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| 1 | MicroRNAs and immunity in periodontal health and disease显示文摘MicroRNAs(miRNAs) are critical regulators of the host immune and inflammatory response against bacterial pathogens. In the present review, we discuss target genes, target gene functions, the potential regulatory role of miRNAs in periodontal tissues, and the potential role of miRNAs as biomarkers and therapeutics. In periodontal disease, miRNAs exert control over all aspects of innate and adaptive immunity, including the functions of neutrophils, macrophages, dendritic cells and T and B cells. Previous human studies have highlighted some key miRNAs that are dysregulated in periodontitis patients. In the present study, we mapped the major miRNAs that were altered in our reproducible periodontitis mouse model relative to control animals. The miRNAs that were upregulated as a result of periodontal disease in both human and mouse studies included miR-15 a, miR-29 b, miR-125 a, miR-146 a,miR-148/148 a and miR-223, whereas miR-92 was downregulated. The association of individual miRNAs with unique aspects of periodontal disease and their stability in gingival crevicular fluid underscores their potential as markers for periodontal disease progression or healthy restitution. Moreover, miRNA therapeutics hold great promise for the future of periodontal therapy because of their ability to modulate the immune response to infection when applied in conjunction with synthetic antagomirs and/or relatively straightforward delivery strategies. | Xianghong Luan Xiaofeng Zhou Afsar Naqvi Marybeth Francis Deborah Foyle Salvador Nares Thomas G.H.Diekwisch | 2018 | International Journal of Oral Science2018，10，3： | 10 |
| 2 | Monovalent cation perm-selective membranes(MCPMs)'New developments and perspectives显示文摘As one of the most typical and promising membrane processes, electrodialysis(ED) technique plays a more and more significant role in industrial separation. Especially, the separation of monovalent cations and multivalent cations is currently a hot topic, which is not only desirable for many industries but also challenging for academic explorations. The main aim of the present contribution is to view the advances of a wide variety of monovalent cation perm-selective membranes(MCPMs) and their preparation technologies including(1) covalent crosslinking,(2) surface modification,(3) polymer blending,(4) electrospinning,(5) nanofiltration alike membrane,and(6) organic–inorganic hybrid. The relevant advantages and disadvantages with respect to some specific cases have been discussed and compared in detail. Furthermore, we elaborately discuss the opportunities and challenges of MCPMs, the fabricating strategies to take and the future perspectives. | Liang Ge Bin Wu Dongbo Yu Abhishek N.Mondal Linxiao Hou Noor U1 Afsar Qiuhua Li Tingting Xu Jibin Miao Tongwen Xu | 2017 | Chinese Journal of Chemical Engineering2017，25，11： | 8 |
| 3 | An overview of inflammation: mechanism and consequences显示文摘Inflammation is an essential response provided by the immune systems that ensures the survival duringinfection and tissue injury. Inflammatory responses are essential for the maintenance of normal tissue homeostasis. Themolecular mechanism of inflammation is quite a complicated process which is initiated by the recognition of specificmolecular patterns associated with either infection or tissue injury. The entire process of the inflammatory response ismediated by several key regulators involved in the selective expression of proinflammatory molecules. Prolongedinflammations are often associated with severe detrimental side effects on health. Alterations in inflammatory responsesdue to persistent inducers or genetic variations are on the rise over the last couple of decades, causing a variety ofinflammatory diseases and pathophysiological conditions. | Afsar U.AHMED | 2011 | Frontiers in Biology2011，6，4： | 6 |
| 4 | Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla显示文摘Uncaria rhynchophylla is commonly recognized as a traditional treatment for dizziness,cerebrovascular diseases,and nervous disorders in China.Previously,the neuro-protective activities of the alkaloids from U.rhynchophylla were intensively reported.In current work,three new indole alkaloids(1–3),identified as geissoschizic acid(1),geissoschizic acid N4-oxide(2),and 3b-sitsirikine N4-oxide(3),as well as 26 known analogues were isolated from U.rhynchophylla.However,in the neural stem cells(NSCs)proliferation assay for all isolated compounds,geissoschizic acid(1),geissoschizic acid N4-oxide(2),isocorynoxeine(6),isorhynchophylline(7),(4S)-akuammigine N-oxide(8),and(4S)-rhynchophylline N-oxide(10)showed unexpected inhibitory activities at 10 μM.Unlike previous neuro-protective reports,as a warning or caution,our finding showcased a clue for possible NSCs toxicity and the neural lesions risk of U.rhynchophylla,while the structure–activity relationships of the isolated compounds were discussed also. | Xin Wei Li-Ping Jiang Ying Guo Afsar Khan Ya-Ping Liu Hao-Fei Yu Bei Wang Cai-Feng Ding Pei-Feng Zhu Ying-Ying Chen Yun-Li Zhao Yong-Bing Chen Yi-Fen Wang Xiao-Dong Luo | 2017 | Natural Products and Bioprospecting2017，7，5： | 4 |
| 5 | 新型磺酸功能化吡啶盐酸盐离子液体催化剂用于六氢喹啉合成(英文)显示文摘Sulfonic acid functionalized pyridinium chloride [pyridine-SO3 H]Cl has been synthesized as a novel Brnsted acidic ionic liquid and characterized on the basis of its FT-IR,1H and 13C NMR,MS,ther-mogravimetry,and derivative thermogravimetry data.The material has also been used as a highly efficient,homogeneous,and reusable catalyst for the preparation of hexahydroquinolines according to the one-pot multi-component condensation of arylaldehydes,dimedone(5,5-dimethylcyclohexane-1,3-dione),β-ketoesters,and ammonium acetate under solvent-free conditions. | Ardeshir Khazaei Mohammad Ali Zolfigol Ahmad Reza Moosavi-Zare Javad Afsar Abdolkarim Zare Vahid Khakyzadeh Mohammad Hassan Beyzavi | 2013 | 催化学报2013，34，10： | 4 |
| 6 | Sustained virological response based on rapid virological response in genotype-3 chronic hepatitis C treated with standard interferon in the Pakistani population显示文摘AIM:To document the sustained virological response (SVR) in rapid virological responders (RVR) of genotype-3 chronic hepatitis C with standard interferon (SdIF). METHODS:Hepatitis C genotype-3 patients during the period July 2006 and June 2007 were included. Complete blood counts, prothrombin time, ALT, albumin, qualitative HCV RNA were done. SdIF and ribavirin were given for 4 wk and qualitative HCV RNA was repeated. Those testing negative were allocated to group-A while the rest were allocated to group-B. Treatment was continued a total of 16 and 24 wk for group A and B respectively. HCV RNA was repeated after 24 wk of treatment. End virological and sustained virological responses were compared by χ2 test. ROC of pretreatment age, ALT and albumin were plotted for failure to achieve SVR. RESULTS:Of 74 patients treated, RCV RNA after 16 wk of therapy became undetectable in 34 (45.9%) and was detectable in 40 (54.1%) and were allocated to groups A and B respectively. SVR was achieved in 58.8% and 27.8% in groups A and B respectively. SVR rates were significantly higher in patients who had RVR as compared to those who did not (P = 0.0;γ = 2). Both groups combined ETR and SVR were 70% and 33% respectively. ROC plots of pretreatment age, ALT and albumin for SVR showed only ALT to have a significantly large area under the curve.CONCLUSION:SVR rates were higher in patients who had RVR with SdIF and high pre treatment ALT values correlated to probability of having RVR. | Bader Faiyaz Zuberi Faisal Faiyaz Zuberi Sajjad Ali Memon Muhammad Hafeez Qureshi Sheikh Zafar Ali Salahuddin Afsar | 2008 | World Journal of Gastroenterology2008，14，14： | 3 |
| 7 | A High Dielectric N-Type Small Molecular Acceptor Containing Oligoethyleneglycol Side-Chains for Organic Solar Cellst显示文摘 | Bomee Jang Changyeon Lee Young Woong Lee Donguk Kim Mohammad Afsar Uddin Felix Sunjoo Kim Bumjoon J. Kim Han Young Woo | 2018 | Chinese Journal of Chemistry2018，36，3： | 3 |
| 8 | Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways显示文摘 | Claudio Alarcón Alexia-Ileana Zaromytidou Qiaoran Xi Sheng Gao Jianzhong Yu Sho Fujisawa Afsar Barlas Alexandria N. Miller Katia Manova-Todorova Maria J. Macias Gopal Sapkota Duojia Pan Joan Massagué | 2009 | Cell2009，，4： | 2 |
| 9 | 血压晨峰、血尿酸与高血压患者心血管预后间关系显示文摘高血压为高发慢性病之一,将增加心血管疾病的不良预后,尤以血压晨峰(MBPS)危害更大,亦为其重要危险因素之一。然而既往关于MBPS与血尿酸(SUA)间关系,以及两者与心血管疾病不利预后间关系均不清楚,现就此进行分析。受测对象为921例高血压患者,女性45.6%,男性54.4%,且160例(17.4%)伴有糖尿病,204例(22.2%)吸烟,372例(40.4%)服用降压药,8例(8.7%)伴冠心病史,14例(1.5%)伴外周动脉病,10例(1.09%)伴主动脉瘤。 | Turak O Afsar B Ozcan F 袁志敏 | 2015 | 心血管病学进展2015，36，4： | 2 |
| 10 | The Behavior of Rectangular and Circular Reinforced Concrete Columns Under Biaxial Multiple Excitation显示文摘The aim of this study is to investigate the dynamic performance of rectangular and circular reinforced concrete(RC)columns considering biaxial multiple excitations.For this purpose,an advanced nonlinear finite element model which can simulate various features of cyclic degradation in material and structural components is used.The implemented nonlinear fiber beam-column model accounts for inelastic buckling and low-cycle fatigue degradation of longitudinal reinforcement and can simulate multiple failure modes of RC columns under dynamic loading.Hypothetical rectangular and circular columns are used to investigate the failure modes of RC columns.A detailed ground motion selection is implemented to generate real mainshock and aftershocks.It was found that multiple excitations due to aftershock has the potential of increasing the damage of the RC columns and longitudinal reinforcements are significantly affected low-cycle fatigue.Also,it was found that rectangular column is more sensitive to accumulative damage due to cyclic fatigue.This study increases the accuracy of structural analysis of RC columns and consequently improves understanding the failure modes of RC columns with different cross-sectional shapes. | Mohammad Reza Salami Ebrahim Afsar Dizaj Mohammad Mehdi Kashani | 2019 | Computer Modeling in Engineering & Sciences2019，，9： | 2 |
| 11 | Change in ploidy can modify epigenetic silencing显示文摘 | Scheid O M Jakovleva L Afsar K Maluszynska J Paszkowski J A | 1996 | Proc Natl Acad Sci USA1996，93，71： | 2 |
| 12 | Sedative and antinociceptive activities of two new sesquiterpenes isolated from Ricinus communis显示文摘Two new sesquiterpenes, trivially named ricinusoids A(1) and ricinusoids B(2), were isolated from ethyl acetate fraction of Ricinus communis. The structures of new compounds were elucidated by detailed spectroscopic techniques, including 1 D-and 2 D-NMR, UV, IR spectroscopy, and mass spectrometry. The compounds(1-2) were also assessed for in-vivo sedative and analgesic like effects in open field and acetic acid induced writhing tests respectively at 5, 10, and 20 mg·kg^(–1) i.p. Pretreatment of both test compounds caused significant(P ≤ 0.05) reduction in locomotive activity like sedative agents and abdominal constrictions like analgesics. Both compounds(1-2) possessed marked sedative and antinociceptive effects in animal models. | Umar Farooq Ajmal Khan Sadia Naz Abdur Rauf Haroon Khan Afsar Khan Irfan Ullah Syed Majid Bukhari | 2018 | Chinese Journal of Natural Medicines2018，16，3： | 2 |
| 13 | Multistage-batch bipolar membrane electrodialysis for base production from high-salinity wastewater显示文摘Bipolar membrane electrodialysis(BMED)is considered a state-of-the-art technology for the conversion of salts into acids and bases.However,the low concentration of base generated from a traditional BMED process may limit the viability of this technology for a large-scale application.Herein,we report an especially designed multistage-batch(two/three-stage-batch)BMED process to increase the base concentration by adjusting different volume ratios in the acid(Vacid),base(Vbase),and salt compartments(Vsalt).The findings indicated that performance of the two-stage-batch with a volume ratio of Vacid:Vbase:Vsalt=1:1:5 was superior in comparison to the threestage-batch with a volume ratio of Vacid:Vbase:Vsalt=1:1:2.Besides,the base concentration could be further increased by exchanging the acid produced in the acid compartment with fresh water in the second stage-batch process.With the two-stage-batch BMED,the maximum concentration of the base can be obtained up to 3.40 mol∙L^(-1),which was higher than the most reported base production by BMED.The low energy consumption and high current efficiency further authenticate that the designed process is reliable,cost-effective,and more productive to convert saline water into valuable industrial commodities. | Arif Hussain Haiyang Yan Noor Ul Afsar Chenxiao Jiang Yaoming Wang Tongwen Xu | 2022 | Frontiers of Chemical Science and Engineering2022，16，5： | 2 |
| 14 | Comparison of UHMWPE particles in synovial fluid and tissues from failed THA显示文摘 | Mabrey J D Afsar Keshmiri A McClung G A | 2001 | J Biomed Mater Res2001，58，2： | 1 |
| 15 | Comparison of mean platelet volume in patients with diabetes mellitus,impaired fasting glucose and non-diabetic subjects显示文摘 | Zuberi BF Akhtar N Afsar S | 2008 | Singapore Med J2008，49，2： | 1 |
| 16 | Urinary albumin excretion among nondipper hypertensive patients is closely related with the pattern of nondipping显示文摘 | AFSAR B ELSURER R | 2010 | J Am Soc Hypertens2010，4，4： | 1 |
| 17 | Genotype frequen- cies of selected drug metabolizing enzymes and ABC drug transporters among breast cancer patients on FAC chemother- apy显示文摘 | Afsar NA Haenisch S Mateen A | 2010 | Basic Clin Pharmacol Toxicol2010，107，： | 1 |
| 18 | 显示文摘 | Wang Y Afsar M N | 2004 | Microwave Opt Technol Lett2004，42，： | 1 |
| 19 | The effect of piracetam on atax- ia: clinical observations in a group of autosomal dominant cerebellar ataxia patients显示文摘 | Ince Gunal D Agan K Afsar N | 2008 | J Clin Pharm Ther2008，33，： | 1 |
| 20 | Malnutrition-inflammation score in peritoneal dialysis: growing reliability 显示文摘 | Afsar B Sezer S Elsurer R | 2008 | Petit Dial Int2008，28，2： | 1 |
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