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| 1 | Biomass-derived porous carbon highly efficient for removal of Pb(Ⅱ) and Cd(Ⅱ)显示文摘The utilization of abundant and renewable biomass to fabricate advanced functional materials is considered a promising route for environmental applications.Herein,Lignin-based porous carbon with layered graphene-like structure(LPC)is successfully synthesized and applied to efficiently remove Pb(Ⅱ)and Cd(Ⅱ).The as-synthesized LPC materials are systematically characterized and these results show that LPC has a porous graphene-like structure,facilitating the diffusion and immobilization of heavy metal ions.The influence of different reaction parameters(solution pH,initial concentration of metal ions,contact time and adsorbent amount)on the adsorption performance is investigated in details.The results demonstrate that LPC can achieve superior adsorption capacities of 250.5 mg·g^-1 for Pb(Ⅱ)and 126.4 mg·g^-1 for Cd(Ⅱ),which are far superior to the previously reported adsorbents.Pseudo-second order kinetics model and Freundlich isotherm model describe the adsorption process well.Furthermore,the exhausted LPC can be regenerated easily and exhibits the removal efficiency of 96%and 92%for Pb(Ⅱ)and Cd(Ⅱ)after five continuous runs,respectively.This study shows a sustainable strategy for the design of porous carbon material from na?ve biomass and highlights the great potential in wastewater treatment. | Anqi Wang Zhikeng Zheng Ruiqi Li Di Hu Yiran Lu Huixia Luo Kai Yan | 2019 | Green Energy & Environment2019，4，4： | 10 |
| 2 | Percent free prostate-specific antigen for prostate cancer diagnosis in Chinese men with a PSA of 4.0-10.0 ng/mL:Results from the Chinese Prostate Cancer Consortium显示文摘Objective:To test the diagnostic performance of percent free prostate-specific antigen(%fPSA)in predicting any prostate cancer(PCa)and high-grade prostate cancer(HGPCa)in a retrospective multi-center biopsy cohort with a PSA level of 4.0e10.0 ng/mL in China.Methods:Consecutive patients with a PSA of 4.0-10.0 ng/mL who underwent transrectal ultrasound-guided biopsy were enrolled at 16 Chinese medical centers from January 1st,2010 to December 31st,2013.Total and free serum PSA determinations were performed using three types of electro-chemiluminescence immunoassays recalibrated to the World Health Organization(WHO)standard.The diagnostic accuracy of PSA,%fPSA,and %fPSA in combination with PSA(%fPSA t PSA)was determined using the area under the receiver operating characteristic(ROC)curve(AUC).Results:A total of 2310 consecutive men with PSA levels between 4.0 and 10.0 ng/mL were included,and the detection rate of PCa was 25.1%.The AUC of%fPSA and %fPSA t PSA in predicting any PCa was superior to PSA alone in men aged≥60 years(0.623 vs.0.534,p<0.0001)but not in men aged 40e59 years(0.517 vs.0.518,p=0.939).Similar result was yield in predicting HGPCa.Conclusion:In a clinical setting of Chinese men with 4.0e10.0 ng/mL PSA undergoing initial prostate biopsy,adding %fPSA to PSA can moderately improve the diagnostic accuracy for any PCa and HGPCa compared with PSA alone in patients≥60 but not in patients aged 40-59 years. | Rui Chen Liping Xie Xiaobing Cai Yiran Huang Liqun Zhou Lulin Ma Xu Gao Chuanliang Xu Shancheng Ren Pengfei Shao Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Li Lu Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tie Zhou Fubo Wang Biming He Yinghao Sun | 2015 | Asian Journal of Urology2015，2，2： | 8 |
| 3 | Three-dimensional discharge simulation of inductively coupled plasma (ICP) etching reactor显示文摘More and more importance has been attached to inductively coupled plasma (ICP) in semiconductor manufacture. For a deep understanding of the plasma discharge process in the etching reactor, this study made a three-dimensional simulation on the Ar plasma discharge process with the commercial software CFD-ACE, which is according to the real experiment conditions and data supplied by North Microelec-tronic Corporation. The error of the simulation results is in the range of ±20% with credibility. The numerical results show that the three-dimentional spatial distribu-tion of electron density is reduced from the chamber center to the wall. The distri-bution of electron density, electron temperature and power deposition is related to the shape and placement of the coil. | AN YiRan LU YiJia LI DongSan CHEN YaoSong | 2008 | Science China(Technological Sciences)2008，51，6： | 2 |
| 4 | Evaluation of the performance of a centralized ground-water heat pump system in cold climate region显示文摘这研究的目的是评估集中的开环的地下水热泵(GWHP ) 的表演为在有在中国的冷气候的北京的气候调节的系统。因此,长期的测试从 2011 年 12 月在一个跑的 GWHP 系统上被进行加热季节到 2012 年 3 月。严峻的数据的分析显示性能(警察) 和系统(警察) 的 COP 的平均热泵系数是 4.27 和 2.59。在警察的范围的低价值和大变化被发现被热刺穿在发行量环在含水土层和 bypass 引起。因此,一些建议被建议在中国在冷气候区域为 GWHP 改进表演。 | Shilei LU Zhe CAI Yiran LI Li ZHANG | 2014 | Frontiers in Energy2014，8，3： | 1 |
| 5 | Characteristics of plankton Hg bioaccumulations based on a global data set and the implications for aquatic systems with aggravating nutrient imbalance显示文摘The bioaccumulation of mercury(Hg)in aquatic ecosystem poses a potential health risk to human being and aquatic organism.Bioaccumulations by plankton represent a crucial process of Hg transfer from water to aquatic food chain.However,the current understanding of major factors affecting Hg accumulation by plankton is inadequate.In this study,a data set of 89 aquatic ecosystems worldwide,including inland water,nearshore water and open sea,was established.Key factors influencing plankton Hg bioaccumulation(i.e.,plankton species,cell sizes and biomasses)were discussed.The results indicated that total Hg(THg)and methylmercury(MeHg)concentrations in plankton in inland waters were significantly higher than those in nearshore waters and open seas.Bioaccumulation factors for the logarithm of THg and MeHg of phytoplankton were 2.4–6.0 and 2.6–6.7 L/kg,respectively,in all aquatic ecosystems.They could be further biomagnified by a factor of 2.1–15.1 and 5.3–28.2 from phytoplankton to zooplankton.Higher MeHg concentrations were observed with the increases of cell size for both phyto-and zooplankton.A contrasting trend was observed between the plankton biomasses and BAF_(MeHg),with a positive relationship for zooplankton and a negative relationship for phytoplankton.Plankton physiologic traits impose constraints on the rates of nutrients and contaminants obtaining process from water.Nowadays,many aquatic ecosystems are facing rapid shifts in nutrient compositions.We suggested that these potential influences on the growth and composition of plankton should be incorporated in future aquatic Hg modeling and ecological risk assessments. | Zhike Li Jie Chi Zhenyu Wu Yiyan Zhang Yiran Liu Lanlan Huang Yiren Lu Minhaz Uddin Wei Zhang Xuejun Wang Yan Lin Yindong Tong | 2022 | Frontiers of Environmental Science & Engineering2022，16，3： | 1 |
| 6 | Tumor neoantigens: Novel strategies for application of cancer immunotherapy显示文摘Neoantigen-targeted immunotherapy is a rapidly advancing field that holds great promise for treating cancer.The recognition of antigens by immune cells is a crucial step in tumor-specific killing,and neoantigens generated by mutations in cancer cells possess high immunogenicity and are selectively expressed in tumor cells,making them an attractive therapeutic target.Currently,neoantigens find utility in various domains,primarily in the realm of neoantigen vaccines such as DC vaccines,nucleic acid vaccines,and synthetic long peptide vaccines.Additionally,they hold promise in adoptive cell therapy,encompassing tumor-infiltrating cells,T cell receptors,and chimeric antigen receptors which are expressed by genetically modified T cells.In this review,we summarized recent progress in the clinical use of tumor vaccines and adoptive cell therapy targeting neoantigens,discussed the potential of neoantigen burden as an immune checkpoint in clinical settings.With the aid of state-of-the-art sequencing and bioinformatics technologies,together with significant advancements in artificial intelligence,we anticipated that neoantigens will be fully exploited for personalized tumor immunotherapy,from screening to clinical application. | HANYANG GUAN YUE WU LU LI YABING YANG SHENGHUI QIU ZHAN ZHAO XIAODONG CHU JIASHUAI HE ZUYANG CHEN YIRAN ZHANG HUI DING JINGHUA PAN YUNLONG PAN | 2023 | Oncology Research2023，31，4： | 1 |
| 7 | Nitrogen-doped pyrogenic carbonaceous matter facilitates azo dye decolorization by sulfide: The important role of graphitic nitrogen显示文摘Pyrogenic carbonaceous matter(PCM) catalyzes azo dye decolorization by sulfide, but the nitrogen doping catalytic mechanisms are poorly understood. In this study, we found that stagnate time of azo dye methyl orange(MO) decolorization was reduced to 0.54-18.28 min in the presence of various nitrogen-doped graphenes(NGs), remarkably lower compared to graphene itself. Particularly, graphitic nitrogen played a critical role in NGs-catalyzed MO decolorization by sulfide. Gas chromatography-mass spectrometry and in-situ surface Raman analysis demonstrated that doping nitrogen, especially graphite one facilitated reactive intermediate polysulfides formation. This is attributed to the improved electron conductivity through graphitic nitrogen doping, and the enhanced interactions between sulfide and carbon atoms bonded to graphitic nitrogen. This study not only provides a better understanding of PCM impact on transformations and fates of organic pollutants in natural environments, but also offer a new regulation strategy for more efficient wastewater treatment processes in PCM-catalyzed engineering systems. | Han-Qing Zhao Wen-Qiang Li Nannan Hou Lei Li Yiran Wang Peili Lu Yang Mu | 2023 | Chinese Chemical Letters2023，34，2： | 1 |
| 8 | Numerical investigation of flow over a two-dimensional square cylinder with a synthetic jet generated by a bi-frequency signal显示文摘The flow around a square cylinder with a synthetic jet positioned at the rear surface is numerically investigated with the unsteady Reynolds-averaged Navier-Stokes(URANS)method.Instead of the typical sinusoidal wave,a bi-frequency signal is adopted to generate the synthetic jet.The bi-frequency signal consists of a basic sinusoidal wave and a high-frequency wave.Cases with various amplitudes of the high-frequency component are simulated.It is found that synthetic jets actuated by bi-frequency signals can realize better drag reduction with lower energy consumption when appropriate parameter sets are applied.A new quantity,i.e.,the actuation efficiency Ae,is used to evaluate the controlling efficiency.The actuation efficiency Ae reaches its maximum of 0.2668 when the amplitude of the superposed high-frequency signal is 7.5%of the basic signal.The vortex structures and frequency characteristics are subsequently analyzed to investigate the mechanism of the optimization of the bi-frequency signal.When the synthetic jet is actuated by a single-frequency signal with a characteristic velocity of 0.112 m/s,the wake is asymmetrical.The alternative deflection of vortex pairs and the peak at half of the excitation frequency in the power spectral density(PSD)function are detected.In the bi-frequency cases with the same characteristic velocity,the wake gradually turns to be symmetrical with the increase in the amplitude of the high-frequency component.Meanwhile,the deflection of the vortex pairs and the peak at half of the excitation frequency gradually disappear as well. | Yiran LU Yuan QU Jiangsheng WANG Jinjun WANG | 2022 | Applied Mathematics and Mechanics(English Edition)2022，43，10： | 1 |
| 9 | A core epitope targeting antibody of SARS-CoV-2显示文摘Dear Editor,Tremendous efforts have been made globally to develop therapeutics and prophylactics against severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)which has caused thousands of millions of infections and deaths worldwide.A series of potent neutralizing antibodies with defined epitopes targeting RBD have been recently identified with different strategies.However,being an RNA virus,the instability of the SARS-CoV-2 genome results in numerous S-protein variants with altered viral phenotypes. | Simeng Zhao Fengjiang Liu Shizhen Qiu Qiaoshuai Lan Yiran Wu Wei Xu Junzi Ke Jie Yang Xiaoyan Liu Kun Wang Hangtian Guo Shuai Xia Fangfang Zhang Jiabei Wang Xiaowen Hu Lu Lu Shibo Jiang Suwen Zhao Lianxin Liu Youhua Xie Xiuna Yang Haopeng Wang Guisheng Zhong | 2023 | Protein & Cell2023，14，1： | 0 |
| 10 | 五羟色胺2C受体结构揭示GPCR多重药理学特性的结构基础显示文摘文章简介有些药物往往需要作用于多个靶点,即多重药理学作用发挥其疗效。目前,针对多种血清素受体的药物,包括5-HT2C受体,对治疗肥胖、药物滥用和精神分裂症意义重大。 | 彭瑶 John D.McCorvy Kasper Harpsoe Katherine Lansu Shuguang Yuan Petr Popov Lu Qu Mengchen Pu Tao Che Louise F.Nikolajsen Xi-Ping Huang Yiran Wu Ling Shen Walden E.Bjorn-Yoshimoto Kang Ding Daniel Wacker Gye Won Han Jianjun Cheng Vsevolod Katritch Anders A.Jensen Michael A.Hanson Suwen Zhao David E.Gloriam Bryan L.Roth Raymond C.Stevens 刘志杰 | 2019 | 科学新闻2019，0，2： | 0 |
| 11 | Epidemiological survey and genetic characterization of type 3 vaccine-derived poliovirus isolated from a patient with four doses of inactivated polio vaccine in Henan Province,China显示文摘Background:Vaccine-derived poliovirus(VDPV)is a potential threat to polio eradication because they can reintroduce into the general population and cause paralytic polio outbreaks,a phenomenon that has recently emerged as a prominent public health concern at the end of global polio eradication.This study aimed to describe the epidemiology and genetic characteristics of the frst VDPV identifed from a patient with acute faccid paralysis(AFP),with four doses of inactivated polio vaccine immunization in Henan Province,China in 2017.Methods:The patient was diagnosed with type 3 VDPV.Subsequently,a series of epidemiological approaches was implemented,including a retrospective search of AFP cases,rate of vaccination assessment,study of contacts,and supplementary immunization activities.Fecal samples were collected,viral isolation was performed,and the viral isolates were characterized using full-length genomic sequencing and bioinformatic analysis.Results:Phylogenetic analysis showed that the viral isolates from the patient were diferent from other reported genetic clusters of type 3 VDPV worldwide.They were identifed as a Sabin 3/Sabin 1 recombinant VDPV with a crossover site in the P2 region.Nucleotide substitutions,including U→C(472)and C→U(2493),have been identifed,both of which are frequently observed as reversion mutations in neurovirulent type 3 poliovirus.A unique aspect of this case is that the patient had been vaccinated with four doses of inactive polio vaccine,and the serum neutralizing antibody for Sabin types 1 and 3 were 1∶16 and 1∶512,respectively.Thus,the patient was speculated to have been infected with type 3 VDPV,and the virus continued to replicate and be excreted for at least 41 d.Conclusions:The existence of this kind of virus in human population is a serious risk and poses a severe challenge in maintaining a polio-free status in China.To the best of our knowledge,this is the frst report of VDPV identifed in the Henan province of China.Our results highlight the importance of maintaining a high-level vaccination rate and highly sensitive AFP case surveillance system in intercepting VDPV transmission. | Mingyu Zhang Jianhui Yang Yiran Bai Hui Zhu Changshuang Wang Lu Zhang Jin Xu Mingxia Lu Xiaoxiao Zhang Zhanpei Xiao Yating Ma Yan Wang Xiaolei Li Dongyan Wang Shuangli Zhu Dongmei Yan Wenbo Xu Yong Zhang Yanyang Zhang | 2022 | Infectious Diseases of Poverty2022，11，6： | 0 |
| 12 | The effect of discharge conditions of ICP etching reactor on plasma parameters显示文摘This study investigated the inductively coupledplasma etching reactor and RF coils developed by NorthMicroelectronic Corporation. Full three dimensional simulationswere made at different discharge conditions. Thesimulations examined and compared the distribution andnon-uniformity of several plasma parameters at a fixed positionupon the wafer at different pressures and coil currents.These parameters included electron density, electron temperatureand power deposition. The results demonstrate that theelectron density, power deposition and uniformity increasewith either higher pressure or stronger coil currents, while theelectron temperature decreases at this condition. Coil numberincrease can reduce the non-uniformity of parametersin the spatial distribution. The linear relationship betweenpower deposition and electron density does not always exist.The comparison between simulation results and experimentresults is also presented in the paper. | Yijia Lu Yaosong Chen Yiran An LTCS, College of Engineering, Peking University,100871 Beijing, China | 2009 | Acta Mechanica Sinica2009，25，6： | 0 |
| 13 | 人源大麻素受体CB1晶体结构显示文摘人源大麻素受体(human Cannabinoid Receptor1,CB1)是G蛋白偶联受体(Gproteincoupledreceptor,GPCR)ClassA家族的一员.其主要分布在中怄神经系统,尤其是大脑皮层、基底核、海马和小脑区域,是人类大脑中表达量最高的GPCR之一. | Tian Hua Kiran Vemuri Mengchen Pu Lu Qu Gye Won Han Yiran Wu Suwen Zhao Wenqing Shui Shanshan Li Anisha Korde Robert B.Laprairie Edward L.Stahl Jo-Hao Ho Nikolai Zvonok Han Zhou Irina Kufareva Beili Wu Qiang Zhao Michael A.Hanson Laura M.Bohn Alexandros Makriyannis Raymond C.Stevens 刘志杰 | 2017 | 科学新闻2017，19，4： | 0 |
| 14 | 人源大麻素受体CB2的晶体结构显示文摘文章简介大麻素受体CB2主要分布在人体的免疫系统,选择性调控大麻素受体CB2对炎症、纤维化及神经退行性疾病等具有较好的治疗潜力,同时可避免由大麻素受体CB1引起的精神活性。本研究报道了大麻素受体CB2与新型拮抗剂AM0257复合物2.8埃分辨率的晶体结构。经结构对比分析,发现同处于拮抗状态的CB2与CB1不但结构差别极大。 | Xiaoting Li Tian Hua Kiran Vemuri Jo-Hao Ho Yiran Wu Lijie Wu Petr Popov Othman Benchama Nikolai Zvonok K’ara Locke Lu Qu Gye Won Han Malliga R.Iyer Resat Cinar Nathan J.Coffey Jingjing Wang Meng Wu Vsevolod Katritch Suwen Zhao George Kunos Laura M.Bohn Alexandros Makriyannis Raymond C.Stevens 刘志杰 | 2020 | 科学新闻2020，，2： | 0 |
| 15 | Therapeutic potential of an anti-HER2 single chain antibody-DM1 conjugates for the treatment of HER2-positive cancer显示文摘Antibody–drug conjugates(ADCs)take the advantage of monoclonal antibodies to selectively deliver highly potent cytotoxic drugs to tumor cells,which have become a powerful measure for cancer treatment in recent years.To develop a more effective therapy for human epidermal growth factor receptor 2(HER2)-positive cancer,we explored a novel ADCs composed of anti-HER2 scFv–HSA fusion antibodies conjugates with a potent cytotoxic drug DM1.The resulting ADCs,T-SA1–DM1 and T-SA2–DM1(drug-to-antibody ratio in the range of 3.2–3.5)displayed efficient inhibition in the growth of HER2-positive tumor cell lines and the half-maximal inhibitory concentration on SKBR-3 and SKOV3 cells were both at the nanomolar levels in vitro.In HER2-positive human ovarian cancer xenograft models,T-SA1–DM1 and T-SA2–DM1 also showed remarkable antitumor activity.Importantly,three out of six mice exhibited complete remission without regrowth in the high-dose group of T-SA1–DM1.On the basis of the analysis of luminescence imaging,anti-HER2 scFv–HSA fusion antibodies,especially T-SA1,showed strong and rapid tumor tissue penetrability and distribution compared with trastuzumab.Collectively,the novel type of ADCs is effective and selective targeting to HER2-positive cancer,and may be a promising antitumor drug candidate for further studies. | Hang Zhang Yuxi Wang Yangping Wu Xiaohua Jiang Yiran Tao Yuqin Yao Yujia Peng Xiangzheng Chen Yuyin Fu Lin Yu Ruixue Wang Qinhuai Lai Weirong Lai Wenting Li Yuhuan Kang Shuli Yi Ying Lu Lantu Gou Min Wu Jinliang Yang | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 0 |
| 16 | Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G_(s)显示文摘Dear Editor,The ten mammalian Frizzleds(FZD1–10)belong to the class F of G protein-coupled receptors(GPCRs)and mediate WNT signaling through interaction with transducer proteins including Dishevelled(DVL)or heterotrimeric G proteins.1 Their involvement in human disease has put FZDs at the forefront of drug targets,especially anti-cancer therapy. | Lu Xu Bo Chen Hannes Schihada Shane C.Wright Ainoleena Turku Yiran Wu Gye-Won Han Maria Kowalski-Jahn Pawel Kozielewicz Carl-Fredrik Bowin Xianjun Zhang Chao Li Michel Bouvier Gunnar Schulte Fei Xu | 2021 | Cell Research2021，31，12： | 0 |
| 17 | Lrrc34 Is Highly Expressed in SSCs and Is Necessary for SSC Expansi on In Vitro显示文摘Objective To discover critical genes contributing to the sternness and maintenance of spermatogonial stem cells(SSCs)and provide new insights into the function of the leucine-rich repeat(LRR)family member Lrrc34(leudne-rich repeat-containing 34)in SSCs from mice.Methods Bioinformatic methods,including differentially expressed gene(DEG),gene ontology(GO)enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analyses,were used to uncover latent pluripotency-related genes.Reverse transcription-polymerase chain reaction(RT-PCR)and immunofluorescence analyses were utilized to verify the mRNA and protein expression levels,respectively.RNA interference of Lrrc34 using siRNA was performed to detect its transient impact on SSCs.Results Eight DEGs between ID4-EGFP+(G)and ID4-EGFP+/TSPAN8Hig11(TH),eight DEGs between G and ID4-EGFP+/TSPAN8Uw(TL)and eleven DEGs between TH and TL were discovered,and eleven proteinprotein interaction(PPI)modules were found to be significant in the PPI network of DEGs.One of the DEGs,Lrrc34,was selected as a potential pluripotency?related gene due to its differential expression among ID4-EGFP+spermatogonia subsets and its interaction with fibroblast growth factor 2 in the fifth module.Immunofluorescence experiments exhibited specific expression of Lrrc34 in a subpopulation of undifferentiated spermatogonia marked by LIN28A,and RT-PCR experiments confirmed the high expression of Lrrc34 in SSCs from P7 and adult mice.The transient knockdown of Lrrc34 in SSCs resulted in reduced colony sizes and significant changes in the transcriptome and apoptotic pathways.Conclusion Lrrc34 is highly expressed in mouse SSCs and is required for SSC proliferation in vitro through effects on transcriptome and signaling transduction pathways. | Jinhuan Ou Yiran Li Zhipeng Wang Cheng Jin Kai Li Yan Lu Dingfeng Zou Pengyu Li Mengzhen Li Shiying Miao Linfang Wang Wei Song | 2020 | Chinese Medical Sciences Journal2020，35，1： | 0 |
| 18 | Creating a semi-opened micro-cavity ovary through sacrificial microspheres as an in vitro model for discovering the potential effect of ovarian toxic agents显示文摘The bio-engineered ovary is an essential technology for treating female infertility.Especially the development of relevant in vitro models could be a critical step in a drug study.Herein,we develop a semi-opened culturing system(SOCS)strategy that maintains a 3D structure of follicles during the culture.Based on the SOCS,we further developed micro-cavity ovary(MCO)with mouse follicles by the microsphere-templated technique,where sacrificial gelatin microspheres were mixed with photo-crosslinkable gelatin methacryloyl(GelMA)to engineer a micro-cavity niche for follicle growth.The semi-opened MCO could support the follicle growing to the antral stage,secreting hormones,and ovulating cumulus-oocyte complex out of the MCO without extra manipulation.The MCO-ovulated oocyte exhibits a highly similar transcriptome to the in vivo counterpart(correlation of 0.97)and can be fertilized.Moreover,we found that a high ROS level could affect the cumulus expansion,which may result in anovulation disorder.The damage could be rescued by melatonin,but the end of cumulus expansion was 3h earlier than anticipation,validating that MCO has the potential for investigating ovarian toxic agents in vitro.We provide a novel approach for building an in vitro ovarian model to recapitulate ovarian functions and test chemical toxicity,suggesting it has the potential for clinical research in the future. | Min Ye Yiran Shan Bingchuan Lu Hao Luo Binhan Li Yanmei Zhang Zixuan Wang Yuzhi Guo Liliang Ouyang Jin Gu Zhuo Xiong Ting Zhang | 2023 | Bioactive Materials2023，，8： | 0 |
| 19 | Synthesis and Performance of an Associative Anti-shear Drag Reducer Based on Hydrogen Bond Association of Dodecyl Methacrylate显示文摘Using K2S2O8-Na2SO3 as the redox initiation system,a hydrogen-bond-association-based dodecyl methacrylate system associative anti-shear drag reducer was synthesised by standard emulsion polymerisation.The reaction process was simple and gentle as well as safe and stable.Molecular design was carried out using molecular dynamics simulation methods.The results of infrared spectroscopy,thermogravimetric analysis,differential scanning calorimetry,gel chromatography,and laser light scattering showed that the reaction polymerisation was relatively complete,the product was uniform,the molecular weight distribution was controllable,and the synthesised polymer had good flexibility.The donor lauryl methacrylate-styrene-methacrylic acid(LMA-St-MAA)and acceptor lauryl methacrylate-styrene-dimethylaminoethyl methacrylate(LMA-St-DMA)polymers had an associative intermolecular interaction force,which increased the molecular cluster size of the associative system complex.The complex had good shear resistance,and the test results of the tube pump shear test showed that the synthesised associative oil-soluble polymer drag reduction system exhibited better drag reduction rate performance than poly-α-olefins over repeated cycles.The research results provide a reference plan for minimising the number of station-to-station inputs,thereby ensuring the stability of oil pipelines and reducing transportation costs. | Lu Yong Li Chenhao Li Hao Chen Yue Xu Dan Wang Yiran Meng Yeqiao Zhang Xiaolai | 2023 | China Petroleum Processing & Petrochemical Technology2023，25，1： | 0 |
| 20 | Optimization model analysis of centralized groundwater source heat pump system in heating season显示文摘地下水热泵系统(GWHP ) 为当消费一点电能时,加热并且冷却提供一个高有效的方法。由于为操作控制策略的科学指导的缺乏,系统和单位的性能(警察) 的系数仍然是很低的。在这份报纸, GWHP 的跑的策略被学习。首先,地下水在慢热刺穿下面的热转移计算和短暂的热刺穿被计算热转移模拟软件流动热和使用的修正因素建立。下次,加热参数基于造的热负担和终端设备特征方程被计算。然后,为单位和泵的精力消费计算模型被建立,基于哪个优化方法和限制被建立。最后,在北京的一个 GWHP 系统上的地测试被进行,模型被使用。为 GWHP 支持每进在这份报纸提出了的报道的新系统操作优化想法有重要指导意义到地下的水来源热泵的实际操作。 | Shilei LU Yunfang QI Zhe CAI Yiran LI | 2015 | Frontiers in Energy2015，9，3： | 0 |
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