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| 1 | Antigenic variation of the human influenza A(H3N2) virus during the 2014–2015 winter season显示文摘The human influenza A(H3N2) virus dominated the 2014–2015 winter season in many countries and caused massive morbidity and mortality because of its antigenic variation. So far, very little is known about the antigenic patterns of the recent H3N2 virus. By systematically mapping the antigenic relationships of H3N2 strains isolat ed since 2010, we discov ered that two groups with obvious antigenic divergence, named SW13(A/Switzerland/9715293/2013-like strains) and HK14(A/Hong Kong/5738/2014-like strains), co-circulated during the 2014–2015 winter season. HK14 group co-circulated with SW13 in Europe and the United States during this season, while there were few strains of HK14 in China's Mainland, where SW13 has dominated since 2012. Furthermore, we found that substitutions near the receptor-binding site on hemagglutinin played an important role in the antigenic variation of both the groups. These findings provide a comprehensive understanding of the recent antigenic evolution of H3N2 virus and will aid in the selection of vaccine strains. | HUA Sha LI XiYan LIU Mi CHENG YanHui PENG YouSong HUANG WeiJuan TAN MinJu WEI HeJiang GUO JunFeng WANG DaYan WU AiPing SHU YueLong JIANG TaiJiao | 2015 | Science China(Life Sciences)2015，58，9： | 17 |
| 2 | Sedimentary Records of Mangrove Evolution During the Past one Hundred Years Based on Stable Carbon Isotope and Pollen Evidences in Maowei, SW China显示文摘Mangroves accumulate sedimentary sequences, where cores can provide historical records of mangrove evolution with past climate change and human activity. The study traced the history of mangrove evolution during the past one hundred years in a mangrove swamp of Maowei Sea, SW China. The sedimentation rates(0.38-0.95 cm yr^(-1)) were calculated on the basis of ln(^(210)Pb_(xs)/Al) and mass depth in the core sediments. Chemical tracers, such as δ^(13)C_(org) and C:N values, were utilized to trace the contribution of mangrove-derived organic matter using a ternary mixing model. Because of potential diagenetic alteration and / or overlap in the isotopic signatures of different components, simultaneous use of mangrove pollen diagrams can help to supplement some of these limitations. Combined with mangrove pollen, mangrove evolution was reconstructed and could be divided into three stages: flourishment(1886-1905 AD), slight degradation(1905-1949 AD) and rapid degradation period(1949-2007 AD), which was consistent with previous reports. The reclamation of mangrove swamps to shrimp ponds was the major reason for rapid degradation of mangrove ecosystems in recent years, rather than climate change in the region. | XIA Peng MENG Xianwei LI Zhen FENG Aiping | 2016 | Journal of Ocean University of China2016，15，3： | 3 |
| 3 | Organic carbon isotope and pollen evidence for mangrove development and response to human activity in Guangxi(Southwest China) over the last 140 years显示文摘Mangrove degradation must reduce carbon sequestration in recent years, thereby aggravating global warming.Thus, short-term impacts of human activity on mangrove ecosystems are cause for concern from local governments and scientists. Mangroves sediments can provide detailed records of mangrove species variation in the last one hundred years, based on detailed 210 Pb data. The study traced the history of mangrove development and its response to environmental change over the last 140 years in two mangrove swamps of Guangxi, Southwest China. Average sedimentation rates were calculated to be 0.48 cm/a and 0.56 cm/a in the Yingluo Bay and the Maowei Sea, respectively. Chemical indicators(δ13Corg and C:N) were utilized to trace the contribution of mangrove-derived organic matter(MOM) using a ternary mixing model. Simultaneous use of mangrove pollen can help to supplement some of these limitations in diagenetic/overlap of isotopic signatures. We found that vertical distribution of MOM was consistent with mangrove pollen, which could provide similar information for tracing mangrove ecosystems. Therefore, mangrove development was reconstructed and divided into three stages: flourishing, degradation and re-flourishing/re-degradation period. The significant degradation, found in the period of 1968–1998 and 1907–2007 in the Yingluo Bay and the Maowei Sea, respectively, corresponding to a rapid increase of reclamation area and seawall length, rather than climate change as recorded in the region. | XIA Peng MENG Xianwei LI Zhen FENG Aiping | 2017 | Acta Oceanologica Sinica2017，36，2： | 3 |
| 4 | Organic anion transporters also mediate the drug–drug interaction between imipenem and cilastatin显示文摘This study aimed to clarify that organic anion transporters(OATs)mediate the drug–drug interaction(DDI)between imipenem and cilastatin.After co-administration with imipenem,the plasma concentrations and the plasma concentration-time curve(AUC)of cilastatin were significantly increased,while renal clearance and cumulative urinary excretion of cilastatin were decreased.At the same time,imipenem significantly inhibited the uptake of cilastatin in rat kidney slices and in human OAT1(hOAT1)-HEK293 and human OAT3(hOAT3)-HEK293 cells.Probenecid,p-aminohippurate,and benzylpenicillin inhibited the uptake of imipenem and cilastatin in rat kidney slices and in hOAT1-and hOAT3-HEK 293 cells,respectively.The uptakes of imipenem and cilastatin in hOAT1-and hOAT3-HEK 293 cells were significantly higher than that in mock-HEK-293 cells.Moreover,the K m values of cilastatin were increased in the presence of imipenem with unchanged V max,indicating that imipenem inhibited the uptake of cilastatin in a competitive manner.When imipenem and cilastatin were co-administered,the level of imipenem was higher compared with imipenem alone both in vivo and in vitro.But,cilastatin significantly inhibited the uptake of imipenem when dehydropeptidase-1(DPEP1)was silenced by RNAi technology in hOAT1-and hOAT3-HEK 293 cells.In conclusion,imipenem and cilastatin are the substrates of OAT1 and OAT3.OAT1 and OAT3 mediate the DDI between imipenem and cilastatin.Meanwhile,cilastatin also reduces the hydrolysis of imipenem by inhibiting the uptake of imipenem mediated by OAT1 and OAT3 in the kidney as a complement. | Yanna Zhu Xiaokui Huo Changyuan Wang Qiang Meng Zhihao Liu Huijun Sun Aiping Tan Xiaodong Ma Jinyong Peng Kexin Liu | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 3 |
| 5 | ^(210)Pb Chronology and Trace Metal Geochemistry in the Intertidal Sediment of Qinjiang River Estuary, China显示文摘Historical records of metal inputs were studied by using a sediment core collected from a sand-rich mudflat in the Qinjiang River estuary, China. 210Pb chronology was used to reconstruct the fluxes of Hg, Cu, Pb, Zn, Cd, Cr and As to the core site during the last 86 years. Based on the constant initial concentration model, the sedimentation rates are 1.18 cm year-1 in the top 30 cm sandy layer and 0.92 cm year-1 in the muddy bottom layer. To compensate for grain-size and mineralogy effects on metal concentra-tions, aluminum was used as the normalizing element. The enrichment factors (EF) indicate that the natural inputs had prevailed up to the early 1980s. After this period, the intensity of human activities has resulted in continual increasing trend of metals towards the surface. Recent sediment samples from the Qinjiang River estuary are found moderately enriched by Cd (EF>1.5) and slightly enriched by other metals (EF<1.5). Considering that the drainage area of the Qinjiang River is mostly agricultural land, the increased Cd may be due to the usage of fertilizers and pesticides in agricultural activities and the combustion of fossil fuels. | XIA Peng MENG Xianwei FENG Aiping YIN Ping WANG Xiangqin ZHANG Jun | 2012 | Journal of Ocean University of China2012，11，2： | 2 |
| 6 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 7 | Dengue Fever Outbreaks Caused by Varied Serotype Dengue Virus--Guangdong Province,China,2019显示文摘What is already known about this topic?Dengue fever(DF)outbreaks affect hundreds of millions of people worldwide and have increased significantly in Guangdong Province in 2019.What is added by this report?This paper described briefly DF outbreaks were attributed to several types of dengue virus(DENV)including DENV-1,DENV-2,and DENV-3 in 2019 in Guangdong,tracked the sources of viruses through phylogenetic analysis and epidemiological investigation,and primarily revealed the epidemiological links among the outbreaks.What are the implications for public health practice?The introduction of DENV from DF endemic areas increased pressure on the prevention and control of DF in Guangdong.Early detection of suspected cases and typing and genotyping of circulating viruses should be prioritized and enhanced to promptly assess the likelihood of local transmission,of introduction,and of subsequent sustained local transmission of the virus to implement optimal prevention and control strategies and measures. | De Wu Xin Zhang Aiping Deng Huan Zhang Yintao Zhang Qiqi Tan Zhiqiang Peng Jiandong Li Tie Song | 2020 | China CDC weekly2020，2，38： | 1 |
| 8 | 2012, Geochemical characteristics of heavy metals in coastal sediments from the northern Beibu Gulf (SW China): the background levels and recent contamination显示文摘 | XIA PENG MENG XIANWEI FENG AIPING | 2012 | Environ- mental Earth Science2012，66，5： | 1 |
| 9 | Oxygen-Containing Functional Groups Regulating the Carbon/Electrolyte Interfacial Properties Toward Enhanced K^(+)Storage显示文摘Oxygen-containing functional groups were found to e ectively boost the K^(+)storage performance of carbonaceous materials,however,the mechanism behind the performance enhancement remains unclear.Herein,we report higher rate capability and better long-term cycle performance employing oxygen-doped graphite oxide(GO)as the anode material for potassium ion batteries(PIBs),compared to the raw graphite.The in situ Raman spectroscopy elucidates the adsorption-intercalation hybrid K^(+)storage mechanism,assigning the capacity enhancement to be mainly correlated with reversible K^(+)adsorption/desorption at the newly introduced oxygen sites.It is unraveled that the C=O and COOH rather than C-O-C and OH groups contribute to the capacity enhancement.Based on in situ Fourier transform infrared(FT-IR)spectra and in situ electrochemical impedance spectroscopy(EIS),it is found that the oxygen-containing functional groups regulate the components of solid electrolyte interphase(SEI),leading to the formation of highly conductive,intact and robust SEI.Through the systematic investigations,we hereby uncover the K^(+)storage mechanism of GO-based PIB,and establish a clear relationship between the types/contents of oxygen functional groups and the regulated composition of SEI. | Yufan Peng Zhen Chen Rui Zhang Wang Zhou Peng Gao Jianfang Wu Hui Liu Jilei Liu Aiping Hu Xiaohua Chen | 2021 | Nano-Micro Letters2021，13，12： | 1 |
| 10 | Network of co-mutations in Ebola virus genome predicts the disease lethality显示文摘 | Lizong Deng Mi Liu Sha Hua Yousong Peng Aiping Wu F Xiao-Feng Qin Genhong Cheng Taijiao Jiang | 2015 | Cell Research2015，25，6： | 1 |
| 11 | Growth of aligned carbon nanotube arrays on metallic substrate and its application to supercapacitors 显示文摘 | Gao Lijun Peng Aiping | 2008 | Solid State Communications2008，146，： | 1 |
| 12 | Responsive plas- monie assemblies of amphiphilie nanoerystals at oil-water interfaees显示文摘 | Cheng Lin Liu Aiping Peng Shuo | 2010 | ACS Nano2010，4，10： | 1 |
| 13 | Constitutive expression of a chrysanthemum phospholipase Dα gene in Chrysanthemum morifolium enhances drought tolerance显示文摘Drought causes water shortage and consequent retardation of plants growth and development.Therefore,improving the drought tolerance of plants is necessary for expanding cultivation and resource promotion.Increasing evidence indicates that phospholipase is involved in the response of plants to drought stress.The objective of this study was to create new drought-tolerant chrysanthemum germplasm,which lays a foundation for the study of the molecular mechanism of phospholipase mediated stress response in chrysanthemum.CmPLDαhas the closest relationship with sunflower HaPLDα,and belongs to the PLDαfamily.CmPLDαover-expressing plants showed a slight shrinking under 20%PEG6000 treatment.The survival rate increased significantly by 1.7−1.8 times that of the wild type.Relative water content(RWC)of CmPLDαover-expressing plants were nearly 10%higher than that of the wild type.Relative electrical conductivity and MDA content were significantly lower than those of the wild type.ABA content of the over-expression lines Z1,Z2 were 1.3 and 1.22 times that of wild type,but ABA content of antisense lines F1,F2 was approximately 0.83 and 0.81 of those of wild type.Most plants of antisense transgenic lines F1,F2 were wrinkled,with a wilting index of 5 and 6,and the survival rate was also lower than that of the wild type after recovery growth.RWC of antisense lines were lower than over-expression lines,relative electrical conductivity and MDA content were significantly higher than those of the wild type.In summary,CmPLDαcould enhance tolerance of chrysanthemum to drought conditions. | Lisheng Zhai Xiaochen Zhu Shujin Yang Chunsun Gu Peng Liu Aiping Song Jiafu Jiang Zhiyong Guan Weimin Fang Fadi Chen Sumei Chen | 2021 | Ornamental Plant Research2021，1，1： | 1 |
| 14 | Unraveling the decomposition mechanism of Li_(2)CO_(3)in the aprotic medium by isotope-labeled differential electrochemical mass spectrometry显示文摘Rechargeable lithium-ion batteries(LIBs)represent the highest energy density in the contemporary energy storage community,typically delivering a practical energy density of 150-350 Wh kg-1in the current technique,which can hardly satisfy the evergrowing demand for the portable electronic devices and power tools requiring long service time[1-3]. | Lipo Ma Aiping Wang Shoufeng Zhang Peng Zhang Jiawei Wang | 2022 | Journal of Energy Chemistry2022，31，10： | 0 |
| 15 | Modeling and Verification of an Astronaut Handling Large-mass Payload显示文摘The experiments on astronaut motions are difficult to conduct due to the limitation and high cost of constructing or simulating the microgravity environment of space. Therefore, the method of computer simulation on astronaut extravehicular activity is broadly promoted. However, validations and verifications for these simulations stated in related literatures are incomplete such as comparing with the limits of human body movements or reconstructing a three-dimensional movement for some parts of EVA video. Novel modeling and verification methods for the task of an astronaut handling large-mass payload during EVA were revealed. A simplified model of an astronaut was constructed, and the astronaut motion was conceived as a planar movement of a multi-body system which includes seven segments with six revolute joints in the human body sagittal plane. The inverse kinematics method was used to calculate joint angles, joint velocities, and joint accelerations in time domain. The solution of joint torques using the inverse recursive dynamics was achieved. Furthermore, a virtual model with the ADAMSTM software was developed and implemented to verify the results by adding the kinematical data calculated to joints in order to achieve the trace of the center of mass of the hand. Additionally, the joints kinematics and kinetics data with time in the virtual model were obtained and compared with the corresponding calculated data. This result indicates that the modeling methods proposed can be employed as a solid algorithm to conduct the simulation of astronaut’s tasks in EVA, and verification using the virtual model can be easily operated and has a good accuracy. This study provides an effective and economical way of modeling and simulation for extravehicular missions. | YANG Aiping YANG Chunxin KE Peng | 2010 | Chinese Journal of Mechanical Engineering2010，23，4： | 0 |
| 16 | Role of the STAT3/survivin signaling pathway in the EML4-ALK-positive lung adenocarcinoma cell line H2228 before and after crizotinib-induced resistance显示文摘Objective This study investigated the role of the STAT3/survivin signaling pathway in the EML4-ALK–positive lung adenocarcinoma cell line H2228 before and after crizotinib-induced resistance. The mechanism of resistance was studied. Methods Cell viability was determined using the MTT assay. Crizotinib-induced apoptosis in H2228 and H2228 crizotinib-resistant cells treated with the indicated doses of crizotinib was measured at different times(24 h, 48 h, 72 h) using flow cytometry. The levels of p-ALK, ALK, p-STAT3, STAT3, and survivin after treatment of cells with 0, 0.3, and 1 μM crizotinib for 72 h were determined using Western blot analysis. DNA sequencing was used to identify mutations in H2228 crizotinib-resistant cells. Results The crizotinib IC50 values in H2228 and H2228 crizotinib-resistant cells at 72 h were 334.5 n M and 3418 n M, respectively. The resistance index of H2228 crizotinib-resistant cells was 10.20. Crizotinib induced apoptosis in H2228 cells and reduced the levels of p-ALK, p-STAT3, and survivin. In contrast, no changes in the levels of p-ALK, p-STAT3, and survivin were observed in H2228 crizotinib-resistant cells. The mutations 2067G→A and 2182G→C in EML4-ALK were present in the H2228 crizotinib-resistant cells. Conclusion Crizotinib decreased the viability of H2228 cells in a dose- and time-dependent manner. In the STAT3/survivin pathway, downregulation of p-ALK, p-STAT3, and survivin might contribute to crizotinib-induced apoptosis in H2228 cells. However, the STAT3/survivin pathway in H2228 crizotinib-resistant cells was unaffected by crizotinib treatment. Acquired resistance in H2228 cells might be related to ALK mutations. | Haiyan Peng Wenhua Zhao Cuiyun Su Xiangqun Song Aiping Zeng Huilin Wang Ruiling Ning Shaozhang Zhou | 2015 | The Chinese-German Journal of Clinical Oncology2015，14，2： | 0 |
| 17 | Progress and Challenge in Computational Identification of Influenza Virus Reassortment显示文摘Genomic reassortment is an important evolutionary mechanism for influenza viruses.In this process,the novel viruses acquire new characteristics by the exchange of the intact gene segments among multiple influenza virus genomes,which may cause flu endemics and epidemics within or even across hosts.Due to the safety and ethical limitations of the experimental studies on influenza virus reassortment,numerous computational researches on the influenza virus reassortment have been done with the explosion of the influenza virus genomic data.A great amount of computational methods and bioinformatics databases were developed to facilitate the identification of influenza virus reassortments.In this review,we summarized the progress and challenge of the bioinformatics research on influenza virus reassortment,which can guide the researchers to investigate the influenza virus reassortment events reasonably and provide valuable insight to develop the related computational identification tools. | Xiao Ding Luyao Qin Jing Meng Yousong Peng Aiping Wu Taijiao Jiang | 2021 | Virologica Sinica2021，36，6： | 0 |
| 18 | Dynamic emission characteristics and control strategies of air pollutants from motor vehicles in downtown Beijing,China显示文摘This study combined the real-time monitoring and investigation of traffic flows to comprehensively analyze the road traffic flow and vehicle structure in downtown Beijing.A dynamic emission inventory of motor vehicle air pollutants in downtown Beijing in 2021 was established,and the impact of these emissions on air quality was simulated and quantified,and different emission reduction control scenarios were proposed to evaluate their environmental improvement effects and explore measures to mitigate the impact of pollution emissions.The results show that the high traffic flow and the structure of the motor vehicle emissions in downtown Beijing are the main causes of severe motor vehicle pollution.Monitoring data shows that traffic flow in central Beijing is dominated by small passenger vehicles,while the vehicle mix is better than in other regions,with 72.0%of vehicles meeting'National V'or higher emission standards.However,to achieve higher air quality goals,further reducing vehicle emissions is necessary.Based on dynamic traffic flow,the average daily emissions of nitrogen oxides(NOX),particulate matters(PM_(2.5))and volatile organic compounds(VOC)from motor vehicles in central Beijing are 17.7 tons,0.6 tons and 14.0 tons,respectively,accounting for 23.0%of the city’s average daily motor vehicle emissions.If a zero-emission zone for motor vehicles were implemented in central Beijing,the annual average emission level of pollutants will be reduced by 10.4%to 21.0%.The designation of ultra-low emission zones for motor vehicles could be effective in improving the air quality in the center of Beijing. | Yan Shen Tongran Wu Aiping Lian Jie Gao Fei Peng Guohua Song Xuefang Wu Yangyang Cui Xinyu Liu Yunfei Wan Jing Yan Yifeng Xue | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 19 | PREDAV-H1: a user-friendly web server for predicting antigenic variants of influenza H1N1 viruses显示文摘Dear Editor,The influenza H1N1 virus has caused three global pandemics since the beginning of the 20th century(Liu et al.,2015).The first is the notorious Spanish flu in 191&which killed 20-100 million people in the world.It circulated for nearly 40 years and was replaced by influenza H2N2 virus.In 1977,the virus reappeared in Russia and caused global pandemics.It continued to circulate until 2009 when it was replaced by the pandemic H1N1 virus.Influenza H1N1 viruses cause large morbidity and mortality to human society,and will continue to threaten humans.Vaccination is the most effective way to fight against the virus.However,due to rapid mutation of the virus,antigenic drift happens frequently,which leads to inefficiency of influenza vaccines.How to timely identify antigenic variants is an important question in influenza surveillance. | Congyu Lu Mi Liu Aiping Wu Yuelong Shu Yousong Peng Taijiao Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 0 |
| 20 | Identification of genome-wide nucleotide sites associated with mammalian virulence in influenza A viruses显示文摘The virulence of influenza viruses is a complex multigenic trait.Previous studies about the virulence determinants of influenza viruses mainly focused on amino acid sites,ignoring the influence of nucleotide mutations.In this study,we collected>200 viral strains from 21 subtypes of influenza A viruses with virulence in mammals and obtained over 100 mammalian virulence-related nucleotide sites across the genome by computational analysis.Fifty of these nucleotide sites only experienced synonymous mutations.Experiments showed that synonymous mutations in three high-scoring nucleotide sites,i.e.,PB1–2031,PB1–633,and PB1–720,enhanced the pathogenicity of the influenza A(H1N1)viruses in mice.Besides,machine-learning models with accepted accuracy for predicting mammalian virulence of influenza A viruses were built.Overall,this study highlighted the importance of nucleotide mutations,especially synonymous mutations in viral virulence,and provided rapid methods for evaluating the virulence of influenza A viruses.It could be helpful for early warning of newly emerging influenza A viruses. | Peng Yousong Zhu Wenfei Feng Zhaomin Zhu Zhaozhong Zhang Zheng Chen Yongkun Liu Suli Wu Aiping Wang Dayan Shu Yuelong Jiang Taijiao | 2020 | Biosafety and Health2020，2，1： | 0 |
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