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| 1 | Hybridizing grey wolf optimization with differential evolution for global optimization and test scheduling for 3D stacked SoC显示文摘A new meta-heuristic method is proposed to enhance current meta-heuristic methods for global optimization and test scheduling for three-dimensional(3D) stacked system-on-chip(SoC) by hybridizing grey wolf optimization with differential evolution(HGWO). Because basic grey wolf optimization(GWO) is easy to fall into stagnation when it carries out the operation of attacking prey, and differential evolution(DE) is integrated into GWO to update the previous best position of grey wolf Alpha, Beta and Delta, in order to force GWO to jump out of the stagnation with DE's strong searching ability. The proposed algorithm can accelerate the convergence speed of GWO and improve its performance.Twenty-three well-known benchmark functions and an NP hard problem of test scheduling for 3D SoC are employed to verify the performance of the proposed algorithm. Experimental results show the superior performance of the proposed algorithm for exploiting the optimum and it has advantages in terms of exploration. | Aijun Zhu Chuanpei Xu Zhi Li Jun Wu Zhenbing Liu | 2015 | Journal of Systems Engineering and Electronics2015，26，2： | 83 |
| 2 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 3 | Aerosol and boundary-layer interactions and impact on air quality显示文摘Air quality is concerned with pollutants in both the gas phase and solid or liquid phases. The latter are referred to as aerosols, which are multifaceted agents affecting air quality, weather and climate through many mechanisms. Unlike gas pollutants, aerosols interact strongly with meteorological variables with the strongest interactions taking place in the planetary boundary layer(PBL). The PBL hosting the bulk of aerosols in the lower atmosphere is affected by aerosol radiative effects. Both aerosol scattering and absorption reduce the amount of solar radiation reaching the ground and thus reduce the sensible heat fluxes that drive the diurnal evolution of the PBL. Moreover, aerosols can increase atmospheric stability by inducing a temperature inversion as a result of both scattering and absorption of solar radiation, which suppresses dispersion of pollutants and leads to further increases in aerosol concentration in the lower PBL.Such positive feedback is especially strong during severe pollution events. Knowledge of the PBL is thus crucial for understanding the interactions between air pollution and meteorology. A key question is how the diurnal evolution of the PBL interacts with aerosols, especially in vertical directions, and affects air quality.We review the major advances in aerosol measurements, PBL processes and their interactions with each other through complex feedback mechanisms, and highlight the priorities for future studies. | Zhanqing Li Jianping Guo Aijun Ding Hong Liao Jianjun Liu Yele Sun Tijian Wang Huiwen Xue Hongsheng Zhang Bin Zhu | 2017 | National Science Review2017，4，6： | 37 |
| 4 | Roles of Chemokine Receptor 4 (CXCR4) and Chemokine Ligand 12 (CXCL12) in Metastasis of Hepatocellular Carcinoma Cells显示文摘Chemokines are involved in human hepatocellular carcinoma (HCC) carcinogenesis. However, the exact mechanism of chemokines in HCC carcinogenesis remains unknown. Here we investigated the roles of chemokine receptor 4 (CXCR4) and chemokine ligand 12 (CXCL12) in the metastasis of HCC. We found that the expression levels of CXCR4 mRNA in HCC tissues, MHCC97 cells, and HUVEC cells were 2.52 ± 1.13, 2.34 ± 1.16 and 1.63 ± 1.26, respectively and that the CXCR4 protein levels were 1.38 ± 0.13, 1.96 ± 0.32 and 1.86 ± 0.21, respectively. In contrast, CXCR4 was not detected in normal hepatic tissues. In 78 HCC patients, we also found that the concentration of CXCL12 in cancerous ascitic fluid was 783-8,364 pg/ml and that CXCL12 mRNA level in HCC metastasis portal lymph nodes was 1.21 ± 0.87 but undetectable in normal hepatic tissues. Finally we discovered that recombinant human CXCL12 could induce MHCC97 cells and HUVEC cells to migrate with chemotactic indexes (CI) of 3.9 ± 1.1 and 4.1 ± 1.6, respectively. Cancerous ascitic fluid could also induce the migration of MHCC97 cells with a CI of 1.9 ± 0.8. Thus, our data suggest that CXCR4 and CXCL12 may play an important role in the metastasis of HCC by promoting the migration of tumor cells. | Hui Liu Zeya Pan Aijun Li Siyuan Fu Yin Lei Hangyong Sun Mengchao Wu Weiping Zhou | 2008 | Cellular & Molecular Immunology2008，5，5： | 30 |
| 5 | Effect of Ce doping of TiO_2 support on NH_3-SCR activity over V_2O_5–WO_3/CeO_2–TiO_2 catalyst显示文摘CeO2–TiO2composite supports with different Ce/Ti molar ratios were prepared by a homogeneous precipitation method, and V2O5–WO3/CeO2–TiO2catalysts for the selective catalytic reduction(SCR) of NOx with NH3 were prepared by an incipient-wetness impregnation method. These catalysts were characterized by means of BET, XRD, UV–Vis,Raman and XPS techniques. The results showed that the catalytic activity of V2O5–WO3/TiO2 was greatly enhanced by Ce doping(molar ratio of Ce/Ti = 1/10) in the TiO2 support.The catalysts that were predominantly anatase TiO2 showed better catalytic performance than the catalysts that were predominantly fluorite CeO2. The Ce additive could enhance the surface adsorbed oxygen and accelerate the SCR reaction. The effects of O2 concentration, ratio of NH3/NO, space velocity and SO2 on the catalytic activity were also investigated. The presence of oxygen played an important role in NO reduction. The optimal ratio of NH3/NO was 1/1 and the catalyst had good resistance to SO2 poisoning. | Kai Cheng Jian Liu Tao Zhang Jianmei Li Zhen Zhao Yuechang Wei Guiyuan Jiang Aijun Duan | 2014 | Journal of Environmental Sciences2014，26，10： | 18 |
| 6 | NH_3-SCR denitration catalyst performance over vanadium–titanium with the addition of Ce and Sb显示文摘Selective catalytic reduction technology using NH3 as a reducing agent(NH3-SCR) is an effective control method to remove nitrogen oxides. TiO2-supported vanadium oxide catalysts with different levels of Ce and Sb modification were prepared by an impregnation method and were characterized by X-ray diffractometer(XRD), Brunauer–Emmett–Teller(BET), Transmission electron microscopy(TEM), Fourier transform infrared spectroscopy(FT-IR), UV–Vis diffuse reflectance spectroscopy(UV–Vis DRS), Raman and Hydrogen temperature-programmed reduction(H2-TPR). The catalytic activities of V5 CexS by/TiO2 catalysts for denitration were investigated in a fixed bed flow microreactor. The results showed that cerium, vanadium and antimony oxide as the active components were well dispersed on TiO2, and the catalysts exhibited a large number of d–d electronic transitions, which were helpful to strengthen SCR reactivity. The V5 CexS by/TiO2 catalysts exhibited a good low temperature NH3-SCR catalytic activity. In the temperature range of 210 to 400℃, the V5 CexS by/TiO2 catalysts gave NO conversion rates above 90%. For the best V5Ce35Sb2/TiO2 catalyst, at a reaction temperature of 210℃, the NO conversion rate had already reached 90%. The catalysts had different catalytic activity with different Ce loadings. With the increase of Ce loading, the NO conversion rate also increased. | Chi Xu Jian Liu Zhen Zhao Fei Yu Kai Cheng Yuechang Wei Aijun Duan Guiyuan Jiang | 2015 | Journal of Environmental Sciences2015，27，5： | 17 |
| 7 | Precision orchard sprayer based on automatically infrared target detecting and electrostatic spraying techniques显示文摘There is an urgent need for new chemical application techniques and sprayers in Chinese orchard spraying.A new tractor-mounted automatic target detecting electrostatics,and air-assisted orchard sprayer was designed and developed to meet the demand of chemical pest control in orchards.This sprayer light weighted,highly efficient,reduces pesticide use and is friendly to the environment.The techniques of automatic target detecting,electrostatics,and air-assisted spraying were combined in this system.The electrostatically charged droplets are projected toward the target by the assistance of an air stream that increases the droplets penetration within canopy.Experimental results show that the new automatic target detecting orchard sprayer with an infrared sensor can save more than 50%to 75%of pesticides,improve the utilization rate(over 55%),control efficiency,and significantly reduce environmental pollution caused by the pesticide application.At the same time the key technological problems related to air-assisted low volume and electrostatic spraying were solved. | He Xiongkui Zeng Aijun Liu Yajia Song Jianli | 2011 | International Journal of Agricultural and Biological Engineering2011，4，1： | 17 |
| 8 | MiR-30a Positively Regulates the Inflammatory Response of Microglia in Experimental Autoimmune Encephalomyelitis显示文摘Multiple sclerosis(MS) is a classical inflammatory demyelinating disease of the central nervous system(CNS). Microglia are the main resident immune cells in the CNS and are closely associated with the pathogenesis of MS.In the present study, we found that mi R-30 a was highly expressed in jellyfish-like microglia in chronic active lesions of MS patients, as well as in the microglia of mice with experimental autoimmune encephalomyelitis(EAE) at the chronic phase. In vitro, the conditioned supernatant of mouse microglia overexpressing miR-30 a promoted the apoptosis of oligodendrocyte precursor cells(OPCs), and inhibited OPC differentiation. In vivo, overexpressing miR-30 a in transplanted microglia exacerbated the progression of EAE.Overexpression and knock-down experiments in primary cultured mouse microglia showed that mi R-30 a increased the expression of IL-1 b and i NOS, which are pro-inflammatory, while inhibiting the expression of Ym-1 and CD206.Mechanistically, mi R-30 a inhibited the expression of Ppargc1 b, which is the co-activator of peroxisome proliferator-activated receptor gamma, resulting in pro-inflammatory effects. Our work shows that mi R-30 a is an important regulator of the inflammatory response in microglia, and may be a promising therapeutic target for inflammatory diseases like MS in the CNS. | Xue Fang Dingya Sun Zhihong Wang Zhongwang Yu Weili Liu Yingyan Pu Dan Wang Aijun Huang Mingdong Liu Zhenghua Xiang Cheng He Li Cao | 2017 | Neuroscience Bulletin2017，33，6： | 16 |
| 9 | A novel four-way combining catalysts for simultaneous removal of exhaust pollutants from diesel engine显示文摘A novel four-way combining catalysts containing double layers was applied to simultaneously remove four kinds of exhaust pollutants(NOx,CO,HC and PM) emitted from diesel engine.The four-way catalysts were characterized using scanning electron microscope(SEM) and Ultraviolet visible diffuse reflectance spectroscopy(UV-Vis DRS).Their catalytic performances were evaluated by temperature-programmed reaction technology.The double layer catalysts could effectively remove the four main pollutants.The highest catalytic activity was given by the two-layered catalysts of La0.6K0.4CoO3/Al2O3 and W/HZSM-5.Under the simulated exhaust gases conditions,the peak temperature of the soot combustion was 421°C,the maximal conversion of NO to N2 was 74%,the temperature of the HC total conversion was 357°C,and the maximum conversion ratio of CO was 99%. | Jian Liu,Jie Xu,Zhen Zhao,Aijun Duan,Guiyuan Jiang,Yanni Jing State Key Laboratory of Heavy Oil Processing,China University of Petroleum,Beijing 102249,China. | 2010 | Journal of Environmental Sciences2010，22，7： | 11 |
| 10 | Scheduling optimization of task allocation in integrated manufacturing system based on task decomposition显示文摘How to deal with the collaboration between task decomposition and task scheduling is the key problem of the integrated manufacturing system for complex products. With the development of manufacturing technology, we can probe a new way to solve this problem. Firstly, a new method for task granularity quantitative analysis is put forward, which can precisely evaluate the task granularity of complex product cooperation workflow in the integrated manufacturing system, on the above basis; this method is used to guide the coarse-grained task decomposition and recombine the subtasks with low cohesion coefficient. Then, a multi-objective optimieation model and an algorithm are set up for the scheduling optimization of task scheduling. Finally, the application feasibility of the model and algorithm is ultimately validated through an application case study. | Aijun Liu Michele Pfund John Fowler | 2016 | Journal of Systems Engineering and Electronics2016，27，2： | 10 |
| 11 | Expert consensus on the glycemic management of critically ill patients显示文摘Introduction The incidence of hyperglycemia is 40-60%in critically ill patients and is up to 60-80%in those who have undergone car-diac surgery.[1]The results of an epidemiological study in the United States showed that 28.6%of diabetic patients and 9.3%of non-diabetic patients had elevated mean daily glucose on the day of ICU admission.[2]In critically ill patients,elevated blood glucose is primarily the result of stress,and stress-induced hy-perglycemia is an independent risk factor associated with prog-nosis,regardless of a previous diagnosis of diabetes.Nutritional therapy has become an integral treatment option for patients in the ICU,[3,4]though nearly 30%of patients with enteral nu-trition and 44-50%with parenteral nutrition(PN)experience elevated glucose.[5,6]Intensive insulin therapy(IIT)is an impor-tant treatment for controlling hyperglycemia in critically ill pa-tients,but it also carries a corresponding risk of hypoglycemia. | Zhixiong Wu Jiao Liu Dong Zhang Kai Kang Xiangrong Zuo Qianghong Xu Aijun Pan Wei Fang Fen Liu You Shang Haiyan Yin Juntao Hu Jinglun Liu Jiangquan Fu Wei Zhang Yuan Zong Min Shao Feng Zhao Mei Meng Yanfei Mao Yingchuan Li Dechang Chen | 2022 | Journal of Intensive Medicine2022，2，3： | 9 |
| 12 | Organic-inorganic bismuth (lll)-based material: A lead- free, air-stable and solution-processable light-absorber beyond organolead perovskites显示文摘 | Miaoqiang Lyu Jung-Ho Yun Molang Cai Yalong Jiao Paul V. Bernhardt Meng Zhang Qiong Wang Aijun Du Hongxia Wang Gang Liu Lianzhou Wang | 2016 | Nano Research2016，9，3： | 8 |
| 13 | Preparation of cationic polyacrylamide microsphere emulsion and its performance for permeability reduction显示文摘In this paper, cationic polyacrylamide microspheres(CPAM) were synthesized using acrylamide(AM) and methacryloyloxyethyl trimethyl ammonium chloride(TMAEMC) as monomers, ammonium sulfate as dispersant, poly(acryloyloxyethyl trimethyl ammonium chloride)(PAETAC) as dispersion stabilizer, and ammonium persulfate as initiator. The synthetic method was dispersion polymerization. The effects of monomer ratio(AM/TMAEMC), dispersant concentration, and dispersion stabilizer dosage on dispersion polymerization were systematically studied to determine the optimal preparation conditions. The structure and viscosity of the synthesized polymer were characterized by FTIR and capillary viscometry, respectively, and the particle sizes and distribution of the polymer microspheres were characterized by microscopy and dynamic light scattering, respectively. Finally, flow tests were conducted to measure the permeability reduction performance of the microspheres at various concentrations in sand packs with different permeability. Results show that CPAM emulsion of a solids content of 1wt% has excellent performance in low-to-medium permeability formations(< 1,000 mD), and the efficiency may reach above 90%. | Guo Aijun Geng Yiran Zhao Lili Li Jun Liu Dong Li Peng | 2014 | Petroleum Science2014，11，3： | 8 |
| 14 | Design and experiment of variable rate orchard sprayer based on laser scanning sensor显示文摘During different growth periods,canopy size and density in orchards are variable,which need application conditions(flow rate and air flow)to be adjusted to match the canopy’s characteristics.In order to improve orchard sprayer’s automatic operating performance,an automatic variable-rate orchard sprayer(VARS)fixed with 40 electromagnetic valves and 8 brushless fans was developed based on the canopy’s spatial dimensions.Each solenoid valve and brushless motor can be individually adjusted in real-time through pulse width modulation(PWM)signals emitted by a control system to adjust each nozzle’s spout and fan rotation speed.A high-precision laser scanning sensor(light detecting and ranging,LIDAR)was adopted as the detector to measure the canopy volume using the variable rate algorithm principle.Field experiments were conducted in an apple orchard,and conventional air blast sprayer(CABS)and directed air-jet sprayer(DAJS)were tested as a comparison.Results showed that on average,46%less spraying solution was applied compared to conventional applications,while penetration rate was similar to DAJS.Normalized deposition in the canopy with variable application was higher than that of conventional applications,indicating that electronic sprayers are more efficient than conventional sprayers.It was also observed that VARS could significantly reduce off-target loss.The field experiment showed that the newly developed variable-rate sprayer can greatly reduce pesticide use and protect the environment for the orchard fruit production,and also provide a reference for design and performance optimization for plant protection machinery. | Longlong Li Xiongkui He Jianli Song Yajia Liu Aijun Zeng Liu Yang Chaohui Liu Zhixiong Liu | 2018 | International Journal of Agricultural and Biological Engineering2018，11，1： | 8 |
| 15 | Mesoscale eddy effects on the wintertime vertical mixing in the formation region of the North Pacific Subtropical Mode Water显示文摘Mesoscale eddy effects on the wintertime verti-cal mixing in the formation region of the North Pacific Sub-tropical Mode Water (NPSTMW) are studied using hydro-graphic data from Argo profiling floats deployed in the Ku-roshio recirculation region in February and March of 2001. Anticyclonic (warm) eddy enhances the wintertime vertical mixing and results in the deep mixed layer and the deep thermocline. Consequently, a large volumetric water mass with low potential vorticity corresponding to the prototype of NPSTMW tends to be formed. By contrast, cyclonic (cold) eddy is unfavorable for the vertical mixing process and halts the deepening of the mixed layer and thus the formation of mode water. Further analysis shows that cyclonic eddies prevail in the late 1990s in the formation region of NPSTMW, which lead to significant suppression of the wintertime ver-tical mixing (96-98) and thus are unfavorable for the for-mation of NPSTMW; while the situation is completely re-versed in the early 1990s (93-95). | PAN Aijun LIU Qinyu | 2005 | Chinese Science Bulletin2005，50，17： | 7 |
| 16 | 2-Gy whole-body irradiation significantly alters the balance of CD4^(+)CD25^(-) T effector cells and CD4^(+)CD25^(+)Foxp3^(+) T regulatory cells in mice显示文摘CD4^(+)CD25^(+) T regulatory(Treg)cells are critical in inducing and maintaining immunological self-tolerance as well as transplant tolerance.The effect of low doses of whole-body irradiation(WBI)on CD41CD251Foxp31 Treg cells has not been determined.The proportion,phenotypes and function of CD4^(+)CD25^(+) Treg cells were investigated 0.5,5 and 15 days after euthymic,thymectomized or allogeneic bone marrow transplanted C57BL/6 mice received 2-Gy c-rays of WBI.The 2-Gy WBI significantly enhanced the ratios of CD41CD251 Treg cells and CD4^(+)CD25^(+)Foxp3^(+) Treg cells to CD41 T cells in peripheral blood,lymph nodes,spleens and thymi of mice.The CD41CD251 Treg cells of the WBI-treated mice showed immunosuppressive activities on the immune response of CD4^(+)CD25^(+) T effector cells to alloantigens or mitogens as efficiently as the control mice.Furthermore,2-Gy c-ray WBI significantly increased the percentage of CD4^(+)CD25^(+)Foxp3^(+) Treg cells in the periphery of either thymectomized mice or allogeneic bone marrow transplanted mice.The in vitro assay showed that ionizing irradiation induced less cell death in CD4^(+)CD25^(+)Foxp3^(+) Treg cells than in CD4^(+)CD25^(+) T cells.Thus,a low dose of WBI could significantly enhance the level of functional CD41CD251Foxp31 Treg cells in the periphery of naive or immunized mice.The enhanced proportion of CD41CD251Foxp31 Treg cells in the periphery by a low dose of WBI may make hosts more susceptible to immune tolerance induction. | Yanyan Qu Baojun Zhang Shuchun Liu Aijun Zhang Tingting Wu Yong Zhao | 2010 | Cellular & Molecular Immunology2010，7，6： | 7 |
| 17 | Synthesis of a new ordered mesoporous NiMoO_4 complex oxide and its efficient catalytic performance for oxidative dehydrogenation of propane显示文摘Highly ordered mesoporous NiMoO4material was successfully synthesized using mesoporous silica KIT-6 as hard template via vacuum nanocasting method. The structure was characterized by means of XRD, TEM, N2adsorption-desorption, Raman and FT-IR. The mesoporous NiMoO4with the coexistence of α-NiMoO4and β-NiMoO4showed well-ordered mesoporous structure, a bimodal pore size distribution and crystalline framework. The catalytic performance of NiMoO4was investigated for oxidative dehydrogenation of propane. It is demonstrated that the mesoporous NiMoO4catalyst with more surface active oxygen species showed better catalytic performance in oxidative dehydrogenation of propane in comparison with bulk NiMoO4. | Xiaoqiang Fan Jianmei Li Zhen Zhao Yuechang Wei Jian Liu Aijun Duan Guiyuan Jiang | 2014 | Journal of Energy Chemistry2014，23，2： | 6 |
| 18 | Dendrite‐free lithium and sodium metal anodes with deep plating/stripping properties for lithium and sodium batteries显示文摘Although lithium(Li)and sodium(Na)metals can be selected as the promising anode materials for next‐generation rechargeable batteries of high energy density,their practical applications are greatly restricted by the uncontrollable dendrite growth.Herein,a platinum(Pt)–copper(Cu)alloycoated Cu foam(Pt–Cu foam)is prepared and then used as the substrate for Li and Na metal anodes.Owing to the ultrarough morphology with a threedimensional porous structure and the quite large surface area as well as lithiophilicity and sodiophilicity,both Li and Na dendrite growths are significantly suppressed on the substrate.Moreover,during Li plating,the lithiated Pt atoms can dissolve into Li phase,leaving a lot of microsized holes on the substrate.During Na plating,although the sodiated Pt atoms cannot dissolve into Na phase,the sodiation of Pt atoms elevates many microsized blocks above the current collector.Either the holes or the voids on the surface of Pt–Cu foam what can be extra place for deposited alkali metal,what effectively relaxes the internal stress caused by the volume exchange during Li and Na plating/stripping.Therefore,the symmetric batteries of Li@Pt–Cu foam and Na@Pt–Cu foam have both achieved long‐term cycling stability even at ultrahigh areal capacity at 20 mAh cm−2. | Jianyi Wang Qi Kang Jingchao Yuan Qianru Fu Chunhua Chen Zibo Zhai Yang Liu Wei Yan Aijun Li Jiujun Zhang | 2021 | Carbon Energy2021，3，1： | 6 |
| 19 | Hybrid customer requirements rating method for customer-oriented product design using QFD显示文摘Quality function deployment(QFD) is a well-known customer-oriented product design methodology. Rating the final importance of customer requirements(CRs) is really a very essential starting point in the implementation of QFD, since it largely affects the target setting value of design requirements. This paper aims to propose a novel method to deal with the relative importance ratings(RIRs) of CRs problem considering customers' diversified requirements and unknown information on customers' weights, which is an indispensable process for determining the final importance ratings of CRs. First, a new concept of customer's assessment structure is proposed according to the basic idea of grey relational analysis(GRA), and then a constrained nonlinear optimization model is constructed to describe the assessment information aggregation factors of CRs considering customers' personalized and diversified requirements. Furthermore, an immune particle swarm optimization(IPSO) algorithm is designed to solve the model, and the weight vector of customers is obtained.Finally, a car door design example is introduced to illustrate the novel hybrid GRA-IPSO method's potential application in determining the RIRs of CRs. | Fang Wang Hua Li Aijun Liu Xiao Zhang | 2015 | Journal of Systems Engineering and Electronics2015，26，3： | 6 |
| 20 | Deficiency of Mouse CD4^+CD25^+Foxp3^+ Regulatory T Cells in Xenogeneic Pig Thymus-Grafted Nude Mice Suffering from Autoimmune Diseases显示文摘Xenogeneic thymus transplantation can efficiently induce specific immune tolerance to donor antigens in athymic recipients. However, many nude mice suffer from autoimmune diseases (AID) for over 10 weeks after xenogeneic thymus transplantation. CD4+CD25+Foxp3+ regulatory T (Treg) cells were recently determined to play a pivotal role in keeping immune tolerance in humans and mice. Thus, we investigated this subpopulation of Treg cells in the periphery of pig thymus-grafted nude mice suffering from AID. Our results showed that the expression of Foxp3, CTLA-4 and GITR on mouse CD4+CD25+ T cells and the ratio of CD4+CD25+Foxp3+ Treg cells to CD4+ T cells were significantly decreased in the periphery of pig thymus-grafted nude mice suffering from AID, compared with healthy pig or mouse thymus-grafted nude mice. Furthermore, mouse CD4+CD25+ T cells in pig thymus-grafted nude mice suffering from AID showed more severe deficiency in immunosuppressive function compared with the counterpart in xenogeneic pig or syngeneic thymus-grafted nude mice without AID. Thus, the decreased frequency, altered phenotype and functional deficiency of mouse CD4+CD25+ Treg cells in pig thymus-grafted nude mice may contribute to the development of AID in this model. | Baojun Zhang Chenming Sun Yanyan Qu Aijun Zhang Jun Liu Lianjun Zhang Zeqing Niu Yong Zhao | 2008 | Cellular & Molecular Immunology2008，5，5： | 6 |
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