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| 1 | Urban traffic congestion propagation and bottleneck identification显示文摘Bottlenecks in urban traffic network are sticking points in restricting network collectivity traffic efficiency. To identify network bottlenecks effectively is a foundational work for improving network traffic condition and preventing traffic congestion. In this paper, a congestion propagation model of urban network traffic is proposed based on the cell transmission model (CTM). The proposed model includes a link model, which describes flow propagation on links, and a node model, which represents link-to-link flow propagation. A new method of estimating average journey velocity (AJV) of both link and network is developed to identify network congestion bottlenecks. A numerical example is studied in Sioux Falls urban traffic network. The proposed model is employed in simulating network traffic propagation and congestion bottleneck identification under different traffic demands. The simulation results show that continual increase of traffic demand is an immediate factor in network congestion bottleneck emergence and increase as well as reducing network collectivity capability. Whether a particular link will become a bottleneck is mainly determined by its position in network, its traffic flow (attributed to different OD pairs) component, and network traffic demand. | LONG JianCheng GAO ZiYou REN HuaLing LIAN AiPing | 2008 | Science in China(Series F)2008，51，7： | 25 |
| 2 | Effect of soothing liver therapy on oocyte quality and growth differentiation factor-9 in patients undergoing in vitro fertilization and embryo transfer显示文摘OBJECTIVE:To investigate the effect of Soothing liver therapy on infertile women undergoing in vitro fertilization and embryo transfer(IVF-ET)and to explore its mechanism.METHODS:Fifty-eight women with tubal infertility were randomized into two groups:30 in an experimental group treated with Xiaoyao powder(Shugan)plus gonadotropin-releasing hormone analog(GnRHa)/follicle-stimulating hormone(FSH)/human chorionic gonadotropin(hCG)and 28 in the control group who were treated with GnRHa/FSH/hCG only.The total gonadotropin(Gn)doses required,endometrial thickness,oocyte numbers,high quality embryo production rate and pregnancy rate of the two groups were compared.The concentration of growth differentiation factor-9(GDF-9)in follicular fluid was detected by western blotting and the expression of GDF-9 mRNA in granulosa cells was measured using reverse tran-scription-polymerase chain reaction amplification.RESULTS:In the experimental group,the Gn dose was significantly lower than that in the control group;the endometrial thickness,high quality embryo production and pregnancy rates were significantly higher and the expression of GDF-9 mRNA was also significantly higher than in the control group(all P<0.05).CONCLUSION:Shugan treatment can improve the pregnancy rate of women with tubal infertility;its mechanism is possibly related to the increased expression of GDF-9 in granulosa cells. | Xing Gao Xiufeng Chang Huilan Du Min Zhang Jianping Zhang Aiping Zhu | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 11 |
| 3 | IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity显示文摘Obesity and associated metabolic diseases are characterized by a chronic low-grade inflammatory state with the infiltration of many inflammatory cells,especially macrophages.Immune molecules,including some cytokines,have a close relationship with metabolism.Interleukin(IL)-25 is a member of the IL-17 cytokine family that can regulate macrophages and alleviate some metabolic dysfunction;however,its role and mechanisms in lipid metabolism remain to be extensively clarified.Human serum and liver biopsy specimens,high-fat diet-induced obesity mice and DB/DB(Lepr−/−)animal models were used to examine IL-25 expression in obesity and nonalcoholic fatty liver diseases(NAFLD).To observe the role of IL-25 in lipid metabolism,model mice were administered with IL-25 or adoptively transferred with IL-25-educated macrophages in vivo,whereas bone marrow-derived macrophages,the macrophage cell line RAW264.7 and adipocytes differentiated from 3T3-L1 were used in vitro.IL-25 was decreased in NAFLD patients and obese mice.In addition,IL-25 reduced body weight gain and lipid accumulation,enhanced lipid uptake by macrophages and increased the expression of lipolysis andβ-oxidation enzymes via alternatively activating macrophages.IL-25 also promoted lipolysis and suppressed lipogenesis in adipocytes co-cultured with the IL-25-educated macrophages.Furthermore,IL-25 improved the mitochondrial respiratory capacity and oxygen consumption rate of macrophages and produced more NAD+/NADH and ATP.In conclusion,IL-25 can stimulate M2 macrophage polarization and thereby promote lipolysis and mitochondrial respiratory capacity,highlighting the potential for IL-25 to be used as a therapeutic agent against obesity and associated metabolic syndromes. | Juan Feng Lingyi Li Zhiying Ou Qiao Li Baoyong Gong Zhenxian Zhao Weiwei Qi Ti Zhou Jun Zhong Weibin Cai Xia Yang Aiping Zhao Guoquan Gao Zhonghan Yang | 2018 | Cellular & Molecular Immunology2018，15，5： | 10 |
| 4 | Effects of long-term fertilization with different substitution ratios of organic fertilizer on paddy soil显示文摘In recent years,the abuse of chemical fertilizers has caused numerous environmental problems,such as soil acidification and compaction.Replacing chemical fertilizers with organic fertilizers can effectively alleviate these problems.However,the effects of alternative organic fertilizers remain unclear.To explore the effects of organic fertilizer substitution on rice yield and paddy soil physicochemical properties and bacterial community structure,we conducted a 5-year experiment using different proportions of organic fertilizer substitution in a double-cropping rice field in Jiangxi,China.Our results showed that replacing chemical fertilizers with organic fertilizers can reduce soil acidification,increase soil organic matter content,nutrient contents,and enzyme activities,improve soil physicochemical properties and microbial community,and enhance soil metabolism.Appropriate organic substitution also had positive effects on rice production.These findings enhance our understanding of the effects of different alternative organic fertilization methods and have important theoretical significance for the promotion of the use of organic fertilizers in the future. | Weifeng SONG Aiping SHU Jiai LIU Wenchong SHI Mingcong LI Wenxue ZHANG Zuzhang LI Guangrong LIU Fusheng YUAN Shuxin ZHANG Zengbing LIU Zheng GAO | 2022 | Pedosphere2022，32，4： | 7 |
| 5 | High detectivity photodetectors based on perovskite nanowires with suppressed surface defects显示文摘Solution-processable,single-crystalline perovskite nanowires are ideal candidates for developing low-cost photodetectors,but their detectivities are limited due to a high level of unintentional defects.Through the surfaceinitiated solution-growth method,we fabricated high-quality,single-crystalline,defects-suppressed MAPbI_(3) nanowires,which possess atomically smooth side surfaces with a surface roughness of 0.27 nm,corresponding to a carrier lifetime of 112.9 ns.By forming ohmic MAPbI_(3)∕Au contacts through the dry contact method,highperformance metal–semiconductor–metal photodetectors have been demonstrated with a record large linear dynamic range of 157 dB along with a record high detectivity of 1.2×10^(14) Jones at an illumination power density of 5.5 nW∕cm^(2).Such superior photodetector performance metrics are attributed to,first,the defects-suppressed property of the as-grown MAPbI_(3) nanowires,which leads to a quite low noise current in the dark,and second,the ohmic contact between MAPbI_(3) and Au interfaces,which gives rise to an improved responsivity compared with the Schottky contact counterpart.The realized high-performance MAPbI_(3) nanowire photodetector advances the development of low-cost photodetectors and has potential applications in weak-signal photodetection. | GUOHUI LI RUI GAO YUE HAN AIPING ZHAI YUCHENG LIU YUE TIAN BINING TIAN YUYING HAO SHENGZHONG LIU YUCHENG WU YANXIA CUI | 2020 | Photonics Research2020，8，12： | 4 |
| 6 | A Volumetric Model for Evaluating Tight Sandstone Gas Reserves in the Permian Sulige Gas Field,Ordos Basin,Central China显示文摘To accurately measure and evaluate reserves is critical for ensuring successful production of unconventional oil and gas. This work proposes a volumetric model to evaluate the tight sandstone gas reserves of the Permian Sulige gas field in the Ordos Basin. The reserves can be determined by four major parameters of reservoir cutoffs, net pay, gas-bearing area and compression factor Z, which are controlled by reservoir characteristics and sedimentation. Well logging, seismic analysis, core analysis and gas testing, as well as thin section identification and SEM analysis were used to analyze the pore evolution and pore-throat structure. The porosity and permeability cutoffs are determined by distribution function curve,empirical statistics and intersection plot. Net pay and gas-bearing area are determined based on the cutoffs, gas testing and sand body distribution, and the compression factor Z is obtained by gas component. The results demonstrate that the reservoir in the Sulige gas field is characterized by ultralow porosity and permeability, and the cutoffs of porosity and permeability are 5% and 0.15×10^(–3) μm^2, respectively. The net pay and gas-bearing area are mainly affected by the sedimentary facies, sand body types and distribution. The gas component is dominated by methane which accounts for more than 90%, and the compression factor Z of H_8(P_2h_8) and S_1(P_1s_1) are 0.98 and 0.985, respectively. The distributary channels stacked and overlapped, forming a wide and thick sand body with good developed intergranular pores and intercrystalline pores. The upper part of channel sand with good porosity and permeability can be sweet spot for gas exploration. The complete set of calculation systems proposed for tight gas reserve calculation has proved to be effective based on application and feedback. This model provides a new concept and consideration for reserve prediction and calculation in other areas. | CUI Mingming FAN Aiping WANG Zongxiu GAO Wanli LI Jinbu LI Yijun | 2019 | Acta Geologica Sinica(English Edition)2019，93，2： | 4 |
| 7 | Enhanced Potassium‑Ion Storage of the 3D Carbon Superstructure by Manipulating the Nitrogen‑Doped Species and Morphology显示文摘Potassium-ion batteries(PIBs)are attractive for gridscale energy storage due to the abundant potassium resource and high energy density.The key to achieving high-performance and large-scale energy storage technology lies in seeking eco-efficient synthetic processes to the design of suitable anode materials.Herein,a spherical sponge-like carbon superstructure(NCS)assembled by 2D nanosheets is rationally and efficiently designed for K+storage.The optimized NCS electrode exhibits an outstanding rate capability,high reversible specific capacity(250 mAh g^(−1) at 200 mA g^(−1) after 300 cycles),and promising cycling performance(205 mAh g^(−1) at 1000 mA g^(−1) after 2000 cycles).The superior performance can be attributed to the unique robust spherical structure and 3D electrical transfer network together with nitrogen-rich nanosheets.Moreover,the regulation of the nitrogen doping types and morphology of NCS-5 is also discussed in detail based on the experiments results and density functional theory calculations.This strategy for manipulating the structure and properties of 3D materials is expected to meet the grand challenges for advanced carbon materials as high-performance PIB anodes in practical applications. | Yanhua Li Kui Xiao Cong Huang Jin Wang Ming Gao Aiping Hu Qunli Tang Binbin Fan Yali Xu Xiaohua Chen | 2021 | Nano-Micro Letters2021，13，1： | 2 |
| 8 | Self-immolative micellar drug delivery:The linker matters显示文摘Redox-responsive polymer-drug conjugate micelles are excellent nanoscale vehicles for self-immolative intracellular drug delivery.To covalently connect the polymer and drug,disulfide-bearing linkers,such as 3,3'-dithiodipropionic acid (DDPA) and 4,4'-dithiodibutyric add (DDBA),are used.In this paper,we report the influence of linker length on the therapeutic outcome of redox-sensitive conjugate micelles.Curcumin was selected as the model drug and it was conjugated to a multivalent methoxy poly(ethylene glycol)-polylysine copolymer with DDPA or DDBA as the linker.The obtained two polymer-curcumin conjugates were amphiphilic and could self-assemble into micelles that have a hydrodynamic diameter less than 100 nm.The loading of curcumin in both micelles was above 20% (w/w).Irrespective of the linker type,micelle disassembly was observed due to the collapse of the disulfide bond in a reducing environment.However,the rate of curcumin release was much faster with the DDBA linker than with the DDPA linker as the side product was a 5-membered ring with a low ring strain.The linker length-induced variation of curcumin release kinetics caused a significant difference in the intracellular drug concentration and a higher cytotoxicity was witnessed in three model cell lines (HeLa,PC3,and 4T1) for the micelles with a DDBA linker compared to those containing a DDPA linker.As expected,this phenomenon was also observed in HeLa tumor-bearing nude mice in vivo.The current work highlights the significance of linker length in engineering redox-responsive on-demand delivery systems. | Xuan Meng Min Gao Jian Deng Di Lu Aiping Fan Dan Ding Deling Kong Zheng Wang Yanjun Zhao | 2018 | Nano Research2018，11，12： | 2 |
| 9 | Innovative color jet 3D printing of levetiracetam personalized paediatric preparations显示文摘3D printing is a promising technology used in the fabrication of complex oral dosage delivery pharmaceuticals.This study first reports an innovative color jet 3D printing(CJ-3DP)technology to produce colorful cartoon levetiracetam pediatric preparations with high accuracy and reproducibility.For this study,the ideal printing ink consisted of 40%(v/v)isopropanol aqueous solution containing 0.05%(w/w)polyvinylpyrrolidone and 4%(w/w)glycerin,which was satisfied with scale-up of the production.The external and internal spatial structures of the tablets were designed to control the appearance and release,and cartoon tablets with admirable appearances and immediate release characteristics were printed.The dosage model showed a good linear relationship between the model volume and the tablet strength(r>0.999),which proved the potential of personalized administration.The surface roughness indicated that the appearance of the CJ-3DP tablets was significantly better than the first listed 3D printed drug(Spritam R).Moreover,the scanning electron microscopy and porosity results further showed that the tablets have a structure of loose interior and tight exterior,which could ensure good mechanical properties and rapid dispersion characteristics simultaneously.In conclusion,the innovative CJ-3DP technology can be used to fabricate personalized pediatric preparations for improved compliance.Due to the stable formulation and fabrication process,this technology has the potential in scale-up production. | Zengming Wang Xiaolu Han Ruxin Chen Jingru Li Jing Gao Hui Zhang Nan Liu Xiang Gao Aiping Zheng | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，3： | 2 |
| 10 | Molecular Characterisation of the Faecal Microbiota in Patients with Type II Diabetes显示文摘 | Xiaokang Wu Chaofeng Ma Lei Han Muhammad Nawaz Fei Gao Xuyan Zhang Pengbo Yu Chang’an Zhao Lianchuan Li Aiping Zhou Juan Wang John E. Moore B. Cherie Millar Jiru Xu | 2010 | Current Microbiology2010，，1： | 2 |
| 11 | Correlation between cold and hot pattern in traditional Chinese medicine and gene expression profiles in rheumatoid arthritis显示文摘Clinical manifestations of rheumatoid arthritis(RA)are diversified,and based on the manifestations,the patients with RA could be classified into different patterns under traditional Chinese medicine.These patterns decide the selection of herbal prescription,and thus they can help find a subset of rheumatoid arthritis patients for a type of therapy.In the present study,we combine genome-wide expression analysis with methods of systems biology to identify the functional gene networks for the sets of clinical symptoms that comprise the major information for pattern classification.Clinical manifestations in rheumatoid arthritis were clustered with factor analysis,and two factors(similar to cold and hot patterns in traditional Chinese medicine)were found.Microarray technology was used to reveal gene expression profiles in CD4^(+)T cells from 21 rheumatoid arthritis patients.Protein-protein interaction information for these genes from databases and literature data was searched.The highly-connected regions were detected to infer significant complexes or pathways in this protein-protein interaction network.The significant pathways and function were extracted from these subnetworks using the Biological Network Gene Ontology tool.The genes significantly related to hot and cold patterns were identified by correlations analysis.MAPK signalling pathway,Wnt signaling pathway,and insulin signaling pathway were found to be related to hot pattern.Purine metabolism was related to both hot and cold patterns.Alanine,aspartate,and tyrosine metabolism were related to cold pattern,and histindine metabolism and lysine degradation were related to hot pattern.The results suggest that cold and hot patterns in traditional Chinese medicine were related to different pathways,and the network analysis might be used for identifying the pattern classification in other diseases. | Miao Jiang Cheng Xiao Gao Chen Cheng Lu Qinglin Zha Xiaoping Yan Weiping Kong Shijie Xu Dahong Ju Pu Xu Youwen Zou Aiping Lu | 2011 | Frontiers of Medicine2011，5，2： | 2 |
| 12 | Total flavonoids of Astragalus membranaceus protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice by inhibiting ferroptosis through SLC7A11/GPX-4 signaling pathway显示文摘Parkinson’s disease(PD)is a common neurodegenerative disorder with no cure.Astragalus membranaceus is used in Chinese culture as a food supplement to boost immunity.The present study aimed to explore the neuroprotective effects of total flavonoids extracted from A.membranaceus(TFA)and their protective mechanisms.TFA offered neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)in the mouse model of Parkinsonism,by improving behavior performance in the gait analysis and pole test,and inhibiting the decline of tyrosine hydroxylase(TH)positive neurons and TH protein expression in substantia nigra of mice.TFA also prevented 1-methyl-4-phenylpyridinium(MPP+)induced neurotoxicity in SHSY5Y cells,by increasing GSH and GSH/GSSG ratio,and reducing reactive oxygen species.In addition,the neuroprotective effects of TFA were associated with its ability to restore MPTP/MPP+induced downregulation of SLC7A11 and glutathione peroxidase 4(GPX-4).In conclusion,we demonstrated that TFA exerted significant neuroprotection against MPTP/MPP+induced neurodegeneration by inhibiting ferroptosis through the regulation of SLC7A11/GPX-4 axis,suggesting the use of TFA as a possible food supplement in the prevention of PD. | Zitian Gao Gaorui Wang Yujie Chen Wuke Yuan Jun Cai Aiping Feng Jie Fang Qi Xu Xiaojun Wu | 2024 | Food Science and Human Wellness2024，13，1： | 1 |
| 13 | Completeness of Eigenfunctions of Sturm-Liouville Problems with Transmi-ssion Conditions 显示文摘 | Aiping Wang Jiong Sun Pengfei Gao | 2005 | J Speetral Math Appl2005，，： | 1 |
| 14 | Oxygen-Containing Functional Groups Regulating the Carbon/Electrolyte Interfacial Properties Toward Enhanced K^(+)Storage显示文摘Oxygen-containing functional groups were found to e ectively boost the K^(+)storage performance of carbonaceous materials,however,the mechanism behind the performance enhancement remains unclear.Herein,we report higher rate capability and better long-term cycle performance employing oxygen-doped graphite oxide(GO)as the anode material for potassium ion batteries(PIBs),compared to the raw graphite.The in situ Raman spectroscopy elucidates the adsorption-intercalation hybrid K^(+)storage mechanism,assigning the capacity enhancement to be mainly correlated with reversible K^(+)adsorption/desorption at the newly introduced oxygen sites.It is unraveled that the C=O and COOH rather than C-O-C and OH groups contribute to the capacity enhancement.Based on in situ Fourier transform infrared(FT-IR)spectra and in situ electrochemical impedance spectroscopy(EIS),it is found that the oxygen-containing functional groups regulate the components of solid electrolyte interphase(SEI),leading to the formation of highly conductive,intact and robust SEI.Through the systematic investigations,we hereby uncover the K^(+)storage mechanism of GO-based PIB,and establish a clear relationship between the types/contents of oxygen functional groups and the regulated composition of SEI. | Yufan Peng Zhen Chen Rui Zhang Wang Zhou Peng Gao Jianfang Wu Hui Liu Jilei Liu Aiping Hu Xiaohua Chen | 2021 | Nano-Micro Letters2021，13，12： | 1 |
| 15 | A generalized Gronwall inequality and its application to a fractional differential equation显示文摘 | Ye H aiping Gao Jianming Ding Yongsheng | 2007 | J Math Anal Appl2007，328，2： | 1 |
| 16 | Continuous spinning of a single-walled carbon nanotube-nylon com- posite fiber显示文摘 | Gao Junbo Mikhail E I Yu Aiping | 2005 | Journal of The American Chemical Soci- ety2005，127，11： | 1 |
| 17 | Ultrasound-assisted extraction of polysaccharides from litchi seed by response surface methodology and their structural characteristics 显示文摘 | Chen Yeyuan Luo Haiyan Gao Aiping | 2011 | Innovative Food Science and Emerging Technologies2011，，30： | 1 |
| 18 | Chrysanthemum CmWRKY53 negatively regulates the resistance of chrysanthemum to the aphid Macrosiphoniella sanborni显示文摘Chrysanthemum is frequently attacked by aphids,which greatly hinders the growth and ornamental value of this plant species.WRKY transcription factors play an important role in the response to biotic stresses such as pathogen and insect stresses.Here,chrysanthemum CmWRKY53 was cloned,and its expression was induced by aphid infestation.To verify the role of CmWRKY53 in resistance to aphids,CmWRKY53 transgenic chrysanthemum was generated.CmWRKY53 was found to mediate the susceptibility of chrysanthemum to aphids.The expression levels of secondary metabolite biosynthesis genes,such as peroxidase-and polyphenol oxidase-encoding genes,decreased in CmWRKY53-overexpressing(CmWRKY53-Oe)plants but dramatically increased in chimeric dominant repressor(CmWRKY53-SRDX)plants,suggesting that CmWRKY53 contributes to the susceptibility of chrysanthemum to aphids,possibly due to its role in the regulation of secondary metabolites. | Wanwan Zhang Tianwei Gao Peiling Li Chang Tian Aiping Song Jiafu Jiang Zhiyong Guan Weimin Fang Fadi Chen Sumei Chen | 2020 | Horticulture Research2020，7，1： | 1 |
| 19 | A Credit Card Fraud Detection Model Based on Multi-Feature Fusion and Generative Adversarial Network显示文摘Credit Card Fraud Detection(CCFD)is an essential technology for banking institutions to control fraud risks and safeguard their reputation.Class imbalance and insufficient representation of feature data relating to credit card transactions are two prevalent issues in the current study field of CCFD,which significantly impact classification models’performance.To address these issues,this research proposes a novel CCFD model based on Multifeature Fusion and Generative Adversarial Networks(MFGAN).The MFGAN model consists of two modules:a multi-feature fusion module for integrating static and dynamic behavior data of cardholders into a unified highdimensional feature space,and a balance module based on the generative adversarial network to decrease the class imbalance ratio.The effectiveness of theMFGAN model is validated on two actual credit card datasets.The impacts of different class balance ratios on the performance of the four resamplingmodels are analyzed,and the contribution of the two different modules to the performance of the MFGAN model is investigated via ablation experiments.Experimental results demonstrate that the proposed model does better than state-of-the-art models in terms of recall,F1,and Area Under the Curve(AUC)metrics,which means that the MFGAN model can help banks find more fraudulent transactions and reduce fraud losses. | Yalong Xie Aiping Li Biyin Hu Liqun Gao Hongkui Tu | 2023 | Computers, Materials & Continua2023，76，9： | 1 |
| 20 | Growth of aligned carbon nanotube arrays on metallic substrate and its application to supercapacitors 显示文摘 | Gao Lijun Peng Aiping | 2008 | Solid State Communications2008，146，： | 1 |
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