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| 1 | Effects of acupuncture on the relationship between cerebral hemodynamics and arterial blood pressure in patients with hypertension显示文摘The present study aimed to investigate the effect of an auricular acupuncture intervention on the relationship between changes in oxyhemoglobin concentration(Δ[O2Hb])and arterial blood pressure(ABP).The cerebral oxygenation signals in the bilateral prefrontal cortex(PFC),sensorimotor cortex(SMC),and temporal lobe cortex(TLC)of 15 patients with hypertension were measured by a 24-channel functional near-infrared spectroscopy(fNIRS)device before(State_R)and after(State_AT)the auricular acupuncture intervention.Coupling strength was used to quantitatively evaluate the strength of the couplings between ABP andΔ[O2Hb]in low-frequency oscillations(LF,0.07–0.2 Hz)and very-low-frequency oscillations(VLF,0.02–0.07 Hz).Results showed that the changes in wavelet amplitudes in the LF and VLF intervals did not exhibit significant differences after auricular acupuncture.The coupling strength from ABP toΔ[O2Hb]was significantly lower in the LF range after auricular acupuncture in the bilateral PFC,SMC,and TLC(p<0.0083).Additionally,the coupling strength from ABP toΔ[O2Hb]in the VLF range was significantly lower in the bilateral PFC in State_AT than in State_R(p<0.0083).These results indicated that fNIRS together with ABP can effectively evaluate cerebral hemodynamic responses to interventions and is therefore capable of guiding more individualized acupuncture strategies.The auricular acupuncture intervention improved hemodynamic responses in patients suffering from hypertension. | Wenhao Li Hongmei Liu Congcong Huo Gongcheng Xu Tengyu Zhang Zengyong Li | 2021 | Medicine in Novel Technology and Devices2021，，4： | 4 |
| 2 | A novel glasses-free virtual reality rehabilitation system on improving upper limb motor function among patients with stroke:A feasibility pilot study显示文摘Background:Virtual reality(VR)technology is increasingly used in stroke rehabilitation.This study aimed to investigate the effectiveness of using the glasses-free VR training to improve motor function of upper limb in patients with stroke.Methods:Twelve patients with stroke were recruited to participate in the intervention of 3 weeks.At the baseline and post intervention,two times of evaluation including Fugl-Meyer upper-extremity scale(FMS-UE),transcranial magnetic stimulation(TMS)measurement and motion evaluation were performed.Results:No significant difference was observed between two groups at baseline evaluation.After the intervention,the FMS-UE scores presented a greater improvement in the VR group compared with the control group.TMS measurement showed that there was significant difference in cortex latency and central motor conduction time between two groups after the intervention,but no significant difference in the amplitude of motor event potential was observed.In addition,there was a significant correlation between game scores and FMS-UE scores.Conclusions:The novel glasses-free VR training was at least as effective as conventional occupational therapy in upper limb motor function,improving nerve conduction time and corticospinal excitability in patient with stroke. | Haoyu Xie Hantao Zhang Haowen Liang Hang Fan Jianying Zhou Wai Leung Ambrose Lo Le Li | 2021 | Medicine in Novel Technology and Devices2021，，3： | 2 |
| 3 | Research hotspots and trends of cardiopulmonary exercise test:Visualization analysis based on citespace显示文摘The study aims to grasp the hot spots and trends of global cardiopulmonary exercise research.Web of Science(WoS)core collection and Derwent Innovation Index database were retrieved to collect literature from 2002 to 2022 with Cardiopulmonary Exercise Test(CPET)as the retrieval theme.CiteSpace was used to conduct bibliometrics and visual analysis of 6679 pieces of literature in the web of science core collection database and 251 patent data in the Derwent Innovation Index database.The results show that:(1)the number of CPET theme research papers is increasing year by year,and the main research fields are cardiology,respiratory system,sports science,etc.;(2)The main research hot spots of CPET include exercise prescription,exercise and heart failure,COVID-19 cardiopulmonary rehabilitation and evaluation,etc.;(3)The development trend of CPET technology is majorly in the direction of intelligence,portability,individualization and the integration of Virtual Reality(VR)technology and evidence-based research of CPET guiding clinical decision-making. | Yu Zhao Jianchao Li Chunjing Tao Rongjing Ding | 2022 | Medicine in Novel Technology and Devices2022，，4： | 1 |
| 4 | Industrial low-temperature gas plasma sterilization 显示文摘 | Graham GS Mielnik TJ | 1997 | Medicine Device Technology1997，8，6： | 1 |
| 5 | Gender differences in cardiovascular disease显示文摘Cardiovascular disease(CVD)is one of the leading causes of death worldwide.Although the incidence of CVD in women is usually lower than in men,women have a higher mortality and worse prognosis after acute cardiovascular events.These gender differences exist in various CVDs,including coronary heart disease,stroke,heart failure and aortic diseases.These gender differences have caused widespread concerns and the consideration of gender differences is of great importance for the prevention,diagnosis,treatment and management of CVD.This review aims to provide an overview of gender-related differences in several typical CVDs and to list and to analyze the possible causes associated with the differences,in order to highlight the necessity of taking into account gender differences in determination of the cardiovascular risk profile.Future research can focus on how to define and add gender-related indicators to current risk assessment and management strategies. | Zujie Gao Zengsheng Chen Anqiang Sun Xiaoyan Deng | 2019 | Medicine in Novel Technology and Devices2019，，4： | 1 |
| 6 | A pilot study of aortic hemodynamics before and after thoracic endovascular repair with a double-branched endograft显示文摘Branched endografts have been developed to treat complex pathology in the aortic arch and ascending aorta.This study aims to evaluate the haemodynamic performance of a double-branched thoracic endograft by detailed comparison of flow patterns and wall shear stress in the aorta and supra-aortic branches before and after stentgraft implantation.Pre-and post-intervention CT images were acquired from two patients who underwent thoracic endovascular aortic repair(TEVAR)with a double-branched endograft for thoracic aortic aneurysms.These images were used to reconstruct patient-specific models,which were analysed using computational fluid dynamics employing physiologically realistic boundary conditions.Our results showed that there was sufficient blood perfusion through the arch branches.The presence of inner tunnels caused flow derangement and asymmetric wall shear stress in the ascending aorta,where shear range index was up to 6 times higher than in the preintervention model.Wall shear stress in the aortic arch increased considerably after intervention as a result of accelerated flow.The maximum flow-induced displacement forces on the branched endografts were around 22 N for both patients,which was below the threshold for device migration.Results from this pilot study demonstrated that aortic flow patterns were significantly altered by the branched endograft which caused increased spatial variation of wall shear stress in the ascending aorta and the arch.Although no obvious adverse hemodynamic features were found immediately after intervention for the cases we analysed,follow-up studies will be needed to assess durability of the device. | Yu Zhu Wenbo Zhan Mohamad Hamady Xiao Yun Xu | 2019 | Medicine in Novel Technology and Devices2019，，4： | 1 |
| 7 | Nano-hydroxyapatite(n-HA)involved in the regeneration of rat nerve injury triggered by overloading stretch显示文摘Damage of axon and glial scars formation both inhibit nerve regenerative growth during nerve injury.In addition,mechanical stretch at high displacement rates of 10%tensile strain can cause marked nerve injury,it is important for finding a proper nano biomaterial to repair nerve injury.Nano-hydroxyapatite(n-HA)has excellent biocompatibility and high bioactivity,which is a good candidate for biomedical engineering applications.But the certain mechanism of n-HA on the injured nerve is seldom reported.In this study,we determined the role of n-HA on the mechanical stretch-induced nerve injury at adult rat spine.Mechanical stretch under strain 10%at displacement rates of 60 mm/min can cause marked broken vessels and edema in spinal cord and dorsal root ganglion tissue in haematoxylin-eosin(HE)staining.However,n-HA application can reverse hemorrhage and edema triggered by high rates of 60 mm/min stretch.Moreover,n-HA can promote positive staining of Netrin-1 increase significantly in spinal cord and dorsal root ganglion tested by immunohistochemistry(IHC)staining.In general,our study indicated that n-HA can repair mechanical stretch-induced nerve injury,it may provide a new approach to block injury and accelerate nerve regeneration in future. | Meili Liu Chongquan Huang Zhijun Zhao Anqing Wang Ping Li Yubo Fan Gang Zhou | 2019 | Medicine in Novel Technology and Devices2019，，4： | 1 |
| 8 | Influence of aortic branch arteries on the hemodynamics of patient-specific type B aortic dissection following TEVAR显示文摘Objective:Because of the difficulty in obtaining patient specific flow data,branch arteries are often neglected in the flow simulations of a patient-specific type B aortic dissection(AD)following thoracic endovascular repair(TEVAR).This study aims to investigate the influence of the aortic branch arteries on the hemodynamics and physical flow phenomena commonly associated with aortic modeling of an AD after TEVAR.Methods:The three-dimensional geometry of a type B AD following TEVAR was generated from a high-quality CT dataset.Simulations were performed with all branch arteries,without the four visceral arteries of the abdominal aorta(FVAoAA),and without the upper three branches of the aortic arch(UTBoAA).Results:The removal of the UTBoAA has marginal effect on the flow patterns and hemodynamic parameters in the false lumen(FL);however,regardless of whether there are aorta branches supplied to the FL or not,the omission of FVAoAA will result in a wrong prediction of the flow direction at tears and flow volume to the FL.Conclusions:The omission of aorta branch arteries has great impact on the hemodynamic prediction including flow field and wall shear stress related parameters in a type B AD after TEVAR,which may induce misleading estimates of the potential thrombus in the FL.It is strongly recommended to keep aorta branches in the computational model to predict the post-operative hemodynamic performance in a type B AD following TEVAR. | Yi Jiang Yue Qiu Da Li Ding Yuan Tinghui Zheng Liqing Peng | 2019 | Medicine in Novel Technology and Devices2019，，4： | 1 |
| 9 | Donkey pericardium as a select sourcing to manufacture percutaneous heart valves:Decellularization has not yet demonstrated any clear cut advantage to glutaraldehyde treatment显示文摘Background:The donkey pericardium is considered a good candidate to manufacture percutaneous heart valves based upon its thinness,low cellularity and undulating collagen bundles and laminates.Decellularization represents an avenue worth exploring,should its superiority to glutaraldehyde-treated pericardium be demonstrated.Materials and methods:Donkey pericardium was divided into two groups:regular glutaraldehyde fixation and mild decellularization.The treated pericardia were observed using scanning electron microscopy,histology and transmission electron microscopy.Tensile tests were performed along the axial and perpendicular directions,with the data fitted into both the Gasser–Ogden–Holzapfel(GOH)material model and the Fung’s anisotropic one.Results:The microstructures of the pericardia processed by the two protocols were similar,showing collagen bundles and laminates free of flaws.The decellularization eliminated most of the cells,however leaving the structure somehow compressed.The collagen filaments in bundles were slightly blurry.The anisotropy rates of the non-decellularized specimens were almost identical to the decellularized ones.The decellularized pericardium appeared stiffer.Conclusion:The decellularization proved to be effective.However,it makes the tissue stiffer,which may lead to higher shear concentration during cardiac cycles and reduce its wavy microstructure.Therefore,it appears premature to select decellularized donkey pericardium to manufacture heart valves. | Aisa Rassoli Yiming Li Xianhao Bao Fabien Kawecki Xinzhe Zhao Daniel Chappard Gaetan Le-Bel Jiaxuan Feng Benedikt Weber Nasser Fatouraee Ze Zhang Zaiping Jing Lucie Germain Lu Wang Robert Guidoin | 2019 | Medicine in Novel Technology and Devices2019，，4： | 1 |
| 10 | Interaction of arterial proteoglycans with low density lipoproteins(LDLs):From theory to promising therapeutic approaches显示文摘Although atherosclerosis is a multifactorial process,proteoglycans mediated lipoprotein(LDL)retention at the subendothelial space is a necessary and sufficient event in provoking lesion initiation.Proteoglycans(PGs)are usually composed of one core protein backbone with one or more glycosaminoglycan chains(GAGs)covalently linked,mainly include perlecan,biglycan,versican,and decorin.The interaction between LDL and proteoglycans is apparently mediated by the basic amino acids in apoB-100,the moiety of LDL,electrostatic interacting with the negatively charged GAGs(sulfate or carbohydrate groups)of proteoglycans or though some bridge molecules like sphingomyelinase(SMase)or lipoprotein lipase(LpL).In the later section,we collate the promising therapeutic approaches that have been proposed up to now,targeting LDL-PGs interaction.It should be concluded that previous studies on interaction between LDL and PGs mainly focused on perlecan,biglycan,decorin,and versican that all located in the extracellular matrix(ECM),future studies should pay more attention to the endothelial surface glycocalyx and its interaction with LDLs,seeking promising therapeutic targets more specifically. | Hongyan Kang Jinyan Lu Jiali Yang Yubo Fan Xiaoyan Deng | 2019 | Medicine in Novel Technology and Devices2019，，3： | 1 |
| 11 | Migration of a red blood cell in a permeable microvessel显示文摘One of the important features of the microvessels is with permeable vessels.The hyperpermeablility is especially prounounced due to the fast grow of the microvessel in the tumor tissues.Flow field induced by leakage often presents a different figure compared to that of the health vessel.Non-uniform velocity and pressure distribution are found in the simulation by using Lattice Boltzmann Method combined with Starling law.This non-uniform flow field has significant influence on the mass transport in permeable mocrovessel,such as the motion of red blood cell.Using 2D spring network model to express the red blood cell and immersed boundary method to implement the coupling of fluid and structure,numerical simulations were carried out to study the migration of a red blood cell in a straight permeable channel.The results show that the staying time of red blood cell in the leakage region increases with the intensity of leakage.We also found that the leakage can weaken the lateral migration of the red blood cell from the wall to the channel center,and even tune the migration towards the wall when the leakage is reasonably strong. | Zaiyi Shen Ying He | 2019 | Medicine in Novel Technology and Devices2019，，3： | 1 |
| 12 | Feature extraction based on empirical mode decomposition for automatic mass classification of mammogram images显示文摘Breast cancer is one of the major health problems that leads to early mortality in women.To aid the radiologists,computer aided diagnosis provides a second opinion for the detection and classification of breast cancer.In this paper,two texture feature extraction methods using Empirical Mode Decomposition(EMD)have been proposed to classify the masses in mammogram images into benign or malignant.The first feature extraction method is based on Bi-dimensional Empirical Mode Decomposition(BEMD).On performing BEMD on Region of Interest(ROI)of mammogram image,the ROI is decomposed into a set of different frequency components called Bi-dimensional Intrinsic Mode Functions(BIMFs).Gray Level Co-occurrence Matrix(GLCM)and Gray Level Run Length Matrix(GLRM)features are extracted from these BIMFs and are given as input to the classifier for classification into benign or malignant.Due to the mode mixing problem that exists in BEMD,BIMFs obtained from BEMD are less orthogonal to each other.To overcome this drawback,the second feature extraction method called Modified Bidimensional Empirical Mode Decomposition(MBEMD)is proposed.The BIMFs are extracted by employing the proposed MBEMD on mammogram ROI.Features are extracted in a similar way as BEMD method.Support Vector Machine(SVM)and Linear Discriminant Analysis(LDA)classifiers are used for the classification of mammogram mass.The classification accuracy of 88.8%,96.2%and Area Under the Curve(AUC)of Receiver Operating Characteristics(ROC)of 0.9,0.96 are obtained with SVM classifier for BEMD,proposed MBEMD based features respectively.The results show that the proposed method yields consistent performance when applied across different databases. | Vaijayanthi Nagarajan Elizabeth Caroline Britto Senthilvel Murugan Veeraputhiran | 2019 | Medicine in Novel Technology and Devices2019，，1： | 1 |
| 13 | Finite element modeling and simulation of the implantation of braided stent to treat cerebral aneurysm显示文摘Braided stents were widely used to treat cerebral aneurysms and computational fluid dynamics(CFD)was used to evaluate the therapeutic effects.But the aneurysm-artery geometry used in CFD were usually undeformed which is inconsistent with clinical findings.Our team developed a finite element modeling workflow to simulate implantation of braided stents in patient-specific aneurysm-artery model.An LVIS-based braided stent was deployed into an aneurysm-artery model.The stent fully expanded,causing obvious deformation on the aneurysm-artery model.The workflow which we developed could provide reasonable deformed geometries of aneurysm-artery and braided stent for CFD computation and possibly assist surgical planning. | Yunhan Cai Zhuangyuan Meng Yeqing Jiang Xiaolong Zhang Xinjian Yang Shengzhang Wang | 2020 | Medicine in Novel Technology and Devices2020，，1： | 1 |
| 14 | Detection of anemia using conjunctiva images:A smartphone application approach显示文摘Anemia is one of the public health issues that affect children and pregnant women globally.Anemia occurs when the level of red blood cells within the body is reduced.Detecting anemia requires expert blood draw for clinical analysis of hemoglobin quantity.Although this standard method is accurate,it is costive and consumes enough time,unlike the non-invasive approach which is cost-effective and takes less time.This study focused on pallor analysis and used images of the conjunctiva of the eyes to detect anemia using machine learning techniques.This study used a publicly available dataset of 710 images of the conjunctiva of the eyes acquired with a unique tool that eliminates any interference from ambient light.We combined Convolutional Neural Networks,Logistic Regression,and Gaussian Blur algorithm to develop a conjunctiva detection model and an anemia detection model which runs on a Fast API server connected to a frontend mobile app built with React Native.The developed model was embedded into a smartphone application that can detect anemia by capturing and processing a patient's conjunctiva with a sensitivity of 90%,a specificity of 95%,and an accuracy of 92.50%on average performance in about 50 s. | Peter Appiahene Enoch Justice Arthur Stephen Korankye Stephen Afrifa Justice Williams Asare Emmanuel Timmy Donkoh | 2023 | Medicine in Novel Technology and Devices2023，，2： | 1 |
| 15 | Computational models of flatfoot with three-dimensional fascia and bulk soft tissue interaction for orthosis design显示文摘The finite element(FE)method has been widely used to investigate the internal force of plantar fascia,which could reveal the relationship between plantar fascia dysfunction and flatfoot deformity during weight-bearing conditions.However,for most foot FE models,plantar fascia utilized truss elements or three-dimensional geometry that did not consider the interaction between plantar fascia and bulk soft tissue.These configurations could ignore the impact of superoinferior loading induced by arch support and underestimate the plantar fascia loading.This study aims to investigate how the fascia-bulk soft tissue interaction affects the internal foot biomechanics in the flatfoot FE analysis with a three-dimensional plantar fascia model,which included both fascia-bone and fascia-bulk soft tissue interactions(3DBPT).To evaluate the effect of fascia-bulk soft tissue interaction on internal foot mechanics,this study compared the 3DBPT model with the other two plantar fascia models,including linear fascia(BPL)and three-dimensional plantar fascia without fascia-bulk soft tissue interaction(3DBP).The predicted foot contact pressure in the 3DBPT model was compared with the measured value obtained by the F-Scan pressure measurement system in balanced standing.Peak von Mises stresses in the plantar fascia and foot ligaments were reported.The stress of the plantar fascia in the 3DBPT model was higher than that of 3DBP.In the 3DBPT model,the superoinferior loading exerted on the bulk soft tissue could be directly transferred to the plantar fascia.The proposed model,including the plantar fascia and bulk soft tissue interaction,could reveal relatively reliable plantar fascia loading in flatfoot deformity,thereby contributing to the development of orthotic designs for the flatfoot deformity. | Yinghu Peng Duo Wai-Chi Wong Yan Wang Tony Lin-Wei Chen Guoxin Zhang Fei Yan Ming Zhang | 2021 | Medicine in Novel Technology and Devices2021，，1： | 1 |
| 16 | Customized and in situ fenestrated stent-grafts:A reinforced poly-ε-caprolactone branch cuff designed to prevent type III endoleaks and enhance hemodynamics显示文摘Superior long-term anchorage of the bridging stent-grafts from the fenestrated main body endograft could be achieved with the addition of a flared cuff,capable of preventing the previously observed fabric fraying around the fenestration as a result of the balloon angioplasty of the seal zone.This novel stent cuff design will also facilitate more complete biointegration of the devices,eliminate the hemodynamic variation as well as significantly reduce the possibility of a Type III endoleak.The feasibility of this concept is demonstrated by observations made from in-situ tests performed in a Beta endograft design.Flared cuffs made of poly(ε-caprolactone)supported with a weft-knitted polyester structure can be manufactured with various configurations to optimize the transition from the main body of the endograft,thus preventing the currently marketed designs’hemodynamic perturbation while also promoting endograft biointegration.This concept represents an evolution in branch graft design,which may enhance the long-term durability of customized fenestrations and open new applications for in-vivo graft fenestration in the near future.Further ongoing investigation to optimize its structure,X-ray opacity,fixation to the flared stent,and material biocompatibility are still required to build upon this concept’s proof. | Fujun Wang Chaojing Li Robert Guidoin Abedalwafa Mohammed Graeham Douglas Fan Zhao Guy Dionne Ze Zhang Haripriya Ramesh Lu Wang Mark Nutley | 2021 | Medicine in Novel Technology and Devices2021，，1： | 1 |
| 17 | A proposed design of flow diverter and it’s hemodynamic validation显示文摘Flow diverter intervention is a cutting-edge treatment for intracranial aneurysms by altering the flow field and reducing the pressure in the aneurysm sac.However,the rupture rate and complications rate are still high.In this study,a new design of flow diverter based on Bernoulli’s equation was proposed and hemodynamics evaluation of it was conducted.The numerical model of a patient specific internal carotid aneurysm was established based on computed tomography scan images(Model C).The aneurysm models with normal diverter(ND)and local stenosed diverter(LSD)were modified from the patient-specific model.The blood flow characteristics were obtained and analyzed by numerical simulation while the in vitro experiments were conducted using three-dimensional printed silicone models and pressure measurement system.In both ND and LSD models,the blood flow into the aneurysm have been significantly blocked by the diverters and the pressure in the aneurysm sac have been decreased.The pressure drop and the wall shear stress on the aneurysm wall in the LSD model are higher than that in the ND model.The oscillatory shear index and relative residence time in the aneurysm wall of LSD are lower than that in the ND model.The pressure measurement in the vitro experiment also qualitatively verified the results of pressure comparison in the numerical simulation.In conclusion,the simulation results and in vitro experiments verified that diverter can certainly reduce the pressure in the aneurysm,and the newly design diverter with local stenosis can strengthening this effect. | Anqiang Sun Chengcheng Zhao Zujie Gao Xiaoyan Deng Hancheng Qiu | 2021 | Medicine in Novel Technology and Devices2021，，1： | 1 |
| 18 | 2020 update on human coronaviruses:One health,one world显示文摘Since human coronavirus(HCoVs)was first described in the 1960s,seven strains of respiratory human coronaviruses have emerged and caused human infections.After the emergence of severe acute respiratory syndrome coronavirus(SARS-CoV)and Middle East respiratory syndrome coronavirus(MERS-CoV),a pneumonia outbreak of coronavirus disease 2019(COVID-19)caused by a novel coronavirus(SARS-CoV-2)has represented a pandemic threat to global public health in the 21st century.Without effectively prophylactic and therapeutic strategies including vaccines and antiviral drugs,these three coronaviruses have caused severe respiratory syndrome and high case-fatality rates around the world.In this review,we detail the emergence event,origin and reservoirs of all HCoVs,compare the differences with regard to structure and receptor usage,and summarize therapeutic strategies for COVID-19 that cause severe pneumonia and global pandemic. | Xinbin Zhao Yuecheng Ding Jing Du Yubo Fan | 2020 | Medicine in Novel Technology and Devices2020，，4： | 1 |
| 19 | In vitro fluidic systems: Applying shear stress on endothelial cells显示文摘Endothelial cells(ECs)that reside on the surface of blood vessels are constantly exposed to mechanical stimulation,including shear stress.Fluid shear stress(FSS)controls multiple physiological processes in ECs,regulating various pathways that maintain vascular tone and homeostasis function.The complexity of in vivo biological systems raises a demand for better in vitro techniques,which can generate FSS to closely mimic the cellular microenvironment.Through the rational design and use of flow chamber devices,in vitro fluidic systems are critical for a deeper understanding of endothelial responses to various shear conditions.The paper describes principal types of FSS systems,including functional attributes,development process and recent experiments on ECs.Finally,we prospect their possible contribution in the field of endothelial diseases. | Fanzhe Meng Hong Cheng Jiayi Qian Xinyuan Dai Yan Huang Yubo Fan | 2022 | Medicine in Novel Technology and Devices2022，，3： | 1 |
| 20 | CP-AnemiC:A conjunctival pallor dataset and benchmark for anemia detection in children显示文摘Anemia is a universal public health issue,which occurs as the result of a reduction in red blood cells.This disease is common among children in Africa and other developing countries.If not treated early,children may suffer longterm consequences such as impairment in social,emotional,and cognitive functioning.Early detection of anemia in children is highly desirable for effective treatment measures.While there has been research into the development of computer-aided diagnosis(CAD)systems for anemia diagnosis,a significant proportion of these studies encountered limitations when working with limited datasets.To overcome the existing issues,this paper proposes a large dataset,named CP-AnemiC,comprising 710 individuals(range of age,6–59 months),gathered from several hospitals in Ghana.The conjunctiva image-based dataset is supported with Hb levels(g/dL)annotations for accurate diagnosis of anemia.A joint deep neural network is developed that simultaneously classifies anemia and estimates hemoglobin levels(g/dL)based on the conjunctival pallor images.This paper conducts a comprehensive experiment on the CP-AnemiC dataset.The experimental results demonstrate the efficacy of the joint deep neural network in both the tasks of anemia classification and Hb levels(g/dL)estimation. | Peter Appiahene Kunal Chaturvedi Justice Williams Asare Emmanuel Timmy Donkoh Mukesh Prasad | 2023 | Medicine in Novel Technology and Devices2023，，2： | 1 |
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