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| 1 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 2 | A pair of transposon-derived proteins function in a histone acetyltransferase complex for active DNA demethylation显示文摘Transposons 被 epigenetic 机制通常包括 DNA methylation 使沉默。这里,我们识别了一双先驱导出 transposon 的蛋白质(HDP ) , HDP1 和 HDP2,在 Arabidopsis 的反沉默因素。hdp1 和 hdp2 异种显示了 transgenes 和某 transposons 的提高的 silencing。种系发生的分析表明 HDP1 和 HDP2 分别地从先驱编码 transposon 的 transposase 和 DNA 有约束力的蛋白质被共同驯养。HDP1 在原子核与 HDP2 交往,类似于他们的 transposon 对应物。而且, HDP1 和 HDP2 与组成在 DNA demethylation 工作的 histone acetyltransferase 建筑群的 IDM1, IDM2, IDM3 和 MBD7 被联系。HDP2 和 methyl-DNA-binding 蛋白质 MBD7 分享普通 genomic 绑定地点的一个大集合,显示他们联合决定 histone acetyltransferase 建筑群的目标特性。因此,我们的数据表明 HDP1 和 HDP2 组成被招募了到 histone acetyltransferase 建筑群阻止 DNA hypermethylation 和 epigenetic silencing 的一个功能的模块。 | Cheng-Guo Duan Xingang Wang Shaojun Xie Li Pan Daisuke Miki Kai Tang Chuan-Chih Hsu Mingguang Lei Yingli Zhong Yueh-Ju Hou ZhijuanWang Zhengjing Zhang Satendra K Mangrauthia Huawei Xu Heng Zhang Brian Dilkes W Andy Tao Jian-Kang Zhu | 2017 | Cell Research2017，27，2： | 6 |
| 3 | A Chaos Sparrow Search Algorithm with Logarithmic Spiral and Adaptive Step for Engineering Problems显示文摘The sparrow search algorithm(SSA)is a newly proposed meta-heuristic optimization algorithm based on the sparrowforaging principle.Similar to other meta-heuristic algorithms,SSA has problems such as slowconvergence speed and difficulty in jumping out of the local optimum.In order to overcome these shortcomings,a chaotic sparrow search algorithm based on logarithmic spiral strategy and adaptive step strategy(CLSSA)is proposed in this paper.Firstly,in order to balance the exploration and exploitation ability of the algorithm,chaotic mapping is introduced to adjust the main parameters of SSA.Secondly,in order to improve the diversity of the population and enhance the search of the surrounding space,the logarithmic spiral strategy is introduced to improve the sparrow search mechanism.Finally,the adaptive step strategy is introduced to better control the process of algorithm exploitation and exploration.The best chaotic map is determined by different test functions,and the CLSSA with the best chaotic map is applied to solve 23 benchmark functions and 3 classical engineering problems.The simulation results show that the iterative map is the best chaotic map,and CLSSA is efficient and useful for engineering problems,which is better than all comparison algorithms. | Andi Tang Huan Zhou Tong Han Lei Xie | 2022 | Computer Modeling in Engineering & Sciences2022，，1： | 5 |
| 4 | Treatment of postoperative infectious complications in patients with human immunodef iciency virus infection显示文摘BACKGROUND: Antibiotics are widely given for surgical patients to prevent infection. Because of the lack of study on the rational use of antibiotics in patients with human immunodef iciency virus(HIV)-infected during surgical procedures, we analyzed the risk factors affecting postoperative infectious complications in HIV-infected patients and explore the rational use of perioperative antibiotics.METHODS: This retrospective study consisted of 308 HIV-infected patients, 272 males and 36 females, who had undergone operation at the Shanghai Public Health Clinical Center from November 2008 to April 2012. The patients were divided into postoperative infection and non-infection groups. Their age and clinical variables were compared. The correlation between surgical incision, surgical site infection(SSI) and postoperative sepsis was analyzed. Prophylactic antibiotics were used for patients with type I and II incisions for less than 2 days. Patients with type III incisions were given antibiotics until the infection was controlled. Antiretroviral therapy(ART) was prescribed preoperatively for patients whose preoperative CD4 count was <350 cells/μL. For those patients whose preoperative CD4 count was <200 cells/μL, sulfamethoxazole and fluconazole were given preoperatively as prophylactic agents controlling Pneumocystis carinii pneumonia and fungal infection.RESULTS: A total of 196 patients developed postoperative infectious complications, and 7 patients died. Preoperative CD4 counts, ratio of CD4/CD8 cells, hemoglobin level, and postoperative CD4 counts, hemoglobin and albumin levels were risk factors of perioperative infection in HIV-infected patients. Patients with a preoperative CD4 count <200 cell/μL, anemia, a postoperative CD4 count <200 cell/μL or albumin levels <35 g/L were correlated with a higher rate of perioperative infection. There was a signif icant correlation between SSI and the type of surgical incision. The rate of SSI in patients with type I surgical incision was 2% and in those with type II surgical incision was 38%. All the patients who received type III surgical incision developed SSI, and they were more likely to develop postoperative sepsis.CONCLUSIONS: HIV-infected patients are more likely to develop postoperative infectious complications. The rational use of antibiotics in HIV-infected patients could help to reduce the rate of postoperative infectious complications in these patients. | Bao-chi Liu Lei Zhang Jin-song Su Andy Tsun Bin Li | 2014 | World Journal of Emergency Medicine2014，5，2： | 4 |
| 5 | Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos显示文摘 | Yuyu Niu Bin Shen Yiqiang Cui Yongchang Chen Jianying Wang Lei Wang Yu Kang Xiaoyang Zhao Wei Si Wei Li Andy Peng Xiang Jiankui Zhou Xuejiang Guo Ye Bi Chenyang Si Bian Hu Guoying Dong Hong Wang Zuomin Zhou Tianqing Li Tao Tan Xiuqiong Pu Fang Wang Shaohu | 2014 | Cell2014，，： | 3 |
| 6 | Progressive silencing of the zinc transporter Zip8 (Sic39a8) in chronic cadmium-exposed lung epithelial cells显示文摘镉(Cd ) ,非本质的金属,暗地里由利用进口小径的必要金属进入房间。锌 transporters Zip8 , Zip14 ,和二价的金属 transporter ( Dmt1 ) 1 现在作为涉及细胞的 Cd 加入的几重要金属 transporters 正在出现,他们的表情被显示了下面调整在几Cd抵抗( Cd R )房间线,然而这些 transporters 的参与在在肺房间的Cd抵抗的发展期间是不清楚的。在这研究,我们因此在我们的以前确定的老鼠肺检查这些金属 transporters 的表示上皮的房间(LEC ) 和 Zip8 的水平是的表演日益增多地 silenced 当 LEC 被使适应增加 CdCl 2 的集中时(从 1 ~ 20 M ) 。细胞的 Cd 内容的随后的测量显示了那 Cd R LEC 展出 Cd 累积的显著减少,可能由于 Zip8 的损失表示。我们调查由 DNA hypermethylation 的 Zip8 基因的 epigenetic silencing 涉及 Zip8 表示的下面规定的可能性。Cd R LEC 比父母房间显示出 DNA methyltransferase 3b (Dnmt3b ) 的更高的 mRNA 水平。Cd 有 5-aza-2-deoxycytidine 的 R LEC, DNA methyltransferases 的一个禁止者,回复到在这些房间的 Cd 的 Zip8 和敏感的表示,为 Cd 进口显示 Zip8 的关键角色。一起拿,我们的结果证明 Zip8 表示的进步 silencing 在肺房间对 Cd 涉及抵抗的获得,代表抵抗导致 Cd 的 cytotoxicity 的适应幸存机制。 | Yangmin Gao Yanming Xu Dandan Wu Feiyuan Yu Lei Yang Yue Yao Zhanling Liang Andy T. Y. Lau | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 2 |
| 7 | Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos显示文摘 | Yuyu Niu Bin Shen Yiqiang Cui Yongchang Chen Jianying Wang Lei Wang Yu Kang Xiaoyang Zhao Wei Si Wei Li Andy Peng Xiang Jiankui Zhou Xuejiang Guo Ye Bi Chenyang Si Bian Hu Guoying Dong Hong Wang Zuomin Zhou Tianqing Li Tao Tan Xiuqiong Pu Fang Wang Shaohu | 2014 | Cell2014，，： | 1 |
| 8 | Clinical Practice Guidance for Radiotherapy Planning After Induction Chemotherapy in Locoregionally Advanced Head-and-Neck Cancer显示文摘 | Joseph K. Salama Robert I. Haddad Merril S. Kies Paul M. Busse Lei Dong David M. Brizel Avraham Eisbruch Roy B. Tishler Andy M. Trotti Adam S. Garden | 2009 | International Journal of Radiation Oncology Biology Physics2009，，3： | 1 |
| 9 | Adaptive Channel Equalization of Room Acoustics Exploiting Sparseness Constraint 显示文摘 | LEI L ANDY W H | 2011 | IEEE Signal Processing Letters2011，18，4： | 1 |
| 10 | A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis显示文摘The testis is pivotal for male reproduction,and its progressive functional decline in aging is associated with infertility.However,the regulatory mechanism underlying primate testicular aging remains largely elusive.Here,we resolve the aging-related cellular and molecular alterations of primate testicular aging by establishing a single-nucleus transcriptomic atlas.Gene-expression patterns along the spermatogenesis trajectory revealed molecular programs associated with attrition of spermatogonial stem cell reservoir,disturbed meiosis and impaired spermiogenesis along the sequential continuum.Remarkably,Sertoli cell was identified as the cell type most susceptible to aging,given its deeply perturbed age-associated transcriptional profiles.Concomitantly,downregulation of the transcription factor Wilms'Tumor 1(WTi),essential for Sertoli cell homeostasis,was associated with accelerated cellular senescence,disrupted tight junctions,and a compromised cell identity signature,which altogether may help create a hostile microenvironment for spermatogenesis.Collectively,our study depicts in-depth transcriptomic traits of non-human primate(NHP)testicular aging at single-cell resolution,providing potential diagnostic biomarkers and targets for therapeutic interventions against testicular aging and age-related male reproductive diseases. | Daoyuan Huang Yuesheng Zuo Chen Zhang Guoqiang Sun Ying Jing Jinghui Lei Shuai Ma Shuhui Sun Huifen Lu Yusheng Cai Weiqi Zhang Fei Gao Andy Peng Xiang Juan Carlos Izpisua Belmonte Guang-Hui Liu Jing Qu Si Wang | 2023 | Protein & Cell2023，14，12： | 0 |
| 11 | Characterizing cellular mechanical phenotypes with mechanonode-pore sensing显示文摘The mechanical properties of cells change with their differentiation,chronological age,and malignant progression.Consequently,these properties may be useful label-free biomarkers of various functional or clinically relevant cell states.Here,we demonstrate mechano-node-pore sensing(mechano-NPS),a multi-parametric single-cell-analysis method that utilizes a four-terminal measurement of the current across a microfluidic channel to quantify simultaneously cell diameter,resistance to compressive deformation,transverse deformation under constant strain,and recovery time after deformation.We define a new parameter,the whole-cell deformability index(wCDI),which provides a quantitative mechanical metric of the resistance to compressive deformation that can be used to discriminate among different cell types.The wCDI and the transverse deformation under constant strain show malignant MCF-7 and A549 cell lines are mechanically distinct from non-malignant,MCF-10A and BEAS-2B cell lines,and distinguishes between cells treated or untreated with cytoskeleton-perturbing small molecules.We categorize cell recovery time,ΔT_(r),as instantaneous(ΔTr~0 ms),transient(ΔT_(r)≤40 ms),or prolonged(ΔT_(r)>40 ms),and show that the composition of recovery types,which is a consequence of changes in cytoskeletal organization,correlates with cellular transformation.Through the wCDI and cell-recovery time,mechano-NPS discriminates between sub-lineages of normal primary human mammary epithelial cells with accuracy comparable to flow cytometry,but without antibody labeling.Mechano-NPS identifies mechanical phenotypes that distinguishes lineage,chronological age,and stage of malignant progression in human epithelial cells. | Junghyun Kim Sewoon Han Andy Lei Masaru Miyano Jessica Bloom Vasudha Srivastava Martha R.Stampfer Zev J.Gartner Mark A.LaBarge Lydia L.Sohn | 2018 | Microsystems & Nanoengineering2018，4，1： | 0 |
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