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| 1 | Machine-learned multi-system surrogate models for materials prediction显示文摘Surrogate machine-learning models are transforming computational materials science by predicting properties of materials with the accuracy of ab initio methods at a fraction of the computational cost.We demonstrate surrogate models that simultaneously interpolate energies of different materials on a dataset of 10 binary alloys(AgCu,AlFe,AlMg,AlNi,AlTi,CoNi,CuFe,CuNi,FeV,and NbNi)with 10 different species and all possible fcc,bcc,and hcp structures up to eight atoms in the unit cell,15,950 structures in total.We find that the deviation of prediction errors when increasing the number of simultaneously modeled alloys is<1 meV/atom.Several state-of-the-art materials representations and learning algorithms were found to qualitatively agree on the prediction errors of formation enthalpy with relative errors of<2.5% for all systems. | Chandramouli Nyshadham Matthias Rupp Brayden Bekker Alexander V.Shapeev Tim Mueller Conrad W.Rosenbrock Gábor Csányi David W.Wingate Gus L.W.Hart | 2019 | npj Computational Materials2019，，1： | 8 |
| 2 | 从天然提取物或分离部位中以碳酸酐酶II为靶点的抗骨质疏松活性筛选(英文)显示文摘目的是以碳酸酐酶II (CAII)为靶点筛选其抑制剂 ,以期寻找抗骨质疏松活性样品。实验是在 96孔酶标板上对来源于 1 78个科、 60 8个属、 1 0 2 0种动植物 2 91 9个提取物或分离部位样品在CA II模型上进行了批量筛选。结果表明在 1 0 μg ml浓度下发现了来源于 40个科、61个属、72个种的 1 0 0个样品有活性 ,其中 5个样品的IC50 小于 2 50 μg ml,2 2个样品的IC50 在 2 51~ 5 0 0 μg ml范围 ,73个样品的IC50 在 5 0 1~1 0 0 0 μg ml范围。通过以上工作我们认为以碳酸酐酶II为分子靶点的体外筛选方法稳定、方便、快速、微量、有效 ,特别适用于天然产物的抗骨质疏松活性筛选。 | 付祥 谭宁华 姜立花 贾锐锐 嵇长久 LANDRO James FEKETE Alexander MUELLER Hartwig HENKEL Thomas | 2003 | 云南植物研究2003，25，6： | 2 |
| 3 | Excluding infection through procalcitonin testing improves outcomes of congestive heart failure patients presenting with acute respiratory symptoms: Results from the randomized ProHOSP trial显示文摘 | Philipp Schuetz Alexander Kutz Eva Grolimund Sebastian Haubitz Désirée Demann Alaadin V?geli Fabienne Hitz Mirjam Christ-Crain Robert Thomann Claudine Falconnier Claus Hoess Christoph Henzen Robert J. Marlowe Werner Zimmerli Beat Mueller | 2014 | International Journal of Cardiology2014，，3： | 2 |
| 4 | Determinants of agricultural land abandonment in Post-soviet European Russia显示文摘 | Prishchepov Alexander V Mueller Daniel | 2013 | Land Use Policy2013，30，1： | 1 |
| 5 | Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease显示文摘 | Besler Christian Heinrich Kathrin Rohrer Lucia Doerries Carola Riwanto Meliana Shih Diana M Chroni Angeliki Yonekawa Keiko Stein Sokrates Schaefer Nicola Mueller Maja Akhmedov Alexander Daniil Georgios Manes Costantina Templin Christian Wys | 2011 | Journal of Clinical Investigation2011，，7： | 1 |
| 6 | The Role of Patients’ Explanatory Models and Daily-Lived Experience in Hypertension Self-Management显示文摘 | Barbara G. Bokhour Ellen S. Cohn Dharma E. Cortés Jeffrey L. Solomon Gemmae M. Fix A. Rani Elwy Nora Mueller Lois A. Katz Paul Haidet Alexander R. Green Ann M. Borzecki Nancy R. Kressin | 2012 | Journal of General Internal Medicine2012，，12： | 1 |
| 7 | Role of regenerating islet-derived proteins in inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD)is an inflammatory disorder of the gastrointestinal tract that affects millions of patients worldwide.It has a complex and multifactorial etiology leading to excessive exposure of intestinal epithelium to microbial antigens,inappropriate activation of the immune system and ultimately to the damage of intestinal tissues.Although numerous efforts have been made to improve the disease management,IBD remains persistently recurring and beyond cure.This is due largely to the gaps in our understanding of the pathogenesis of IBD that hamper the development of timely diagnoses and effective treatment.However,some recent discoveries,including the beneficial effects of interleukin-22(IL-22)on the inflamed intestine,have shed light on a self-protective mechanism in IBD.Regenerating islet-derived(REG/Reg)proteins are small secretory proteins which function as IL-22’s downstream effectors.Mounting studies have demonstrated that IBD patients have significantly increased REG expressions in the injured intestine,but with undefined mechanisms and roles.The reported functions of REG/Reg proteins in intestinal homeostasis,such as those of antibacterial,anti-inflammatory and tissue repair,lead us to discuss their potential mechanisms and clinical relevance in IBD in order to advance IBD research and management. | Jodi-Ann Edwards Nicholas Tan Nadlie Toussaint Peiqi Ou Cathy Mueller Albert Stanek Vladimir Zinsou Sean Roudnitsky Michelle Sagal Lisa Dresner Alexander Schwartzman Chongmin Huan | 2020 | World Journal of Gastroenterology2020，26，21： | 1 |
| 8 | Methodological Aspects of Aerobic High- Intensity Interval Exercise in Cardiac Rehabilitation 显示文摘 | Gerhard Tschakert Julia Kroepfl Alexander Mueller | 2012 | Med Sci Sports Exerc2012，44，5： | 1 |
| 9 | An alteration in the levels of populations of CD4 + Treg is in part responsible for altered cytokine production by cells of aged mice which follows injection with a fetal liver extract显示文摘 | R.M. Gorczynski C. Alexander W. Bessler K. Brandenburg K. Fournier J.P. Mach S. Mueller E.Th. Rietschel A.J. Ulmer Th. Waelli U. Zahringer I. Khatri | 2007 | Immunology Letters2007，，2： | 1 |
| 10 | Effect of hyperglycaemia on inflammatory and stress responses and clinical outcome of pneumonia in non-critical-care inpatients: results from an observational cohort study显示文摘 | Philipp Schuetz Natalie Friedli Eva Grolimund Alexander Kutz Sebastian Haubitz Mirjam Christ-Crain Robert Thomann Werner Zimmerli Claus Hoess Christoph Henzen Beat Mueller | 2014 | Diabetologia2014，，2： | 1 |
| 11 | Evaluation of cardioprotective effects of recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in myocardial ischemia-reperfusion injury by real-time myocardial contrast echocardiography显示文摘 | Alexander Hansen Anjali Kumar David Wolf Kamilla Frankenbergerova Arthur Filusch Marie-Luise Gross Sebastian Mueller Hugo Katus Helmut Kuecherer | 2004 | Journal of the American College of Cardiology2004，，4： | 1 |
| 12 | Progressive femoral cortical and cancellous bone density loss after uncemented tapered-design stem fixation显示文摘 | Lutz A Mueller Tobias E Nowak Lothar Haeberle Lars P Mueller Alexander Kress Michael Voelk David Pfander Raimund Forst Rainer Schmidt | 2010 | Acta Orthopaedica2010，，2： | 1 |
| 13 | Genetic variantswithin the dopaminergic system interact to modulate endo-crine stress reactivity and recovery显示文摘 | Alexander N Osinsky Rt Mueller E | 2011 | Behav Brain Res2011，216，1： | 1 |
| 14 | In intermediate stage hepatocellular carcinoma: radioembolization with yttrium 90 or chemoembolization?显示文摘 | Amr El Fouly Judith Ertle Ahmed El Dorry Mohamed K. Shaker Alexander Dechêne Heba Abdella Stefan Mueller Eman Barakat Thomas Lauenstein Andreas Bockisch Guido Gerken Joerg F. Schlaak | 2015 | Liver Int2015，，2： | 1 |
| 15 | Modifiable determinants of attitude towards dengue vaccination among healthy inhabitants of Aceh,Indonesia:Findings from a community-based survey显示文摘Objective:To explore and understand the attitude towards dengue vaccination and its modifiable determinants among inhabitants of Aceh(northern Sumatra Island,Indonesia),the region that was most severely affected by the earthquake and tsunami of 26 December 2004.Methods:A communitybased,cross-sectional study was conducted among 535 healthy inhabitants in nine regencies(Kabupaten or Kotamadya) of Aceh that were selected randomly from November 2014 to March 2015.A set of validated,pre-tested,structured questionnaires was used to guide the interviews.The questionnaires covered a range of explanatory variables and one outcome variable(attitude to dengue vaccination).Multi-step logistic regression analysis and Spearman's rank correlation were used to test the role of explanatory variables for the outcome variable.Results:More than 70%of the participants had a poor attitude towards dengue vaccination.Modifiablc determinants associated with poor attitude to dengue vaccination were low education level,working as farmers and traditional market traders,low socioeconomic status and poor knowledge,attitude and practice regarding dengue fever(P<0.05).The KAP domain scores were correlated strongly with attitude to dengue vaccination,r_s=0.25,r_S=0.67 and r_s=0.20,respectively(P<0.001).Multivariate analysis found that independent predictors associated with attitude towards dengue vaccination among study participants were only sex and attitude towards dengue fever(P<0.001).Conclusions:This study reveals that low KAP regarding dengue fever,low education level and low socioeconomic status are associated with a poor attitude towards dengue vaccination.Therefore,inhabitants of suburbs who are working as larmers or traditional market traders with low socioeconomic status are the most appropriate target group for a dengue vaccine introduction program. | Harapan Harapan Samsul Anwar Aslam Bustaman Arsil Radiansyah Pradiba Angraini Riny Fasli Salwiyadi Salwiyadi Reza Akbar Bastian Ade Oktiviyari Imaduddin Akmal Muhammad Iqbalamin Jamalul Adil Fenni Henrizal Darmayanti Darmayanti Rovy Pratama Jhony Karunia Fajar Abdul Malik Setiawan Mandira Lamichhane Dhimal Ulrich Kuch David Alexander Groneberg R.Tedjo Sasmono Meghnath Dhimal Ruth Mueller | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，11： | 0 |
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