|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 2 | Pancreaticoduodenectomy with Mesentericoportal Vein Resection for Adenocarcinoma of the Pancreatic Head显示文摘 | Nicolas Carrère MD Alain Sauvanet MD Diane Goere MD Reza Kianmanesh MD PhD Marie-Pierre Vullierme MD Anne Couvelard MD PhD Philippe Ruszniewski MD Jacques Belghiti MD | 2006 | World Journal of Surgery2006，，8： | 2 |
| 3 | Modern epidemiology, prophylaxis, and diagnosis and therapy for infective endocarditis显示文摘 | Lisa G. Winston MD Ann F. Bolger MD | 2006 | Current Cardiology Reports2006，，2： | 1 |
| 4 | Superior Survival in Treatment of Primary Nonmetastatic Pediatric Osteosarcoma of the Extremity显示文摘 | Ross M. Wilkins MD John W. Cullen MD Lorrie Odom MD Brandt A. Jamroz MD Patsy McGuire Cullen MS CPNP Kyle Fink MD Sanford D. Peck MD Sydney L. Stevens MD Cynthia M. Kelly MD Anne B. Camozzi BA | 2003 | Annals of Surgical Oncology2003，，5： | 1 |
| 5 | An Overview of Metformin in the Treatment of Type 2 Diabetes Mellitus显示文摘 | Mayer B Davidson MD Anne L Peters MD | 1997 | The American Journal of Medicine1997，，1： | 1 |
| 6 | Transcriptional and posttranscriptional regulation of interstitial collagenase by plateletderived growth factor BB in bone cell cultures显示文摘 | Varghese S Anne MD Liang L | 1996 | Endocrinology1996，137，2： | 1 |
| 7 | Pancreaticoduodenectomy with Mesentericoportal Vein Resection for Adenocarcinoma of the Pancreatic Head显示文摘 | Nicolas Carrère MD Alain Sauvanet MD Diane Goere MD Reza Kianmanesh MD PhD Marie-Pierre Vullierme MD Anne Couvelard MD PhD Philippe Ruszniewski MD Jacques Belghiti MD | 2006 | World Journal of Surgery2006，，8： | 1 |
| 8 | Obstetric somatic and demographic risk factom for postpartum depressive symptoms显示文摘 | Ann J Lisbeth MD Angelsioo MD | 2010 | Am J Obstey Gynecol2010，99，： | 1 |
| 9 | Chemoprevention of Cancer显示文摘 | Anne S Tsao MD Edward SK | 2004 | CA Cancer J Clin2004，54，： | 1 |
| 10 | The metastasis-associated metalloproteinase stromelysin-3 is induced by transforming growth factor-b in osteoblasts and fibroblasts显示文摘 | Anne MD Emesto C | 2001 | Endocrinology2001，142，4： | 1 |
| 11 | Aortic dissection in pregnancy:analysis of risk factors and outcome显示文摘 | Franz FI MD Anne G | 2003 | Ann Thorac Surg2003，76，： | 1 |
| 12 | Timing of estrogen replacement the rapy following hysterec to my with ophorecto my foren dometriosis显示文摘 | Timothy Hickman MD Anne | 1998 | Obstet Gynecol1998，91，： | 1 |
| 13 | Arthroscopic surgery for knee osteoarthritis显示文摘 | Anne MD Bernard MD John MD | 2009 | The Journal of Family Practice2009，58，3： | 1 |
| 14 | Limited literacy and mortality in the elderly显示文摘 | Rebecca L. Sudore MD Kristine Yaffe MD Suzanne Satterfield MD Tamara B. Harris MD Kala M. Mehta DSc Eleanor M. Simonsick PhD Anne B. Newman MD Caterina Rosano MD Ronica Rooks PhD Susan M. Rubin MPH Hilsa N. Ayonayon PhD Dean Schillinger MD | 2006 | Journal of General Internal Medicine2006，，8： | 1 |
| 15 | Tming of estrogen replacement therapy following hysterectomy with oophorectomy for endometriosis显示文摘 | Tmothy N Hickman MD Anne B | 1998 | Obstet Gynecol1998，91，6： | 1 |
| 16 | Can an FDG-PET/CT Predict Tumor Clearance of the Mesorectal Fascia after Preoperative Chemoradiation of Locally Advanced Rectal Cancer?显示文摘 | Roy F. A. Vliegen MD Regina G. Beets-Tan Bart Vanhauten Ann Driessen Michel Oellers Alfons G. Kessels Ann Arens Geerard L. Beets Jeroen Buijsen Angela Baardwijk Dirk Ruysscher Guido Lammering | 2008 | Strahlentherapie und Onkologie2008，，9： | 1 |
| 17 | Diabetes disease management:past,present,and future显示文摘 | Anne L Peters MD | 2001 | Endocrinologist2001，11，： | 1 |
| 18 | CCAAT/Enhancer Binding Protein Homologous Protein (DDIT3) Induces Osteoblastic Cell Differentiation显示文摘 | Renata CP Anne MD Ernesto C | 2004 | Endocrinology2004，145，4： | 1 |
| 19 | Internal Mammary Nodal Chain Drainage Is a Prognostic Indicator in Axillary Node-Positive Breast Cancer显示文摘 | Michelle S. Yao Brenda F. Kurland Anne H. Smith Erin K. Schubert Lisa K. Dunnwald David R. Byrd David A. Mankoff MD PhD | 2007 | Annals of Surgical Oncology2007，，10： | 1 |
| 20 | Manual versus target-con-trolled in fusion remifentanil administration in Spontaneously breathing Patients显示文摘 | Annelies T M LucL H Martine MD eta1 | 2009 | Anesth Analg2009，108，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员