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| 1 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 2 | Ecosystem health towards sustainability显示文摘Ecosystems are becoming damaged or degraded as a result of stresses especially associated with human activities.A healthy ecosystem is essential to provide the services that humans and the natural environment require and has tremendous social and economic value.Exploration of the definition of ecosystem health includes what constitutes health and what it means to be healthy.To evaluate ecosystem health,it is necessary to quantify ecosystem conditions using a variety of indicators.In this paper,the main principles and criteria for indicator selection,classification of indicators for different kinds of ecosystems,the most appropriate indicators for measuring ecosystem sustainability,and various methods and models for the assessment of ecosystem health are presented.Drivers,sustainability,and resilience are considered to be critical factors for ecosystem health and its assessment.Effective integration of ecological understanding with socioeconomic,biophysical,biogeochemical,and public-policy dimensions is still the primary challenge in this field,and devising workable strategies to achieve and maintain ecosystem health is a key future challenge. | Yonglong Lu Ruoshi Wang Yueqing Zhang Hongqiao Su Pei Wang Alan Jenkins Rober C.Ferrier Mark Bailey Geoff Squire | 2015 | Ecosystem Health and Sustainability2015，1，1： | 3 |
| 3 | Using a 3-D multicellular simulation of spinal cord injury with live cell imaging to study the neural immune barrier to nanoparticle uptake显示文摘nanoparticle (NP ) 的开发基于治疗在中央神经系统的地点支持新生(CNS;即大脑和针的绳索) 病理极其依靠在 vivo 提供 NP 命运的生物学上有效的预言的试验性的模型的可获得性。然而,有模仿病理学的复杂性的生物模型的主要缺乏在 vivo 指向神经地点,特别地居民的回答神经有免疫力的房间到 NP。这里,我们利用了一以前在创伤的针的绳索损害的 vitro 模型发展了(基于 3-D organotypic 片数组) 与动态时间消逝成像揭示在即时在损害 foci 以内的 NP 的尖锐细胞的命运。我们在由 CNS (microglia ) 的内在的有免疫力的房间揭示渴望的 NP 隐遁的很好记录的现象表明我们的模型的用途。如此的有免疫力的隐遁是对为神经病学的损害的基于 NP 的治疗学的使用的一个已知的翻译障碍。因此,我们建议我们在 mimicking microglial 隐遁行为的模型的用途提供一个珍贵研究工具评估策略在一个简单、生物学上相关的试验性的系统以内克服这细胞的回答,虽然减少神经病学的损害为如此的研究建模的活动物的使用。 | Alan P. Weightman Stuart I. Jenkins Divya M. Chari | 2016 | Nano Research2016，9，8： | 2 |
| 4 | Paclitaxel Stent Coating Inhibits Neointimal Hyperplasia at 4 Weeks in a Porcine Model of Coronary Restenosis显示文摘 | Alan W. Heldman Linda Cheng G. Mark Jenkins Phillip F. Heller Dong-Woon Kim Melvin Ware Cynthia Nater Ralph H. Hruban Banafsheh Rezai Benjamin S. Abella Katherine E. Bunge James L. Kinsella Steven J. Sollott Edward G. Lakatta Jeffrey A. Brinker William L. | 2001 | Circulation: Journal of the American Heart Association2001，，： | 1 |
| 5 | Evidence that Soil Carbon Pool Determines Susceptibility of Semi-Natural Ecosystems to Elevated Nitrogen Leaching显示文摘 | Christopher D. Evans Brian Reynolds Alan Jenkins Rachel C. Helliwell Christopher J. Curtis Christine L. Goodale Robert C. Ferrier Bridget A. Emmett Michael G. Pilkington Simon J. M. Caporn Jacky A. Carroll David Norris Jennifer Davies Malcolm C. Coull | 2006 | Ecosystems2006，，3： | 1 |
| 6 | Human herpesvirus 8 seroconversion in a population‐based cohort of men in Tobago显示文摘 | Alicia C. McDonald Frank J. Jenkins Clareann H. Bunker John W. Wilson Alan L. Patrick Joel L. Weissfeld | 2015 | J. Med. Virol2015，，： | 1 |
| 7 | The Burden of Acute Heart Failure on U.S. Emergency Departments显示文摘 | Alan B. Storrow Cathy A. Jenkins Wesley H. Self Pauline T. Alexander Tyler W. Barrett Jin H. Han Candace D. McNaughton Benjamin S. Heavrin Mihai Gheorghiade Sean P. Collins | 2014 | JACC: Heart Failure2014，，3： | 1 |
| 8 | Impacts of Elevated Carbon Dioxide and Temperature on a Boreal Forest Ecosystem (CLIMEX Project)显示文摘 | Nico van Breemen Alan Jenkins Richard F. Wright David J. Beerling Wim J. Arp Frank Berendse Claus Beier Rob Collins Douwe van Dam Lennart Rasmussen Paul S. J. Verburg Mark A. Wills | 1998 | Ecosystems1998，，4： | 1 |
| 9 | Device Closure Rates of Simple Atrial Septal Defects Optimized by the STARFlex Device显示文摘 | Alan W. Nugent Amy Britt Kimberlee Gauvreau Gary E. Piercey James E. Lock Kathy J. Jenkins | 2006 | Journal of the American College of Cardiology2006，，3： | 1 |
| 10 | 年龄相关性黄斑变性产生的脉络膜新生血管自发荧光成像显示文摘目的:描述年龄相关性黄斑变性(AMD)患者中脉络膜新生血管(CNV)的自发荧光(AF)特征。
方法:对连续的患者不同发展阶段的65只CNV眼的自发荧光图像作了分析。其中25幅图像为新近发生的CNV(第1组)。8幅为诊断CNV后1到6个月(第2组)。37幅为晚期CNV(第3组)。对第1组和第2组的自发荧光图像与荧光素眼底血管造影(FFA)图像进行了比较。
结果:第1组的20例中有16例显示FFA强荧光区与正常AF区相对应。13例的邻近区域显示为AF增强。20例中有18例异常AF的主要范围大于异常FFA荧光的主要范围。第2组和第3组显示AF减弱区对应于FFA原先渗漏区(在第2组)或者萎缩区。
结论:第1组中保存的AF提示视网膜色素上皮细胞(RIPE)仍有活性。这暗示了视力的预后。第2组和第3组AF降低提示RIPE和光感受器的丢失。自发荧光成像可以增进我们对年龄相关性黄斑变性中CNV的了解。 | Samantha S. Dandekar Sharon A. Jenkins Tunde Peto Hendrik P. N.Scholl Kulwant S. Sehmi Fred W. Fitzke Alan C. Bird Andrew R. Webster 李越(译) 惠延年(校) | 2006 | 美国医学会眼科杂志(中文版)2006，18，3： | 1 |
| 11 | Impacts of Elevated Carbon Dioxide and Temperature on a Boreal Forest Ecosystem (CLIMEX Project)显示文摘 | Nico van Breemen Alan Jenkins Richard F. Wright David J. Beerling Wim J. Arp Frank Berendse Claus Beier Rob Collins Douwe van Dam Lennart Rasmussen Paul S. J. Verburg Mark A. Wills | 1998 | Ecosystems1998，，4： | 1 |
| 12 | Exaggerated Left Ventricular Dilation and Reduced Collagen Deposition After Myocardial Infarction in Mice Lacking Osteopontin显示文摘 | Nathan A. Trueblood Zhonglin Xie Catherine Communal Flora Sam Soeun Ngoy Lucy Liaw Alan W. Jenkins Jing Wang Douglas B. Sawyer Oscar H.L. Bing Carl S. Apstein Wilson S. Colucci Krishna Singh | 2001 | Circulation Research: Journal of the American Heart Association2001，，10： | 1 |
| 13 | Evidence that Soil Carbon Pool Determines Susceptibility of Semi-Natural Ecosystems to Elevated Nitrogen Leaching显示文摘 | Christopher D. Evans Brian Reynolds Alan Jenkins Rachel C. Helliwell Christopher J. Curtis Christine L. Goodale Robert C. Ferrier Bridget A. Emmett Michael G. Pilkington Simon J. M. Caporn Jacky A. Carroll David Norris Jennifer Davies Malcolm C. Coull | 2006 | Ecosystems2006，，3： | 1 |
| 14 | Impacts of Elevated Carbon Dioxide and Temperature on a Boreal Forest Ecosystem (CLIMEX Project)显示文摘 | Nico van Breemen Alan Jenkins Richard F. Wright David J. Beerling Wim J. Arp Frank Berendse Claus Beier Rob Collins Douwe van Dam Lennart Rasmussen Paul S. J. Verburg Mark A. Wills | 1998 | Ecosystems1998，，4： | 1 |
| 15 | Impacts of Elevated Carbon Dioxide and Temperature on a Boreal Forest Ecosystem (CLIMEX Project)显示文摘 | Nico van Breemen Alan Jenkins Richard F. Wright David J. Beerling Wim J. Arp Frank Berendse Claus Beier Rob Collins Douwe van Dam Lennart Rasmussen Paul S. J. Verburg Mark A. Wills | 1998 | Ecosystems1998，，4： | 1 |
| 16 | The murine perilipin gene: the lipid droplet-associated perilipins derive from tissue-specific, mRNA splice variants and define a gene family of ancient origin显示文摘 | Xinyue Lu Jasmine Gruia-Gray Neal G. Copeland Debra J. Gilbert Nancy A. Jenkins Constantine Londos Alan R. Kimmel | 2001 | Mammalian Genome2001，，9： | 1 |
| 17 | Impacts of Elevated Carbon Dioxide and Temperature on a Boreal Forest Ecosystem (CLIMEX Project)显示文摘 | Nico van Breemen Alan Jenkins Richard F. Wright David J. Beerling Wim J. Arp Frank Berendse Claus Beier Rob Collins Douwe van Dam Lennart Rasmussen Paul S. J. Verburg Mark A. Wills | 1998 | Ecosystems1998，，4： | 1 |
| 18 | Mapping Critical Loads of Acid Deposition for Soils in China显示文摘A method described is to produce critical load maps of acid deposition for soils in China. Critical loads were assigned to the most sensitive soil in each 0.1°×0.1° grid square of China based on the Skokloster classification [1] and adjusted for temperature and land use. The map shows that soils with small critical load (<0.5keq·ha -1 ·a -1 ) i.e., highly sensitive to acid deposition, dominate in the south and northeast China. As a result of the adjustment, much of the acid sensitive area in the south estimated by the Skokloster method is lost. This reflects the decreased sensitivity as a result of agricultural activities and increased weathering rate in response to high temperature. Based on the 0.1°×0.1° map, a series of percentile critical load maps at 1°×1° scale were compiled for integrated assessments, as well as a critical load map using the minimum critical load for each grid. Comparison of critical loads with sulphur deposition in 1995 led to the critical load exceedance maps for sulphur deposition, which show that high exceedance areas do not correlate well with the low critical load areas, and almost one fourth of the land area, mainly in the southeast, is subject to the risk of acidification. | 段雷 郝吉明 Alan Jenkins' Rob Collins Chris Evans 谢绍东 | 2000 | Tsinghua Science and Technology2000，5，3： | 1 |
| 19 | Impacts of Elevated Carbon Dioxide and Temperature on a Boreal Forest Ecosystem (CLIMEX Project)显示文摘 | Nico van Breemen Alan Jenkins Richard F. Wright David J. Beerling Wim J. Arp Frank Berendse Claus Beier Rob Collins Douwe van Dam Lennart Rasmussen Paul S. J. Verburg Mark A. Wills | 1998 | Ecosystems1998，，4： | 1 |
| 20 | Interaction between pollution and climate change augments ecological risk to a coastal ecosystem显示文摘Pollution and climate change are among the most challenging issues for countries with developing economies,but we know little about the ecological risks that result when these pressures occur together.We explored direct effects of,and interactions between,environmental pollution and climate change on ecosystem health in the Bohai Sea region of Northern China.We developed an integrated approach to assess ecological risks to this region under four scenarios of climate change.Although ecological risks to the system from pollution alone have been declining,interactions between pollution and climate change have enhanced ecological risks to this coastal/marine ecosystem.Our results suggest that current policies focused strictly on pollution control alone should be changed to take into account the interactive effects of climate change so as to better forecast and manage potential ecological risks. | Yonglong Lu Ruoshi Wang Yajuan Shi Chao Su Jingjing Yuan Andrew C.Johnson Alan Jenkins Robert C.Ferrier Deliang Chen Hanqin Tian Jerry Melillo Shuai Song Aaron M.Ellison | 2018 | Ecosystem Health and Sustainability2018，4，7： | 0 |
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