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| 1 | Proanthocyanidins Inhibit Seed Germination by Maintaining a High Level of Abscisic Acid in Arabidopsis thaliana显示文摘Proanthocyanidins (PAs) are the main products of the flavonoid biosynthetic pathway in seeds, but their biological function during seed germination is still unclear. We observed that seed germination is delayed with the increase of exogenous PA concentration in Arabidopsis. A similar inhibitory effect occurred in peeled Brassica napus seeds, which was observed by measuring radicle elongation. Using abscisic acid (ABA), a biosynthetic and metabolic inhibitor, and gene expression analysis by real-time polymerase chain reaction, we found that the inhibitory effect of PAs on seed germination is due to their promotion of ABA via de novo biogenesis, rather than by any inhibition of its degradation. Consistent with the relationship between PA content and ABA accumulation in seeds, PA-deficient mutants maintain a lower level of ABA compared with wild-types during germination. Our data suggest that PA distribution in the seed coat can act as a doorkeeper to seed germination. PA regulation of seed germination is mediated by the ABA signaling pathway. | Liguo Jia Qiuyu Wu Nenghui Ye Rui Liu Lu Shi Weifeng Xu Hui Zhi A. N. M. Rubaiyath Bin Rahman Yiji Xia Jianhua Zhang | 2012 | Journal of Integrative Plant Biology2012，54，9： | 9 |
| 2 | Molecular evolution of the rice miR395 gene family显示文摘MicroRNAs (miRNAs) are 20-22 nucleotide non-coding RNAs that play important roles in plant and animal development. They are usually processed from larger precursors that can form stem-loop structures. Among 20 miRNA families that are conserved between Arabidopsis and rice, the rice miR395 gene family was unique because it was organized into compact clusters that could be transcribed as one single transcript. We show here that in fact this family had four clusters of total 24 genes. Three of these clusters were segmental duplications. They contained miR395 genes of both 120 bp and 66 bp long. However, only the latter was repeatedly duplicated. The fourth cluster contained miR395 genes of two different sizes that could be the consequences of intergenic recombination of genes from the first three clusters. On each cluster, both 1-duplication and 2-duplication histories were observed based on the sequence similarity between miR395 genes, some of which were nearly identical suggesting a recent origin. This was supported by a miR395 locus survey among several species of the genus Oryza, where two clusters were only found in species with an AA genome, the genome of the cultivated rice. A comparative study of the genomic organization of Medicago truncatula miR395 gene family showed significant expansion of intergenic spaces indicating that the originally clustered genes were drifting away from each other. The diverse genomic organizations of a conserved microRNA gene family in different plant genomes indicated that this important negative gene regulation system has undergone dramatic tune-ups in plant genomes. | Sreelatha GUDDETI De Chun ZHANG Ai Li LI Chuck H. LESEBERG Hui KANG Xiao Guang LI Wen Xue ZHAI Mitrick A. JOHNS Long MAO | 2005 | Cell Research2005，15，8： | 7 |
| 3 | 用于生物医学的新型多孔Ti6Al4V植入物的仿生设计和3D打印(英文)显示文摘目的:多孔结构植入体在骨科修复领域具有极大的应用前景.本研究提出了一种在结构与力学性能方面更贴近人体骨组织的多孔Ti6Al4V植入体.创新点:针对骨组织的结构特点,提出了'分层设计'理念,以期更好地模拟皮质骨和松质骨的结构.除了结构相似以外,这种植入体在力学性能和结构稳定性方面同样具有优势.方法:将传统多孔植入体三维晶胞设计方法转化为二维设计理念,设计出一种分层杆连接多孔结构,并利用选择性激光熔融(SLM)技术打印出样品;然后通过光学显微镜评测打印效果,利用单轴压缩试验研究分析样品的力学性能;最后利用有限元方法分析多孔结构的结构稳定性.结论:本研究所设计的新型分层杆连接结构可以通过SLM实现高质量的打印,且尺寸合理,力学性能与骨组织相接近,结构稳定性优于传统多孔结构.这种新型多孔结构植入体在骨缺损修复领域具有较好的潜在应用前景. | Wen-ming Peng Yun-feng Liu Xian-feng Jiang Xing-tao Dong Janice Jun Dale A. Baur Jia-jie Xu Hui Pan Xu Xu | 2019 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2019，20，8： | 7 |
| 4 | Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn’s and Colitis Epidemiology Study显示文摘 | Siew C. Ng Whitney Tang Jessica Y. Ching May Wong Chung Mo Chow A.J. Hui T.C. Wong Vincent K. Leung Steve W. Tsang Hon Ho Yu Mo Fong Li Ka Kei Ng Michael A. Kamm Corrie Studd Sally Bell Rupert Leong H. Janaka de Silva Anuradhani Kasturiratne M.N.F. Mufeen | 2013 | Gastroenterology2013，，1： | 6 |
| 5 | Pine wilt disease in Yunnan, China: Evidence of non-local pine sawyer Monochamus alternatus (Coleoptera: Cerambycidae) populations revealed by mitochondrial DNA显示文摘 | Da-Ying Fu Shao-Ji Hu Hui Ye Robert A. Haack Ping-Yang Zhou | 2010 | Insect Science2010，17，5： | 4 |
| 6 | Orientational Domains at Room Temperature in La_(0.33) Ca_(0.67) MnO_3 Perovskite显示文摘Orientational domains at room temperature in orthorhombic perovskite La 0.33 Ca 0.67 MnO 3 were studied by group theory and observed systematically using transmission electron microscopy. There are six orientational variants ( A, A’, B,B’, C and C’ ) in orthorhombic perovskite La 0.33 Ca 0.67 MnO 3. Their orthorhombic b O directions are parallel to the a P, b P and c P directions of the cubic prototypic perovskite, respectively. In each case there are two orientational variants (e.g., A and A’ ) with their a O and c O axes interchanged. Among the possible 15 boundaries between these 6 variants there are only two types of domain boundaries: (1) m<100> boundaries C’/C, A’/A, and B’/B. (2) m<110> boundaryies C’/A, C’/A’, C’/B, C’/B’, C/A, C/A’, C/B, C/B’, B’/A, B’/A’, B/A, and B/A’ . | WANG Ren hui 1,2) ,GUI Jia nian 1,2) ,ZHU Yi mei 2) , A. R. Moodenbaugh 2) 1. Department of Physics, Wuhan University, Wuhan 430072, China 2. Department of Applied Science, Brookhaven National Laboratory, Upton, NY 11973 | 1999 | Wuhan University Journal of Natural Sciences1999，4，4： | 3 |
| 7 | Weekly nab-Paclitaxel in Combination With Carboplatin Versus Solvent-Based Paclitaxel Plus Carboplatin as First-Line Therapy in Patients With Advanced Non–Small-Cell Lung Cancer: Final Results of a Phase III Trial显示文摘 | Mark A. Socinski Igor Bondarenko Nina A. Karaseva Anatoly M. Makhson Igor Vynnychenko Isamu Okamoto Jeremy K. Hon Vera Hirsh Paul Bhar Hui Zhang Jose L. Iglesias Markus F. Renschler | 2012 | Journal of Clinical Oncology2012，，17： | 3 |
| 8 | Principles of microRNA involvement in human cancers显示文摘Naturally occurring microRNAs (miRNAs), small non-coding RNAs of 19 to 24 nucleotides (nt), are encoded in the genomes of invertebrates, vertebrates, and plants. miRNAs act as regulators of gene expression during development and differentiation at the transcriptional, posttranscriptional, and/or translational levels, although most target genes are still elusive. Many miRNAs are conserved in sequence between distantly related organisms, suggesting that these molecules participate in essential processes. In this review, we present principles related to the basic and translational research that has emerged in the last decade, a period that can be truly considered the 'miRNA revolution' in molecular oncology. These principles include the regulation mechanism of miRNA expression, functions of miRNAs in cancers, diagnostic values and therapeutic potentials of miRNAs. Furthermore, we present a compendium of information about the main miRNAs that have been identified in the last several years as playing important roles in cancers. Also, we orient the reader to several additional reviews that may provide a deeper understanding of this new and exciting field of research. | Hui Ling Wei Zhang George A. Calin | 2011 | Chinese Journal of Cancer2011，30，11： | 3 |
| 9 | A clean slate 4D approach to network control and management显示文摘 | Albert Greenberg Gisli Hjalmtysson David A. Maltz Andy Myers Jennifer Rexford Geoffrey Xie Hong Yan Jibin Zhan Hui Zhang | 2005 | ACM SIGCOMM Computer Communication Review2005，，5： | 2 |
| 10 | Continuous lobe reconnectionin the mid-tail and its relationship to substorms:Cluster observations of continuous lobe reconnection in the mid-magneto tail显示文摘When the IMF turns southward, a great amount of magnetic energy is stored in the magnetotail, and the electric field across the magnetotail substantially en-hances. As long as magnetic reconnection (MR) in the mag-netotail initiates and continues, the magnetic field and plasma in the central plasma sheet are carried away to the near-Earth and down to the tail, the magnetic field and plasma in the lobe region enter the CPS and are involved in MR. We call this process “Continuous Lobe Reconnection (CLR)”. In this paper a detailed analysis of Cluster observa-tion of MR through 2001―2003 is made. Plenty of CLR events are found that led to considerable changes of tail con-figuration, appearance of BBF, as well as large-scale bubbles in which both plasma temperature and number density sub-stantially decrease. It is shown that in general CLR events last for dozens of minutes and have good correspondence to substorm initiation under the condition of continuous southward IMF. | CAO Xin PU Zuyin ZHANG Hui FU Suiyan XIAO Chijie LIU Zhenxing J. B. cao A. Korth M. Frazen Q. G. Zong H. Reme K. H. Glassmeier | 2005 | Chinese Science Bulletin2005，50，18： | 2 |
| 11 | Does diffusion kurtosis imaging lead to better neural tissue characterization? A rodent brain maturation study显示文摘 | Matthew M. Cheung Edward S. Hui Kevin C. Chan Joseph A. Helpern Liqun Qi Ed X. Wu | 2008 | Neuroimage2008，，2： | 2 |
| 12 | Increased activity of the complement system in the liver of patients with alcoholic hepatitis显示文摘 | Hong Shen Barbara A. French Hui Liu Brittany C. Tillman Samuel W. French | 2014 | Experimental and Molecular Pathology2014，，3： | 2 |
| 13 | TLR3/4 signaling is mediated via the NFκB-CXCR4/7 pathway in human alcoholic hepatitis and non-alcoholic steatohepatitis which formed Mallory–Denk bodies显示文摘 | Hui Liu Jun Li Brittany Tillman Timothy R. Morgan Barbara A. French Samuel W. French | 2014 | Experimental and Molecular Pathology2014，，2： | 2 |
| 14 | The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: An international collaborative study显示文摘 | Neeraj Bhala Paul Angulo David van der Poorten Eric Lee Jason M. Hui Giorgio Saracco Leon A. Adams Phunchai Charatcharoenwitthaya Joanne H. Topping Elisabetta Bugianesi Christopher P. Day Jacob George | 2011 | Hepatology2011，，4： | 2 |
| 15 | Quantitative dynamics of hepatitis B basal core promoter and precore mutants before and after HBeAg seroconversion显示文摘 | Hui Nie Alison A. Evans W. Thomas London Timothy M. Block Xiangdong David Ren | 2011 | Journal of Hepatology2011，，4： | 2 |
| 16 | Pancreatic ductal adenocarcinoma: Long-term survival does not equal cure显示文摘 | Cristina R. Ferrone Rafael Pieretti-Vanmarcke Jordan P. Bloom Hui Zheng Jackye Szymonifka Jennifer A. Wargo Sarah P. Thayer Gregory Y. Lauwers Vikram Deshpande Mari Mino-Kenudson Carlos Fernández-del Castillo Keith D. Lillemoe Andrew L. Warshaw | 2012 | Surgery2012，，： | 2 |
| 17 | MicroRNA-124 Controls the Proliferative, Migratory, and Inflammatory Phenotype of Pulmonary Vascular Fibroblasts显示文摘 | Daren Wang Hui Zhang Min Li Maria G. Frid Amanda R. Flockton B. Alexandre McKeon Michael E. Yeager Mehdi A. Fini Nicholas W. Morrell Soni S. Pullamsetti Sivareddy Velegala Werner Seeger Timothy A. McKinsey Carmen C. Sucharov Kurt R. Stenmark | 2014 | Circulation Research2014，，1： | 1 |
| 18 | Genome and Comparative Transcriptomics of African Wild Rice Oryza Iongistaminata Provide Insights into Molecular Mechanism of Rhizomatousness and Self-Incompatibility显示文摘Dear Editor, Oryza Iongistaminata is an African wild rice species with AA genome type possessing special traits that are highly valued for improving cultivated rice,such as strong resistance to biotic and abiotic stresses (Song et al.,1995) for improving resistance of cultivars,rhizomatousness for perennial breeding (Glover et al.,2010),and self-incompatibility (SI) for new ways to produce hybrid seeds (Ghesquiere,1986).Deciphering the genome of O.longistaminata will be the key to uncovering the mechanism of these hallmark traits and improving cultivated rice. | Yesheng Zhang Shilai Zhang Hui Liu Binying Fu Lijuan Li Min Xie Yue Song Xin Li Jing Cai Wenting Wan Ling Kui Hui Huang Jun Lyu Yang Dong Wensheng Wang Liyu Fluang Jing Zhang Qinzhong Yang Qinfi Shan Qiong Li Wangqi Huang Dayun Tao Muhua Wang Mingsheng Chen Yeisoo Yu Rod A. Wing Wen Wang Fengyi Hu | 2015 | Molecular Plant2015，8，11： | 1 |
| 19 | LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models显示文摘 | S. Betty Yan Victoria L. Peek Rose Ajamie Sean G. Buchanan Jeremy R. Graff Steven A. Heidler Yu-Hua Hui Karen L. Huss Bruce W. Konicek Jason R. Manro Chuan Shih Julie A. Stewart Trent R. Stewart Stephanie L. Stout Mark T. Uhlik Suzane L. Um Yong Wang Wenj | 2013 | Investigational New Drugs2013，，4： | 1 |
| 20 | Short-term outcome of critically ill patients with severe acute respiratory syndrome显示文摘 | Charles D. Gomersall Gavin M. Joynt Philip Lam Thomas Li Florence Yap Doris Lam Thomas A. Buckley Joseph J. Y. Sung David S. Hui Gregory E. Antonio Anil T. Ahuja Patricia Leung | 2004 | Intensive Care Medicine2004，，3： | 1 |
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