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| 1 | Surface Rupture and Co-seismic Displacement Produced by the Ms 8.0 Wenchuan Earthquake of May ^(12)th,2008,Sichuan,China:Eastwards Growth of the Qinghai-Tibet Plateau显示文摘女士 8 的地震给 Wenchuan 以县,西方的四川,中国,在 2008 年 5 月 12 日并且导致了长表面破裂(> 300 km ) 。关于表面破裂的第一手的观察在 Yingxiu, Beichuan 和 Qingchuan 的最糟点击的区域由地震生产了,查明地震的原因的结构在 Longmenshan 构造的带的中央差错地区。沿着 Yingxiu-Beichuan 破裂地区活动范围 2.5-4 m 的单个差错的平均 co 地震的垂直排水量和越过中央、正面的 Longmenshan 差错的累积垂直排水量系上带子是大约 56 m。表面破裂力量从 Beichuan 的北方被归结为 Qingchuan 县和表演 23 m 右罢工滑倒部件。Wenchuan 指责戳的地震是在印度、欧亚的大陆的连续集中的行动下面的西藏的高原的东方生长的表明。 | DONG Shuwen ZHANG Yueqiao WU Zhenhan YANG Non MA Yinsheng SHI Wei CHEN Zhengle LONG Changxin AN Meijian | 2008 | Acta Geologica Sinica(English Edition)2008，82，5： | 59 |
| 2 | The Reference Genome of Tea Plant and Resequencing of 81 Diverse Accessions Provide Insights into Its Genome Evolution and Adaptation显示文摘Tea plant is an important economic crop,which is used to produce the world's oldest and most widely consumed tea beverages.Here,we present a high-quality reference genome assembly of the tea plant(Camellia sinensis var.sinensis)consisting of 15 pseudo-chromosomes.LTR retrotransposons(LTR-RTs)account for 70.38%of the genome,and we present evidence that LTR-RTS play critical roles in genome size expansion and the transcriptional diversification of tea plant genes through preferential insertion in promoter regions and introns.Genes,particularly those coding for terpene biosynthesis pro-teins,associated with tea aroma and stress resistance were significantly amplified through recent tandem duplications and exist as gene clusters in tea plant genome.Phylogenetic analysis of the sequences of 81 tea plant accessions with diverse origins revealed three well-differentiated tea plant populations,support-ing the proposition for the southwest origin of the Chinese cultivated tea plant and its later spread to western Asia through introduction.Domestication and modern breeding left significant signatures on hundreds of genes in the tea plant genome,particularly those associated with tea quality and stress resis-tance.The genomic sequences of the reported reference and resequenced tea plant accessions provide valuable resources for future functional genomics study and molecular breeding of improved cul-tivars of tea plants. | Enhua Xia Wei Tong Yan Hou Yanlin An Linbo Chen Qiong Wu Yunlong Liu Jie Yu Fangdong Li Ruopei Li Penghui Li Huijuan Zhao Ruoheng Ge Jin Huang Ali Inayat Mallano Yanrui Zhang Shengrui Liu Weiwei Deng Chuankui Song Zhaoliang Zhang Jian Zhao Shu Wei Zhengzhu Zhang Tao Xia Chaoling Wei Xiaochun Wan | 2020 | Molecular Plant2020，13，7： | 51 |
| 3 | BMP-6 inhibits microRNA-21 expression in breast cancer through repressing 6EF1 and AP-1显示文摘 | Jun Du Shuang Yang Di An Fen Hu Wei Yuan Chunli Zhai Tianhui Zhu | 2009 | Cell Research2009，19，4： | 44 |
| 4 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of ischaemic cerebrovascular diseases显示文摘Aim Stroke is the leading cause of disability and death in China.Ischaemic stroke accounts for about 60%-80%of all strokes.It is of considerable significance to carry out multidimensional management of ischaemic cerebrovascular diseases.This evidence-based guideline aims to provide the latest detailed and comprehensive recommendations on the diagnosis,treatment and secondary prevention of ischaemic cerebrovascular diseases.Methods We had performed comprehensive searches of MEDLINE(via PubMed)(before 30 June 2019),and integrated the relevant information into charts and distributed to the writing group.Writing group members discussed and determined the recommendations through teleconference.We used the level of evidence grading algorithm of Chinese Stroke Association to grade each recommendation.The draft was reviewed by the Guideline Writing Committee of Chinese Stroke Association Stroke and finalised.This guideline is fully updated every 3 years.results This evidence-based guideline is based on the treatment,care and prevention of ischaemic cerebrovascular diseases,which emphasises on pathogenesis evaluation,intravenous thrombolysis,endovascular therapy,antiplatelet therapy,prevention and treatment of complications,and risk factor management.Conclusions This updated guideline presents a framework for the management of ischaemic cerebrovascular diseases.Timely first-aid measures,professional care in the acute stage,and proactive secondary prevention will be helpful to patients. | Liping Liu Weiqi Chen Hongyu Zhou Wanying Duan Shujuan Li Xiaochuan Huo Weihai Xu Li'an Huang Huaguang Zheng Jingyi Liu Hui Liu Yufei Wei Jie Xu Yongjun Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 42 |
| 5 | Effect of NF-κB and p38 MAPK in activated monocytes/macrophages on pro-inflammatory cytokines of rats with acute pancreatitis显示文摘AIM: Proinfiammatory cytokines TNF-α and IL-6 play a main role in acute pancreatitis (AP). Cytokine biosynthesis runs through two major signaling pathways at the level of proteins: nuclear transcription factor-κB (NF-κB) and p38 mitogen-activated protein kinase (p38 MAPK). The aim of the study was to investigate the effect of NF-κB and p38 MAPK in activated monocytes/macrophages on cytokines of rats with acute pancreastitis.METHODS: Taurocholate (3 % and 5 %) at doses of 1 mL/kg was administered into the biliopancreatic duct of male Sprague-Dawley (SD) rats to reduce acute edematous pancreariris (AEP) and acute necrotizing pancreatitis (ANP).Pancreatic tissues were prepared immediately after death.At this point, blood was obtained for determination of serum amylase and pro-inflammatory TNF-α and IL-6. Activated monocytes/macrophages were captured from blood and so were ascites. NF-κB and p38 MAPK in activated monocytes/macrophages were measured by immunohistochemistry method. Pancreatic tissue samples were prepared for routine light microscopy, using hematoxylin and eosin (HE) staining.RESULTS: The serum levels of amylase were 3 056.00±1 232.35 IU/L and 4 865.12±890.34 IU/L at 3 and 6 hours in ANP group, which were significantly higher than those (3 056.00±1 232.35 TU/L and 3 187.17±821.16 IU/L) (P<0.05,respectively) in AEP group. In ascites the levels were 3.32±1.01 g and 3.76±1.12 g at 3 and 6 hours in ANP group,which were significantly higher than those (1.43±1.02 g and 2.56±1.21 g) (P<0.05, respectively) in AEP group. The serum levels of TNF-α were 54.27±23.48 pg/ml and 67.83±22.02 pg/ml in AEP group and 64.28±20.79 pg/ml and 106.59±43.71 pg/ml in ANP group, and the serum levels of IL-6 were 428.12±140.30 pg/ml and 420.13±139.40 pg/ml in AEP group and 1 600.32±309.78 pg/ml and 2 203.76±640.85 pg/ml in ANP group, which were far significantly higher than those in sham group (P<0.001, respectively). The serum level of TNF-α 6 hours after establishment of the studied model and that of IL-6 at 3 and 6 hours in ANP group were significantly higher than those in AEP (P<0.05, P<0.001, P<0.05). In ANP group, the levels of serum TNF-α and IL-6 6 hours after establishment of the studied model were significantly higher than those 3 hours after establishment of studied model (P<0.05, P<0.05, respectively). Three and 6 hours after establishment of the model, typical pathological changes of AEP and ANP were found, such as large numbers of inflammatory cells, edema, hemorrhage, necrosis, large amount of ascites. In AEP, NF-κB and p38 MAPK in activated monocytes/macrophages were moderately found at 3 and 6 hours after introduction of the model. However, in ANP,the expression of NF-κB and p38 MAPK in activated monocytes/macrophages was upregulated evidently at 3 and 6 hours after introduction of the model, reaching their highest levels at 6 hours after introduction of the model, which were consistent with the levels of TNF-α and IL-6.CONCLUSION: Cytokine TNF-α and IL-6 play a main rolein acute pancreatitis, expression of NF-κB and p38 MAPK in activated monocytes/macrophages might play a major role in cytokine transcription and biosynthesis. | Hong-Shan Liu Cheng-En Pan Qing-Guang Liu Wei Yang Xue-Min Liu, Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China | 2003 | World Journal of Gastroenterology2003，9，11： | 42 |
| 6 | Roles of liver innate immune cells in nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease in the United States and other developed countries and is expected to increase in the next few years. Emerging data suggest that some patients with NAFLD may progress to nonalcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma. NAFLD can also promote the development and progression of disease in other organ systems, such as the cardiovascular and endocrine (i.e. diabetes) systems. Thus, understanding the pathogenesis of NAFLD is of great clinical importance and is critical for the prevention and treatment of the disease. Although the 'two-hit hypothesis' is generally accepted, the exact pathogenesis of NAFLD has not been clearly established. The liver is an important innate immune organ with large numbers of innate immune cells, including Kupffer cells (KCs), natural killer T (NKT) cells and natural killer (NK) cells. Recent data show that an imbalance in liver cytokines may be implicated in the development of fatty liver disease. For example, Th1 cytokine excess may be a common pathogenic mechanism for hepatic insulin resistance and NASH. Innate immune cells in the liver play important roles in the excessive production of hepatic Th1 cytokines in NAFLD. In addition, liver innate immune cells participate in the pathogenesis of NAFLD in other ways. For example, activated KCs can generate reactive oxygen species, which induce liver injury. This review will focus primarily on the possible effect and mechanism of KCs, NKT cells and NK cells in the development of NAFLD. | Yu-Tao Zhan Wei An | 2010 | World Journal of Gastroenterology2010，16，37： | 35 |
| 7 | Contemporary crustal movement of continental China obtained by global positioning system(GPS) measurements显示文摘We obtain a unified horizontal velocity field of continental China and vicinity through measurements at 81 GPS stations provided by the National Key Infrastructure Project, Crustal Movement Observation Network of China. The velocity field delineates patterns of movements and deformation of active crustal blocks in continental China under the Eurasia-fixed reference frame. The space-based geodesy also clearly shows for the first time the horizontal movementand deformation of continental China induced by indentation of the Indian plate. The data provide kinematic constraints for simulating dynamic process of continental litho-spheric deformation. | MA Zongjin, CHEN Xinlian, YE Shuhua, LAI Xian, WEI Ziqing, CHEN Junrong, NING Jinsheng, XU Huoze & DING Guoyu1. Insitute of Geology, China Seismological Bureau, Beijing 100029, China (e-mail: disgroup@publi.bta.net.cn)2. Center for Analysis and Prediction, China Seismological Bureau, Beijing 100036, China 3. Shanghai Astronomic Observatory, Chinese Academy of Sciences, Shanghai 200030, China 4. Institute of Seismology, China Seismological Bureau, Wuhan 430077, China 5. Institute of Survey and Mapping, Xi’an 710054, China 6. National Bureau of Survey and Mapping, Beijing 100830, China 7. Wuhan University, Wuhan 430077, China 8. Institute of Geodesy and Geophysics, Wuhan 430077, China 9. China Seismological Bureau, Beijing 100036, China | 2001 | Chinese Science Bulletin2001，46，18： | 34 |
| 8 | Constraining the timing of the India-Asia continental collision by the sedimentary record显示文摘Placing precise constraints on the timing of the India-Asia continental collision is essential to understand the successive geological and geomorphological evolution of the orogenic belt as well as the uplift mechanism of the Tibetan Plateau and their effects on climate,environment and life.Based on the extensive study of the sedimentary record on both sides of the Yarlung-Zangbo suture zone in Tibet,we review here the present state of knowledge on the timing of collision onset,discuss its possible diachroneity along strike,and reconstruct the early structural and topographic evolution of the Himalayan collided range.We define continent-continent collision as the moment when the oceanic crust is completely consumed at one point where the two continental margins come into contact.We use two methods to constrain the timing of collision onset:(1) dating the provenance change from Indian to Asian recorded by deep-water turbidites near the suture zone,and(2) dating the age of unconformities on both sides of the suture zone.The first method allowed us to constrain precisely collision onset as middle Palaeocene(59±l Ma).Marine sedimentation persisted in the collisional zone for another 20-25 Ma locally in southern Tibet,and molassic-type deposition in the Indian foreland basin did not begin until another 10-15 Ma later.Available sedimentary evidence failed to firmly document any significant diachroneity of collision onset from the central Himalaya to the western Himalaya and Pakistan so far.Based on the Cenozoic stratigraphic record of the Tibetan Himalaya,four distinct stages can be identified in the early evolution of the Himalayan orogen:(1) middle Palaeocene-early Eocene earliest Eohimalayan stage(from 59 to 52 Ma):collision onset and filling of the deep-water trough along the suture zone while carbonate platform sedimentation persisted on the inner Indian margin;(2) early-middle Eocene early Eohimalayan stage(from 52 to 41 or 35 Ma):filling of intervening seaways and cessation of marine sedimentation;(3) late Eocene-Oligocene late Eohimalayan stage(from 41 to 25 Ma):huge gap in the sedimentary record both in the collision zone and in the Indian foreland;and(4) late Oligocene-early Miocene early Neohimalayan stage(from 26 to 17 Ma):rapid Himalayan growth and onset of molasse-type sedimentation in the Indian foreland basin. | HU XiuMian WANG JianGang AN Wei Eduardo GARZANTI LI Juan | 2017 | Science China Earth Sciences2017，60，4： | 32 |
| 9 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 10 | Studies of Chemical Constituents and Their Antioxidant Activities From Astragalus mongholicus Bunge显示文摘Objective To evaluate the antioxidant activities of different chemical constituents from Astragalus mongholicus Bunge and their protection against xanthine (XA)/xanthine oxidase (XO)-induced toxicity in PC12 cells. Methods The compounds of Astragalus mongholicus Bunge were isolated by chromatography and the structures were elucidated on the basis of spectral data interpretation. Their antioxidant activities were detected by 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities in a cell-free system. Meanwhile, the effects against XA/XO-induced toxicity were assessed using MTT assay in PC12 cells. Results Ten principal constituents were isolated and identified as formononetin (I), ononin (II), calycosin (III), calycosin-7-O-β-D-glucoside (IV), 9,10-dimethoxypterocarpan-3-O-β-D-glucoside (V), adenosine (VI), pinitol (VII), daucosterol (VIII), β-sitoster (IX) and saccharose (X) from Astragalus mongholicus Bunge. The compounds I, III, and IV scavenged DPPH free radicals in vitro. Formononetin and calycosin were found to inhibit XA/XO-induced cell injury significantly, with an estimated EC50 of 50 ng/mL. Conclusion Compound Ⅱ, Ⅵ, and Ⅶ are first reported in this plant. Calycosin exhibits the most potent antioxidant activity both in the cell-free system and in the cell system. | DE-HONG YU YONG-MING BAO CHAO-LIANG WEI, LI-JIA AN | 2005 | Biomedical and Environmental Sciences2005，18，5： | 23 |
| 11 | Metallothionein mediates cardioprotection of isoliquiritigenin against ischemia-reperfusion through JAK2/STAT3 activation显示文摘瞄准:检验 isoliquiritigenin (ISL ) 是否能稀释心肌的 ischemiareperfusion (MI/R ) 在由通过双面联胎激酶的激活导致 metallothionein (MT ) 的老鼠的损害 2 (JAK 2 )/signal 变换器和抄写 3 的使活跃之物(STAT 3 ) 小径。方法:在老鼠的 MI/R 的试验性的模型被局部缺血和灌注的 30 min 为 2 h 产生。MT, COX-2,和 i NOS 的 mRNA 表示被 RT-PCR 测量。MT, JAK/STAT,细胞外的调整信号的激酶(英皇家空军之阶级最低之兵) ,和 Akt 的蛋白质表情被在一个 JAK 激酶禁止者的缺席或存在的西方的弄污决定, tyrphostin AG490 (1.0 mg/kg, iv,在局部缺血前的 1 h ) 。结果:有 ISL 的预告的处理显著地减少了导致 reperfusion 的心律不齐和心肌的梗塞尺寸的严厉。在 ISL 20 mg/kg 组,当时, lactate 脱氢酶(LDH ) 和肌酸酐磷酸激酶(CPK ) 的活动被 38.4% 和 51.3% 减少与车辆组相比。增加的 JAK 2/STAT 3 磷酸化被 MT 然而并非 COX-2 或 i NOS 的增加的合成在对待 ISL 的组伴随。AG490 能显著地削弱导致 ISL 的 cardioprotection 并且阻止 MT 表示和 JAK 2/STAT 的增加 3 磷酸化。结论:ISL 通过 JAK 2/STAT 的激活保护了 MI/R 损害 3 信号转导变异小径,它可能涉及调停起来 MT 的规定表示。 | Wei AN Jing YANG Ying AO | 2006 | Acta Pharmacologica Sinica2006，27，11： | 23 |
| 12 | Inhibition of 12-lipoxygenase reduces proliferation and induces apoptosis of hepatocellular carcinoma cells in vitro and in vivo显示文摘BACKGROUND:12-lipoxygenase(12-LOX) has been reported to be an important gene in cancer cell proliferation and survival,and tumor metastasis.However,its role in hepatocellular carcinoma(HCC) cells remains unknown.METHODS:Expression of 12-LOX was assessed in a diethylnitrosamine-induced rat HCC model,and in SMMC-7721,HepG2 and L-02 cells using immunohistochemical staining and reverse transcriptase-polymerase chain reaction(RT-PCR).GST-π and Ki-67 were determined in vivo by immunohistochemical staining.Apoptosis was evaluated by TUNEL assay.Cell viability and apoptosis were determined by MTT assay and flow cytometry,respectively.Apoptosis-related proteins in SMMC-7721 and HepG2 cells were detected by Western blotting.RESULTS:Immunohistochemical staining and RT-PCR showed that 12-LOX was over-expressed in rat HCC and two HCC cell lines,while the expression was inhibited by baicalein,a specific inhibitor of 12-LOX.Baicalein inhibited cell proliferation and induced apoptosis in rat HCC and both cell lines in a dose-and time-dependent manner.Our in vivo study demonstrated that baicalein also reduced neoplastic nodules.Mechanistically,baicalein reduced Bcl-2 protein expression coupled with a slight increase of the expression of Bax and activation of caspase-3.Furthermore,baicalein inhibited the activation of ERK-1/2(phosphorylated).Interestingly,the effects of baicalein were reversed by 12(S)-HETE,a metabolite of 12-LOX.CONCLUSIONS:Inhibition of 12-LOX leads to reduced numbers of HCC cells,partially caused by increased apoptosis.12-LOX may be a potential molecular target for HCC prevention and treatment. | Xi-Ming Xu,Guang-Jin Yuan,Jun-Jian Deng,Hong-Ting Guo,Miao Xiang,Fang Yang,Wei Ge and Shi-You Chen Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, China Cancer Center, the 82nd Hospital of the Chinese PLA, Huai’an 223001, China Department of Physiology, Medical College of Wuhan University, Wuhan 430071, China Department of Physiology & Pharmacology, University of Georgia, Athens, GA 30602, USA | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 20 |
| 13 | Studies on mechanism of Sialy Lewis-X antigen in liver metastases of human colorectal carcinoma显示文摘INTRODUCTIONSialyl Lewis-X antigen ,correlated with carcinoma, is a group of carbohydrate antigen containing oligosaccharide expressed of embryonic tisue and glycoproteins on cell surface of embryonic tissue[1].The SLeX antigen located on cell surface is synthesized principally by two enzymes ,al ,3fucosyltransfrease and a2, 3sialyctransferase.In adults ,SLeX antigen is expressed principally on the surfaces of granulocytic cells and some tumor cells . | Xiao Wei Li~1 Yan Qing Ding~1 Jun Jie Cai~1 Shao Qing Yang~2 Lian Bing An~3 Dong Fang Qiao~3 ~1Department of Pathology,Nanfang Hospital of the First Military Medical University,Guangzhou 510515,Guangdong Province,China ~2The Northern Hospital of PLA,Shenyang 110015,Liaoning Province,China ~3Department of Electronmicroscopy,First Military Medical University,Guangzhou 510515,Gangdong Province,ChinaDr.Xiao Wei Li graduated from the First Military Medical University with a MM degree in 1999.Physician in Charge of pathology,having 6 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 19 |
| 14 | Numerical modeling and dynamic analysis of the 2017 Xinmo landslide in Maoxian County, China显示文摘A catastrophic landslide occurred at Xinmo village in Maoxian County, Sichuan Province,China, on June 24, 2017. A 2.87×106 m3 rock mass collapsed and entrained the surface soil layer along the landslide path. Eighty-three people were killed or went missing and more than 103 houses were destroyed. In this paper, the geological conditions of the landslide are analyzed via field investigation and high-resolution imagery. The dynamic process and runout characteristics of the landslide are numerically analyzed using a depth-integrated continuum method and Mac Cormack-TVD finite difference algorithm.Computational results show that the evaluated area of the danger zone matchs well with the results of field investigation. It is worth noting that soil sprayed by the high-speed blast needs to be taken into account for such kind of large high-locality landslide. The maximum velocity is about 55 m/s, which is consistent with most cases. In addition, the potential danger zone of an unstable block is evaluated. The potential risk area evaluated by the efficient depthintegrated continuum method could play a significant role in disaster prevention and secondary hazard avoidance during rescue operations. | OUYANG Chao-jun ZHAO Wei HE Si-ming WANG Dong-po ZHOU Shu AN Hui-cong WANG Zhong-wen CHENG Duo-xiang | 2017 | Journal of Mountain Science2017，14，9： | 19 |
| 15 | Tanshinone IIA therapeutically reduces LPS-induced acute lung injury by inhibiting inflammation and apoptosis in mice显示文摘目的: 到学习, lipopolysaccharide (LPS ) 上的 tanshinone IIA (TIIA ) 的效果在老鼠和内在的机制导致了尖锐的肺损害。 | Min xu Fa-le CAO Yu-fei ZHANG Liang SHAN Xiao-ling JIANG Xiao-jing AN Wei XU Xiu-zhi LIU Xiao-yan WANG | 2015 | Acta Pharmacologica Sinica2015，36，2： | 19 |
| 16 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 17 | Track-before-detect for Infrared Maneuvering Dim Multi-target via MM-PHD显示文摘In this paper, we present a novel and efficient track-before-detect (TBD) algorithm based on multiple-model probability hypothesis density (MM-PHD) for tracking infrared maneuvering dim multi-target. Firstly, the standard sequential Monte Carlo probability hypothesis density (SMC-PHD) TBD-based algorithm is introduced and sequentially improved by the adaptive process noise and the importance re-sampling on particle likelihood, which result in the improvement in the algorithm robustness and convergence speed. Secondly, backward recursion of SMC-PHD is derived in order to ameliorate the tracking performance especially at the time of the multi-target arising. Finally, SMC-PHD is extended with multiple-model to track maneuvering dim multi-target. Extensive experiments have proved the efficiency of the presented algorithm in tracking infrared maneuvering dim multi-target, which produces better performance in track detection and tracking than other TBD-based algorithms including SMC-PHD, multiple-model particle filter (MM-PF), histogram probability multi-hypothesis tracking (H-PMHT) and Viterbi-like. | LONG Yunli XU Hui AN Wei LIU Li | 2012 | Chinese Journal of Aeronautics2012，25，2： | 17 |
| 18 | A fishy odor episode in a north China reservoir: Occurrence, origin, and possible odor causing compounds显示文摘A significant outbreak of fishy odor occurred in a reservoir located in Inner Mongolia, China, in the winter of 2011, and the odor rating, algal density and concentrations of some potential odorous compounds were monitored over a period of two months. The peak odor rating of the fishy odor was 7 according to flavor profile analysis. Among the dominant algal species(two diatom and one chrysophyte species) observed during the survey, the chrysophyte Dinobryon sp. was the most abundant species, with the peak density recorded at 88,520 cells/mL. Seven potential algal metabolites including heptanal, 2,4-heptadienal, 2,4-decadienal, nonanal, 2-octenal, 2,6- nonadienal and hexanal were detected. The principal component analysis result showed that n-hexanal, n-heptanal and 2,4-decadienal, possibly the metabolites of diatoms, and 2,4-heptadienal, possibly the metabolite of Dinobryon sp., might have contributed to the fishy odor episode. This study demonstrated that the fishy odor episode in this reservoir might be caused by the abnormal growth of chrysophytes and diatoms under the ice-cover. | Yunyun Zhao Jianwei Yu Ming Su Wei An Min Yang | 2013 | Journal of Environmental Sciences2013，25，12： | 17 |
| 19 | Soil Bacterial Communities Under Different Long-Term Fertilization Regimes in Three Locations Across the Black Soil Region of Northeast China显示文摘Although soil bacteria play critical roles in agro-ecosystems, the knowledge of their response to long-term fertilization across the black soil region of Northeast China is limited. In this study, we sequenced 16 S rRNA genes to assess the effects of four long-term fertilization regimes—non-fertilization(NoF), chemical fertilizer(CF), manure(M), and chemical fertilizer plus manure(CFM)—on soil properties and bacterial communities in three locations, the northern, middle, and southern parts, across the black soil region. Results showed that the influence of fertilization regimes on soil properties varied significantly among the three locations. Manure fertilization significantly increased microbial biomass carbon and relative abundance of copiotrophic bacteria. Principal component analysis(PCA)showed that the total bacterial communities were separated into three groups according to the sampling location despite long-term fertilization, and that soil pH was the most important factor in shifting bacterial communities. In addition, similar fertilization regimes resulted in different influences on bacterial community composition, and the most influential soil properties varied among the three locations. Our results highlighted that geographical separation was a more dominant factor affecting bacterial communities than fertilization, and that long-term similar fertilization regimes did not induce consistent changes in bacterial community composition in the black soil region. | HU Xiaojing LIU Junjie WEI Dan ZHU Ping CUI Xi'an ZHOU Baoku CHEN Xueli JIN Jian LIU Xiaobing WANG Guanghua | 2018 | Pedosphere2018，28，5： | 17 |
| 20 | Influence of microwave treatment under a hydrogen or methane atmosphere on the flotability of the macerals in Shenfu coals显示文摘The modification of Shenfu coals by a microwave treatment carried out under a hydrogen or a methane atmosphere, and the subsequent maceral separation by flotation, are described in this paper. The surface contact angle and the Zeta potential of the coal macerals were measured both with and without the treat- ment. The results show that the surface wettability of SFF (Shenfu Fusain) and SFV (Shenfu Vitrain) can be changed by the microwave treatment. An increase in the difference in surface wettability of SFF and SFV causes in a subsequent increase in the enrichment of inertinite and vitrinite. The results of the Zeta potential measurements show that the surface potentials of SFF and SFV are also changed by the treatment. | Zhao Wei Yang Fusheng Li Yuangang Qu Jianlin Zhou Anning | 2011 | Mining Science and Technology2011，21，6： | 15 |
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