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| 1 | Endovascular treatment of patients with high-risk symptomatic intracranial vertebrobasilar stenoses:long-term outcomes显示文摘background and purpose We present the long-term outcome after endovascular treatment of symptomatic intracranial posterior circulation stenoses.Methods 30 patients with symptomatic intracranial posterior circulation stenoses exceeding 70% underwent endovascular treatment between 2006 and 2012.Data regarding presentation,follow-up,procedure details,complications and imaging follow-up were reviewed.All surviving patients underwent a phone interview to establish their current Modified Ranking Scales(MRS).results Stenoses of the intracranial vertebral artery(24 patients)and basilar artery(6 patients)were treated with stents(10 patients),angioplasty alone(13 patients)or both(5 patients).Two procedures failed.One patient(3.3%)died after the procedure,two had stroke(6.6%)and one a subarachnoid haemorrhage without ensuing deficit.Two patients(6.7%)had asymptomatic complications(dissection and pseudoaneurysm).The median clinical follow-up time was 7 years.Of the 29 patients who survived the procedure,6 died due to unrelated causes.Three patients(10%)had recurrent strokes and two(6.7%)a transient ischaemic attack in the posterior circulation.Two patients had subsequent middle cerebral artery strokes.Five(16.7%)patients had recurrent stenoses and three(10%)occlusions of the treated artery.Retreatment was performed in six patients,three(10%)with PTA and three(10%)with stenting.Current MRS scores were as follows:nine MRS 0,eight MRS 1,four MRS 2 and one MRS 4.Conclusions Long-term follow-up after endovascular treatment of high-risk symptomatic intracranial posterior circulation stenoses shows few stroke recurrences.Treatment of intracranial vertebral artery stenosis may be beneficial in appropriately selected patients. | Tanja Djurdjevic AndréCunha Ursula Schulz Dennis Briley Peter Rothwell Wilhelm Küker | 2019 | Stroke & Vascular Neurology2019，4，4： | 1 |
| 2 | Mucinous carcinoma of the breast: a pathologic study of 82 cases显示文摘 | Andre S Cunha F Bemardo M | 1995 | J Surg Oncol1995，58，3： | 1 |
| 3 | Mucinous carcinoma of the breast:a pathologic study of 82 cases显示文摘 | Andre S Cunha F Bernardo M | 1995 | J Surg On- co11995，58，3： | 1 |
| 4 | The Resin from Protium heptaphyllum Prevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms显示文摘 | Karine Maria Martins Bezerra Carvalho José Delano Barreto Marinho Filho Tiago Sousa de Melo Ana Jérsia Araújo Josiane da Silva Quetz Maria do Perpétuo Socorro Saldanha da Cunha Karina Moura de Melo Armenio Andre de Carvalho Almeida da Silva Adriana Rocha | 2015 | Evidence-Based Complementary and Alternative Medicine2015，，： | 1 |
| 5 | Endoscopic Sphincterotomy Before Deployment of Covered Metal Stent is Associated With Greater Complication Rate: A Prospective Randomized Control Trial显示文摘 | Everson L. A. Artifon Paulo Sakai Shinichi Ishioka Sérgio B. Marques André S. Lino José E. M. Cunha José Jukemura Ivan Cecconello Flair J. Carrilho Eduardo Opitz Atul Kumar | 2008 | Journal of Clinical Gastroenterology2008，，7： | 1 |
| 6 | Lymph Node Involvement and Not the Histophatologic Subtype Is Correlated with Outcome After Resection of Adenocarcinoma of the Ampulla of Vater显示文摘 | Luciana Bertocco Haddad Rosely Antunes Patzina S?nia Penteado André Luiz Montagnini José Eduardo Monteiro Cunha Marcel Cerqueira César Machado José Jukemura | 2010 | Journal of Gastrointestinal Surgery2010，，4： | 1 |
| 7 | Progressive decline in stroke mortality in Brazil from 1980 to 1982,1990 to 1992, and 2000 to 2002显示文摘 | Andre C Curioni CC Braga da Cunha C | 2006 | Stroke2006，37，： | 1 |
| 8 | Purification,biochemical characterization and antifungal activity of a new lipid transfer protein (LTP) from Coffea ccmephora seeds with a-amylase inhibitor properties显示文摘 | Umberto Zottich Maura Da Cunha Andr O Carvalho et 01 | 2011 | Bioehimica et Biophysica Acta2011，1810，4： | 1 |
| 9 | 腐殖质和生物肥料对植物发育和微生物活性的协同作用显示文摘鉴于农业地区投入物的循环利用,农业生态系统和生态循环是开放的。不可再生资源从空气、水和土地中转化或迁移到农业生态系统中,并作为废物而非可再生、可循环利用的资源流出。当前的环境状况,正推动开发能够优化养分循环、最大限度地减少外部投入物的使用并提高其使用效率的方法,一些源于小麦秸秆和生物肥料中的腐殖质产品可以作为堆肥茶和粪肥茶,以减少化学合成物质的使用。本文旨在加深我们对腐殖质与生物肥料联合使用的认识,同时阐述了每一种化合物的生物刺激作用。因此,本文提出了疑问:腐殖质和生物肥料的联合应用是否可以促进二者的协同作用并有可能提高药效?由于腐殖质和生物肥料对植物和微生物的促进效果是相互联系的,所以二者的效果可能会被混淆。例如,腐殖质促进的根伸长可能会增加菌根真菌的定殖。因此,本文被划分为3个部分:腐殖质和生物肥料对植物、真菌、细菌的影响。研究结果表明,腐殖质的来源和施用量对植物生长和微生物活性具有强烈影响,而腐殖质的作用效果也因微生物种类和植物的类型而不同。从本文中所涉及的文献的数据可以看出,联合使用腐殖质和生物肥料来刺激植物发育和微生物活性在农业系统中具有巨大前景。 | Jose Franco Da Cunha Leme Filho Wade E.Thomason Gregory K.Evanylo Xunzhong Zhang Michael S.Strickland Bee K.Chim Andre A.Diatta 黄亚茹(译) 李冬梅(译) 袁红莉(译) | 2022 | 腐植酸2022，，2： | 1 |
| 10 | TDBS:A Time Di- Vision Beacon Scheduling Mechanism for Zigbee Cluster-Tree Wireless Sensor Networks 显示文摘 | Anis Koubaa Andre Cunha Mario Alves | 2008 | Real- Time Systems2008，40，3： | 1 |
| 11 | Prognostic significance of epidermal growth factor receptor overexpression in pancreas cancer and nodal metastasis显示文摘 | Marcos Vinicius Perini Andre Luis Montagnini Renata Coudry Rosely Patzina Sonia Penteado Emilio Elias Abdo Alessandro Diniz Jose Jukemura Jose Eduardo Monteiro Cunha | 2015 | ANZ J Surg2015，，3： | 1 |
| 12 | Evidence that AKT and GSK-3β pathway are involved in acute hyperhomocysteinemia显示文摘 | Aline A. da Cunha Ana Paula Horn Juliana B. Hoppe Patrícia B. Grudzinski Samanta O. Loureiro Andréa G.K. Ferreira Maira J. da Cunha Felipe Schmitz Christianne G. Salbego Angela T.S. Wyse | 2012 | International Journal of Developmental Neuroscience2012，，5： | 1 |
| 13 | 高危症状性颅内椎基底动脉狭窄患者血管内治疗的远期疗效显示文摘背景和目的探讨血管内治疗对症状性颅内后循环动脉狭窄患者的长期疗效。方法收集2006—2012年经血管内治疗的30例症状性、颅内后循环动脉狭窄超过70%的患者。回顾性分析患者的临床资料、手术过程、并发症、影像学和随访资料。所有存活的患者都接受了电话随访,以获取他们当前的改良Rankin量表(mRS)评分。结果30例患者中有24例为颅内椎动脉狭窄,6例为基底动脉狭窄。其中10例患者行支架植入术治疗,13例行经皮穿刺腔内血管成形术(PTA)治疗,还有5例患者同时行支架植入和PTA治疗。另有2例患者手术失败。术后死亡患者1例(3.3%),卒中患者2例(6.6%),1例为原发性蛛网膜下腔出血。2例患者(6.7%)出现无症状并发症(夹层和假性动脉瘤)。本研究的中位数临床随访时间为7年。在29例术后存活患者中,有6例死于其他无关因素。有3例患者(10%)出现卒中复发,2例(6.7%)为短暂性后循环缺血发作。2例患者出现继发性大脑中动脉卒中。5例患者(16.7%)再次出现动脉狭窄,其中3例为(10%)手术的动脉血管闭塞。有6例患者接受了二次手术治疗,其中3例患者(10%)行PTA治疗,另3例(10%)行支架植入术治疗。患者当前的mRS评分结果为:9例mRS评分为0分,8例mRS评分为1分,4例mRS评分为2分,1例mRS评分为4分。结论通过长期随访发现,高危症状性颅内后循环动脉狭窄患者经血管内治疗后,卒中复发率较低。选择合适的颅内椎动脉狭窄患者并予以血管内治疗可能使其获益。 | Tanja Djurdjevir AndréCunha Ursula Schulz Dennis Brilev Peter Rothwell Wilhelm Kuker 许倩(译) | 2020 | 英国医学杂志中文版2020，23，5： | 1 |
| 14 | Efficacy of melatonin in the treatment of endometriosis: A phase II, randomized, double-blind, placebo-controlled trial显示文摘 | André Schwertner Claudia C. Concei??o dos Santos Gislene Dalferth Costa Alícia Deitos Andressa de Souza Izabel Cristina Custodio de Souza Iraci L.S. Torres Jo?o Sabino L. da Cunha Filho Wolnei Caumo | 2013 | Pain2013，，6： | 1 |
| 15 | An Estimate of the Cost of Hepatitis C Treatment for the Brazilian Health System显示文摘 | Carine Raquel Blatt Noemia Liege Maria da Cunha Bernardo Junior Andre Rosa Fabiola Bagatini Rodrigo Fernandes Alexandre Giacomo Balbinotto Neto Uwe Siebert Mareni Rocha Farias | 2012 | Value in Health Regional Issues2012，，： | 1 |
| 16 | TDBS: a Time Division Beacon Scheduling Mechanism for Zigbee Cluster-Tree Wireless Sensor Networks 显示文摘 | Anis Koubaa Andre Cunha Mario Alves | 2008 | Real-Time Systems2008，40，3： | 1 |
| 17 | Increased inflammatory markers in brain and blood of rats subjected to acute homocysteine administration显示文摘 | Aline A. Cunha Andréa G. K. Ferreira Angela T. S. Wyse | 2010 | Metabolic Brain Disease2010，，2： | 1 |
| 18 | Radiographic and tomographic description of marlin sucker Remora osteochir, Pisces: Echeneidae—preliminary data of one specimen显示文摘Remoras are commensal fish of various marine species,such as sharks,swordfishes,turtles,dolphins,manta rays and whales.One specimen of marlin sucker Remora osteochir was evaluated using computed tomography for skeletal digital reconstruction,digital radiology for general evaluation and bone counting,and the double contrast technique to distinguish coelomic organs.In radiographic images,it was possible to observe otoliths in the center of the neurocranium,to count 27 vertebrae,nine pairs of ribs,and to detect the presence of the hipural and epural bones near of the caudal fin.In double contrast images,it was possible to visualize the swim bladder,gills,heart,liver,stomach and intestines.From the tomographic images and reconstructions,it was possible to identify the intercalar bones of the cephalic disc;the spine with vertebral bodies composed of neural arches and ventral ribs;and the pectoral girdle formed by posttemporal,cleithrum and scapulocoracoid bones.It was concluded that digital radiology and computed tomography were able to describe anatomical structures of marlin sucker R.osteochir without the need for dissection. | AndréLuiz Veiga Conrado Renata Stecca lunes Carlos Eduardo Malavasi Bruno Aline Tiemi Shiraishi Rocha JoséRoberto Machado Cunha da Silva | 2020 | Marine Life Science & Technology2020，2，3： | 0 |
| 19 | 一氧化氮合成酶、环氧化酶-2、硝基酪氨酸及血管生成与软骨肉瘤预后的相关性研究显示文摘背景:免疫组织化学标记物有助于肿瘤诊断及预后评估。通过对硝基酪氨酸分析及采用一氧化氮合成酶1(NOS1)、一氧化氮合成酶2(NOS2)、一氧化氮合成酶3(NOS3)检测分析可了解一氧化氮(NO)与肿瘤的相关性。NO与超氧阴离子反应产生的过氧亚硝酸对基因有毒性作用,过氧亚硝酸传递一个硝基基团到酪氨酸的苯环上形成硝基酪氨酸。细胞内硝基酪氨酸的积累说明过氧亚硝酸持续生成。NO刺激所生成的环氧化酶-2(COX-2)与肿瘤内新生血管水平相关,研究表明新生血管影响肿瘤预后,免疫组化标记CD34可表示微血管生成,从而被用于预测肿瘤预后。本研究检测上述标记物在软骨肉瘤中的表达并分析与软骨肉瘤分级和预后的相关性。方法:101例软骨肉瘤患者肿瘤组织样本采用甲醛固定,组织样本采用免疫组织化学染色,指标为:NOS1、NOS2、NOS3、COX-2、硝基酪氨酸和CD34。5例正常软骨样本作为对照。研究分析患者特征、手术变量、肿瘤分级与这些指标的相关性。使用Kaplan—Meier多变量统计学方法分析生存曲线及生存率。结果:硝基酪氨酸、COX-2和CD34与组织学分级有明显相关性(p=0.022,p=0.014,p=0.028),但与总体预后无相关性(p=0.064,p=0.143,p=0.581)。NOS2阳性表达常预示较高的局部复发率(p=0.038)。NOS1、NOS2阳性表达预示较低的生存率(p=0.007,p〈0.001)。通过多变量分析处理,NOS2的表达被证实可作为局部复发率的独立预后判断因素;NOS1、NOS2的表达作为因变量,它们单独或复合阳性表达常与较低的总生存率有关(p=0.046,p=0.004)[危险率,3.17(95%置信区间,1.0-9.8)和5.58(95%置信区间,1.7-18.0)]。 | Suely Akiko Nakagawa Ademar Lopes Andre Lopes de Carvalho Benedito Mauro Rossi Isabela Werneck da Cunha Fernando Augusto Soares Wu Tu Chung Luciola Assuncao 刘沛宜(译) 张伟滨(译) | 2010 | 中华骨科杂志2010，30，12： | 0 |
| 20 | Overweight and abdominal fat are associated with normal bone mineral density in patients with ulcerative colitis显示文摘BACKGROUND Low bone mineral density(BMD)is common in patients with inflammatory bowel disease.However,nutritional risk factors for low BMD in the ulcerative colitis(UC)population are still poorly understood.AIM To investigate the association of anthropometric indicators and body composition with BMD in patients with UC.METHODS This is a cross-sectional study on adult UC patients of both genders who were followed on an outpatient basis.A control group consisting of healthy volunteers,family members,and close people was also included.The nutritional indicators evaluated were body mass index(BMI),total body mass(TBM),waist circumference(WC),body fat in kg(BFkg),body fat in percentage(BF%),trunk BF(TBF),and also lean mass.Body composition and BMD assessments were performed by dual-energy X-ray absorptiometry.RESULTS The sociodemographic characteristics of patients with UC(n=68)were similar to those of healthy volunteers(n=66)(P>0.05).Most patients(97.0%)were in remission of the disease,58.8%were eutrophic,33.8%were overweight,39.0%had high WC,and 67.6%had excess BF%.However,mean BMI,WC,BFkg,and TBF of UC patients were lower when compared to those of the control group(P<0.05).Reduced BMD was present in 41.2%of patients with UC(38.2%with osteopenia and 2.9%with osteoporosis)and 3.0%in the control group(P<0.001).UC patients with low BMD had lower BMI,TBM,and BFkg values than those with normal BMD(P<0.05).Male patients were more likely to have low BMD(prevalence ratio[PR]=1.86;95%confidence interval[CI]:1.07-3.26).Those with excess weight(PR=0.43;95%CI:0.19-0.97)and high WC(PR=0.44;95%CI:0.21-0.94)were less likely to have low BMD.CONCLUSION Patients with UC in remission have a high prevalence of metabolic bone diseases.Body fat appears to protect against the development of low BMD in these patients. | Mirella Brasil Lopes Andre Castro Lyra Raquel Rocha Fernanda Gomes Coqueiro Carla Andrade Lima Carolina Cunha de Oliveira Genoile Oliveira Santana | 2022 | World Journal of Gastrointestinal Pharmacology and Therapeutics2022，13，4： | 0 |
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