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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 3 | The prevalence and etiology of elevated aminotransferase levels in the United States显示文摘 | Jeanne M Clark Frederick L Brancati Anna Mae Diehl | 2003 | The American Journal of Gastroenterology2003，，5： | 2 |
| 4 | In vivo single branch axotomy in- duces GAP - 43 - dependent sprouting and synaptic remodeling in cerebellarcortex 显示文摘 | Anna L Allegra M Paolo C | 2013 | PNAS2013，5，10： | 1 |
| 5 | Plasma Fatty Acid-Binding Protein 4 Increases with Renal Dysfunction in Type 2 Diabetic Patients without Microalbuminuria显示文摘 | Cabré Anna Lázaro Iolanda Girona Josefa Manzanares Josep M Marimón Francesc Plana Núria Heras Mercedes Masana Lluís | 2008 | Clinical Chemistry2008，，1： | 1 |
| 6 | A review and a new hypothesis for non-immunological pathogenetic mechanisms in vitiligo显示文摘 | Dell'anna M L Pieardo M | 2006 | Pigment Cell Res2006，19，5： | 1 |
| 7 | Structure and correlations of the flux line lattice in crystalline Nb through the peak effect显示文摘 | Gammel P L Yaron U Ramirez A P Bishop D J Chang A M Ruel R Pfeiffer L N Bucher E D'Anna G Huse D A Mortensen K Eskildsen M R Kes P H | | 0，，： | 1 |
| 8 | Adipone-ctin oligomers as potential indicators of adipose tissue improvement in obese subjects显示文摘 | Anna DR Maria L Monaco M | 2013 | European journal of endocrinology / European Federation of Endocrine Societies2013，169，1： | 1 |
| 9 | Treatment and detoxication of a sanitary landfill leachate 显示文摘 | Silva A C Dezotti M Sant'Anna G L Jr | 2004 | Chemosphere2004，55，2： | 1 |
| 10 | Determi- nation of blood total, reduced and oxidized glutathi- one in pediatric subjects 显示文摘 | Mattia L Anna L R Laura M G | 2001 | Clinical Chemistry2001，47，8： | 1 |
| 11 | Biological Signatures of Asymptomatic Extra- and Intracranial Atherosclerosis: The Barcelona-AsIA (Asymptomatic Intracranial Atherosclerosis) Study显示文摘 | Elena López-Cancio Amparo Galán Laura Dorado Marta Jiménez María Hernández Mónica Millán Silvia Reverté Anna Su?ol Jaume Barallat Anna Massuet Maria Teresa Alzamora Antonio Dávalos Juan Francisco Arenillas | 2012 | Stroke2012，，10： | 1 |
| 12 | A nongradient based algorithm for the determination of surface tension from a pendant drop:Application to low Bond number drop shapes显示文摘 | ALVAREZ N J WALKER L M ANNA S L | | 0，，2： | 1 |
| 13 | Sol-gel combustion synthesis of BNBT powders显示文摘 | Elisa M Carmen G Anna L C | 2008 | Journal of Sol-Gel Science and Technology2008，46，： | 1 |
| 14 | Treatment and detoxification of a sanitary landfill leachate 显示文摘 | Silva A C Dezotti M Sant'Anna G L | 2004 | Chemosphere2004，55，2： | 1 |
| 15 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 16 | Effeet of eider maturation on the chemical and sensory characteristics of fresh eider spirits显示文摘 | Roberto R M Anna P L Juan J M A | 2010 | Food Research International2010，43，： | 1 |
| 17 | Photocatalytic/H2O2 treatment of oil fie1d produced waters显示文摘 | Bessa E Sant'Anna G L Dezotti M | 2001 | Appl Catal B2001，29，2： | 1 |
| 18 | Treatment and detoxication of a sanitary landfill leachate显示文摘 | Silva A C Dezotti M G L Sant'Anna Jr | 2004 | Chemosphere2004，55，2： | 1 |
| 19 | A study on the influence of fucosterol on thermal polymerization of purified high oleic sun-flower triacylglycerols显示文摘 | Anna M L Lena H D | 1999 | J Sci Food Agric1999，79，： | 1 |
| 20 | Caveolae and caveolin isoforms in rat peritoneal macrophages 显示文摘 | Anna L Kiss A T Nandor M | 2002 | Micron2002，33，1： | 1 |
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