|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 西方现代教学理念与策略之剖析显示文摘当代西方教育理念的发展趋势已转入以建构主义学习理论为指导,以学生为中心,以问题为基础的学习(Problem-basedlearning,PBL)、个案学习(Casestudy)、概念图形成(Conceptmapping)、团队工作(Teamwork)及网络学习(e-learning),是国际上流行的几种发展学生自主性学习、主动学习、个性化学习的教学策略与方法,有效学习评估体系特别是过程性评估是实施高等教育改革的必要保证。 | 陈萍 臧伟进 | 2005 | 中国高等医学教育2005，，3： | 118 |
| 2 | 耳鸣的流行病学研究显示文摘 | 徐霞 卜行宽 | 2005 | 中华耳科学杂志2005，3，2： | 62 |
| 3 | 2006~2008年重庆大气降水δD和δ18 O特征初步分析显示文摘大气降水稳定同位素组成受到温度、蒸发、水汽源地等多种因素的复杂影响,在不同时间和不同地区具有很大差异。通过分析2006~2008年间重庆雨水样品的δD和δ18O,初步建立了当地的大气降水线方程。当地的大气降水稳定同位素组成在不同季节变化明显:夏季降水中的稳定同位素值普遍偏轻,而冬季降水中稳定同位素值普遍偏重。水汽来源是控制当地大气降水稳定同位素组成的最重要原因,而蒸发作用等是控制短期次降水事件中雨水稳定同位素组成的重要影响因素。 | 李廷勇 李红春 沈川洲 杨朝秀 李俊云 衣成城 袁道先 王建力 谢世友 Ting-yong Hong-chun Chuan-zhou Chao-xiu Jun-yun Cheng-cheng Dao-xian Jian-li Shi-you | 2010 | 水科学进展2010，21，6： | 55 |
| 4 | 进展性脑卒中的研究进展显示文摘 | 马莉 张苏明 | 2006 | 卒中与神经疾病2006，13，3： | 57 |
| 5 | Procedure for prolapse and hemorrhoids vs traditional surgery for outlet obstructive constipation显示文摘AIM: To compare the clinical efficacies of two surgical procedures for hemorrhoid rectal prolapse with outlet obstruction-induced constipation.METHODS: One hundred eight inpatients who underwent surgery for outlet obstructive constipation caused by internal rectal prolapse and circumferential hemorrhoids at the First Affiliated Hospital of Xinjiang Medical University from June 2012 to June 2013 were prospectively included in the study.The patients with rectal prolapse hemorrhoids with outlet obstructioninduced constipation were randomly divided into two groups to undergo either a procedure for prolapse and hemorrhoids(PPH)(n = 54) or conventional surgery(n = 54; control group).Short-term(operative time,postoperative hospital stay,postoperative urinary retention,postoperative perianal edema,and postoperative pain) and long-term(postoperative anal stenosis,postoperative sensory anal incontinence,postoperative recurrence,and postoperative difficulty in defecation) clinical effects were compared between the two groups.The short- and long-term efficacies of the two procedures were determined.RESULTS: In terms of short-term clinical effects,operative time and postoperative hospital stay were significantly shorter in the PPH group than in the control group(24.36 ± 5.16 min vs 44.27 ± 6.57 min,2.1 ± 1.4 d vs 3.6 ± 2.3 d,both P < 0.01).The incidence of postoperative urinary retention was higher in the PPH group than in the control group,but the difference was not statistically significant(48.15% vs 37.04%).Theincidence of perianal edema was significantly lower in the PPH group(11.11% vs 42.60%,P < 0.05).The visual analogue scale scores at 24 h after surgery,first defecation,and one week after surgery were significantly lower in the PPH group(2.9 ± 0.9 vs 8.3 ± 1.1,2.0 ± 0.5 vs 6.5 ± 0.8,and 1.7 ± 0.5 vs 5.0 ± 0.7,respectively,all P < 0.01).With regard to long-term clinical effects,the incidence of anal stenosis was lower in the PPH group than in the control group,but the difference was not significant(1.85% vs 5.56%).The incidence of sensory anal incontinence was significantly lower in the PPH group(3.70% vs 12.96%,P < 0.05).The incidences of recurrent internal rectal prolapse and difficulty in defecation were lower in the PPH group than in the control group,but the differences were not significant(11.11% vs 16.67% and 12.96% vs 24.07%,respectively).CONCLUSION: PPH is superior to the traditional surgery in the management of outlet obstructive constipation caused by internal rectal prolapse with circumferential hemorrhoids. | Ming Lu Bo Yang Yang Liu Qing Liu Hao Wen | 2015 | World Journal of Gastroenterology2015，21，26： | 57 |
| 6 | 不同草莓品种果实品质的比较研究显示文摘以大棚草莓栽培品种丰香、明宝、雪蜜、红颊、章姬为试材,从果实外观品质和果实营养成分上对5个草莓品种进行了分析研究。结果表明,红颊和章姬草莓果实大,平均单果重分别为21.25和21.97 g,外形美观,富有光泽;在果实经济性状上红颊优于其他4个品种,果实酸甜适口,香味浓,口感好,品质极佳,果实硬度适中,耐贮运性好,是当前大棚草莓栽培中较为理想的优质大果型草莓品种。雪蜜和丰香草莓果实营养成分上无显著差异,但在耐储性上,雪蜜果实硬度较低,不利于远距离运输,而丰香草莓果实硬度达到了4.00 Pa/cm2,耐储性好。在实际栽培过程中应结合实际情况加以选用。明宝草莓果实颜色橙红色,光泽强,香气浓,酸甜适中,平均单果重为19.32 g,可溶性固形物、蛋白质、糖、酸和维生素C含量上在5个品种中处于中间位置,但其果实硬度最低,只有2.53 Pa/cm2,耐储性最差,适宜在当地自产自销。 | 陈卫平 | 2010 | 江西农业学报2010，22，9： | 44 |
| 7 | Trends in Lipids Level and Dyslipidemia among Chinese Adults, 2002-2015显示文摘Objective To investigate the trends of lipid profiles and dyslipidemia among Chinese adults from 2002 to 2015.Methods Data were collected from three nationally representative cross-sectional surveys.Fasting venous blood samples were collected and serum lipids were tested by biochemical analysis and enzymatic determination.Lipid levels and the prevalence of dyslipidemia among adults were analyzed with complex sampling weighting adjustment for age and gender.Results The weighted means of TC, TG, and LDL-c significantly increased linearly from 3.93, 1.12, and 2.12 mmol/L in 2002 to 4.59, 1.41, and 2.78 mmol/L in 2010 and then to 4.63, 1.47, and 2.87 mmol/L in 2015, respectively;by contrast, HDL-c levels decreased significantly from 1.30 mmol/L to 1.26 mmol/L over the same period.Similar trends in mean non-HDL-c and lipid-related ratios were observed.The weighted dyslipidemia prevalence linearly increased;in particular, hypercholesterolemia increased from 1.6% to 5.6% and then to 5.8%, hypertriglyceridemia increased from 5.7% to 13.6% and then to 15.0%, low HDL-c increased from 18.8% to 35.5% and then to 24.9%, and high LDL-c increased from 1.3% to 5.6% and then to 7.2%(P for trend <0.001).Conclusion Dyslipidemia increased among Chinese adults from 2002 to 2015.Development of a comprehensive strategy to decrease lipid levels in this population is urgently required. | SONG Peng Kun MAN Qing Qing LI Hong PANG Shao Jie JIA Shan Shan LI Yu Qian HE Li ZHAO Wen Hua ZHANG Jian | 2019 | Biomedical and Environmental Sciences2019，32，8： | 45 |
| 8 | Evaluation of diffusion weighted imaging of magnetic resonance imaging in small focal hepatic lesions:a quantitative study in 56 cases显示文摘Diffusion-weighted imaging (DWI) as a new technique of magnetic resonance imaging (MRI) is used to detect focal hepatic lesions. This study was designed to evaluate the significance of DWI to differentiate focal hepatic lesions less than 3 cm in diameter by the quantitation of apparent diffusion coefficient (ADC) values. METHODS:DWI using 1.5T MRI scanner unit was performed with a spin-echo single-shot echo planar imaging (EPI) in 56 cases of small focal hepatic lesions, including hepatocellular carcinoma (11), hepatic metastatic tumor (15 ), hepatic cavernous hemangioma (14), and hepatic cyst (16).The ADC values of these lesions were calculated respectively. The ratios of the ADC values of lesion/liver in hepatocellular carcinomas and hepatic metastatic tumors were also estimated. RESULTS:The mean ADC values (mm2/s) were (0.93±0.06) ×10-3 in hepatocellular carcinomas, (1.09±0.18)×10-3 in hepatic metastatic tumors,(1.95±0.38)×10-3 in hepatic cavernous hemangiomas, and (3.18±0.33) ×10-3 in hepatic cysts. The ratios of ADC values of lesion/liver were 0.90±0.06 and 1.15±0.14 in hepatocellular carcinoma and hepatic metastatic tumors respectively, which were significantly different (P<0.05). CONCLUSION:The measurement of ADC values and the ratios of ADC values of lesion/liver are helpful in MR diagnosis and differentiation of focal hepatic lesions. | Xian-Yue Quan, Xi-Jie Sun, Zhi-Jian Yu and Ming Tang Imaging Center, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 39 |
| 9 | 藏北羌塘中部绒玛地区蓝片岩岩石学、矿物学和^(40)Ar/^(39)Ar年代学显示文摘藏北羌塘中部沿龙木错-双湖-线出露一条低温高压变质带,目前已有多处蓝片岩的报道。然而,除冈玛错地区产有典型的蓝闪石外,多数地区并没有典型蓝闪石的报道。绒玛蓝片岩位于羌塘中部高压变质带的中段,是该带中规模最大、保存最好的蓝片岩,对蓝片岩进行了详细的岩石学和矿物学研究,钠质角闪石主要为蓝闪石、青铝闪石、钠闪石和镁钠闪石。对蓝片岩中蓝闪石和多硅白云母进行了^(40)Ar/^(39)Ar定年,获得了227.3±3.8Ma和215±1.5Ma的坪年龄,分别代表蓝片岩快速俯冲消减和俯冲作用结束开始折返抬升的时代。绒玛蓝片岩岩石学、矿物学和^(40)Ar/^(39)Ar年代学研究为羌塘中部高压变质带的研究提供了新的资料。 | 翟庆国 李才 王军 陈文 张彦 | 2009 | 岩石学报2009，25，9： | 38 |
| 10 | 河南省栾川南泥湖斑岩型钼钨矿床流体包裹体研究显示文摘河南省栾川县南泥湖超大型钼钨矿床形成于秦岭造山带的燕山期大陆碰撞体制,流体成矿过程包括早、中、晚3个阶段,分别以石英+钾长石±辉钼矿±黄铁矿、石英+多金属硫化物±碳酸盐和石英+碳酸盐+萤石组合为标志,矿石矿物主要沉淀于中阶段。早、中阶段石英中可见纯CO_2包裹体、CO_2-H_2O型包裹体、水溶液包裹体和含子晶多相包裹体,但晚阶段萤石中只发育水溶液包裹体。早阶段流体包裹体均一温度集中于350~460℃,盐度为5.68 wt%~17.87 wt%NaCl.eqv。中阶段包裹体均一温度集中在250~380℃,盐度为3.00 wt%~38.16 wt%NaCl.eqv;中阶段多相包裹体中常见石盐、黄铜矿和未知种类的子矿物,指示流体具有沸腾所致的还原性、过饱和特征;盐度相差悬殊的含子晶多相包裹体、富气相水溶液包裹体和富液相水溶液包裹体共存,在相近温度下异相均一,表明流体沸腾的存在。晚阶段流体包裹体均一温度集中在115~265℃,盐度介于0.53 wt%~1.23、wt%NaCl.eqv之间。估算早、中阶段流体捕获压力分别为70~300MPa和30~150MPa,推测成矿深度约为3km。总之,成矿流体具高温、高盐度、高氧逸度、富CO_2的特征;流体沸腾导致CO_2逃逸,氧化性降低,成矿物质沉淀。 | 杨永飞 李诺 杨艳 | 2009 | 岩石学报2009，25，10： | 37 |
| 11 | CCK-8法与MTT法检测人前列腺癌PC3细胞活性的比较研究显示文摘目的探讨CCK-8法和MTT法的最佳实验条件。方法以人前列腺癌PC3细胞作为研究对象,采用CCK-8和MTT法检测抗肿瘤药物阿霉素(ADM)对PC3细胞增殖的影响。结果 CCK-8法的最佳检测波长为450 nm,最佳检测时间为加入CCK-8试剂后4 h,适宜细胞数量范围为8×102~1×105个。结论 CCK-8法较MTT法检测的灵敏度高,准确性好,是一种优于MTT法的检测细胞增殖活性的方法。 | 万文婷 李宁 刘静 金林红 | 2010 | 时珍国医国药2010，21，12： | 31 |
| 12 | Experimental study on the mechanical properties of rocks at high temperature显示文摘The mechanical properties of marble, limestone, and sandstone as well as the stress-strain curve, the varying characteristics of the peak strength, the peak strain and elastic modulus were studied by using the MTS810 Rock Mechanics Servo-controlled Testing System under the action of temperatures rang- ing from room temperature to 800℃ . Results show that (1) the peak strength and elastic modulus of marble fluctuate at the temperature from normal to 400 ℃ ; and they decrease gradually over 400℃ . (2) With the rise of the temperature, the peak strength and elastic modulus of limestone show downward trend from normal temperature to 200 ℃ ; have little change from 200 ℃ to 600 ℃; and decrease sharply over 600 ℃ . (3) The peak strength of sandstone shows a downward trend while a little change for elastic modulus at normal temperature to 200 ℃ ; and from 200 ℃ to 600 ℃ , the peak strength of sandstone in- creases while a little change for elastic modulus; the peak strength and elastic modulus decrease rap- idly at the temperature over 600 ℃ . (4) The peak strain of limestone shows little change at normal tem- perature to 600 ℃ , however, the peak strain increases rapidly over 600 ℃; and for marble and sandstone, the peak strain decreases with the rise of the temperature from normal temperature to 200℃ , the peak strain increases rapidly over 200℃. The result can provide valuable references for the rock engineering design at high temperature. | ZHANG LianYing MAO XianBiao LU AiHong | 2009 | Science China(Technological Sciences)2009，52，3： | 30 |
| 13 | 冰川泥石流形成机理研究进展显示文摘由于冰川泥石流的广泛分布及其发育地的特殊性使得对其开展全面治理较为困难,因此,有效开展冰川泥石流的预警预报具有重要意义。虽然近年来对冰川泥石流的研究有了较多的成果,但目前对其形成机理的认识还存在很大的局限,在很大程度上制约了防灾减灾的进展。为深入探讨冰川泥石流的形成机理,文章回顾了国内外学者在相关领域的研究成果,系统总结了现有冰川泥石流形成机理的研究现状,并对冰川泥石流形成机理的未来研究方向做了展望。 | 铁永波 李宗亮 | 2010 | 水科学进展2010，21，6： | 28 |
| 14 | Morphological study on colonic pathology in ulcerative colitis treated by moxibustion显示文摘AIM To observe the therapeutic effect ofmoxibustion on ulcerative colitis and itsinfluence on the colonic mucosal morphology.METHODS Forty-six patients with ulcerativecolitis were randomly divided into themoxibustion with herbal medicine underneathgroup and the western medicine group.Thirtypatients were treated with the abovemoxibustion and 16 patients with Salicylayefapyridine(SASP).The colonic mucosa of 13patients in the moxibustion group was observedby colonoscopy before and after the treatment.Mucin was also analyzed by H.E and AB-PASstaining.RESULTS Seventeen patients were clinicallycured,12 were improved and 1 unchanged in themoxibustion group.In the control group,5patients were clinically cured,7 improved and 4unchanged.Thirteen patients with active UCwere taken as the subjects for histopathologicanalysis in this study.The colonic mucosallesions were remarkably improved and thecharacteristic of the mucin also changed.Inmost sections,the chronic inflammation ofmucosa was geatly ameliorated(P<0.01).Theinflammatory cell infiltratation much decreased and neutrophils,disapeared in most sections(P<0.001).The goblet cells significantlyincreased(P<0.001);crypt paracrypt abscessor mucosal ulceration was seen(P<0.001).CONCLUSION The rate of cure of ulcerative colitis by moxibustion with herbal medicine beneath is superior to that by SASP. This sort of moxibustion can effectively improve the colonic mucosal lesions and restore the proportion of mucoprotein to near normal. | Huan Gan Wu Li Bin Zhou Da Ren Shi Shi Min Liu Hui Rong Liu Bi Meng Zhang Han Ping Chen Lin Shan Zhang | 2000 | World Journal of Gastroenterology2000，6，6： | 28 |
| 15 | Cluster analysis for syndromes of real-world coronary heartdisease with angina pectoris显示文摘Syndromes of coronary heart disease with angina pectoris were analyzed to provide guidance forclinical practice and to improve accuracy of traditional Chinese medicine (TCM) diagnoses and efficacy of TCMtreatment. A total of 860 cases with coronary heart disease with angina pectoris were selected from TCM ClinicalResearch Information Sharing System for TCM clinics and research. Syndromes were automatically extractedwith the cluster method and were analyzed to provide objective evidence for clinical studies. Final syndromeclassifications were recognized and confirmed by clinical experts. Popular syndromes included Qi and blooddeficiency, blood stasis and obstruction collaterals, liver depression and spleen deficiency, and Qi stagnation andblood stasis. Syndromes Qi and blood deficiency and blood stasis and obstruction collaterals accounted for 28.61%of total syndromes, whereas liver depression and spleen deficiency and Qi stagnation and blood stasis accountedfor 26.44%. The main syndrome elements comprised Qi deficiency, blood deficiency, blood stasis, and Qistagnation. | Yufeng Zhao Xueyun Yu Xinyu Cao Lin Luo Liyun He Shusong Mao Li Ma Peijing Rong Yuxue Zhao Guozheng Li Baoyan Liu | 2018 | Frontiers of Medicine2018，12，5： | 28 |
| 16 | 内蒙古阿鲁科尔沁旗敖仑花斑岩铜钼矿床成矿时代和流体包裹体研究显示文摘内蒙古阿鲁科尔沁旗敖仑花铜钼矿床位于华北克拉通北缘西拉沐伦钼矿带,是典型的斑岩型铜钼矿床。对6件辉钼矿样品进行了铼-锇同位素分析,获得的等时线年龄为129.4±3.4Ma,表明成矿作用发生在早白垩世。根据成矿中的流体过程可分为三个阶段:早阶段以发育石英-黄铁矿脉为标志,中阶段是主要的成矿阶段,以发育石英-多金属硫化物脉为标志。这两个阶段的流体包裹体均一温度分别集中在330~430℃和250~350℃,盐度分别为1.06~>58.41 wt%NaCl eqv和0.88wt%~48.21 wt%NaCl eqv,两个阶段均为多种类型包裹体密切共生,均一温度接近而盐度相差悬殊,且两个阶段的包裹体均一方式多样,这些特征指示了这两个阶段的流体皆发生过沸腾作用。晚阶段以发育石英-碳酸盐细脉为标志,只有少量黄铁矿沉淀,该阶段仅发育富液相包裹体,均一温度<270℃.盐度低,范围为0.71 wt%~8.41 wt%NaCl eqv。激光拉曼光谱分析表明,早、中阶段包裹体的气相成分为H_2O和CO_2,而晚阶段气相中只含H_2O。总体来看,初始流体可能直接来自岩浆房中岩浆流体的上涌,具有高温、高盐度、高氧逸度和富CO_2等特点,在430℃和350℃时流体发生了两次沸腾作用,致使成矿物质快速沉淀,流体氧逸度降低,CO_2逃逸,到了晚期,流体包裹体中基本不再含有子晶和CO_2。 | 舒启海 蒋林 赖勇 鲁颖淮 | 2009 | 岩石学报2009，25，10： | 26 |
| 17 | Multicenter case-control study of the risk factors for ulcerative colitis in China显示文摘AIM:To evaluate potential risk factors in the development of ulcerative colitis(UC) in China.METHODS:A total of 1308 patients with UC and 1308 age-matched and sex-matched controls were prospectively studied in China.The UC cases were collected from 17 hospitals in China from April 2007 to April 2010.Uniform questionnaires were designed to investigate risk factors including smoking,appendectomy,stress,socio-economic conditions,nonsteroidal antiinflammatory drugs(NSAIDs),oral contraceptives,diet,breastfeeding,infections and family sanitary conditions.Group comparisons by each factor were done using simple logistic regression analysis.Conditional logistic regression was used for multivariate analysis.RESULTS:By univariate analysis,the variables predictive of UC included feeling stress,light and heavy alcoholic drinking,spicy food,sugar consumption and infectious diarrhea,while heavy tea intake and tap water consumption were protective against UC.On multivariate analysis,the protective factor for UC was tap water consumption [odds ratios(OR) = 0.424,95%CI:0.302-0.594,P < 0.001];while the potential risk factors for UC were heavy sugar consumption(OR = 1.632,95%CI:1.156-2.305,P < 0.001),spicy food(light intake:OR = 3.329,95%CI:2.282-4.857,P < 0.001;heavy intake:OR = 3.979,95%CI:2.700-5.863,P < 0.001),and often feeling stress(OR = 1.981,95%CI:1.447-2.711,P < 0.001).Other factors,such as smoking habit,appendectomy,breastfeeding,a history of measles,rural or urban residence,education,oral contraceptives,and NSAID use have not been found to have a significant association with the development of UC in the present study.CONCLUSION:Our study showed tap water consumption was a protective factor for UC,while spicy food,heavy sugar consumption and often feeling stress were risk factors for UC in this Chinese population. | Yu-Fang Wang Qin Ou-yang Bing Xia Li-Na Liu Fang Gu Kai-Fang Zhou Qiao Mei Rui-Hua Shi Zhi-Hua Ran Xiao-Di Wang Pin-Jin Hu Kai-Chun Wu Xin-Guang Liu Ying-Lei Miao Ying Han Xiao-Ping Wu Guo-Bing He Jie Zhong Guan-Jian Liu | 2013 | World Journal of Gastroenterology2013，19，11： | 24 |
| 18 | 预埋式槽型锚轨抗拔性能的试验研究显示文摘预埋件在钢筋混凝土结构中的应用较为普遍,但是目前国内采用的预埋件由于规格多、位置要求准确,在设计和施工过程中经常出现遗漏、位置错误等问题。德国某公司的锚轨技术可妥善解决上述种种弊病。对德国某公司生产四种不同型号的HTA,HZA,HZA-R及HTA-R型锚轨进行了单向静力抗拔试验的研究。试验表明,锚轨在受拉荷载作用下具有良好的工作性能,对于生产商提供的工作荷载及预期极限荷载具有较高的安全储备,并且试件在破坏之前有较好的延性。 | 徐淑美 周德源 毕大勇 | 2010 | 结构工程师2010，26，5： | 24 |
| 19 | VIC distributed hydrological model to predict climate change impact in the Hanjiang Basin显示文摘The climate impact studies in hydrology often rely on climate change information at fine spatial resolution. However, the general circulation model (GCM), which is widely used to simulate future climate scenario, operates on a coarse scale and does not provide reliable data on local or regional scale for hydrological modeling. Therefore the outputs from GCM have to be downscaled to obtain the information fit for hydrologic studies. The variable infiltration capacity (VIC) distributed hydrological model with 9×9 km2 grid resolution was applied and calibrated in the Hanjiang Basin. Validation results show that SSVM can approximate observed precipitation and temperature data reasonably well, and that the VIC model can simulate runoff hydrograph with high model efficiency and low relative error. By applying the SSVM model, the trends of precipitation and temperature (including daily mean temperature, daily maximum temperature and daily minimum temperature) projected from CGCM2 under A2 and B2 scenarios will decrease in the 2020s (2011―2040), and increase in the 2080s (2071―2100). However, in the 2050s (2041―2070), the precipitation will be decreased under A2 scenario and no significant changes under B2 scenario, but the temperature will be not obviously changed under both climate change scenarios. Under both climate change scenarios, the impact analysis of runoff, made with the downscaled precipitation and temperature time series as input of the VIC distributed model, has resulted in a decreasing trend for the 2020s and 2050s, and an overall increasing trend for the 2080s. | GUO ShengLian GUO Jing ZHANG Jun CHEN Hua | 2009 | Science China(Technological Sciences)2009，52，11： | 23 |
| 20 | Effects of antiviral therapy on preventing liver tumorigenesis and hepatocellular carcinoma recurrence显示文摘Chronic hepatitis B virus(HBV)infection is the key driving force of liver disease progression,resulting in the development of hepatic dysfunction,cirrhosis and hepatocellular carcinoma(HCC).The primary aim of therapy is to suppress or eliminate HBV replication to reduce the activity of hepatitis,thus reducing the risk of,or slowing the progression of,liver disease.Nucleos(t)ide analogues(Nucs)may result in rapid suppression of HBV replication with normalization of serum transaminases and restore liver function,thus increasing survival in patients with hepatic decompensation.Long-term Nuc therapy may result in histological improvement or reversal of advanced fibrosis and reduction in disease progression,including the development of HCC.The long-term benefits of a finite course of interferon(IFN)-αtherapy also include a sustained and cumulative response,as well as hepatitis B surface antigen seroclearance and reduction in the development of cirrhosis and/or HCC.Pegylated IFN and newer Nucs may achieve better long-term outcomes because of improved efficacy and a low risk of drug resistance.However,treatment outcomes are still far from satisfactory.Understanding the effects of anti-HBV treatment against HCC incidence and recurrence after hepatectomy or liver transplantation is required for further improvement of outcome. | Zhong-Ming Tan Bei-Cheng Sun | 2013 | World Journal of Gastroenterology2013，19，47： | 22 |
您所在的机构暂未开通此部分的功能，请联系管理员