，44，1： | 1 |
| 14 | Control of alternative splicing by forskolin through hnRNP K during neuronal dif- ferentiation显示文摘 | Cao W Razanau A Feng D | 2012 | Nucleic Acids Res2012，40，16： | 1 |
| 15 | Peroxidase activity of hemoglobin-haptoglobin complexes: covalent aggre gation and oxidative stress in plasma and microphage显示文摘 | Kapralov A Vlasova II Feng W | 2009 | J Biol Chem2009，284，30： | 1 |
| 16 | 查看详情显示文摘 | W J Zhang J Feng A G MacDiarmid | | 0，，1： | 1 |
| 17 | A comparative study of pyrolyzed and doped cobalt-polypyrrole eletrocatalysts for oxygen reduction reaction显示文摘 | FENG W LI H Y CHENG X JAO T C WENG F B SU A CHIANG Y C | 2012 | Appl Surf Sci2012，258，8： | 1 |
| 18 | Altered microbial community structure and organic matter composition under elevated CO2and N fertilization in the duke forest显示文摘 | FENG X J SIMPSON A J SCHLESINGER W H | 2010 | Global Change Biology2010，16，： | 1 |
| 19 | Draft genome of the wheata-genome progenitor Triticum urartu显示文摘 | Ling HQ Zhao S Liu D Wang J Sun H Zhang C Fan H Li D Dong L Tao Y Gao C Wu H Li Y Cui Y Guo X Zheng S Wang B Yu K Liang Q Yang W Lou X Chen J Feng M Jian J Zhang X Luo G Jiang Y Liu J Wang Z Sha Y Zhang B WuH Tang D Shen Q Xue P Zou S Wang X Liu X Wang F Yang Y An X Dong Z Zhang K Zhang X Luo MC Dvorak J Tong Y Wang J Yang H Li Z Wang D Zhang A Wang J | 2013 | Nature2013，469，7443： | 1 |
| 20 | High-power ultrasonic treatment of bu- tyl rubber gum : Structure and properties 显示文摘 | Feng W L Isayev A I | 2005 | Journal of Poly-ler Science ( Part B ) : Polymer Physics2005，43，3： | 1 |
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