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| 1 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 2 | Cancer nanotechnology: Enhancing tumor cell response to chemotherapy for hepatocellular carcinoma therapy显示文摘Hepatocellular carcinoma(HCC)is one of the deadliest cancers due to its complexities,reoccurrence after surgical resection,metastasis and heterogeneity.In addition to sorafenib and lenvatinib for the treatment of HCC approved by FDA,various strategies including transarterial chemoembolization,radiotherapy,locoregional therapy and chemotherapy have been investigated in clinics.Recently,cancer nanotechnology has got great attention for the treatment of various cancers including HCC.Both passive and active targetings are progressing at a steady rate.Herein,we describe the lessons learned from pathogenesis of HCC and the understanding of targeted and non-targeted nanoparticles used for the delivery of small molecules,monoclonal antibodies,miRNAs and peptides.Exploring current efficacy is to enhance tumor cell response of chemotherapy.It highlights the opportunities and challenges faced by nanotechnologies in contemporary hepatocellular carcinoma therapy,where personalized medicine is increasingly becoming the mainstay.Overall objective of this review is to enhance our understanding in the design and development of nanotechnology for treatment of HCC. | Yongbing Sun Wen Ma Yuanyuan Yang Mengxue He Aimin Li Lei Bai Bin Yu Zhiqiang Yu | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，6： | 8 |
| 3 | The First Case of Asymptomatic Infection of COVID-19-Kashgar Prefecture, Xinjiang Uygur Autonomous Region, China, October, 2020显示文摘On October 24,2020,a 17-year-old female was detected as having an asymptomatic infection of coronavirus disease 2019(COVID-19)during a regular nucleic acid test in Kashgar Prefecture,Xinjiang Uygur Autonomous Region.She was then transferred to a local designated hospital for medical observation.The patient lived in Shufu County of Kashgar Prefecture and worked in a local garment factory.On the afternoon of October 24 after she was diagnosed as positive,a total of 831 persons in the garment factory were tested and the results were all negative.Afterwards,16 close contacts and 406 of close contacts of close contacts were also tested,and 137 were positive and had asymptomatic infections. | Ji Wang Jun Zhao Xiang Zhao Zhenguo Gao Yang Song Xin Ma Kai Nie Aimin Xu Mahemuti Ling Zhang Wenbo Xu Yan Cui | 2020 | China CDC weekly2020，2，45： | 6 |
| 4 | Standardized Operational Protocol for Human Brain Banking in China显示文摘With the progress of society, there is an increasing need to tackle disorders of the central nervous system. Human brain tissue, unlike animal tissues, is an irreplaceable resource for the study of neurological diseases (1)Aimed at scientific research and education, the roles of human brain tissue repositories are to acquire brain tissue from donors, prepare, process, and preserve collected samples,provide tissue to specific eligible facilities, and determine the characteristics of each tissue sample. | Wenying Qiu Hanlin Zhang Aimin Bao Keqing Zhu Yue Huang Xiaoxin Yan Jing Zhang Chunjiu Zhong Yong Shen Jiangning Zhou Xiaoying Zheng Liwei Zhang Yousheng Shu Beisha Tang Zhenxin Zhang Gang Wang Ren Zhou Bing Sun Changlin Gong Shumin Duan Chao Ma | 2019 | Neuroscience Bulletin2019，35，2： | 6 |
| 5 | Efficacy and safety of Reduqing granules in the treatment of common cold with wind-heat syndrome: a randomized, double-blind, double-dummy, positive-controlled trial显示文摘OBJECTIVE:To assess the efficacy and safety of Reduqing granules in patients with common cold with wind-heat syndrome(CCWHS).METHODS:A randomized, double-blind, double-dummy, parallel, positive-controlled trial included 72 CCWHS patients was performed.The participants were randomly assigned to two groups,Reduqing(RDQ) group and Lianhuaqingwen(LHQW) group, in a 1∶1 ratio.Patients in RDQ group received Reduqing granules and dummy Lianhuaqingwen capsules three times a day and patients in LHQW group received Lianhuaqingwen capsules and dummy Reduqing granules three times daily.The duration of treatment and follow-up were four days.RESULTS:There were no statistically significant differences in total markedly effective rate and total effective rate between RDQ group and LHQW group after treatment.Traditional Chinese Medicine(TCM) symptom score was significantly reduced after treatment in RDQ group, as well as in LHQW group.However, the difference of change in TCM symptom score between two groups was not statistically significant(P > 0.05).There were no significant differences between two groups in the median time to fever relief [RDQ group(4 ± 8) h vs LHQW group(4 ± 5) h] or the median time to fever clearance(RDQ group 47 h vs LHQW 36 h).No serious adverse events were reported during the study.CONCLUSION:Compared with Lianhuaqingwen capsules, Reduqing granules achieved similar therapeutic effect in the treatment of CCWHS and no drug-related adverse events were reported during the study.Therefore, Reduqing granules might be effective and safe in the treatment of CCWHS. | Ma Yanjiao Zhang Zhongyi Wei Lianbo He Shuai Deng Xun Ji Aimin Zhou Benjie Jiang Deqi Li Mingxing Wang Yong | 2017 | Journal of Traditional Chinese Medicine2017，37，2： | 5 |
| 6 | Delivery of triptolide with reduction-sensitive polymer nanoparticles for liver cancer therapy on patient-derived xenografts models显示文摘Hepatocellular carcinoma(HCC)has become the fourth predominant cause of cancer-related deaths worldwide,and HCC is still one of the worst prognoses for survival as it is poorly responsive to both chemotherapy and surgical treatment due to drug resista nce and great toxic effects.Triptolide(TP),a key ingredient from the traditional Chinese medical herb,has been utilized to treat inflammation and antitumor for centuries.However,investigations of this potent agent have been met with only limited success due to the severe systemic toxicities in patients and low water solubility as well as its high toxicity over the past two decades.Herein,we reported the development of a reduction-responsive drug delive ry system loaded with TP fo r glutathione(GSH)-trigge red drug release for cancer therapy.With the GSH-sensitive TP loaded nanoparticles,the remarkable increases in tumor accumulation and amelioration of drug toxicity in animals are demonstrated,which is likely due to sustained stepwise release of active TP within cancer cells.Moreover,in a patient-derived tumor xenograft model of liver cancer,administration of tritolide nanoparticles enhances the antitumor efficacy relative to administration of free TP.These findings indicate that GSH-sensitive release of TP may be a promising strategy for cancer treatment. | Mengxue He Ling Yu Yuanyuan Yang Binhua Zou Wen Ma Meng Yu Jiandong Lu Guoliang Xiong Zhiqiang Yu Aimin Li | 2020 | Chinese Chemical Letters2020，31，12： | 5 |
| 7 | The SOC1-like gene BoMADS50 is associated with the flowering of Bambusa oldhamii显示文摘Bamboo is known for its edible shoots and beautiful texture and has considerable economic and ornamental value.Unique among traditional flowering plants,many bamboo plants undergo extensive synchronized flowering followed by large-scale death,seriously affecting the productivity and application of bamboo forests.To date,the molecular mechanism of bamboo flowering characteristics has remained unknown.In this study,a SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1(SOC1)-like gene,BoMADS50,was identified from Bambusa oldhamii.BoMADS50 was highly expressed in mature leaves and the floral primordium formation period during B.oldhamii flowering and overexpression of BoMADS50 caused early fl owering in transgenic rice.Moreover,BoMADS50 could interact with APETALA1/FRUITFULL(AP1/FUL)-like proteins(BoMADS 14-1/2,BoMADS15-1/2)in vivo,and the expression of BoMADS50 was signi ficantly promoted by BoMADS14-1,further indicating a synergistic effect between BoMADS50 and BoAP1/FUL-like proteins in regulating B.oldhamii flowering.We also identi fi ed four additional transcripts of BoMADS50(BoMADS50-1/2/3/4)with different nucleotide variations.Although the protein-CDS were polymorphic,they had flowering activation functions similar to those of BoMADS50.Yeast one-hybrid and transient expression assays subsequently showed that both BoMADS50 and BoMADS50-1 bind to the promoter fragment of itself and the SHORT VEGETATIVE PHASE(SVP)-like gene BoSVP,but only BoMADS50-1 can positively induce their transcription.Therefore,nucleotide variations likely endow BoMADS50-1 with strong regulatory activity.Thus,BoMADS50 and BoMADS50-1/2/3/4 are probably important positive flowering regulators in B.oldhamii.Moreover,the functional conservatism and speci ficity of BoMADS50 and BoMADS50-1 might be related to the synchronized and sporadic flowering characteristics of B.oldhamii. | Dan Hou Ling Li Tengfei Ma Jialong Pei Zhongyu Zhao Mengzhu Lu Aimin Wu Xinchun Lin | 2021 | Horticulture Research2021，8，1： | 4 |
| 8 | Highway constructions on the Qinghai-Tibet Plateau:Challenge,research and practice显示文摘Highway constructions on the Qinghai-Tibet Plateau(QTP)face great challenges induced by the unique local environmental,geological,and engineering conditions.The large area of permafrost,great temperature variability,strong UV rays,and complex geological conditions are the major factors that adversely influence the longterm performance of pavement systems.Since 1960s,Chinese engineers and researchers have started conducting research on the QTP to enhance the performance and durability of pavement systems.The present paper provide a comprehensive review of challenge,research and practice of highway constructions on the QTP including the special environmental and geological conditions,history of highway constructions on the QTP,major challenges and the state-of-the-art technology of subgrade constructions on permafrost,developments of the pavement structures and materials,performance prediction and maintenance methods of pavement surfaces,and applications of the research achievements on the first expressway on the QTP(i.e.,Gongyu Expressway).Based on the comprehensive literature review,it can be found that(1)frost heave and thaw weakening induced subgrade disease and longitudinal cracks on the pavement surface are complex coupled water-thermal-load problems.Engineering solutions are focusing on active cooling and thermal insulation methods,which can help to reduce temperature variations in the subgrade and thus improving its stability,(2)the harsh environmental and construction conditions may reduce the early strength and induce premature damage of cement-treated base materials.Some field validations showed that geocell-reinforced or asphalt-treated flexible base materials can provide better long-term performance,(3)the large temperature variability and strong UV rays can significantly accelerate aging of asphalt binders and greatly reduce the service life of asphalt mixtures.Various binder modification methods were developed for improving their viscoelasticity and enhance the low-temperature cracking resistance of pavement surface materials but are still lack of field validation data and comparisons of their life cycle costs.Therefore,it is recommended that a demonstration research project build test sections to examine a range of pavement structures and materials,and compare their long-term performance and life cycle costs,which can serve as important reference for future highway constructions on the QTP. | Aimin Sha Biao Ma Hainian Wang Liqun Hu Xuesong Mao Xilan Zhi Huaxin Chen Yu Liu Feng Ma Zhuangzhuang Liu Rui He Wei Si Xuhao Wang Cheng Li | 2022 | Journal of Road Engineering2022，2，1： | 4 |
| 9 | Preparation of a permanent magnetic hypercrosslinked resin and assessment of its ability to remove organic micropollutants from drinking water显示文摘基于新奇永久磁性的 hypercrosslinked 树脂, W150 在喝水为器官的 micropollutants 的移动被建议的一个快速、有效的方法。W150 被暂停和 crosslinking 以后反应准备并且发现了拥有 1149.7 m 的一个高特定的表面区域 < 啜 class= “ a-plus-plus ” > 2 敢漠 ? 桴 ? 潢吗? | Wei WANG Yan MA Qing ZHOU Chendong SHUANG Mancheng ZHANG Aimin LI | 2015 | Frontiers of Environmental Science & Engineering2015，9，1： | 3 |
| 10 | Reliable and Efficient Agrobacterium tumefaciens-Mediated Genetic Transformation of Dianthus spiculifolius显示文摘Dianthus spiculifolius is a perennial herbaceous flower with strong environmental adaptability and is an important ornamental ground cover plant.In this study,seeds of D.spiculifolius were used as explants for callus induction,adventitious bud differentiation,and rooting by adding different concentrations of 2,4-dichlorophenoxyacetic acid(2,4-D),6-benzyl aminopurine(6-BA),and naphthaleneacetic acid(NAA)to Murashige and Skoog medium.The calli generated were co-cultured with Agrobacterium tumefaciens EHA105 containing pBI121-GUS or pBI121-GFP plasmids for 30 min,and transgenic regenerated plants were obtained by kanamycin(30mg·L^−1)screening.RT-PCR confirmed the stable expression of the exogenous GUS and GFP genes in the D.spiculifolius.Theβ-glucuronidase(GUS)histochemical staining confirmed GUS gene expression in transgenic calli,adventitious buds,and regenerated plants of D.spiculifolius.The green fluorescent protein(GFP)visual analysis showed GFP gene expression in transgenic calli.Furthermore,subcellular localization analysis showed that the three organelle marker proteins were not only successfully expressed but also accurately localized to their corresponding organelles in D.spiculifolius callus cells.These results indicated a successful establishment of a reliable and efficient A.tumefaciens-mediated genetic transformation system,which will contribute to functional gene research and genetic improvement of D.spiculifolius. | Jingang Wang Shiyue Liu Hongping Ma Ye Tao Shuang Feng Shufang Gong Jinzhu Zhang Aimin Zhou | 2020 | Horticultural Plant Journal2020，6，3： | 2 |
| 11 | Generation of transgenic cucumbers with expression of a ten-tandem repeat long-acting GLP-1 analogue and their biological function on diabetic rats显示文摘Glucagon-like peptide-1 (GLP-1) is a 30-amino acid peptide hormone, which has the regulatory function of stimulating the secretion of insulin to balance blood glucose levels. In this study, marker-free expression vector pX6 with a fusion gene of ten tandem repeated GLP-1 analog ([Ser8, Gln26 and Asp34]-GLP-1) genes was constructed and transformed into cucumbers by Agrobacterium tumefaciens-mediated transformation method. Four transgenic lines were obtained by PCR and Southern blotting analysis and two transgenic lines successfully expressed the fusion protein (named GLP-T), which was revealed by Western blotting analysis. The biological activity test results showed that the serum glucose level of diabetic rats was significantly decreased after oral administration of the fusion protein GLP-T extracted from the transgenic cucumber fruitage. These results suggest that this may provide a brand-new strategy to prevent and cure the diabetes with no pain. | ZHAO Lei LIAO Fang WANG CuiYan CHEN Miao WEI AiMin DU ShengLi MA BaiCheng HU XiaoYu WU ZhiQiang WANG RuiJu LI MingGang | 2009 | Chinese Science Bulletin2009，54，24： | 2 |
| 12 | Clinical evaluation of Technetium-99m sestamibi myocardial perfusion SPECT in diabetes with suspected coronary artery diseases显示文摘Objective:To study the clinical value of Technetium-99m sestamibi myocardial perfusion single photon emission computed tomography(SPECT) in diabetes with suspected coronary artery diseases.Methods:Seventy-eight diabetic patients complicated with cardiac symptoms or electrocardiogram(ECG) abnormalities and suspected coronary heart disease hospitalized in the department of endocrinology from January,2008 to December,2008 were investigated.Technetium-99m sestamibi myocardial perfusion SPECT was performed in all patients.Exercise stress test was done in 35 cases(group A).Adenosine stress test was done in 43 cases(group B).Results:The positive rates in the two groups were 54.29%(19/35) and 53.48%(23/43),respectively.There was no statistic difference between the 2 groups(P>0.05).The abnormality rates in male and female groups were 63.04% and 28.13%,respectively(P<0.01).Eighty-six segments of perfusion abnormality were detected in 38 positive patients.Four segments of fixed defect were found in 4 cases.Conclusion:As non-invasive method,myocardial perfusion SPECT can play an important role in the treatment of diabetes with suspected coronary artery disease. | Deng Huixing Ma Aiqun Yang Aimin Cheng Hu Ran Hongde | 2010 | Journal of Medical Colleges of PLA(China)2010，25，4： | 2 |
| 13 | Influences of (Ce-Zr-La-Pr)O contents on three-way catalyst performances显示文摘 | Zhang Aimin Ning Ping Ma Liping | 2005 | Journal of Rare Earths2005，23，： | 1 |
| 14 | Theoretical research on naturally curved and twisted beams under complicated loads 显示文摘 | Yu Aimin Fang Mingxia Ma Xing | 2002 | Computers and Structures2002，80，32： | 1 |
| 15 | Influences of (Ce-Zr-La-Pr)O Contents on Three-way catalyst Performances显示文摘 | Zhang Aimin Ning Ping Ma Liping | 2005 | Journal of Rare Earths2005，23，： | 1 |
| 16 | Magnesium regulates intracellular free ionized calcium concentration and cell geometry in vascular smooth muscle cells显示文摘 | Aimin Z Toni PO Burton MA | 1992 | Biochem Biophys1992，1134，1： | 1 |
| 17 | Mining plant metabolomes:Methods,applications,and perspectives显示文摘Plants produce a variety of metabolites that are essential for plant growth and human health.To fully understand the diversity of metabolites in certain plants,lots of methods have been developed for metabolites detection and data processing.In the data-processing procedure,how to effectively reduce false-positive peaks,analyze large-scale metabolic data,and annotate plant metabolites remains challenging.In this review,we introduce and discuss some prominent methods that could be exploited to solve these problems,including a five-step filtering method for reducing false-positive signals in LC-MS analysis,QPMASS for analyzing ultra-large GC-MS data,and MetDNA for annotating metabolites.The main applications of plant metabolomics in species discrimination,metabolic pathway dissection,population genetic studies,and some other aspects are also highlighted.To further promote the development of plant metabolomics,more effective and integrated methods/platforms for metabolite detection and comprehensive databases for metabolite identification are highly needed.With the improvement of these technologies and the development of genomics and transcriptomics,plant metabolomics will be widely used in many fields. | Aimin Ma Xiaoquan Qi | 2021 | Plant Communications2021，2，5： | 1 |
| 18 | 查看详情显示文摘 | Zhang Aimin Ning Ping Ma Liping | | 0，，： | 1 |
| 19 | Self-adjustable hyper-graphs for video pose estimation based on spatial-temporal subspace construction显示文摘Dear editor,In recent years many supervised video pose estimation methods have achieved growing successes based on well-labeled training datasets. Nonetheless, when facing roughly-labeled training data, it still remains challenging to intrinsically encode the video contents’ spatial-temporal coherency for robust video pose estimation.Some researches aimed to directly improve and refine the existing confidence maps by combining the spatial-temporal structure models [1, 2]. Li et al. | Jizhou MA Shuai LI Hong QIN Aimin HAO Qinping ZHAO | 2022 | Science China(Information Sciences)2022，65，3： | 1 |
| 20 | Cultivation of a microalga Chlorella vulgaris using recycled aqueous phase nutrients from hydrothermal carbonization process显示文摘 | Zhenyi Du Bing Hu Aimin Shi Xiaochen Ma Yanling Cheng Paul Chen Yuhuan Liu Xiangyang Lin Roger Ruan | 2012 | Bioresource Technology2012，，： | 1 |
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