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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 3 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 4 | Zinc deficiency and oxidation of L-Methionine-methyl^-14 C in rats显示文摘 | Hsu J M Anthony W L Buchanan P J | 1968 | Nutr1968，97，： | 1 |
| 5 | Cognitive existential couple therapy for newly diagnosed prostate cancer patients and their partners : A descriptive pilot study显示文摘 | Anna L Collin's Anthony W Love Sidney Bloeh | 2013 | Psycho - Oncology2013，22，2： | 1 |
| 6 | A thermogravimetric study of the alunites of sodium, potassium and ammonium显示文摘 | FROST R L WAIN D L RACHAEL-ANNE W ANTHONY M WAYDE M | 2006 | Thermochemical Acta2006，443，1： | 1 |
| 7 | Venous thrombosis astociated with the placement of peripherally inserted central catheters显示文摘 | Anthony W Allen MD Jocelyn L et 81 | 2000 | Journal of Vascular and Interventional Radiology2000，11，： | 1 |
| 8 | Venous thrombosis associated with the placement of peripherally inserted central catheters显示文摘 | Anthony W Allen MD Jocelyn L | 2000 | Journal of Vascular and Interventional Radiology2000，11，10： | 1 |
| 9 | Managerial Decision- making Under Crisis:The Role of Emotion in an Intuitive Deci- sion Process 显示文摘 | Sayegh L Anthony W P Perrewe P L | 2004 | Human Resource Management Review2004，14，2： | 1 |
| 10 | Managing crop residues,fertilizers and leaf litters to improve soil C,nutrient balances,and the grain yield of rice and wheat cropping systems in Thailand and Australia显示文摘 | Anthony W Graeme B Yothin K Rod L Kunnika N | | 0，，： | 1 |
| 11 | Why Are We Doing This: Clinician Helplessness in the Face of Suf- fering 显示文摘 | Back Anthony L Rushton Cynda H Kaszniak Alfred W Halifax Joan S | 2015 | Journal of Palliative Medicine2015，15，1： | 1 |
| 12 | Polit- ical skill at work 显示文摘 | Ferris G R Perrewe P L Anthony W P Gilmore D C | 2000 | Organizational Dynamics2000，28，： | 1 |
| 13 | Zinc deficiency and incorporation of 14 C-labeled methionine into tissue proteins in rats 显示文摘 | HSU J M ANTHONY W L BUCHANAN P J | 1969 | Journal of Nutrition1969，99，： | 1 |
| 14 | Venous thrombosis associated with the placement of peripherally inserted central catheter 显示文摘 | Anthony W Allen M D Jocelyn L | 2000 | JVasclnterv Radiol2000，11，10： | 1 |
| 15 | Effect of exercise mode on heart rate varialility during steady state exercise显示文摘 | ANTHONY S LEICHT W H SINCLAIR W L | 2008 | Europe journal of applied physiological2008，，102： | 1 |
| 16 | Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis显示文摘 | Pierre Blanchard Anne Lee Sophie Marguet Julie Leclercq Wai Tong Ng Jun Ma Anthony T C Chan Pei-Yu Huang Ellen Benhamou Guopei Zhu Daniel T T Chua Yong Chen Hai-Qiang Mai Dora L W Kwong Shie Lee Cheah James Moon Yuk Tung Kwan-Hwa Chi George Fountzilas Li | 2015 | The Lancet Oncology2015，，： | 1 |
| 17 | Carbonation of fly ash in oxy-fuel CFB combustion 显示文摘 | Wang C B Jia L F Tan Y W Anthony E J | 2008 | Fuel2008，87，7： | 1 |
| 18 | Reproducibility of Immunohistochemical Scoring for Epidermal Growth Factor Receptor Expression in Non-Small Cell Lung Cancer: Round Robin Test显示文摘 | R?schoff Josef Kerr Keith M Grote Hans J Middel Peter von Heydebreck Anja Alves Ven?ncio A Baldus Stephan E B?ttner Reinhard Carvalho Lina Fink Ludger Jochum Wolfram Lo Anthony W I L?pez-R?os Fernando Marx Alexander Molina Thierry J Olszews | 2013 | Archives of Pathology & Laboratory Medicine2013，，9： | 1 |
| 19 | Venous thrombosis as sociated with the placement of peripherally inserted central cathe- ters显示文摘 | Anthony W Allen MD Jocelyn L etal | 2000 | Journal of Vascular and Interventional Radiology2000，11，： | 1 |
| 20 | Effects of various feed supplements containing fish protein hydrolysate or fish processing by-products on the innate immune functions of juvenile coho salmon (Oncorhynchus kisutch ) 显示文摘 | Anthony L M Ronald J P Stewart W A | 2003 | Aquaculture2003，220，14： | 1 |
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