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| 1 | In-Season Root-Zone Nitrogen Management Strategies for Improving Nitrogen Use Efficiency in High-Yielding Maize Production in China显示文摘Many recently developed N management strategies have been extremely successful in improving N use efficiency.How-ever,attempts to further increase grain yields have had limited success.Field experiments were conducted in 2007 and 2008 at four sites to evaluate the effect of an in-season root-zone N management strategy on maize (Zea mays L.).According to the in-season root-zone N management,the optimal N rate (ONR) was determined by subtracting measured soil mineral N (NH + 4--N and NO 3--N) in the root zone from N target values.Other treatments included a control without N fertilization,70% of ONR,130% of ONR,and recommended N rate (RNR) by agronomists in China that have been shown to approach maize yield potentials.Although apparent N recovery for the ONR treatment was significantly higher than that under RNR in 2007,grain yield declined from 13.3 to 11.0 Mg ha 1 because of an underestimation of N uptake.In 2008,N target values were adjusted to match crop uptake,and N fertilization rates were reduced from 450 kg N ha-1 for RNR to 225 to 265 kg N ha-1 for ONR.High maize yields were maintained at 12.6 to 13.5 Mg ha 1,which were twice the yield from typical farmers' practice.As a result,apparent N recovery increased from 29% to 66%,and estimated N losses decreased significantly for the ONR treatment compared to the RNR treatment.In conclusion,the in-season root-zone N management approach was able to achieve high yields,high NUE and low N losses. | MENG Qing-Feng CHEN Xin-Ping ZHANG Fu-Suo CAO Ming-Hui CUI Zhen-Ling BAI Jin-Shun YUE Shan-Chao CHEN Su-Yi T.MULLER | 2012 | Pedosphere2012，22，3： | 22 |
| 2 | Spatial-temporal Changes of Vegetation Cover in Guizhou Province, Southern China显示文摘Guizhou Province is an important karst area in the world and a fragile ecological area in China. Ecological risk assessment is very necessary to be conducted in this region. This study investigates different characteristics of the spatial-temporal changes of vegetation cover in Guizhou Province of Southern China using the data set of SPOT VEGETATION(1999–2015) at spatial resolution of 1-km and temporal resolution of 10-day. The coefficient of variation, the Theil-Sen median trend analysis, and the Mann-Kendall test are used to investigate the spatial-temporal change of vegetation cover and its future trend. Results show that: 1) the spatial distribution pattern of vegetation cover in Guizhou Plateau is high in the east whereas low in the west. The average annual normalized difference vegetation index(NDVI) from west to east is higher than that from south to north. 2) Average annual NDVI improved obviously in the past 17 years. The growth rate of average annual NDVI is 0.028/10 yr, which is slower than that of vegetation in the country(0.048/10 yr) from 1998 to 2007. Average annual NDVI in karst area is lower than that in non-karst area. However, the growing rate of average annual NDVI in karst area(0.030/10 yr) is faster than that in non-karst area(0.023/10 yr), indicating that vegetation coverage increases more rapidly in karst area. 3) Vegetation coverage in the study area is stable overall, but fluctuates in the local scales. 4) Vegetation coverage presents a continuous increasing trend. The Hurst exponent of NDVI in different vegetation types has an obvious threshold in various elevations. 5) The proportion of vegetation cover with sustainable increase is higher than that of vegetation cover with sustainable decrease. The improvement in vegetation cover may expand to most parts of the study area. | TIAN Yichao BAI Xiaoyong WANG Shijie QIN Luoyi LI Yue | 2017 | Chinese Geographical Science2017，27，1： | 21 |
| 3 | Clinical evaluation of valsartan and metoprolol tartrate in treatment of diabetic nephropathy with positive β1-adrenergic and anti-angiotensin Ⅱ type 1 receptor antibody显示文摘 | ZHAO Lin-shuang BAI Wei-wei XIANG Guang-da YUE Ling SUN Hui-ling | 2012 | Chinese Medical Journal2012，，19： | 15 |
| 4 | High Serum CEA and CYFRA21-1 Levels after a Two-Cycle Adjuvant Chemotherapy for NSCLC:Possible Poor Prognostic Factors显示文摘Objective The aim of this study was to test whether carcinoembryonic antigen(CEA) and cytokeratin 19 fragments(CYFRA21-1) can be used as a prognostic factor for non-small-cell lung cancer(NSCLC) after two cycles of adjuvant chemotherapy in NSCLC patients. Methods A total of 169 patients underwent at least two cycles of adjuvant chemotherapy.The serum levels of CEA and CYFRA21-1 were recorded after the second cycle of chemotherapy,and the patient follow-up was conducted.Overall survival(OS) and diseasefree survival(DFS) were used as the primary endpoint and the secondary endpoint,respectively. Results The high levels of CEA and CYFRA21-1 after two cycles of adjuvant chemotherapy were poor prognostic factors for OS,with risk ratios(RR) of 2.003 and 1.702,respectively.A high CEA level was a poor prognostic factor(RR 1.152) for DFS.The median survival time(MST) of the high CEA level group was 26 months,whereas that of the normal group was 61 months(P<0.0001).The median DFS time of the high CEA group and the normal group was 34 and 53 months,respectively(P<0.0001).The MST of the high CYFRA21-1 group and the normal group was 43 and 56 months,respectively(PO.0001). Conclusions The high serum levels of CEA or CYFRA21-1 after two cycles of adjuvant chemotherapy are poor prognostic factors for NSCLC patients. | Xue-feng Lin Xiao-dong Wang Da-qiang Sun Zhi Li Yue Bai | 2012 | Clinical oncology and cancer resexreh2012，9，4： | 14 |
| 5 | Anti-fibrotic Effects of Salvia miltiorrhiza and Ligustrazine Injection on LX-2 Cells Involved with Increased N-myc Downstream-Regulated Gene 2 Expression显示文摘Objective: To investigate the effects of Salvia miltiorrhiza and Ligustrazine Injection(SML) on proliferation and apoptosis of human hepatic stellate cell LX-2 and the expression of N-myc downstreamregulated gene 2(NDRG2, a tumor suppressor gene). Methods: HSCs from the LX-2 cell line were cultured in vitro. The proliferative state of different initial LX-2 cell numbers was measured using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) colorimetric assay. LX-2 cells were plated in 96-well plates at an approximate density of 2.50×10~4 cells/mL and cultured for 24 h followed by the application of different concentrations of SML(1, 2, 4 and 8 μL/mL). Cell proliferation was measured using the MTT assay at 24 and 48 h. Apoptosis was detected by flow cytometry at 24 h. LX-2 cells were treated with different concentrations of SML and extracted with protein lysis buffer. The levels of NDRG2 and β-catenin were measured by Western blot. Results: With the exception of the 1 and 2 μL/mL concentrations, 4 and 8 μL/mL SML inhibited cell proliferation in a concentration-dependent manner at 24 and 48 h(P<0.05). With the exception of the 1 and 2 μL/mL concentrations, the NDRG2 expression level was greatly increased in a concentration-dependent manner. However, the level of β-catenin was unaffected. Conclusion: SML inhibit LX-2 cell proliferation in a concentration-dependent manner, and the mechanism may be associated with NDRG2 over-expression. | zheng jin ma li-tian ren qin-you hu yue bai yang bian huan zhang yi zhou yong-chun yang ming-hui | 2017 | Chinese Journal of Integrative Medicine2017，23，12： | 13 |
| 6 | Mineralogy,distribution,occurrence and removability of trace elements during the coal preparation of No.6 coal from Heidaigou mine显示文摘Optical microscopy and scanning electron microscopy in conjunction with energy dispersed X-ray spectrometry(SEM–EDX)were used to study the minerals and the concentrations of 33 trace elements in No.6 coal from Heidaigou mine.The distributions,organic affinity and removability of 18 trace elements were studied by float-sink experiments.A determination of the maceral groups was also undertaken.A high mineral content,dominated by kaolinite,was found in No.6 coal from Heidaigou mine.The bauxite content was relatively high and it was mainly present as individual particles in fusinite lumens or was intimately intergrown with carbonate minerals.The pyrite and quartz contents were low.Some marcasite with a parallel twin structure was observed by cross-polar reflected light.A small amount of bean-like goyazite was present in the calcite.The weighted trace element content in Heidaigou formations is relatively low,which is beneficial for coal processing and utilization.The concentrations of Ga,Hg,Pb,Se,Th,Ta are relatively high compared with the average values of Chinese coals.As,Hg,Mo,Ge,Ga,Ta,Ti,W,Mn are mainly present in minerals while B,Be,Th,P,Sc,Sr,V,Y,Yb are mainly found in organic matter.As,Ge,Hg,Mo are mainly present in sulfides and Be,Th,P,Sc,Sr,Y,Yb are mainly present in inertinite.B and V are mainly present in vitrinite.The high organic affinity and the low theoretical removability of most trace elements cause difficulties in removing them during coal preparation. | Xiangfei Bai Yue Wang Wenhua Li | 2014 | International Journal of Coal Science & Technology2014，1，4： | 12 |
| 7 | Discriminating Potential of Extraintestinal Systemic Manifestations and Colonoscopic Features in Chinese Patients with Intestinal Beh~:et's Disease and Crohn's Disease显示文摘 | Ji Li Pan Li Jing Bai Hong Lyu Yue Li Hong Yang Bo Shen Jia-Ming Qian | 2015 | Chinese Medical Journal2015，，2： | 12 |
| 8 | Species of Botryosphaeriaceae involved in grapevine dieback in China显示文摘Botryosphaeria dieback is a serious disease problem for table and grape wine production worldwide.The disease however,has been less well-studied in China.In this study,we surveyed Botryosphaeria dieback in 72 vineyards of 20 grape-growing regions in China and found that Botryosphaeria dieback occurs in 18 out of 20 provinces.Morphological and multi-gene phylogenetic analyses confirmed that Botryosphaeria dothidea,Diplodia seriata,Lasiodiplodia theobromae and Neofusicoccum parvum are associated with different grapevine dieback symptoms.This study also revealed considerable differences in the geographical distribution of Botryosphaeriaceae species in China with Lasiodiplodia theobromae and Neofusicoccum parvum occurring only in subtropical monsoon climate regions,Diplodia seriata occurring only in temperate monsoon climate regions,and Botryosphaeria dothidea occurring in both temperate and subtropical monsoon climate regions.Analysis of 26 isolates showed that there is little genetic variation within species.Koch’s postulates were satisfied for all species,and pathogenicity testing showed that among the 25 major cultivars growing in China,none was resistant to the four taxa.The current paper represents the first detailed report on Botryosphaeria dieback of grapevines in China. | Ji-Ye Yan Yue Xie Wei Zhang Yong Wang Jian-Kui Liu Kevin D.Hyde Robert C.Seem Guo-Zhen Zhang Zhong-Yue Wang Sheng-Wei Yao Xian-Jin Bai Asha J.Dissanayake You-Liang Peng Xing-Hong Li | 2013 | Fungal Diversity2013，，4： | 11 |
| 9 | Modeling and Robust Backstepping Sliding Mode Control with Adaptive RBFNN for a Novel Coaxial Eight-rotor UAV显示文摘This paper focuses on the robust attitude control of a novel coaxial eight-rotor unmanned aerial vehicles(UAV) which has higher drive capability as well as greater robustness against disturbances than quad-rotor UAV. The dynamical and kinematical model for the coaxial eight-rotor UAV is developed, which has never been proposed before. A robust backstepping sliding mode controller(BSMC) with adaptive radial basis function neural network(RBFNN) is proposed to control the attitude of the eightrotor UAV in the presence of model uncertainties and external disturbances. The combinative method of backstepping control and sliding mode control has improved robustness and simplified design procedure benefiting from the advantages of both controllers. The adaptive RBFNN as the uncertainty observer can effectively estimate the lumped uncertainties without the knowledge of their bounds for the eight-rotor UAV. Additionally, the adaptive learning algorithm, which can learn the parameters of RBFNN online and compensate the approximation error, is derived using Lyapunov stability theorem. And then the uniformly ultimate stability of the eight-rotor system is proved. Finally, simulation results demonstrate the validity of the proposed robust control method adopted in the novel coaxial eight-rotor UAV in the case of model uncertainties and external disturbances. | Cheng Peng Yue Bai Xun Gong Qingjia Gao Changjun Zhao Yantao Tian | 2015 | IEEE/CAA Journal of Automatica Sinica2015，2，1： | 10 |
| 10 | Comparative pharmacokinetic studies of borneol in mouse plasma and brain by different administrations显示文摘Borneol,a monoterpenoid alcohol,is used widely,particularly in combined formulas for preventing and curing cardiovascular and cerebrovascular diseases in traditional Chinese medicine.In order to understand the blood and brain pharmacokinetics after intravenous,intranasal,or oral administration and to investigate the superiority and feasibility of intranasal administration,a simple gas chromatographic (GC) method with flame ionization detection (FID) was developed for the quantification of borneol.Blood samples and brain were collected from mice at 1,3,5,10,20,30,60,90,and 120 min after intravenous,intranasal,or oral administration of borneol at a dosage of 30.0 mg/kg.Sample preparations were carried out by liquid-liquid extraction with an internal standard solution of octadecane.The pharmacokinetic parameters were calculated by the software of Kinetica.The calibration curves were linear in the range of 0.11-84.24 μg/ml and 0.16-63.18 μg/g for borneol in plasma and brain,respectively.The methodological and extraction recoveries were both in the range of 85%-115%.The intra-day and inter-day variabilities for plasma and brain samples were ≤5.00% relative standard deviation (RSD).The absolute bioavailabilities F of intranasal and oral administrations were 90.68% and 42.99%.The relative brain targeted coefficients Re of intranasal and oral administrations were 68.37% and 38.40%.The GC-FID method developed could be applied to determination and pharmacokinetic study.The borneol from injection was distributed and metabolized fast without absorption process.The borneol from oral administration was distributed more slowly and had the lowest absolute bioavailability.Nasal administration of borneol was quickly absorbed into the blood and brain,was easy to use and had a greater safety than infection,which makes it worthy of further development as an administration route for encephalopathy treatment. | Jing-yi ZHAO Yang LU Shou-ying DU Xiao SONG Jie BAI Yue WANG | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，12： | 10 |
| 11 | Relationship between fluorescence characteristics and molecular weight distribution of natural dissolved organic matter in Lake Hongfeng and Lake Baihua,China显示文摘Dissolved organic matter (DOM) is one of the most interesting and difficult problems in recent years due to its important functions in the ecological and environmental system and the complexity of its chemical composition and structure. It is well ac- cepted that fluorescence characteristics and mo- lecular weight distribution are two important pa- rameters in the DOM characterization. However, the relationship between them is still unknown. In this study, fluorescence and molecular weight distribution of DOM in Lake Hongfeng, Lake Baihua and their rivers, and their relationship were investigated using the combination of fluorescence spectroscopy and high-performance size exclusion chromatography (HPSEC) with on-line UV absorbance and fluores- cence detectors. The results show that there were two obvious humic-like fluorescence peaks (Peaks A and B) in DOM from lake water. But there was an- other obvious protein-like fluorescence peak (Peak C) in DOM from river water. The humic-like fluorescence material consisted of DOM fraction with smaller mo- lecular weight, ranging from 1.0 to 3.0 kDa, while the protein-like fluorescence material mainly consisted of DOM fraction with MW larger than 2.0 kDa. The cal- culation of MW using HPSEC was related to the UV absorbance wavelength chosen. | YUE Lanxiu WU Fengchang LiU Congqiang LI Wen FU Pingqing BAI Yingchen WANG Liying YIN Zuoying Lü Zhicheng | 2006 | Chinese Science Bulletin2006，51，1： | 9 |
| 12 | Distributions and sources of n-alkanes in PM_(2.5) at urban,industrial and coastal sites in Tianjin,China显示文摘Aliphatic hydrocarbons(n-alkanes) associated with fine particulate matter were determined in the ambient air of urban,industrial and coastal areas in Tianjin,China,where intensive coal burning for industrial and domestic purpose takes place.n-Alkane homologues from C12 to C35 were quantifiable in all samples with C20-C31 being the most abundant species.Average concentrations of the total n-alkanes were 148.7,250.1 and 842.0 ng/m3 in July,April and January,respectively.Seasonal variations were mainly attributed to ambient temperature changes and coal combustion for residential heating.Among the three studied areas,the highest levels of n-alkanes were observed in the industrial complex in winter and spring,but in summer the coastal alkane concentration moved up to the highest. A mono-modal distribution for n-alkanes was observed in spring and summer with odd carbon number predominance and a maximum centered at C27-C31,suggesting the release of plant wax into the atmosphere.The bimodal distribution with maxima at C22 and C26 observed in winter indicated a substantial influence of fossil fuel sources.All the CPIs(CPI1,CPI2,CPI3) values,varying between 0.64 and 1.97,indicated the influence of anthropogenic emissions on fine organic aerosols.The estimated contributions of plant wax to total n-alkanes were on average of 12.9%,19.1%and 26.1%for winter,spring and summer,respectively. | Weifang Li Yue Peng Zhipeng Bai | 2010 | Journal of Environmental Sciences2010，22，10： | 8 |
| 13 | Self-powered photoelectrochemical biosensing platform based on Au NPs@ZnO nanorods array显示文摘Photoanodes,它在 photoelectrochemical (PEC ) 被使用切开的水,被显示了在一个 PEC biosensing 平台的构造适用。这被用一个适当测试分子的氧化代替水氧化认识到。这里,我们表明了采用由为谷胱甘肽(GSH ) 的自我动力的 PEC bioanalysis 与 plasmonic 金牌 nanoparticles (Au NPs@ZnO NR ) 装饰在的锌氧化物 nanorods 数组组成的 photoanodes 的可行性缓冲磷酸盐盐(PBS ) 在 0 V 对 Ag/AgCl 的一个应用偏爱潜力。因为 Au/ZnO 接口的介绍,这 heterostructure 展出了提高的 PEC 性质。在可见轻照明下面,从在 Au NP 表面的表面电浆子回声(SPR ) 的热电子被注入邻近的 ZnO 并且随后开车到光阴极。在下面紫外(紫外) 轻照明,在 ZnO 的 photogenerated 电子趋于由于逐步的精力乐队结构和在 ZnO/ 电解质接口弯曲的向上的精力乐队转到做氟的符号的听氧化物。这些结果显示 plasmonic 金属 / 半导体 heterostructure photoanodes 为自我动力的 PEC bioanalysis 应用和另外的光电的烽火的扩大的地有大潜力。 | Zhuo Kang Xiaoqin Yan Yunfei Wang Yanguang Zhao Zhiming Bai Yichong Liu Kun Zhao Shiyao Cao Yue Zhang | 2016 | Nano Research2016，9，2： | 8 |
| 14 | High-Resolution Genome-wide Association Study Identifies Genomic Regions and Candidate Genes for Important Agronomic Traits in Wheat显示文摘Wheat(Triticum aestivum)is a major staple food crop worldwide.Genetic dissection of important agronomic traits is essential for continuous improvement of wheat yield to meet the demand of the world's growing population.We conducted a large-scale genome-wide association study(GWAS)using a panel of 768 wheat cultivars that were genotyped with 327609 single-nucleotide polymorphisms generated by genotyping-by-sequencing and detected 395 quantitative trait loci(QTLs)for 12 traits under 7 environments.Among them,273 QTLs were delimited to≤1.0-Mb intervals and 7 of them are either known genes(Rht-D,Vrn-B1,and Vrn-D1)that have been cloned or known QTLs(TaGA2ox8,APO1,TaSus1-7B,and Rht12)that were previously mapped.Eight putative candidate genes were identified for three QTLs that enhance spike seed setting and grain size using gene expression data and were validated in three bi-parental populations.Protein sequence analysis identified 33 putative wheat orthologs that have high identity with rice genes in QTLs affecting similar traits.Large r^2 values for additive effects observed among the QTLs for most traits indicated that the phenotypes of these identified QTLs were highly predictable.Results from this study demonstrated that significantly increasing GWAS population size and marker density greatly improves detection and identification of candidate genes underlying a QTL,solidifying the foundation for large-scale QTL fine mapping,candidate gene validation,and developing functional markers for genomics-based breeding in wheat. | Yunlong Pang Chunxia Liu Danfeng Wang Paul St.Amand Amy Bernardo Wenhui Li Fang He Linzhi Li Liming Wang Xiufang Yuan Lei Dong Yu Su Huirui Zhang Meng Zhao Yunlong Liangi Hongze Jia Xitong Shen Yue Lu Hongming Jiang Yuye Wu Anfei Li Honggang Wang Lingrang Kong Guihua Bai Shubing Liu | 2020 | Molecular Plant2020，13，9： | 8 |
| 15 | Measurement-based Frequency Dynamic Response Estimation Using Geometric Template Matching and Recurrent Artificial Neural Network显示文摘Understanding power system dynamics after an event occurs is essential for the purpose of online stability assessment and control applications.Wide area measurement systems(WAMS)based on synchrophasors make power system dynamics visible to system operators,delivering an accurate picture of overall operating conditions.However,in actual field implementations,some measurements can be inaccessible for various reasons,e.g.,most notably communication failure.To reconstruct these inaccessible measurements,in this paper,the radial basis function artificial neural network(RBF-ANN)is used to estimate the system dynamics.In order to find the best input features of the RBF-ANN model,geometric template matching(GeTeM)and quality-threshold(QT)clustering are employed from the time series analysis to compute the similarity of frequency dynamic responses in different locations of the power system.The proposed method is tested and verified on the Eastern Interconnection(EI)transmission system in the United States.The results obtained indicate that the proposed approach provides a compact and efficient RBF-ANN model that accurately estimates the inaccessible frequency dynamic responses under different operating conditions and with fewer inputs. | Feifei Bai Xiaoru Wang Yilu Liu Xinyu Liu Yue Xiang Yong Liu | 2016 | CSEE Journal of Power and Energy Systems2016，2，3： | 8 |
| 16 | Endothelial cell-specific anticoagulation reduces inflammation in a mouse model of acute lung injury显示文摘Tissue factor (TF)-dependent coagulation contributes to lung inflammation and the pathogenesis of acute lung injury (ALI). In this study, we explored the roles of targeted endothelial anticoagulation in ALI using two strains of transgenic mice expressing either a membrane-tethered human tissue factor pathway inhibitor (hTFPI) or hirudin fusion protein on CD31^+ cells, including vascular endothelial cells (ECs). ALI was induced by intratracheal injection of LPS, and after 24 h the expression of TF and protease-activated receptors (PARs) on EC in lungs were assessed, alongside the extent of inflammation and injury. The expression of TF and PARs on the EC in lungs was upregulated after ALI. In the two strains of transgenic mice, expression of either of hTFPI or hirudin by EC was associated with significant reduction of inflammation, as assessed by the extent of leukocyte infiltration or the levels of proinflammatory cytokines, and promoted survival after LPS-induced ALI. The beneficial outcomes were associated with inhibition of the expression of chemokine CCL2 in lung tissues. The protection observed in the CD31-TFPI-transgenic strain was abolished by injection of an anti-hTFPI antibody, but not by prior engraftment of the transgenic strains with WT bone marrow, confirming that the changes observed were a specific transgenic expression of anticoagulants by EC. These results demonstrate that the inflammation in ALI is TF and thrombin dependent, and that expression of anticoagulants by EC significantly inhibits the development of ALI via repression of leukocyte infiltration, most likely via inhibition of chemokine gradients. These data enhance our understanding of the pathology of ALI and suggest a novel therapeutic strategy for treatment. | Jian Lou Yue Hu Min-dan Wu Luan-qing Che Yin-fang Wu Yun Zhao Bao-ping Tian Zheng-qiang Bao Chen Zhu Yan-ping Wu Lu-lu He Chun-xue Bai Jian Zhou Song-min Ying Wen Li Zhi-hua Chen Da-xin Chen Anthony Dorling Hua-hao Shen | 2019 | Acta Pharmacologica Sinica2019，40，6： | 7 |
| 17 | Spatiotemporal evolution of carbon sequestration of limestone weathering in China显示文摘Carbonate carbon sequestration(CS) can aid in solving the problem of terrestrial residual carbon sinks and imbalances in the global carbon budget. Thus, complete understanding of the magnitude, spatiotemporal distribution, and evolution of this sequestration is highly desirable. On the basis of random forest regression and maximal potential dissolution model for carbonate, we estimated the CS of typical carbonate weathering in China from 2000 to 2014, that is, the sequestration of limestone weathering, using long-term ecologic, meteorological, hydrological raster data, and monitored data from 44 watersheds in China and surrounding regions. We extended our analyses by systematically exploring the spatiotemporal pattern and evolution trend of the flux and total sequestration. High levels of ionic activity coefficients of Ca^(2+) and HCO_3^- in limestone regions were observed to be mainly distributed in Northern and Northwestern China with a clear gradient from northwest to southeast. With a contrary spatial pattern, the annual average CS flux(CSF) of limestone weathering in China was estimated to be 4.28 t C km^(-2) yr^(-1), with high values mainly in the karst zones in Southeastern China. The mean CSF in different latitudes showed that Southern China(south of 28.14°N) was the region with the largest interannual fluctuation of flux and CSF increases as latitude decreases. The mean CSF in subtropical and tropical(TR) regions was the maximum of all major climate types, and for the frigid(F), mid-temperate(MTE), warm temperate(WTE), and temperate(TE) major climates; the CSF in the desert(D)subdivided climate was the minimum of these climates. By contrast, the values in grassland(G) and broad-leaved forest subdivided climate were the maximum. The pixel-based trend analysis indicated that the CSF of limestone weathering in China was slightly increasing in the period 2000–2014 with a rate of 0.036 t C km^(-2) yr^(-1). Furthermore, the annual total CS was estimated to be 7.07 Tg carbon per year(Tg C yr^(-1)) with high levels in 2002, 2008, and 2010, and the minimum appeared in 2011 with a slightly increasing trend of the total CS being observed with a rate of 0.06 Tg C yr^(-1). Tibet Autonomous Region was the administrative division with the largest total CS of limestone weathering(1.20 Tg C yr^(-1)) in China, and karst zones in Southeastern China had the largest total CS(4.95 Tg C yr^(-1)) which accounts for 70.01% of that in the three divided karst regions. On the basis of the diversity of rock chemical weathering carbon cycle mechanisms of different carbonate rock types, we estimated that the total CS of carbonate weathering in China may reach 11.37 Tg C yr^(-1)(the sink was approximately 5.02 t C km^(-2) yr^(-1)),which amounts to 16.20% of the total biomass CS in China, furthermore, the CSF of carbonate weathering in China can reach6.54 t C km^(-2) yr^(-1) if excluding the interference of the negative runoff. This finding indicates that CS of carbonate weathering is an indispensable part of China's terrestrial carbon sink system. The research pattern of this study was important for further improving the accuracy of the estimation for the global carbonate weathering carbon sink. | Huiwen LI Shijie WANG Xiaoyong BAI Yue CAO Luhua WU | 2019 | Science China Earth Sciences2019，62，6： | 7 |
| 18 | Expression of HBsAg and HBcAg in the ovaries and ova of patients with chronic hepatitis B显示文摘AIM: To investigate the expression and distribution of HBV in the ovaries and ova.METHODS: The immunohistochemistry method was used to detect the HBsAg and HBcAg in the ovaries of patients with chronic hepatitis B.RESULTS: Expression of HBsAg in the ova, granular and interstitial cells of the ovaries was located in the cytomembrane and cytoplasm. Expression of HBcAg in the ova, granular, interstitial and endothelial cells of interstitial blood vessels of the ovaries was found in the cytomembrane, cytoplasm, and nuclei. CONCLUSION: HBV can infect the ova at different stages of development and replicate in it. | Feng Ye Ya-Fei Yue Shu-Hong Li Tian-Yan Chen Shu-Ling Zhang Gui-Qin Bai Min Liu | 2005 | World Journal of Gastroenterology2005，11，36： | 7 |
| 19 | The distribution and occurrence of mercury in Chinese coals显示文摘 | Xiangfei Bai Wenhua Li Yue Wang Hua Ding | 2017 | International Journal of Coal Science & Technology2017，4，2： | 6 |
| 20 | Pancreatic lipase inhibitory constituents from Fructus Psoraleae显示文摘Pancreatic lipase(PL), a crucial enzyme in the digestive system of mammals, has been proven as a therapeutic target to prevent and treat obesity. The purpose of this study is to evaluate and characterize the PL inhibition activities of the major constituents from Fructus Psoraleae(FP), one of the most frequently used Chinese herbs with lipid-lowering activity. To this end, a total of eleven major constituents isolated from Fructus Psoraleae have been obtained and their inhibition potentials against PL have been assayed by a fluorescence-based assay. Among all tested compounds, isobavachalcone, bavachalcone and corylifol A displayed strong inhibition on PL(IC50 < 10 μmol·L-1). Inhibition kinetic analyses demonstrated that isobavachalcone, bavachalcone and corylifol A acted as mixed inhibitors against PL-mediated 4-methylumbelliferyl oleate(4-MUO) hydrolysis, with the Ki values of 1.61, 3.77 and 10.16μmol·L-1, respectively. Furthermore, docking simulations indicated that two chalcones(isobavachalcone and bavachalcone) could interact with the key residues located in the catalytic cavity of PL via hydrogen binding and hydrophobic interactions. Collectively, these finding provided solid evidence to support that Fructus Psoraleae contained bioactive compounds with lipid-lowering effects via targeting PL, and also suggested that the chalcones in Fructus Psoraleae could be used as ideal leading compounds to develop novel PL inhibitors. | HOU Xu-Dong SONG Li-Lin CAO Yun-Feng WANG Yi-Nan ZHOU Qi FANG Sheng-Quan WU Da-Chang ZANG Shi-Zhu CHEN Lu BAI Yue GE Guang-Bo HOU Jie | 2020 | Chinese Journal of Natural Medicines2020，18，5： | 6 |
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