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| 1 | Resveratrol inhibits matrix metalloproteinases to attenuate neuronal damage in cerebral ischemia:a molecular docking study exploring possible neuroprotection显示文摘The main pathophysiology of cerebral ischemia is the structural alteration in the neurovascular unit, coinciding with neurovascular matrix degradation. Resveratrol has been reported to be one of the most potent chemopreventive agents that can inhibit cellular processes associated with ischemic stroke. Matrix metalloproteinases(MMPs) has been considered as a potential drug target for the treatment of cerebral ischemia. To explore this, we tried to investigate the interaction of resveratrol with MMPs through molecular docking studies. At 30 minutes before and 2 hours after cerebral ischemia/reperfusion induced by occlusion of the middle cerebral artery, 40 mg/kg resveratrol was intraperitoneally administered. After resveratrol administration, neurological function and brain edema were significantly alleviated, cerebral infarct volume was significantly reduced, and nitrite and malondialdehyde levels in the cortical and striatal regions were significantly decreased. The molecular docking study of resveratrol and MMPs revealed that resveratrol occupied the active site of MMP-2 and MMP-9. The binding energy of the complexes was –37.848672 k J/mol and –36.6345 k J/mol for MMP-2 and MMP-9, respectively. In case of MMP-2, Leu 164, Ala 165 and Thr 227 were engaged in H-Bonding with resveratrol and in case of MMP-9, H-bonding was found with Glu 402, Ala 417 and Arg 424 residues. These findings collectively reveal that resveratrol exhibits neuroprotective effects on cerebral ischemia through inhibiting MMP-2 and MMP-9 activity. | Anand Kumar Pandey Pallab Bhattacharya Swet Chand Shukla Sudip Paul Ranjana Patnaik | 2015 | Neural Regeneration Research2015，10，4： | 12 |
| 2 | Piroxicam-mediated modulatory action of 5-hydroxytryptamine serves as a “brake” on neuronal excitability in ischemic stroke显示文摘Our previous studies indicated an increase in extracellular γ-aminobutyric acid(GABA) in rodent's ischemic brain after Piroxicam administration, leading to alleviation of glutamate mediated excitotoxicity through activation of type A GABA receptor(GABAA). This study was to investigate if GABAA activation by Piroxicam affects extracellular 5-hydroxytryptamine or not. High performance liquid chromatography revealed that there was a significant decrease in extracellular 5-hydroxytryptamine release in ischemic cerebral cortex and striatum in Piroxicam pre-treated rat brains. This suggests a probable role of Piroxicam in reducing extracellular 5-hydroxytryptamine release in ischemic cerebral cortex and striatum possibly due to the GABAA activation by Piroxicam. | Pallab Bhattacharya Anand Kumar Pandey Sudip Paul Ranjana Patnaik | 2015 | Neural Regeneration Research2015，10，9： | 4 |
| 3 | Anticoagulation in simultaneous pancreas kidney transplantation - On what basis?显示文摘BACKGROUND Despite technical refinements,early pancreas graft loss due to thrombosis continues to occur.Conventional coagulation tests(CCT)do not detect hypercoagulability and hence the hypercoagulable state due to diabetes is left untreated.Thromboelastogram(TEG)is an in-vitro diagnostic test which is used in liver transplantation,and in various intensive care settings to guide anticoagulation.TEG is better than CCT because it is dynamic and provides a global hemostatic profile including fibrinolysis.AIM To compare the outcomes between TEG and CCT(prothrombin time,activated partial thromboplastin time and international normalized ratio)directed anticoagulation in simultaneous pancreas and kidney(SPK)transplant recipients.METHODS A single center retrospective analysis comparing the outcomes between TEG and CCT-directed anticoagulation in SPK recipients,who were matched for donor age and graft type(donors after brainstem death and donors after circulatory death).Anticoagulation consisted of intravenous(IV)heparin titrated up to a maximum of 500 IU/h based on CCT in conjunction with various clinical parameters or directed by TEG results.Graft loss due to thrombosis,anticoagulation related bleeding,radiological incidence of partial thrombi in the pancreas graft,thrombus resolution rate after anticoagulation dose escalation,length of the hospital stays and,1-year pancreas and kidney graft survival between the two groups were compared.RESULTS Seventeen patients who received TEG-directed anticoagulation were compared against 51 contemporaneous SPK recipients(ratio of 1:3)who were anticoagulated based on CCT.No graft losses occurred in the TEG group,whereas 11 grafts(7 pancreases and 4 kidneys)were lost due to thrombosis in the CCT group(P=0.06,Fisher’s exact test).The overall incidence of anticoagulation related bleeding(hematoma/gastrointestinal bleeding/hematuria/nose bleeding/re-exploration for bleeding/post-operative blood transfusion)was 17.65%in the TEG group and 45.10%in the CCT group(P=0.05,Fisher’s exact test).The incidence of radiologically confirmed partial thrombus in pancreas allograft was 41.18%in the TEG and 25.50%in the CCT group(P=0.23,Fisher’s exact test).All recipients with partial thrombi detected in computed tomography(CT)scan had an anticoagulation dose escalation.The thrombus resolution rates in subsequent scan were 85.71%and 63.64%in the TEG group vs the CCT group(P=0.59,Fisher’s exact test).The TEG group had reduced blood product usage{10 packed red blood cell(PRBC)and 2 fresh frozen plasma(FFP)}compared to the CCT group(71 PRBC/10 FFP/2 cryoprecipitate and 2 platelets).The proportion of patients requiring transfusion in the TEG group was 17.65%vs 39.25%in the CCT group(P=0.14,Fisher’s exact test).The median length of hospital stay was 18 days in the TEG group vs 31 days in the CCT group(P=0.03,Mann Whitney test).The 1-year pancreas graft survival was 100%in the TEG group vs 82.35%in the CCT group(P=0.07,log rank test)and,the 1-year kidney graft survival was 100%in the TEG group vs 92.15%in the CCT group(P=0.23,log tank test).CONCLUSION TEG is a promising tool in guiding judicious use of anticoagulation with concomitant prevention of graft loss due to thrombosis,and reduces the length of hospital stay. | Jeevan Prakash Gopal Frank JMF Dor Jeremy S Crane Paul E Herbert Vassilios E Papalois Anand SR Muthusamy | 2020 | World Journal of Transplantation2020，10，7： | 2 |
| 4 | Monitoring Greenhouses Gases over China Using Space-Based Observations Monitoring Greenhouses Gases over China Using Space-Based Observations显示文摘The atmospheric carbon dioxide(CO 2)concentration has increased to more than 405 parts per million(ppm.1 ppm=10-6 m/s 2)in 2017 due to human activities such as deforestation,land-use change and burning of fossil fuels.Although there is broad scientific consensus on the damaging consequences of the change in climate associated with increasing concentrations of greenhouse gases,fossil CO 2 emissions have continued to increase in recent years mainly from rapidly developing economies and China is now the largest emitter of CO 2 generating about 30%of all emissions globally.To allow more reliable forecast of the future state of the carbon cycle and to support the efforts for mitigation greenhouse gas emissions,a better understanding of the global and regional carbon budget is needed.Space-based measurements of CO 2 can provide the necessary observations with dense coverage and sampling to provide improved constrains on of carbon fluxes and emissions.The Chinese Global Carbon Dioxide Monitoring Scientific Experimental Satellite(TanSat)was established by the National High Technology Research and Development Program of China with the main objective of monitoring atmospheric CO 2 and CO 2 fluxes at the regional and global scale.TanSat has been successfully launched in December 2016 and as part of the Dragon programme of ESA and the Ministry of Science and Technology(MOST),a team of researchers from Europe(UK and Finland)and China has evaluated early TanSat data and contrast it against data from the GOSAT mission and models.In this manuscript,we report on retrieval intercomparisons of TanSat data using two different retrieval algorithms,on validation efforts for the Eastern Asia region using GOSAT CO 2 data and first assessments of TanSat and GOSAT CO 2 data against model calculations using the GEOS-Chem model. | Hartmut BOESCH Yi LIU Paul I PALMER Johanna TAMMINEN Jasdeep S ANAND Zhaonan CAI Ke CHE Huilin CHEN Xi CHEN Liang FENG Janne HAKKARAINEN Pauli HEIKKINEN Nikoleta KALAITZI Rigel KIVI Robert PARKER Peter SOMKUTI Jing WANG Alex WEBB Dongxu YANG Lu YAO You YI | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 2 |
| 5 | Intermediate to Long-Term Results of Radiofrequency Modified Maze Procedure as an Adjunct to Open-Heart Surgery显示文摘 | Willem P. Beukema Hauw T. Sie Anand R. Ramdat Misier Peter Paul H.M. Delnoy Hein J.J. Wellens Arif Elvan | 2008 | The Annals of Thoracic Surgery2008，，5： | 2 |
| 6 | Optimal part orientation in Rapid Manufacturing process for achieving geometric tolerances显示文摘 | Ratnadeep Paul Sam Anand | 2011 | Journal of Manufacturing Systems2011，，4： | 2 |
| 7 | Capabilities and Achievements:An Empirical Study显示文摘 | Anand Paul Martin van Hees | 2006 | Journal of Socio-Economics2006，，2： | 1 |
| 8 | Molecular pathogenesis in sporadic head and neck paraganglioma显示文摘 | Bikhazi Paul H Mhatre Anand N Goldstein Jayne A | 2000 | Laryngoscope2000，110，8： | 1 |
| 9 | Radiotherapy for Liver Metastases: A Review of Evidence显示文摘 | Morten H?yer Anand Swaminath Sean Bydder Michael Lock Alejandra Méndez Romero Brian Kavanagh Karyn A. Goodman Paul Okunieff Laura A. Dawson | 2012 | International Journal of Radiation Oncology Biology Physics2012，，3： | 1 |
| 10 | Recurrent hepatocellular carcinoma after transplantation: Use of a pathological score on explanted livers to predict recurrence显示文摘 | Jeremy R. Parfitt Paul Marotta Mohammed AlGhamdi William Wall Anand Khakhar Neville G. Suskin Douglas Quan Vivian McAllister Cam Ghent Mark Levstik Carolyn McLean Subrata Chakrabarti Bertha Garcia David K. Driman | 2007 | Liver Transpl2007，，4： | 1 |
| 11 | Morphologieal dila- tion image coding with context weights prediction显示文摘 | Jiaji Wu Anand Paul Yan Xing | 2010 | lm: age Communieation2010，25，10： | 1 |
| 12 | On returns policies with exogenous price显示文摘 | Indranil Bose Paul Anand | 2007 | European J of Operational Research2007，178，3： | 1 |
| 13 | Liver Transplantation for Advanced Hepatocellular Carcinoma Using Poor Tumor Differentiation on Biopsy as an Exclusion Criterion显示文摘 | Derek DuBay Charbel Sandroussi Lakhbir Sandhu Sean Cleary Markus Guba Mark S. Cattral Ian McGilvray Anand Ghanekar Markus Selzner Paul D. Greig David R. Grant | 2011 | Annals of Surgery2011，，1： | 1 |
| 14 | Process energy analysis and optimization in se- lective laser sintering 显示文摘 | Paul R Anand S | 2012 | Journal of Manufacturing Systems2012，31，4： | 1 |
| 15 | Silica Induced Early Fibrogenic Reaction in Lung of Mice Ameliorated by Nyctanthes arbortristis Extract显示文摘Objective To investigate the pharmacological effect of Nyctanthes arbortristis (NAT) leaf extract in the prevention of lung injury induced by silica particles. Method Lung injury was induced in Swiss mice through inhalation exposure to silica particles (<5m) using a Flow Past Nose Only Inhalation Chamber at the rate of -10 mg/m3 respirable mass for 5 h. Lung bronchoalveolar lavage (BAL) fluid collected between 48 and 72 h was subjected to protein profiling by electrophoresis and cytokine evaluation by solid phase sandwich ELISA. Lung histopathology was performed to evaluate lung injury. Results Inhalation of silica increased the level of tumor necrosis factor-a (TNF-a), and of the 66 and 63 kDa peptides in the BAL fluid in comparison to sham-treated control. Pre-treatment of silica exposed mice with NAT leaf extract significantly prevented the accumulation of TNF-a in the BAL fluid, but the 66 and 63 kDa peptides remained unchanged. The extract was also effective in the prevention of silica-induced early fibrogenic reactions like congestion, edema and infiltration of nucleated cells in the interstitial alveolar spaces, and thickening of alveolar septa in mouse lung. Conclusion NAT leaf extract helps in bypassing silica induced initial lung injury in mice. | BHOLA NATH PAUL*,1, ANAND PRAKASH*, SIRISH KUMAR*, AJAY K. YADAV*, U. MANI+, ASHOK K. SAXENA*, ANAND PRAKASH SAHU#, KEWAL LAL+, AND KALYAN K. DUTTA+ *Immunobiology Laboratory +Inhalation Toxicology Laboratory #Preventive Toxicology Laboratory Industrial Toxicology Research Centre, M.G.Marg, Lucknow 226001, U.P. India | 2002 | Biomedical and Environmental Sciences2002，15，3： | 1 |
| 16 | An Investigation on Thermization of Milk in Can Using Computational Fluid Dynamics显示文摘 | D. Anand Paul N. Chhanwal C. Anandharamakrishnan | 2011 | Journal of Food Science and Engineering2011，1，1： | 1 |
| 17 | Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy显示文摘 | Sean M. Bagshaw Stephen Lapinsky Sandra Dial Yaseen Arabi Peter Dodek Gordon Wood Paul Ellis Jorge Guzman John Marshall Joseph E. Parrillo Yoanna Skrobik Anand Kumar | 2009 | Intensive Care Medicine2009，，5： | 1 |
| 18 | Simple proba- bility models for project contracting 显示文摘 | ANAND PAUL GENARO GUTIERREZ | 2005 | European Journal of Operational Research2005，165，2005： | 1 |
| 19 | Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy显示文摘 | Sean M. Bagshaw Stephen Lapinsky Sandra Dial Yaseen Arabi Peter Dodek Gordon Wood Paul Ellis Jorge Guzman John Marshall Joseph E. Parrillo Yoanna Skrobik Anand Kumar | 2009 | Intensive Care Medicine2009，，5： | 1 |
| 20 | Molecular pathogenesis in sporadic head and neck paraganglioma 显示文摘 | Bikhazi Paul H Mhatre Anand N Goldstein Jayne A | 2000 | Laryngoscope2000，110，8： | 1 |
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