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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | Novel aspects of cellular action of dipeptidyl peptidase IV/CD26显示文摘 | Siegfried Ansorge Karsten Nordhoff Ute Bank Anke Heimburg Heiko Julius Doreen Breyer Anja Thielitz Dirk Reinhold Michael T?ger | 2011 | Biological Chemistry2011，，3： | 1 |
| 3 | 维生素D状况、1,25-(OH)_2D_3与免疫系统显示文摘维生素 D 是一重要的免疫系统调节因子。研究表明它的活性形式——1,25-(OH)_2D_3抑制自身免疫性疾病的发展,包括非特异性肠炎(inflammatory bowel disease,IBD)。与之矛盾的是,1,25-(OH)_2D_3不影响其他免疫系统介导的疾病(实验性哮喘,experimental asthma)和对传染原的免疫力是无效的。维生素 D 缺乏对不同的免疫功能也有相似的矛盾效应。维生素 D 及维生素 D 受体缺乏加速 IBD 病情的发展。1,25-(OH)_2D_3对于实验性哮喘的治疗无效,且维生素 D 受体缺陷小鼠的病情较轻。维生素 D 是免疫系统的选择性调节因子,同时1,25-(OH)_2D_3治疗、维生素 D 缺乏或维生素 D 受体缺陷的后果取决于机体免疫应答的性质(如,传染病、哮喘、自身免疫性疾病)。膳食中钙是决定维生素 D 营养状况对免疫功能影响的另一个因素。膳食中钙可单独影响 IBD 病情的严重程度。低钙膳食、维生素 D 缺乏的小鼠 IBD 病情最为严重;而低钙膳食、1,25-(OH)_2D_3的治疗可使病情有所改善。不过,高钙膳食、1,25_(OH)_2D_3治疗时,对 IBD 的治疗效果最好。免疫的类型和机体的钙营养状况决定了维生素 D 营养状况和1,25-(OH)_2D_3对免疫力的影响。 | Margherita T Cantorna Yan Zhu Monica Froicu Anja Wittke 王李伟 王劲 | 2004 | 营养健康新观察2004，0，3： | 1 |
| 4 | A CFD study of fuel evaporation and related thermo-fluid dynamics in the inlet manifold, port and cylinder of the CFR octane engine 显示文摘 | Anja T Garetha F Chris M | 2012 | SAE International Journal of Fuels and Lubricants2012，，3： | 1 |
| 5 | Molecular and immunological characterisatlon of the glucose regulated protein 78 of Leishmania donovani显示文摘 | Anja T R Jensen Joan Curtis Jacqui Montgomery | 2001 | Biochimica et Biophysica Acta2001，1549，： | 1 |
| 6 | Nitrososphaera viennensis, an ammonia oxidizing archaeon from soil 显示文摘 | MARIA T MICHAELA S ANJA S | 2011 | Proceedings of the National Academy of Sciences of the United States of America2011，108，20： | 1 |
| 7 | Electrical and electrochemical characterization of microstructured thin film La1-xZrxCoO3 electrodes 显示文摘 | ANJA B H MARTIN S HARRY L T | 2006 | Solid State Ionics2006，177，1925： | 1 |
| 8 | Molec- ular profiling and predictive value of cir- culating tumor cells in patients with meta-static breast cancer:an option for monito- ring response to breast cancer related ther- apies 显示文摘 | Mitra T Bahriye A Anja W | 2009 | Breast Cancer Research & Treatment2009，115，3： | 1 |
| 9 | Effective dermatomal blockade after subcostal transversus abdonsversus abdominis plane block显示文摘 | Anja UM Henrik T Egon GH | 2012 | Dan Med J2012，59，3： | 1 |
| 10 | A CFD study of fuel evaporation and related thermo-fiuid dynamics in the inlet manifold, port and cylinder of the CFR octane engine 显示文摘 | Anja T Gareth F Chris M | 2012 | SAE International Jour- nal of Fuels and Lubricants2012，，3： | 1 |
| 11 | Comparative kinetic study of mechanical activation process of mica and talc for industrial application显示文摘 | LJUB~A A ANJA T ZAGORKA A P LJUBICA P MILAN P | 2014 | Composites Part B2014，59，： | 1 |
| 12 | Epidemiology of alexithymia among adolescents显示文摘 | Matti J Anja T Miettunen J | 2007 | Journal of Psycho somatic Research2007，63，4： | 1 |
| 13 | MicroRNA-Based Classification of Hepatocellular Carcinoma and Oncogenic Role of miR-517a显示文摘 | Sara Toffanin Yujin Hoshida Anja Lachenmayer Augusto Villanueva Laia Cabellos Beatriz Minguez Radoslav Savic Stephen C. Ward Swan Thung Derek Y. Chiang Clara Alsinet Victoria Tovar Sasan Roayaie Myron Schwartz Jordi Bruix Samuel Waxman Scott L. Friedman T | 2011 | Gastroenterology2011，，5： | 1 |
| 14 | Clinical Heterogeneity in Patients With FOXP3 Mutations Presenting With Permanent Neonatal Diabetes显示文摘 | Rubio-Cabezas Oscar Minton Jayne A L Caswell Richard Shield Julian P Deiss Dorothee Sumnik Zdenek Cayssials Amely Herr Mathias Loew Anja Lewis Vaughan Ellard Sian Hattersley Andrew T | 2009 | Diabetes Care2009，，1： | 1 |
| 15 | Manganese efficiency in barley:I- dentification and characterization of the metal ion transporter HvlRT1 显示文摘 | Pedas P Cecilie K Anja Y T | 2008 | Plant Physiology2008，148，： | 1 |
| 16 | Sorption of polycyclic aromatic hy drocarbons to oil contaminated sediment:Unresolved complex 显示文摘 | MICHIEL T O ANJA J C | 2003 | Environnental Science I Technology2003，37，： | 1 |
| 17 | The in vitro and in vivo behaviour of retinal pigment epithelial cells cultured on ultrathin collagen membranes显示文摘 | Gabriete T Anja V Andrea G | 2009 | Biomaterials2009，30，： | 1 |
| 18 | 1 kb of the lactase-phlori-zin hydrolase promoter Directes post-weaning decline and small in-testinal-specific expression in Transgenic mice显示文摘 | Jesper T Troelsen Anja Mehlum | 1994 | FEBS Letters1994，，342： | 1 |
| 19 | Basics of standardization and calibrationin cytometry显示文摘 | Anja M Attila T | 2009 | J Biophoton2009，89，2： | 1 |
| 20 | Regulation of respiration and Fermentation to Control the Plant Internal Oxygen Concent ration显示文摘 | Ana Zabalza Joost T van Dongen Anja Froehlich | 2009 | Plant Physiology2009，149，： | 1 |
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