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| 1 | Blockade of PD1 and TIM3 Restores Innate and Adaptive Immunity in Patients with Acute Alcoholic Hepatitis显示文摘 | Lee J.L. Markwick Antonio Riva Jennifer M. Ryan Helen Cooksley Elena Palma Tom H. Tranah Godhev K. Manakkat Vijay Nikhil Vergis Mark Thursz Alex Evans Gavin Wright Sarah Tarff John O’Grady Roger Williams Debbie L. Shawcross Shilpa Chokshi | 2014 | Gastroenterology2014，，： | 2 |
| 2 | Acute Mountain Sickness: Pathophysiology, Prevention, and Treatment显示文摘 | Chris Imray Alex Wright Andrew Subudhi Robert Roach | 2010 | Progress in Cardiovascular Diseases2010，，6： | 2 |
| 3 | Enhancing inductive strategizing through sensemaking and scenario thinking 显示文摘 | Alex Wright (2004) | 2004 | Working Paper Series2004，，： | 1 |
| 4 | Evaluation of coagulation abnormalities in acute liver failure显示文摘 | Banwari Agarwal Gavin Wright Alex Gatt Anne Riddell Vishwaraj Vemala Susan Mallett Pratima Chowdary Andrew Davenport Rajiv Jalan Andrew Burroughs | 2012 | Journal of Hepatology2012，，4： | 1 |
| 5 | A phase II trial of the Src-kinase inhibitor saracatinib after four cycles of chemotherapy for patients with extensive stage small cell lung cancer: NCCTG trial N-0621显示文摘 | Julian R. Molina Nathan R. Foster Thanyanan Reungwetwattana Garth D. Nelson Andrew V. Grainger Preston D. Steen Philip J. Stella Randolph Marks John Wright Alex A. Adjei | 2014 | Lung Cancer2014，，： | 1 |
| 6 | Perspectives of paediatric and adult gastroenterologists on transfer and transition care of adolescents with inflammatory bowel disease显示文摘 | E. K. Wright J. Williams J. M. Andrews A. S. Day R. B. Gearry P. Bampton D. Moore D. Lemberg R. Ravikumaran J. Wilson P. Lewindon G. Radford‐Smith J. Rosenbaum A. Catto‐Smith P. V. Desmond W. R. Connell D. Cameron G. Alex S. J. Bell P. De Cruz | 2014 | Intern Med J2014，，5： | 1 |
| 7 | Acute Mountain Sickness : Pathoph ysiology, Prevention, and Treatment 显示文摘 | Chris Imray Alex Wright Andrew Subudhi | 2010 | Progress in Cardiovascular Diseases2010，52，6： | 1 |
| 8 | Nitric oxide-mediated S-nitrosylation of IAA17 protein in intrinsically disordered region represses auxin signaling显示文摘The phytohormone auxin plays crucial roles in nearly every aspect of plant growth and development.Auxin signaling is activated through the phytohormone-induced proteasomal degradation of the Auxin/INDOLE-3-ACETIC ACID(Aux/IAA)family of transcriptional repressors.Notably,many auxin-modulated physiological processes are also regulated by nitric oxide(NO)that executes its biological effects predominantly through protein S-nitrosylation at specific cysteine residues.However,little is known about the molecular mechanisms in regulating the interactive NO and auxin networks.Here,we show that NO represses auxin signaling by inhibiting IAA17 protein degradation.NO induces the S-nitrosylation of Cys-70 located in the intrinsically disordered region of IAA17,which inhibits the TIR1-IAA17 interaction and consequently the proteasomal degradation of IAA17.The accumulation of a higher level of IAA17 attenuates auxin response.Moreover,an IAA17^(C70W)nitrosomimetic mutation renders the accumulation of a higher level of the mutated protein,thereby causing partial resistance to auxin and defective lateral root development.Taken together,these results suggest that S-nitrosylation of IAA17 at Cys-70 inhibits its interaction with TIR1,thereby negatively regulating auxin signaling.This study provides unique molecular insights into the redox-based auxin signaling in regulating plant growth and development. | Hongwei Jing Xiaolu Yang Ryan J.Emenecker Jian Feng Jian Zhang Marcelo Rodrigues Alves de Figueiredo Patarasuda Chaisupa R.Clay Wright Alex S.Holehouse Lucia C.Strader Jianru Zuo | 2023 | Journal of Genetics and Genomics2023，50，7： | 1 |
| 9 | Nurses'knowledge of pain in the eldedy显示文摘 | Rod Sloman Maureen Ahem Alex Wright | | 0，，04： | 1 |
| 10 | Effects of lowdoes heparin on failure of intravenous infusions in children显示文摘 | Alex Wright John Hecker Gall McDonald | 1995 | Heart & Lung1995，21，1： | 1 |
| 11 | 慢性丙型肝炎患者初期治疗应答的多种细胞因子表达谱显示文摘Currently available prognostic tools are inadequate to discern the molecular basis of the heterogenic response in hepatitis C virus (HCV) infected patients treated with the current standard of therapy. The expression and biological function of immune mediators have been shown to be critical in all phases of the immune response to HCV infection and likely therefore influence host response. Herein, a biometric multiplex serum cytokine assay was utilized to characterize the immunomodulatory effects of host response in 10 HCV patients. Serum levels of 17 cytokines were compared before and after 1 month of treatment and against controls. Overall serum cytokine levels were significantly higher in patients (P < 0.05) than controls. Additionally, viral titers decreased in all patients after 1 month of therapy, as did overall serum cytokine levels in the cohort (P < 0.05). To assess relationships between changes in cytokine levels and changes in viral titer, the cohort was divided into three statistically distinct subgroups based on changes in viral titers. Specific sets of cytokines decreased in each group: decreases in CCL4, interleukin (IL)-2, CXCL8, and IL-1β.correlated with the greatest drops in viral titer, decreases in IL-5, granulocyte colony stimulating factor (G-CSF), and CCL4 correlated with moderate drops in viral titer, and only CCL2 correlated with the lowest drops in viral titer. Interestingly, decreases in CCL4 levels correlated with decreases in viral titers in all patients. CCL4 controls leukocyte influx and thus propagates inflammation. In conclusion, these data raise the possibility that characteristic changes in host response modulate the therapeutic response, demonstrating the prognostic power of serum cytokine profiling in chronic HCV. | Wright H. Alex P. Nguyen T. M. Centola 陈云茹 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，3： | 0 |
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