|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Single-cell transcriptomic atlas of primate cardiopulmonary aging显示文摘Aging is a major risk factor for many diseases,especially in highly prevalent cardiopulmonary comorbidities and infectious diseases including Coronavirus Disease 2019(COVID-19).Resolving cellular and molecular mechanisms associated with aging in higher mammals is therefore urgently needed.Here,we created young and old non-human primate single-nucleus/cell transcriptomic atlases of lung,heart and artery,the top tissues targeted by SARS-CoV-2.Analysis of cell type-specific aging-associated transcriptional changes revealed increased systemic inflammation and compromised virus defense as a hallmark of cardiopulmonary aging.With age,expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2(ACE2)was increased in the pulmonary alveolar epithelial barrier,cardiomyocytes,and vascular endothelial cells.We found that interleukin 7(IL7)accumulated in aged cardiopulmonary tissues and induced ACE2 expression in human vascular endothelial cells in an NF-κB-dependent manner.Furthermore,treatment with vitamin C blocked IL7-induced ACE2 expression.Altogether,our findings depict the first transcriptomic atlas of the aged primate cardiopulmonary system and provide vital insights into age-linked susceptibility to SARS-CoV-2,suggesting that geroprotective strategies may reduce COVID-19 severity in the elderly. | Shuai Ma Shuhui Sun Jiaming Li Yanling Fan Jing Qu Liang Sun Si Wang Yiyuan Zhang Shanshan Yang Zunpeng Liu Zeming Wu Sheng Zhang Qiaoran Wang Aihua Zheng Shuguang Duo Yang Yu Juan Carlos Izpisua Belmonte Piu Chan Qi Zhou Moshi Song Weiqi Zhang Guang-Hui Liu | 2021 | Cell Research2021，31，4： | 10 |
| 2 | Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration显示文摘Accumulating evidence indicates an association between the circadian clock and the aging process.However,it remains elusive whether the deregulation of circadian clock proteins underlies stem cell aging and whether they are targetable for the alleviation of aging-associated syndromes.Here,we identified a transcription factor-independent role of CLOCK,a core component of the molecular circadian clock machinery,in counteracting human mesenchymal stem cell(hMSC)decay.CLOCK expression was decreased during hMSC aging.In addition,CLOCK deficiency accelerated hMSC senescence,whereas the overexpression of CLOCK,even as a transcriptionally inactive form,rejuvenated physiologically and pathologically aged hMSCs.Mechanistic studies revealed that CLOCK formed complexes with nuclear lamina proteins and KAP1,thus maintaining heterochromatin architecture and stabilizing repetitive genomic sequences.Finally,gene therapy with lentiviral vectors encoding CLOCK promoted cartilage regeneration and attenuated age-related articular degeneration in mice.These findings demonstrate a noncanonical role of CLOCK in stabilizing heterochromatin,promoting tissue regeneration,and mitigating aging-associated chronic diseases. | Chuqian Liang Zunpeng Liu Moshi Song Wei Li Zeming Wu Zehua Wang Qiaoran Wang Si Wang Kaowen Yan Liang Sun Tomoaki Hishida Yanning Cai Juan Carlos lzpisua Belmonte Pedro Guillen Piu Chan Qi Zhou Weiqi Zhang Jing Qu Guang-Hui Liu | 2021 | Cell Research2021，31，2： | 8 |
| 3 | Crosstalk between TGF-β signaling and epigenome显示文摘在胚胎的开发,织物动态平衡,成年免疫,和创伤的主要角色修理的 ligands 戏的转变生长因素贝它(TGF-) 家庭。表明小径的 TGF- 的 Dysregulation 导致严重疾病。它的关键部件在过去的二十年被揭示了。由激活受体的 cytokines 幕的这个家庭激活的 SMAD (R-SMAD ) 抄写因素,它接着调制目标基因的特定的集合的表示。一个多细胞的有机体的细胞有一样的基因信息,然而,他们由于他们的基因的微分表示显示出结构、功能的差别。研究表明了那条 epigenetic 规定,发信号的 TGF- 的不可分的部分,使房间能察觉到并且对以一种房间上下文依赖者方式发信号的 TGF- 作出回应。作为 TGF- 发信号的中央抄写因素, R-SMAD 能招募塑造 transcriptome 的各种各样的 epigenetic 管理者。在这评论,我们在在哺乳动物的开发和疾病期间发信号的 TGF- 在 epigenetic 上集中规章的机制并且在这条 epigenetic 规定讨论在 R-SMAD 和各种各样的 epigenetic 管理者之间的相互作用的中央角色。在 TGF- 发信号和 epigenome 之间的串音能在疾病的胚胎的开发和前进期间为 transcriptional 规定用作万用的调整机制,特别地癌症。 | Jianbo Bai Qiaoran Xi | 2018 | Acta Biochimica et Biophysica Sinica2018，50，1： | 7 |
| 4 | Role of TRIM33 in Wnt signaling during mesendoderm differentiation显示文摘Tripartite motif 33(TRIM33), a member of the transcription intermediate factor 1(TIF1) family of transcription cofactors,mediates transforming growth factor-beta(TGF-β) signaling through its PHD-Bromo cassette in mesendoderm differentiation during early mouse embryonic development. However, the role of the TRIM33 RING domain in embryonic differentiation is less clear. Here, we report that TRIM33 mediates Wnt signaling by directly regulating the expression of a specific subset of Wnt target genes, and this action is independent of its RING domain. We show that TRIM33 interacts with β-catenin, a central player in Wnt signaling in mouse embryonic stem cells(mESCs). In contrast to previous reports in cancer cell lines, the RING domain does not appear to function as the E3 ligase for β-catenin, since neither knockout nor overexpression of TRIM33 had an effect on β-catenin protein levels in mESCs. Furthermore, we show that although TRIM33 seems to be dispensable for Wnt signaling through a reporter assay, loss of TRIM33 significantly impairs the expression of a subset of Wnt target genes, including Mixl1,in a Wnt signaling-dependent manner. Together, our results indicate that TRIM33 regulates Wnt signaling independent of the E3 ligase activity of its RING domain for β-catenin in mESCs. | Xiaojie Xia Feifei Zuo Maoguo Luo Ye Sun Jianbo Bai Qiaoran Xi | 2017 | Science China(Life Sciences)2017，60，10： | 4 |
| 5 | Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis显示文摘Dear Editor,The axolotl,Ambystoma mexicanum,has extraordinary capability to fully recover multiple tissues after lost,whereas such capability has disappeared in mammals.Thus,deci-phering detailed mechanisms underlying axolotl regenera-tion could provide valuable lessons for regenerative medicine.However,many questions,such as the origin of essential progenitor cells and key responses of individual types of cells for regeneration remain elusive(Haas and Whited,2017).Newly developed single-cell RNA sequenc-ing(scRNA-seq)method enables researchers to observe cellular and molecular dynamics in axolotl regeneration at the single-cell resolution(Gerber et al.,2018;Leigh et al.,2018),but the reported transcriptome landscapes are only for certain cell types or in certain regenerative stages.A complete overview of the regeneration process for all cell types is still lacking. | Hanbo Li Xiaoyu Wei Li Zhou Weiqi Zhang Chen Wang Yang Guo Denghui Li Jjianyang Chen Tianbin Liu Yingying Zhang Shuai Ma Congyan Wang Fujian Tan Jiangshan Xu Yang Liu Yue Yuan Liang Chen Qiaoran Wang Jing Qu Yue Shen Shanshan Liu Guangyi Fan Longqi Liu Xin Liu Yong Hou Guang-Hui Liu Ying Gu Xun Xu | 2021 | Protein & Cell2021，12，1： | 3 |
| 6 | Diffuse Intrinsic Pontine Gliomas Exhibit Cell Biological and Molecular Signatures of Fetal Hindbrain-Derived Neural Progenitor Cells显示文摘Diffuse intrinsic pontine glioma(DIPG) is the main cause of brain tumor-related death among children.Until now, there is still a lack of effective therapy with prolonged overall survival for this disease. A typical strategy for preclinical cancer research is to find out the molecular differences between tumor tissue and para-tumor normal tissue, in order to identify potential therapeutic targets. Unfortunately, it is impossible to obtain normal tissue for DIPG because of the vital functions of the pons.Here we report the human fetal hindbrain-derived neural progenitor cells(pontine progenitor cells, PPCs) as normal control cells for DIPG. The PPCs not only harbored similar cell biological and molecular signatures as DIPG glioma stem cells, but also had the potential to be immortalized by the DIPG-specific mutation H3 K27 M in vitro. These findings provide researchers with a candidate normal control and a potential medicine carrier for preclinical research on DIPG. | Yu Sun Cheng Xu Changcun Pan Xin Chen Yibo Geng Yuliang Wu Peng Zhang Wenhao Wu Yu Wang Deling Li Zhen Wu Junting Zhang Qiaoran Xi Liwei Zhang | 2019 | Neuroscience Bulletin2019，35，2： | 2 |
| 7 | Recent progress and strategies toward high performance zinc-organic batteries显示文摘Energy sustainable development has stimulated the pursuit of an eco-friendly energy storage system.Carbon peak and neutrality targets oriented energy storage development will guide the way of further studies on batteries system.However,conventional batteries system(lead-acid batteries,lithium-ion batteries)based on ungreen transition metal oxide,flammable electrolytes or hazardous metals cannot keep pace with the development of society sooner or later.Thus,vast explorations on the advanced rechargeable battery systems were conducted.Compared with other battery systems,zinc ion battery systems with inherent safety,low cost were widely investigated.Especially,the zinc organic batteries based on the eco-efficiency organic cathodes were promising alternative advanced batteries for future energy storage systems.Therefore,various organics and different electrochemistry mechanisms were explored in the zinc batteries system.Herein,a timely review on elaborate analysis about functional groups,fundamentals,progress accompanied by the discussion on the four core issues:voltage,capacity,rate performance,cycle life was presented.Specifically,aiming at these issues,three levels of solution strategies:materials design concepts,morphology structure optimization and electrolyte environment were summarized and proposed for the development and innovation of zinc organic batteries. | Shibing Zheng Qiaoran Wang Yunpeng Hou Lin Li Zhanliang Tao | 2021 | Journal of Energy Chemistry2021，30，12： | 2 |
| 8 | A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China显示文摘 | Zongxi Han Chuyang Sun Baolong Yan Xiaonan Zhang Yu Wang Chengren Li Qingxia Zhang Yazhen Ma Yuhao Shao Qiaoran Liu Xiangang Kong Shengwang Liu | 2010 | Infection Genetics and Evolution2010，，1： | 2 |
| 9 | Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways显示文摘 | Claudio Alarcón Alexia-Ileana Zaromytidou Qiaoran Xi Sheng Gao Jianzhong Yu Sho Fujisawa Afsar Barlas Alexandria N. Miller Katia Manova-Todorova Maria J. Macias Gopal Sapkota Duojia Pan Joan Massagué | 2009 | Cell2009，，4： | 2 |
| 10 | A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China显示文摘 | Zongxi Han Chuyang Sun Baolong Yan Xiaonan Zhang Yu Wang Chengren Li Qingxia Zhang Yazhen Ma Yuhao Shao Qiaoran Liu Xiangang Kong Shengwang Liu | 2010 | Infection Genetics and Evolution2010，，1： | 2 |
| 11 | Nitrogen-doped Carbon Nanospheres-Modified Graphitic Carbon Nitride with Outstanding Photocatalytic Activity显示文摘Metals and metal oxides are widely used as photo/electro-catalysts for environmental remediation.However,there are many issues related to these metal-based catalysts for practical applications,such as high cost and detrimental environmental impact due to metal leaching.Carbon-based catalysts have the potential to overcome these limitations.In this study,monodisperse nitrogen-doped carbon nanospheres(NCs)were synthesized and loaded onto graphitic carbon nitride(g-C3N4,GCN)via a facile hydrothermal method for photocatalytic removal of sulfachloropyridazine(SCP).The prepared metal-free GCN-NC exhibited remarkably enhanced efficiency in SCP degradation.The nitrogen content in NC critically influences the physicochemical properties and performances of the resultant hybrids.The optimum nitrogen doping concentration was identified at 6.0 wt%.The SCP removal rates can be improved by a factor of 4.7 and 3.2,under UV and visible lights,by the GCN-NC composite due to the enhanced charge mobility and visible light harvesting.The mechanism of the improved photocatalytic performance and band structure alternation were further investigated by density functional theory(DFT)calculations.The DFT results confirm the high capability of the GCN-NC hybrids to activate the electron–hole pairs by reducing the band gap energy and efficiently separating electron/hole pairs.Superoxide and hydroxyl radicals are subsequently produced,leading to the efficient SCP removal. | Qiaoran Liu Hao Tian Zhenghua Dai Hongqi Sun Jian Liu Zhimin Ao Shaobin Wang Chen Han Shaomin Liu | 2020 | Nano-Micro Letters2020，12，2： | 2 |
| 12 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 13 | Mechanism of actions of Oncocin, a proline- rich antimicrobial peptide, in early elongation revealed by single-molecule FRET显示文摘 | Sijia Peng Mengyi Yang Rui Ning Sun Yang Liu Wenjuan Wang Qiaoran Xi Haipeng Gong Chunlai Chen | 2018 | Protein & Cell2018，9，10： | 1 |
| 14 | TGF-β control of stem cell differentiation genes显示文摘 | Joan Massagué Qiaoran Xi | 2012 | FEBS Letters2012，，14： | 1 |
| 15 | Sustainability Intelligent Evaluation of Regional Microgrid Interconnection System Based on Combination Entropy Weight Rank Order-TOPSIS and NILA-KELM显示文摘Sustainability evaluation of regional microgrid interconnection system is conducive to a profound and comprehensive understanding of the impact of interconnection system projects.In order to realize the comprehensive and scientific intelligent evaluation of the system,this paper proposes an evaluation model based on combination entropy weight rank order-technique for order preference by similarity to an ideal solution(TOPSIS)and Niche Immune Lion Algorithm-Extreme Learning Machine with Kernel(NILAKELM).Firstly,the sustainability evaluation indicator system of the regional microgrid interconnection system is constructed fromfour aspects of economic,environmental,social,and technical characteristics,and the evaluation indicators are explained.Then,the classical evaluationmodel based on TOPSIS is constructed,and the entropy weight method and rank order method(RO)are coupled to obtain the indicator weight.The niche immune algorithm is used to improve the lion algorithm,and the improved lion algorithm is used to optimize the parameters of KELM,and the intelligent evaluation model based on NILA-KELM is obtained to realize fast real-time calculation.Finally,the scientificity and accuracy of themodel proposed in this paper are verified.The model proposed in this paper has the lowest RMSE,MAE and RE values,indicating that its intelligent evaluation results are the most accurate.This study is conducive to the horizontal comparison of the overall performance of regional microgrid interconnection system projects,helps investors to choose the most promising project scheme,and helps the government to find feasible project. | Haichao Wang Yingying Fan Weigao Meng Qiaoran Yang | 2022 | Energy Engineering2022，119，3： | 0 |
| 16 | Alloxazine as anode material for high-performance aqueous ammonium-ion battery显示文摘Aqueous ammonium-ion battery(AAIB)has attracted much attention due to its low cost,safety,and environmental friendliness,but its electrode materials have many limitations.Here,alloxazine(ALO)is introduced as the anode for the AAIB.With its pseudocapacitive effect and fast diffusion kinetics of NH4+,ALO anode shows excellent rate performance with a specific capacity of 120 mAh/g at 40 C(10 A/g).The full battery is further fabricated by ALO anode and Prussian white analogs cathode.Its specific capacity can reach 110 mAh/g and it can work up to 10,000 cycles with no obvious capacity fading at 20 C(5 A/g).In addition,the system delivers a high energy density of 122.5 Wh/kg and a power density of 5,055 W/kg.This work broadens the application prospect of the AAIB. | Yuan Ma Tianjiang Sun Qingshun Nian Shibing Zheng Tao Ma Qiaoran Wang Haihui Du Zhanliang Tao | 2022 | Nano Research2022，15，3： | 0 |
| 17 | Technology inflow following high-speed railway:Evidence from Chinese cities显示文摘Urban development thrives from technology inflows,which refers to the transfer of highvalue technology from various cities to local recipients.The asymmetry of technical information-rooted in the tacit knowledge inherent in technology-mandates that technology transfer is heavily dependent on interactions and communication among talented individuals.This study examines the effect of China's high-speed railway(HSR)on technology inflow,with an emphasis on talent interaction in the technology transfer process.The findings suggest that HSR mitigates cross-city commuting costs and facilitates face-to-face interactions between talent,thereby fostering an increase in technology inflows to various cities.'Talent'use HSR to transfer knowledge to cities teeming with such talent resources.Concurrently,areas with robust intellectual property rights protection witness an upsurge in intercity technology transfer via HsR.This study elucidates the macro-mechanism of urban technology flow from the perspective of public transportation offering valuable insights for technology market infrastructure and services. | Dayong Liu Jie Liu Qihang Li Nixuan Guo Tong Chen Qiaoran Menag | 2023 | Journal of Management Science and Engineering2023，8，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员