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| 1 | Relationship of MTHFR gene polymorphisms with renal and cardiac disease显示文摘AIM: To investigate the effects of different methylenetetrahydrofolate reductase(MTHFR) 677C>T gene polymorphism and hyperhomocysteinemia for the development of renal failure and cardiovascular events, which are controversial.METHODS: We challenged the relationship, if any, of MTHFR 677C>T and MTHFR 1298A>C polymorphisms with renal and heart function. The present article is a reappraisal of these concepts, investigating within a larger population, and including a subgroup of dialysis patients, if the two most common MTHFR polymorphisms, C677 T and A1298 C, as homozygous, heterozygous or with a compound heterozygous state, show different association with chronic renal failure requiring hemodialysis. MTHFR polymorphism could be a favorable evolutionary factor, i.e., a protective factor for many ominous conditions, like cancer and renal failure. A similar finding was reported in fatty liver disease in which it is suggested that MTHFR polymorphisms could have maintained and maintain their persistence by an heterozygosis advantage mechanism. We studied a total of 630 Italian Caucasian subject aged 54.60 ± 16.35 years, addressing to the increased hazard of hemodialysis, if any, according to the studied MTHFR genetic polymorphisms. RESULTS: A favorable association with normal renal function of MTHFR polymorphisms, and notably of MTHFR C677 T is present independently of the negative effects of left ventricular hypertrophy, increased IntraRenal arterial Resistance and hyperparathyroidism. CONCLUSION: MTHFR gene polymorphisms could have a protective role on renal function as suggested by their lower frequency among our dialysis patients in end-stage renal failure; differently, the association with left ventricular hypertrophy and reduced left ventricular relaxation suggest some type of indirect, or concurrent mechanism. | Francesca M Trovato Daniela Catalano Angela Ragusa G Fabio Martines Clara Pirri Maria Antonietta Buccheri Concetta Di Nora Guglielmo M Trovato | 2015 | World Journal of Nephrology2015，4，1： | 10 |
| 2 | POSITIVE PSYCHOLOGY IN CLINICAL PRACTICE显示文摘 | Angela Lee Duckworth Tracy A. Steen Martin E.P. Seligman | 2005 | Annual Review of Clinical Psychology (2005)2005，，： | 3 |
| 3 | Corrigendum to “Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis” [Cancer Lett. 328 (2) (2012) 212–221]显示文摘 | Angela L. McCleary-Wheeler Gwen A. Lomberk Frank U. Weiss Günter Schneider Muller Fabbri Tara L. Poshusta Nelson J. Dusetti Sandra Baumgart Juan L. Iovanna Volker Ellenrieder Raul Urrutia Martin E. Fernandez-Zapico | 2013 | Cancer Letters2013，，1： | 2 |
| 4 | Circulating miR-29a, Among Other Up-Regulated MicroRNAs, Is the Only Biomarker for Both Hypertrophy and Fibrosis in Patients With Hypertrophic Cardiomyopathy显示文摘 | Roberta Roncarati Chiara Viviani Anselmi Maria Angela Losi Laura Papa Elena Cavarretta Paula Da Costa Martins Carla Contaldi Gloria Saccani Jotti Anna Franzone Laura Galastri Michael V.G. Latronico Massimo Imbriaco Giovanni Esposito Leon De Windt Sandro B | 2014 | Journal of the American College of Cardiology2014，，9： | 2 |
| 5 | Therapeutic and biological activities of Calotropis procera(Ait.) R.Br.显示文摘Medicinal plants have been used to treat various ailments of the poor population around the world;hence the interest among researchers to know the active ingredients of certain plants has being increased.The Calotropis procera(C.procera) is a plant original from Africa,commonly found in northeastern Brazil.It is well known for their pharmacological properties,since it produces large amounts of latex.The important role that medicinal plants play in folk medicine has led us to develop this article in order to review the major pharmacological activities of C. procera. | Marcia Calheiros Chaves Silva Antonio Batista da Silva Fabiano Moura Teixeira Paulo Cesar Pereira de Sousa Regina Maria Macedo Rondon Jose Eduardo Ribeiro Honorio Junior Luiz Rafael Leite Sampaio Samanda Lima Oliveira Angela Nadyla Martins Holonda Silvania Maria Mendes de Vasconcelos | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，4： | 2 |
| 6 | Characterization of Hepatitis C Virus Resistance from a Multiple-Dose Clinical Trial of the Novel NS5A Inhibitor GS-5885显示文摘 | Kelly A. Wong Angela Worth Ross Martin Evguenia Svarovskaia Diana M. Brainard Eric Lawitz Michael D. Miller Hongmei Mo | 2013 | Antimicrobial Agents and Chemotherapy2013，，12： | 2 |
| 7 | Effects of kinetin and nitrogen on growth rates, pigment and protein contents in wild and phycoerythrin-deficient strains of Hypnea musciformis (Rhodophyta)显示文摘 | Aline P. Martins Nair S. Yokoya Maria Angela M. Carvalho Estela M. Plastino | 2008 | Journal of Applied Phycology2008，，5： | 1 |
| 8 | Bilirubin: A Natural Inhibitor of Vascular Smooth Muscle Cell Proliferation显示文摘 | Robert ?llinger Martin Bilban Anna Erat Alberto Froio James McDaid Shivraj Tyagi Eva Csizmadia Aurelio V. Gra?a-Souza Angela Liloia Miguel P. Soares Leo E. Otterbein Anny Usheva Kenichiro Yamashita Fritz H. Bach | 2005 | Circulation2005，，7： | 1 |
| 9 | Cardiac HCN chan-nels,structure,function,and modulation显示文摘 | Martin B Angela S Christian W | 2002 | Trends inCardiovascular Medicine2002，12，5： | 1 |
| 10 | A comparison of parathyroid hormone‐related protein (1‐36) and parathyroid hormone (1‐34) on markers of bone turnover and bone density in postmenopausal women: The PrOP study显示文摘 | Mara J Horwitz Marilyn Augustine Leila Kahn Emily Martin Christine C Oakley Raquel M Carneiro Mary Beth Tedesco Angela Laslavic Susan M Sereika Alessandro Bisello Adolfo Garcia‐Oca?a Caren M Gundberg Jane A Cauley Andrew F Stewart | 2013 | J Bone Miner Res2013，，11： | 1 |
| 11 | Quangitation of Urinary Glycosaminoglycans with Alcian Blue: Evaluation of the Interference by Tamm-Hofsfaa Glycoprotein显示文摘 | Bhavanandan V P Angela Martin | 1996 | Clinica Chimica Acta1996，251，2： | 1 |
| 12 | Systenfic treatment in severe cases of recurrent aphthous stomatitis显示文摘 | Maria Angela Martins Mimura Silvio Kenji Hirota Norberto Nobuo Sugaya | 2009 | Clinics2009，64，3： | 1 |
| 13 | A 10 -year review of the foodscience summer scholars program : a model forresearch training and for recruiting undergraduatestudents into graduate programs and careers in foodscience 显示文摘 | Angela Roberts Janette Robbins Lynne McLandsborough Martin Wiedraann | 2010 | Journal of Food Science Education2010，，9： | 1 |
| 14 | Effectiveness of Al, Ca, and Fe salts for control of internal phosphorus loading in shallow and deep lakes显示文摘 | G. Dennis Cooke Eugene B. Welch Angela B. Martin Donald G. Fulmer James B. Hyde Garin D. Schrieve | 1993 | Hydrobiologia (-)1993，，1： | 1 |
| 15 | Transport and tourism:Roadmap to integrated planning developing and as-sessing integrated chains显示文摘 | Martin Schiefelbusch Angela Jain | | 0，，： | 1 |
| 16 | Glutamine's protection against cellular injury is dependent on heat shock factor-1 显示文摘 | Angela L M Martin D Kristen D S | 2006 | Cell Physiology2006，290，6： | 1 |
| 17 | Incorporating chemical band-assignment in near infrared spectroscopy regressionmodels显示文摘 | Frank Westad Angela Schmidt Martin Kermit | 2008 | Journal of Near Infrared Spectroscopy2008，，3： | 1 |
| 18 | Genomc-based analysis of the nonhuman primate Macaca fascicularis as a model for drug safety assessment 显示文摘 | Martin Ebeling Erich Kllng Angela See | 2011 | Genome Research2011，21，： | 1 |
| 19 | Effectiveness of Al, Ca, and Fe salts for control of internal phosphorus loading in shallow and deep lakes显示文摘 | G. Dennis Cooke Eugene B. Welch Angela B. Martin Donald G. Fulmer James B. Hyde Garin D. Schrieve | | 0，1993，： | 1 |
| 20 | Comparison of problem- and lecture-based pharmacology teaching 显示文摘 | Martin C Michel Angela Bischoff | 2002 | Trends Pharmacology Sci2002，23，4： | 1 |
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