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| 1 | Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients显示文摘AIM: To determine the composition of both fecal and duodenal mucosa-associated microbiota in irritable bowel syndrome (IBS) patients and healthy subjects using molecular-based techniques. METHODS: Fecal and duodenal mucosa brush samples were obtained from 41 IBS patients and 26 healthy subjects. Fecal samples were analyzed for the composition of the total microbiota using fluorescent in situ hybridization (FISH) and both fecal and duodenal brush samples were analyzed for the composition of bif idobacteria using real-time polymerase chain reaction. RESULTS: The FISH analysis of fecal samples revealed a 2-fold decrease in the level of bifidobacteria (4.2 ± 1.3 vs 8.3 ± 1.9, P < 0.01) in IBS patients compared to healthy subjects, whereas no major differences in other bacterial groups were observed. At the species level, Bifidobacterium catenulatum levels were significantly lower (6 ± 0.6 vs 19 ± 2.5, P < 0.001) in the IBS patients in both fecal and duodenal brush samples than in healthy subjects.CONCLUSION: Decreased bifidobacteria levels in both fecal and duodenal brush samples of IBS patients compared to healthy subjects indicate a role for microbiotic composition in IBS pathophysiology. | Angèle PM Kerckhoffs Melvin Samsom Michel E van der Rest Joris de Vogel Jan Knol Kaouther Ben-Amor Louis MA Akkermans | 2009 | World Journal of Gastroenterology2009，15，23： | 33 |
| 2 | ZmMs30 Encoding a Novel GDSL Lipase Is Essential for Male Fertility and Valuable for Hybrid Breeding in Maize显示文摘Genic male sterility (GMS) is very useful for hybrid vigor utilization and hybrid seed production. Although a large number of GMS genes have been identified in plants, little is known about the roles of GDSL lipase members in anther and pollen development. Here, we report a maize GMS gene, ZmMs30, which encodes a novel type of GDSL lipase with diverged catalytic residues. Enzyme kinetics and activity assays show that ZmMs30 has lipase activity and prefers to substrates with a short carbon chain. ZmMs30 is specifically expressed in maize anthers during stages 7-9. Loss of ZmMs30 function resulted in defective anther cuticle, irregular foot layer of pollen exine, and complete male sterility. Cytological and lipidomics analyses demonstrate that ZmMs30 is crucial for the aliphatic metabolic pathway required for pollen exine formation and anther cuticle development. Furthermore, we found that male sterility caused by loss of ZmMs30 function was stable in various inbred lines with different genetic background, and that it didn't show any negative effect on maize heterosis and production, suggesting that ZmMs30 is valuable for crossbreeding and hybrid seed production. We then developed a new multi-control sterility system using ZmMs30 and its mutant line, and demonstrated it is feasible for generating desirable GMS lines and valu. able for hybrid maize seed production. Taken together, our study sheds new light on the mechanisms of anther and pollen development, and provides a valuable male-sterility system for hybrid breeding maize. | Xueli An Zhenying Dong Youhui Tian Ke Xie Suowei Wu Taotao Zhu Danfeng Zhang Van Zhou Canfang Niu Biao Ma Quancan Hou Jianxi Bao Simiao Zhang Ziwen Li Yanbo Wang Tingwei Yan Xiaojing Sun Yuwen Zhang Jinping Li Xiangyuan Wan | 2019 | Molecular Plant2019，12，3： | 15 |
| 3 | Apatite-fission-track geochronology and its tectonic correlation in the Dabieshan orogen,central China显示文摘AFT data of granitoid and metamorphic samples from the Dabieshan orogen have an age range between 96.4 Ma and 41.9 Ma coupled with confined track lengths of 11.5—14.0 μm, reflecting the cooling time of rocks differentially through the 100℃± isotherm. The Juras- sic-Eogene sediments from the North Huaiyang and Hefei basin, however, yield their AFT ages of 128.8—62.0 Ma with mean track lengths of 8.6—11.9 μm, recording a complicated thermal de- velopment of the basin. These AFT data structurally allowing the coupling between the orogen and the basin are to a great extent considered as the result from the control of NNE-trending regional tectonics. It took place approximately at 95—90 Ma that the orogen developed with an abrupt shift from the doming extension to the differential transtension, which is assumed to be related with the changes of the convergence between the Western Pacific and Eurasia plates. The differentially sinistral strike-slipping from the transtension between Tanlu and Shang- cheng-Macheng faults brought the doming extension of the orogen shrunk sharply in Late Cre- taceous. In Eogene, the full-grown transtension that dominated in East Asia was caused mainly by a rapid decrease of the rates of the Western Pacific convergence, which can be therefore re- garded as a major mechanism creating the zonal anomalies of 60—40 Ma in the orogen. The thermal anomaly of 70—40 Ma zonally along the Tanlu fault cooled more slowly than the anomaly of 60—55 Ma zoning along the Shangcheng-Macheng fault, but the 60—40 Ma anomaly trending E-W in hinterlands of the orogen seems to be relicts of the doming extension as a result of inten- sive rebuilding by the transtension. In addition, the orogen was also reactivated by the far-field effect from India-Asia collision in Eogene, where major NWW-trending faults played an important role in facilitating such far-field tectonic transferring. In Oligocene to Miocene, the Dabieshan orogen remained a few thermal disturbances with their AFT ages particularly in coincidence with the time of opening and closing of the South China Sea. | P. Van Den Haute R. A. Donelick J. De Grave MA Changqian P. W. Reiners | 2005 | Science China Earth Sciences2005，48，4： | 9 |
| 4 | Neogene Paleoseismic Events and the Shanwang Biota's Burial in the Linqu Area,Shandong Province,China显示文摘Several paleoseismic events are recorded in the Neogene Linqu Group, exposed in the Linqu area, Shandong Province, China. The events were interpreted on the basis of fieldwork and laboratory analysis, which showed the presence of seismites with plastically deformed soft-sediment deformation structures in the Shanwang Formation, and of seismic volcanic rocks in the Yaoshan Formation which show brittle deformation. The earthquake-triggered soft-sediment deformations in the seismites include load structures, ball-and-pillow structures, flame structures, pillow-like beds, boudinage structures, slump folds, syn-depositional faults, veins of liquefied sand, and dikes of liquefied sandy lime-mud. The seismic activity is also reflected in what might be called ‘brittle seismites'; these originated when, under the influence of seismic vibrations, semi-consolidated conglomerate was shattered. Moreover, volcanic activity is related to intense earthquakes that affected basalts intercalated with sand layers; these successions are known as ‘seismic volcanic rocks', which are characterized by veins of liquefied sand intruding the basalts. All above traces of paleoseismic activity were left from one single time span of 4 Ma with active seismicity that took place 14–10 Ma. This time span is known as ‘the Linqu Neogene Paleoseismic Active Period', which is divided into four paleoseismic episodes, which were responses to tectonic extension and basin rifting in this area. It even includes the activity of the Yishu Fault Zone during the Miocene and the Neogene. The ratios of trace elements in the seismites, w(La)/w(Sc) and w(La)/w(Th) are higher than the average value of the upper crust, but w(Th)/w(Sc) is lower; this is geochemical evidence for the basin rifting that resulted in a high sedimentation rate. The intense and frequent paleo-earthquakes are held responsible for the rapid burial of the Shanwang Biota. Secondary earthquake-induced processes(e.g. slumping of a lake shore and the strongly increased lacustrine sedimentation rate) contributed to the rapid burial of the biota. | TIAN Hongshui A.J.(Tom) VAN LOON ZHANG Zengqi ZHANG Shenhe ZHANG Banghua Lü Mingying LI Fuchang MA Xuemin | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 7 |
| 5 | Sensory innervation around immediately vs. delayed loaded implants: a pilot study显示文摘Although neurophysiological and psychophysical proof of osseoperception is accumulating, histomorphometric evidence for the neural mechanisms of functional compensation following immediate and delayed implant loading is still lacking. For this randomized split-mouth study, six mongrel dogs randomly received one of four treatment protocols at 36 implant-recipient sites over 16 weeks(third maxillary incisor, third and fourth mandibular premolar): immediate implant placement and immediate loading(IIP1IL);delayed implant placement and delayed loading(DIP1DL); delayed implant placement and immediate loading(DIP1IL); and natural extraction socket healing(control). Histomorphometry was performed in the peri-implant bone and soft tissues within 300 mm around the implants. Immunocytochemistry and transmission electron microscopy were used to confirm the presence of neural structures and to reveal their ultrastructural characteristics, respectively. Myelinated nerve fibres densely populated the peri-implant crestal gingival and apical regions, although they were also identified in the woven bone and in the osteons near the implant threads. Compared with the control group in the mandible, the group that received IIP1 IL showed a higher innervation(in Nmm22, 5.9461.12 vs. 3.1560.63,P,0.001) and smaller fibre diameter(in mm, 1.3760.05 vs. 1.6460.13, P50.016), smaller axon diameter(in mm, 0.8960.05 vs.1.2460.10, P50.009) and g-ratio(0.6460.04 vs. 0.7660.05, P,0.001) in the middle region around the implants. Compared with DIP1 IL in the mandible, IIP1 IL had a higher nerve density(in Nmm22, 13.2362.54 vs. 9.6461.86, P50.027), greater fibre diameter(in mm, 1.3260.02 vs. 1.2060.04, P50.021), greater axon diameter(in mm, 0.9260.01 vs. 0.8960.03, P50.035) and lower g-ratio(0.6960.01 vs. 0.7460.01, P50.033) in the apical region around the implants. It may be assumed that the treatment protocol with IIP1 IL is the preferred method to allow optimized peri-implant re-innervation, but further functional measurements are still required. | Yan Huang Jeroen van Dessel Wendy Martens Ivo Lambrichts Wei-Jian Zhong Guo-Wu Ma Dan Lin Xin Liang Reinhilde Jacobs | 2015 | International Journal of Oral Science2015，7，1： | 7 |
| 6 | A review of soil heavy metal pollution from mines in China: Pollution and health risk assessment显示文摘 | Zhiyuan Li Zongwei Ma Tsering Jan van der Kuijp Zengwei Yuan Lei Huang | 2014 | Science of the Total Environment2014，，： | 7 |
| 7 | Current status of ultrasound-guided surgery in the treatment of breast cancer显示文摘The primary goal of breast-conserving surgery(BCS) is to obtain tumour-free resection margins. Margins positive or focally positive for tumour cells are associated with a high risk of local recurrence, and in the case of tumour-positive margins, re-excision or even mastectomy are sometimes needed to achieve definite clear margins. Unfortunately, tumour-involved margins and re-excisions after lumpectomy are still reported in up to 40% of patients and additionally, unnecessary large excision volumes are described. A secondary goal of BCS is the cosmetic outcome and one of the main determinants of worse cosmetic outcome is a large excision volume. Up to 30% of unsatisfied cosm-etic outcome is reported. Therefore, the search for better surgical techniques to improve margin status, excision volume and consequently, cosmetic outcome has continued. Nowadays, the most commonly used localization methods for BCS of non-palpable breast cancers are wire-guided localization(WGL) and radioguided localization(RGL). WGL and RGL are invasive procedures that need to be performed pre-operatively with technical and scheduling difficulties. For palpable breast cancer, tumour excision is usually guided by tactile skills of the surgeon performing 'blind' surgery. One of the surgical techniques pursuing the aims of radicality and small excision volumes includes intraoperative ultrasound(IOUS). The best evidence available demonstrates benefits of IOUS with a significantly high proportion of negative margins compared with other localization techniques in palpable and non-palpable breast cancer. Additionally, IOUS is non-invasive, easy to learn and can centralize the tumour in the excised specimen with low amount of healthy breast tissuebeing excised. This could lead to better cosmetic results of BCS. Despite the advantages of IOUS, only a small amount of surgeons are performing this technique. This review aims to highlight the position of ultrasoundguided surgery for malignant breast tumours in the search for better oncological and cosmetic outcomes. | José H Volders Max H Haloua Nicole MA Krekel Sybren Meijer Petrousjka M van den Tol | 2016 | World Journal of Clinical Oncology2016，7，1： | 6 |
| 8 | Preferential binding between intracellular organic matters and Al_(13) polymer to enhance coagulation performance显示文摘Coagulation is the best available method for removing intracellular organic matter(IOM),which is released from algae cells and is an important precursor to disinfection by-products in drinking water treatment. To gain insight into the best strategy to optimize IOM removal, the coagulation performance of two Al salts, i.e., aluminum chloride(AlCl_3) and polyaluminum chloride(PACl, containing 81.2% Al_(13)), was investigated to illuminate the effect of Al species distribution on IOM removal. PACl showed better removal efficiency than AlCl_3 with regard to the removal of turbidity and dissolved organic carbon(DOC), owing to the higher charge neutralization effect and greater stability of pre-formed Al_(13) species. High pressure size exclusion chromatography analysis indicated that the superiority of PACl in DOC removal could be ascribed to the higher binding affinity between Al_(13) polymer and the low and medium molecular weight(MW) fractions of IOM. The results of differential log-transformed absorbance at 254 and 350 nm indicated more significant formation of complexes between AlCl_3 and IOM, which benefits the removal of tryptophan-like proteins thereafter. Additionally,PACl showed more significant superiority compared to AlCl_3 in the removal of <5 kD a and hydrophilic fractions, which are widely viewed as the most difficult to remove by coagulation.This study provides insight into the interactions between Al species and IOM, and advances the optimization of coagulation for the removal of IOM in eutrophic water. | Ruiping Liu Tingting Guo Min Ma Mingquan Yan Jing Qi Chengzhi Hu Gang Liu Huijuan Liu Jiuhui Qu Walter van der Meer | 2019 | Journal of Environmental Sciences2019，31，2： | 5 |
| 9 | 颈总动脉内径与心血管事件及死亡风险研究:4项队列研究的汇总分析显示文摘颈动脉内径增加是动脉重构的表现,且可能是心血管病的危险因素。研究者评估颈动脉内径与脑卒中、冠状动脉性心脏病、心血管病及全因死亡的关系,并探讨与血压有关的中膜增厚、动脉僵硬、动脉壁应力及动脉硬化等动脉重构过程能否解释此关系。 | Sedaghat S van Sloten TT Laurent S London GM Pannier Kavousi M Mattace-Raso F Franco OH Boutouyrie P Ikram MA Stehouwer CDA 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，7： | 4 |
| 10 | Physiological evaluation of nitrogen use efficiency of different apple cultivars under various nitrogen and water supply conditions显示文摘Nitrogen(N) deficiency is a common problem for apple(Malus×domestica) production in arid regions of China.However,N utilization efficiency(NUE) of different apple cultivars grown under low N conditions in arid regions has not been evaluated.In this study,NUE was assessed for one-year-old seedlings of six apple cultivars,Golden Delicious,Qinguan,Jonagold,Honeycrisp,Fuji and Pink Lady,grafted onto Malus hupehensis Rehd.rootstocks.Four treatments were used,including control water with control N(CWCN),limited water with control N(LWCN),control water with low N(CWLN) and limited water with low N(LWLN).Our results showed that growth indices such as biomass,plant height and stem diameter,and photosynthetic rate of all cultivars decreased in the order CWCN>CWLN>LWCN>LWLN.When subjected to LWLN treatment,Qinguan showed better growth and photosynthetic characters than other tested cultivars.Additionally,Qinguan and Pink Lady had higher NUE,while Honeycrisp and Jonagold had lower NUE,based on the determination of biomass,photosynthetic parameters,chlorophyll content,the maximal photochemical efficiency of PSII(Fv/Fm),15 N and N contents. | WANG Qian LIU Chang-hai HUANG Dong DONG Qing-long LI Peng-min Steve van NOCKER MA Feng-wang | 2020 | Journal of Integrative Agriculture2020，19，3： | 3 |
| 11 | Haplotype-resolved genome assembly and allele- specific gene expression in cultivated ginger显示文摘Ginger(Zingiber officinale)is one of the most valued spice plants worldwide;it is prized for its culinary and folk medicinal applications and is therefore of high economic and cultural importance.Here,we present a haplotype-resolved,chromosome-scale assembly for diploid ginger anchored to 11 pseudochromosome pairs with a total length of 3.1 Gb.Remarkable structural variation was identified between haplotypes,and two inversions larger than 15Mb on chromosome 4 may be associated with ginger infertility.We performed a comprehensive,spatiotemporal,genome-wide analysis of allelic expression patterns,revealing that most alleles are coordinately expressed.The alleles that exhibited the largest differences in expression showed closer proximity to transposable elements,greater coding sequence divergence,more relaxed selection pressure,and more transcription factor binding site differences.We also predicted the transcription factors potentially regulating 6-gingerol biosynthesis.Our allele-aware assembly provides a powerful platform for future functional genomics,molecular breeding,and genome editing in ginger. | Shi-Ping Cheng Kai-Hua Jia Hui Liu Ren-Gang Zhang Zhi-Chao Li Shan-Shan Zhou Tian-Le Shi Ai-Chu Ma Cong-Wen Yu Chan Gao Guang-Lei Cao Wei Zhao Shuai Nie Jing-Fang Guo Si-Qian Jiao Xue-Chan Tian Xue-Mei Yan Yu-Tao Bao Quan-Zheng Yun Xin-Zhu Wang Ilga Porth Yousry AEl-Kassaby Xiao-Ru Wang Zhen Li Yves Van de Peer Jian-Feng Mao | 2021 | Horticulture Research2021，8，1： | 3 |
| 12 | A Similitude Method and the Corresponding Blade Design of a Low-Speed Large-Scale Axial Compressor Rotor显示文摘A similitude method to model the tip clearance flow in a high-speed compressor with a low-speed model is presented in this paper.The first step of this method is the derivation of similarity criteria for tip clearance flow,on the basis of an inviscid model of tip clearance flow.The aerodynamic parameters needed for the model design are then obtained from a numerical simulation of the target high-speed compressor rotor.According to the aerodynamic and geometric parameters of the target compressor rotor,a large-scale low-speed rotor blade is designed with an inverse blade design program.In order to validate the similitude method,the features of tip clearance flow in the low-speed model compressor are compared with the ones in the high-speed compressor at both design and small flow rate points.It is found that not only the trajectory of the tip leakage vortex but also the interface between the tip leakage flow and the incoming main flow in the high-speed compressor match well with that of its low speed model.These results validate the effectiveness of the similitude method for the tip clearance flow proposed in this paper. | YU Chenghai MA Ning WANG Kai DU Juan Van den Braembussche R.A. LIN Feng | 2014 | Journal of Thermal Science2014，23，2： | 3 |
| 13 | Land tenure security and land investments in Northwest China显示文摘 | Xianlei Ma Nico Heerink Ekko van Ierland Marrit van den Berg Xiaoping Shi | 2013 | China Agricultural Economic Review2013，，2： | 2 |
| 14 | Latest Advances in High-Voltage and High-Energy-Density Aqueous Rechargeable Batteries显示文摘Aqueous rechargeable batteries(ARBs)have become a lively research theme due to their advantages of low cost,safety,environmental friendliness,and easy manufacturing.However,since its inception,the aqueous solution energy storage sys-tem has always faced some problems,which hinders its development,such as the narrow electrochemical stability window of water,poor percolation of electrode materials,and low energy density.In recent years,to overcome the shortcomings of the aqueous solution-based energy storage system,some very pioneering work has been done,which also provides a great inspiration for further research and development of future high-performance aqueous energy storage systems.In this paper,the latest advances in various ARBs with high voltage and high energy density are reviewed.These include aqueous rechargeable lithium,sodium,potassium,ammonium,zinc,magnesium,calcium,and aluminum batteries.Further chal-lenges are pointed out. | Xinhai Yuan Fuxiang Ma Linqing Zuo Jing Wang Nengfei Yu Yuhui Chen Yusong Zhu Qinghong Huang Rudolf Holze Yuping Wu Teunis van Ree | 2021 | Electrochemical Energy Reviews2021，4，1： | 2 |
| 15 | Prophylactic isradipine treatment after kidney transplantation:a prospective double-blind placebo-controlled randomized trial显示文摘 | van den Dorpel MA Zietse R Ijzermans JN | 1994 | Transpl Int1994，71，： | 2 |
| 16 | Isolation and mapping of novel candidate genes for retinal disorders using suppression subtractive hybridization显示文摘 | Van Driel MA De KOK YJ | 1999 | Genomics1999，58，3： | 1 |
| 17 | Expression and prognostic relevance of vascular endothelial growth factor(VEGF ) and its receptor( FLT-1) in nephroblastoma显示文摘 | Ghanem MA van Steenbrugge GJ Sudaryo MK | 2003 | Clin Pathol2003，56，： | 1 |
| 18 | Acute phase proteins in the monitoring of inflammatory disorders显示文摘 | Van L MA Van Rj MH | 2004 | Bailliere''S Clia Rheumatol2004，8，： | 1 |
| 19 | Metabolic myopathies:update 2009显示文摘 | Van Adel BA Tarnopolsky MA | 2009 | Clin Neuromuscul Dis2009，10，3： | 1 |
| 20 | Randomized, clinical trial comparison of trisodium citrate 30% and heparin as catheter-locking solution in hemodialysis patients 显示文摘 | Weijmer MC van den Dorpel MA Van de Ven PJ | 2005 | J Am Soc Nephrol2005，16，9： | 1 |
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