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| 1 | Inhibition of pacemaker activity in interstitial cells of Cajal by LPS via NF-κB and MAP kinase显示文摘AIM:To investigate lipopolysaccharide(LPS) related signal transduction in interstitial cells of Cajal(ICCs) from mouse small intestine.METHODS:For this study,primary culture of ICCs was prepared from the small intestine of the mouse.LPS was treated to the cells prior to measurement of the membrane currents by using whole-cell patch clamp technique.Immunocytochemistry was used to examine the expression of the proteins in ICCs.RESULTS:LPS suppressed the pacemaker currents of ICCs and this could be blocked by AH6809,a prostaglandin E2-EP2 receptor antagonist or NG-Nitro-Larginine Methyl Ester,an inhibitor of nitric oxide(NO) synthase.Toll-like receptor 4,inducible NO synthase or cyclooxygenase-2 immunoreactivity by specific antibodies was detected on ICCs.Catalase(antioxidant agent) had no action on LPS-induced action in ICCs.LPS actions were blocked by nuclear factor kB(NF-kB) inhibitor,actinomycin D(a gene transcription inhibitor),PD 98059(a p42/44 mitogen-activated protein kinases inhibitor) or SB 203580 [a p38 mitogen-activated protein kinases(MAPK) inhibitor].SB 203580 also blocked the prostaglandin E2-induced action on pacemaker currents in ICCs but not NO.CONCLUSION:LPS inhibit the pacemaker currents in ICCs via prostaglandin E2-and NO-dependent mechanism through toll-like receptor 4 and suggest that MAPK and NF-kB are implicated in these actions. | Dong Chuan Zuo Seok Choi Pawan Kumar Shahi Man Yoo Kim Chan Guk Park Young Dae Kim Jun Lee In Yeoup Chang Insuk So Jae Yeoul Jun | 2013 | World Journal of Gastroenterology2013，19，8： | 9 |
| 2 | Anti-parkinsonian effects of octacosanol in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-treated mice显示文摘Our previous research showed that octacosanol exerted its protective effects in 6-hydroxydopamine-induced Parkinsonian rats. The goal of this study was to investigate whether octacosanol would attenuate neurotoxicity in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP)-treated C57BL/6N mice and its potential mechanism. Behavioral tests, tyrosine hydroxylase immunohistochemistry and western blot were used to investigate the effects of octacosanol in a mouse model of Parkinson's disease. Oral administration of octacosanol (100 mg/kg) significantly improved behavioral impairments in mice treated by MPTP and markedly ameliorated morphological appearances of tyrosine hydroxylase-positive neuronal cells in the substantia nigra. Furthermore, octacosanol blocked MPTP-induced phosphorylation of p38MAPK and JNK, but not ERK1/2. These findings implicated that the protective effects afforded by octacosanol might be mediated by blocking the phosphorylation of p38MAPK and JNK on the signal transduction in vivo. Considering its excellent tolerability, octacosanol might be considered as a candidate agent for clinical application in treating Parkinson's disease. | Tao Wang Yanyong Liu Nan Yang Chao Ji Piu Chan Pingping Zuo | 2012 | Neural Regeneration Research2012，7，14： | 7 |
| 3 | The CHADSz and CHA2DS2-VASc scores predict new occurrence of atrial fibrillation and ischemic stroke显示文摘 | Zuo ML Liu S Chan KH | 2013 | J Interv Card Electrophysiol2013，37，1： | 1 |
| 4 | The regeneration of transected sciatic nerves of adult rats using chitosan nerve conduits seeded with bone marrow stromal cell-derived Schwann cells显示文摘 | Qiang Ao Chun-Kit Fung Alex Yat-Ping Tsui Sa Cai Huan-Cong Zuo Ying-Shing Chan Daisy Kwok-Yan Shum | 2010 | Biomaterials2010，，3： | 1 |
| 5 | Blueberry extract prolongs lifespan of Drosophila melanogaster显示文摘 | Cheng Peng Yuanyuan Zuo Kin Ming Kwan Yintong Liang Ka Ying Ma Ho Yin Edwin Chan Yu Huang Hongjian Yu Zhen-Yu Chen | 2011 | Experimental Gerontology2011，，2： | 1 |
| 6 | Intestinal efflux transport kinetics of green tea catechins in Caco-2 monolayer model显示文摘 | Chan KY Zhang L Zuo Z | 2007 | Journal of Pharmacy and Pharmacology2007，59，3： | 1 |
| 7 | The role of herbivores in the grassland carbon budget for Three-Rivers Headwaters region,Qinghai-Tibetan Plateau,China显示文摘Background:An accurate assessment of the carbon budget is a crucial part of projecting future climate change and its impact on ecosystems.Grasslands foster multiple ecological functions including support for wild animals and livestocks.Herbivores intake forage biomass carbon,then digest and metabolize,and finally retain some carbon.The carbon processes have not been well quantified,resulting in uncertainties in the estimation of regional carbon budgets for grassland ecosystems.Methods:An animal metabolic carbon flux model was developed for herbivores in the Three-Rivers Headwaters region of China.The forage intake and metabolic carbon rates were estimated through metabolic body weight and daily digested measures for the main herbivore species.Results:The carbon intake was 5.52 Tg C year−1(45%)from partial aboveground biomass(12.2 Tg C year−1),in which 39.31%was released into the atmosphere by respiration CO_(2),43.77%was returned to the ecosystem as feces and urine,and 16.96%was retained in herbivores for population regeneration or for human well-being.Conclusions:This study,as the first research on this topic,quantified the carbon flux of herbivores and found livestock accounts for a major part of consumed carbon on grasslands,which is important for understanding regional carbon budgets to mitigate and adapt to climate change over grasslands worldwide. | Junbang Wang Xinquan Zhao Xihuang Ouyang Liang Zhao Wenying Wang Chan Zuo Zhenhua Zhang Huakun Zhou Alan Watson Yingnian Li | 2022 | Grassland Research2022，1，3： | 1 |
| 8 | The CHADS2 and CHA 2DS 2-VASc scores predict new occurrence of atrial fibrillation and ischemic stroke显示文摘 | Zuo ML Liu S Chan KH | 2013 | J Interv Cardiol Electrophysiol2013，37，1： | 1 |
| 9 | The CHADS ( 2 ) and CHA ( 2 )DS ( 2 ) -VASc scores predict new occurrence of atrial fibrillationand ischemic stroke显示文摘 | Zuo ML Liu SS Chan KH | 2013 | J Interv Card Electrophysiol2013，37，1： | 1 |
| 10 | Analysis of Selection Criteria for Design-Builders through the Analysis of Request for Proposals(RFPs)显示文摘 | Bo Xia Albert Chan Jian Zuo Keith Millenary | | 0，，： | 1 |
| 11 | Analysis of Selection Criteria for Design-Builders through the Analysis of Requests for Proposal显示文摘 | Bo Xia Albert Chan Jian Zuo Keith Molenaar | 2013 | Journal of Management in Engineering2013，，1： | 1 |
| 12 | FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene显示文摘 | Tao Zuo Lizhong Wang Carl Morrison Xing Chang Huiming Zhang Weiquan Li Yan Liu Yin Wang Xingluo Liu Michael W.Y. Chan Jin-Qing Liu Richard Love Chang-gong Liu Virginia Godfrey Rulong Shen Tim H.-M. Huang Tianyu Yang Bae Keun Park Cun-Yu Wang Pan Zheng Yan | 2007 | Cell2007，，7： | 1 |
| 13 | FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene显示文摘 | Tao Zuo Lizhong Wang Carl Morrison Xing Chang Huiming Zhang Weiquan Li Yan Liu Yin Wang Xingluo Liu Michael W.Y. Chan Jin-Qing Liu Richard Love Chang-gong Liu Virginia Godfrey Rulong Shen Tim H.-M. Huang Tianyu Yang Bae Keun Park Cun-Yu Wang Pan Zheng Yan | 2007 | Cell2007，，7： | 1 |
| 14 | In vitro transport assays of rufinamide,pregabalin,and zonisamide by human P-glycoprotein显示文摘 | Chan PS Zhang C Zuo Z | 2014 | Epilepsy Res2014，，： | 1 |
| 15 | Facile Synthesis of Chiral Conjugated Polymer Based on BINOL Skeleton显示文摘A new type of chiral conjugated polymers 6a-d has been synthesized by the reaction of (R)-2,2’-dihydroxy-1,1’-binaphthyl-6,6’-dicarbaldehyde 5 with corresponding diamine in the presence of acetic acid. | Chun E DONG Yong Gang ZHI Zuo Long YU Liang Fu ZHANG Albert. S. C. CHAN (Chengdu institute of organic chemistry Academ Sinica Chengdu 610041 Hong Kong Polytechnic University, HongKong) | 2000 | Chinese Chemical Letters2000，11，1： | 0 |
| 16 | Functional expression of cystic fibrosis transmembrane conductance regulator in rat oviduct epithelium显示文摘这研究的目的是在老鼠输卵管上皮与 electrophysiological 和分子的技术调查膀胱的纤维变性 transmembrane 传导力管理者(CFTR ) 的功能的表示。在整个房间的补丁夹钳,上皮的房间在没有差距的模式在里面的电流与上升对 100 M 8-bromo-adenosine 3,5-cyclic monophosphate ( 8-Br-cAMP )作出回应的输卵管,它被 5 M CFTR ( inh )-172,连续地禁止一个 CFTR 特定的禁止者,和 1 公里 diphenylamine-2-carboxylate ( DPC ), Cl -隧道 blocker 。激活营地的水流展出了一线性当前电压(I-V ) 关系和时间无关、电压无关的特征。在对称的 Cl - 答案的激活营地的水流的颠倒潜力接近了 Cl - 平衡, 0.5 湩愠獮敷 ? 潴吗? | Minhui Chen Jianyang Du Weijian Jiang Wulin Zuo Fang Wang Manhui Li Zhongluan Wu Hsiaochang Chan Wenliang Zhou | 2008 | Acta Biochimica et Biophysica Sinica2008，40，10： | 0 |
| 17 | TURMERIC-COULD IT BE A MULTI-TARGETED HERB FOR COLORECTAL CANCER ADJUVANT THERAPY?显示文摘Turmeric is a medicinal herb in Asia and as dietary supplement in western countries.Its major active component,curcumin.has good reputation for chemopreventive effects in different cancers.However,poor oral bioavailability of curcumin hinders the wide clinical application of this compound.Our research group made attempts to advance the utilization of the | Grace GL Yue Hin-Fai Kwok Julia KM Lee Lei Jiang Si Gao Carmen KM Chan Eric CW Wong Kwok-Pui Fung Ping-Chung Leung Zhong Zuo Clara BS Lau | 2015 | World Journal of Traditional Chinese Medicine2015，1，4： | 0 |
| 18 | Variation of the circadian rhythm in MPTP- treated PD mice and its possible mechanism显示文摘 | Xiaohong Zuo Yanning Cai Shu Xie Shu Liu Mei Wen Piu Chan | 2007 | 中国药理通讯2007，24，2： | 0 |
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