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| 1 | 内皮细胞和平滑肌细胞氧化应激时Nrf2/ARE信号通路对抗氧化基因表达的调控:与动脉粥样硬化和先兆子痫的关系显示文摘动脉粥样硬化、糖尿病、慢性肾功能衰竭和先兆子痫等血管疾病时活性氧(reactive oxygen species,ROS)生成增加,容易导致内皮依赖性血管舒张功能的损害和血管损伤,而细胞可以诱导多种编码Ⅱ相解毒酶和抗氧化蛋白的基因表达,从而减轻ROS和亲电子物质介导的细胞损伤。一个被称为抗氧化反应元件(antioxidant response element,ARE)或亲电子反应元件(electrophile response element,EpRE)的顺式转录调控元件,可以介导诸如亚铁血红素加氧酶1、γ-谷氨酰半胱氨酸合成酶、硫氧还蛋白还原酶、谷胱甘肽-S转移酶和NAD(P)H:苯醌氧化还原酶等基因的转录。其他抗氧化酶,如超氧化物歧化酶、过氧化氢酶和非酶清除剂(如谷胱甘肽)等也参与ROS的清除。转录因子NF-E2相关因子2(nuclear factor-erythroid 2-related factor 2, Nrf2)是属于Cap‘n’Collar家族的转录因子,具有碱性亮氨酸拉链(basic region-leucine zipper,bZIP),它在ARE介导的抗氧化基因表达中起重要的作用。在正常情况下,Kelch样环氧氯丙烷相关蛋白-1(Kelch-like ECH-associated protein-1,Keapl)与Nrf2耦联,并与肌动蛋白细胞骨架结合被锚定于胞浆,但是在半胱氨酸残基发生氧化的情况下,Nrf2和Keapl解耦联,进入细胞核并与ARE结合,从而激活多种抗氧化基因和Ⅱ相解毒酶基因的转录。蛋白激酶C、丝裂原活化蛋白激酶和磷脂酰肌醇-3激酶参与Nrf2/ARE信号转导的调控。本文综述了有关Nrf2/ARE信号转导通路在血管稳态和动脉硬化、先兆子痫等疾病情况下内皮及平滑肌细胞对抗持续性氧化应激中起的作用。 | Giovanni E. Mann Jorg Niehueser-Saran Alan Watson Ling Gao Tetsuro Ishii Patricia de Winter Richard C. M. Siow | 2007 | 生理学报2007，59，2： | 35 |
| 2 | Liver transplantation for hepatocellular carcinoma: Expansion of the tumor size limits does not adversely impact survival显示文摘 | Francis Y. Yao Linda Ferrell Nathan M. Bass Jessica J. Watson Peter Bacchetti Alan Venook Nancy L. Ascher John P. Roberts | 2001 | Hepatology2001，，6： | 5 |
| 3 | 通过地质导向提高产量显示文摘为了延长老油田的寿命,油气公司需要将通常很难勘探和开采的储量作为开发目标。新的定向深探测随钻测井技术有助于地学专家实时确定高阻层边界和流体接触面的位置。采用这些信息优化井眼轨迹,使作业者能够通过提高产量、减少侧钻以及减少井眼失稳问题来获得更大的经济效益。 | Lawrence Chou Qiming Li Alexis Darquin Jean-Michel Denichou Roger Griffiths Nick Hart Alan Mclnally Gerhard Templeton Dzevat Omeragic Ian Tribe Kim Watson Margrethe Wiig | 2007 | 国外测井技术2007，22，3： | 2 |
| 4 | Liver transplantation for hepatocellular carcinoma: Expansion of the tumor size limits does not adversely impact survival显示文摘 | Francis Y. Yao Linda Ferrell Nathan M. Bass Jessica J. Watson Peter Bacchetti Alan Venook Nancy L. Ascher John P. Roberts | 2001 | Hepatology2001，，6： | 2 |
| 5 | State of art control of dioxins/unintentional POPs in the secondary copper industry: A review to assist policy making with the implementation of the Stockholm Convention显示文摘Article 5 of the Stockholm Convention requires that each Party shall take measures to reduce the releases from anthropogenic sources of unintentional persistent organic pollutants(UPOPs),with the goal of their continuing minimization and,where feasible,their ultimate elimination.A major source of polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/Fs)and other unintentional POPs releases,both in China and worldwide,is the metal industry in particular secondary metal industries such as copper smelting.More than 50%of the global secondary copper production is now in China and high levels of PCDD/Fs are released from these operations with the national inventory of China reporting a total of 1133.8 g toxic equivalents(TEQ)yr1.Consequently the Global Environment Facility(GEF)is supporting the project‘UPOPs Reduction through best available techniques and best environmental practices(BAT/BEP)in the secondary copper production sector’in China compromising>50%of the global secondary copper production.As part of this project,information on relevant UPOPs from the metal industry have been reviewed and is presented here.This information should also be useful for other(developing)countries for controlling UPOPs releases from metal industries.This review and the information it contains provides a robust resource for policy makers,the industry and researchers to improve secondary copper production to BAT/BEP standards in relation to the reduction of PCDD/Fs and other UPOPs release.The contents include the details required to assist the understanding of the formation of chlorinated UPOPs along with their brominated and brominated-chlorinated analogues.It reviews the international sources of information on BAT/BEP,including the integrated approach considered in the European BAT Reference document,and shows how this can be used to achieve an overall reduction of pollutant releases from the industry.The current national standards of PCDD/F limits to air,water and solid residues have been compiled and are also included.Challenges which need to be addressed,such as the current international lack to consider brominated and mixed bromo-chloro PXDD/Fs which might be more environmentally significant than PCDD/Fs in some facilities e are also discussed.The study includes a brief description of the steps China has taken to change the national regulatory framework and to improve the sustainability of its secondary metal industry.The Stockholm Convention BAT/BEP guidelines recommend consideration of integrated pollution prevention and control and sustainable production as general principles which parties may incorporate when applying the BAT/BEP guidelines and guidance.This holistic approach is considered in the current project and in the improvement of the pilot facilities and will also be considered in the replication of experiences in other facilities.Using this approach ensures the implementation of the Stockholm Convention can contribute to integrated pollution prevention and control,the development of a circular economy and consequently to genuinely sustainable development thus contributing to different sustainable development goals(SDGs).It is hoped this approach will be adopted in other developing and transition economies and thus help to achieve improvements of the secondary metal industry globally. | Guanglong Wu Roland Weber Yong Ren Zheng Peng Alan Watson Jiahong Xie | 2020 | Emerging Contaminants2020，6，1： | 2 |
| 6 | Acute care needs in an Indian emergency department: A retrospective analysis显示文摘BACKGROUND: Emergencies such as road traffic accidents(RTAs), acute myocardial infarction(AMI) and cerebrovascular accident(CVA) are the most common causes of death and disability in India. Robust emergency medicine(EM) services and proper education on acute care are necessary. In order to inform curriculum design for training programs, and to improve the quality of EM care in India, a better understanding of patient epidemiology and case burden presenting to the emergency department(ED) is needed.METHODS: This study is a retrospective chart review of cases presenting to the ED at Kerala Institute of Medical Sciences(KIMS), a private hospital in Trivandrum, Kerala, India, from November 1, 2011 to April 21, 2012 and from July 1, 2013 to December 21, 2013. De-identified charts were systematically sampled and reviewed.RESULTS: A total of 1 196 ED patient charts were analyzed. Of these patients, 55.35%(n=662) were male and 44.7%(n=534) were female. The majority(67.14%, n=803) were adults, while only 3.85%(n=46) were infants. The most common chief complaints were fever(21.5%, n=257), renal colic(7.3%, n=87), and dyspnea(6.9%, n=82). The most common ED diagnoses were gastrointestinal(15.5%, n=185), pulmonary(12.3%, n=147), tropical(11.1%, n=133), infectious disease and sepsis(9.9%, n=118), and trauma(8.4%, n=101).CONCLUSION: The patient demographics, diagnoses, and distribution of resources identifi ed by this study can help guide and shape Indian EM training programs and faculty development to more accurately refl ect the burden of acute disease in India. | Elizabeth G. Clark Jessica Watson Allison Leemann Alan H. Breaud Frank G. Feeley III James Wolff Tamorish Kole Gabrielle A. Jacquet | 2016 | World Journal of Emergency Medicine2016，7，3： | 2 |
| 7 | Feed-forward space vector modulation for single- phase multilevel cascaded converters with any DC voltage ratio显示文摘 | Jose I Leon Sergio Vazquez Alan J Watson | 2009 | IEEE Transactions on Industry applications2009，56，2： | 1 |
| 8 | The Evolution of Law: The Roman System of Contracts显示文摘 | Alan Watson | 1984 | Law and History Review1984，，1： | 1 |
| 9 | Education to reduce impact in forest campgrounds显示文摘 | Susan Oliver Joseph Roggenbuck Alan Watson | 1985 | Journal of Forestry1985，83，4： | 1 |
| 10 | High-Density Lipoprotein Function显示文摘 | Benjamin J. Ansell Karol E. Watson Alan M. Fogelman Mohamad Navab Gregg C. Fonarow | 2005 | Journal of the American College of Cardiology2005，，10： | 1 |
| 11 | Grass overseeding and a fungus combine to control Taraxacum officinale显示文摘 | Abu Dieyeh Mohammed H Watson Alan K | 2007 | Journal of Applied Ecology2007，44，1： | 1 |
| 12 | The role of herbivores in the grassland carbon budget for Three-Rivers Headwaters region,Qinghai-Tibetan Plateau,China显示文摘Background:An accurate assessment of the carbon budget is a crucial part of projecting future climate change and its impact on ecosystems.Grasslands foster multiple ecological functions including support for wild animals and livestocks.Herbivores intake forage biomass carbon,then digest and metabolize,and finally retain some carbon.The carbon processes have not been well quantified,resulting in uncertainties in the estimation of regional carbon budgets for grassland ecosystems.Methods:An animal metabolic carbon flux model was developed for herbivores in the Three-Rivers Headwaters region of China.The forage intake and metabolic carbon rates were estimated through metabolic body weight and daily digested measures for the main herbivore species.Results:The carbon intake was 5.52 Tg C year−1(45%)from partial aboveground biomass(12.2 Tg C year−1),in which 39.31%was released into the atmosphere by respiration CO_(2),43.77%was returned to the ecosystem as feces and urine,and 16.96%was retained in herbivores for population regeneration or for human well-being.Conclusions:This study,as the first research on this topic,quantified the carbon flux of herbivores and found livestock accounts for a major part of consumed carbon on grasslands,which is important for understanding regional carbon budgets to mitigate and adapt to climate change over grasslands worldwide. | Junbang Wang Xinquan Zhao Xihuang Ouyang Liang Zhao Wenying Wang Chan Zuo Zhenhua Zhang Huakun Zhou Alan Watson Yingnian Li | 2022 | Grassland Research2022，1，3： | 1 |
| 13 | Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex显示文摘 | Ilaria Guella Adolfo Sequeira Brandi Rollins Linda Morgan Federica Torri Theo G.M. van Erp Richard M. Myers Jack David Barchas Alan F. Schatzberg Stanley J. Watson Huda Akil William E. Bunney Steven G. Potkin Fabio Macciardi Marquis P. Vawter | 2013 | Journal of Psychiatric Research2013，，9： | 1 |
| 14 | Beyond the commodity metaphor: Examining emotional and symbolic attachment to place显示文摘 | Daniel R. Williams Michael E. Patterson Joseph W. Roggenbuck Alan E. Watson | 1992 | Leisure Sciences1992，，： | 1 |
| 15 | Liver transplantation for hepatocellular carcinoma: Expansion of the tumor size limits does not adversely impact survival显示文摘 | Francis Y. Yao Linda Ferrell Nathan M. Bass Jessica J. Watson Peter Bacchetti Alan Venook Nancy L. Ascher John P. Roberts | 2001 | Hepatology2001，，6： | 1 |
| 16 | The REMATCH trial: rationale, design, and end points显示文摘 | Eric A Rose Alan J Moskowitz Milton Packer Josephine A Sollano Deborah L Williams Anita R Tierney Daniel F Heitjan Paul Meier Deborah Davis Ascheim Ronald G Levitan Alan D Weinberg Lynne Warner Stevenson Peter A Shapiro Ronald M Lazar John T Watson Daniel | 1999 | The Annals of Thoracic Surgery1999，，3： | 1 |
| 17 | Design and use of the Microsoft Excel Solver显示文摘 | Daniel Fylstra Leon Lasdon John Watson Alan Waren | 1998 | INFORMS INTERFACES1998，28，5： | 1 |
| 18 | Liver transplantation for hepatocellular carcinoma: Expansion of the tumor size limits does not adversely impact survival显示文摘 | Francis Y. Yao Linda Ferrell Nathan M. Bass Jessica J. Watson Peter Bacchetti Alan Venook Nancy L. Ascher John P. Roberts | 2001 | Hepatology2001，，6： | 1 |
| 19 | The Evolution of Law: The Roman System of Contraets显示文摘 | Alan Watson | 1984 | 2 Law and History Review (1984) : 21984，2，1984： | 1 |
| 20 | Blocked and non-blocked ricin immunotoxins against the CD4 antigen exhibit higher cytotoxic potency than a ricin A chain immunotoxin potentiated with ricin B chain or with a ricin B chain immunotoxin显示文摘 | Edward J. Wawrzynczak Graham J. Watson Alan J. Cumber Raymond V. Henry Geoffrey D. Parnell E. Peter Rieber Philip E. Thorpe | 1991 | Cancer Immunology Immunotherapy1991，，5： | 1 |
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