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| 1 | Entrance Effect on Load Capacity of Orifice Compensated Aerostatic Bearing with Feeding Pocket显示文摘The current research of the aerostatic thrust bearing mainly focuses on the porous material bearing and inherent compensated air bearing, which aims at obtaining small physical dimension and large load capacity. Although porous material bearing appears larger load capacity, materials anisotropy itself and void content distortion caused in heat-treating, and machining processes add greater complexity to internal flow transfer process. Inherent compensated air bearing has the advantages of simple structure and good stability, but its load capacity and static stiffness is not worth somewhat. In this paper, based on hydrostatic lubrication theory, finite volume method is presented for taking entrance effects into account in computing pressure distribution, load capacity and mass flow rates of circular aerostatic thrust bearings. Technical analysis, numerical simulations and laboratory demonstration tests of influence of pocket diameter and pocket depth on loading capacity of aerostatic thrust bearing are carried out on simple orifice compensated air bearings with feeding pockets. The static parameters, such as air consumption and pressure distributions, are measured as a function of supply pressure and air gap height for several different orifices and pockets size. Entrance effects are described in term of typical throttling types, and the effect of pocket diameter and pocket depth on load capacity is systematically described respectively. The proposed research results uncover the causation of throttling action of the orifice compensated air bearing with feed pocket and further develop and improve the design theory of air bearing. | LONG Wei BAO Gang | 2010 | Chinese Journal of Mechanical Engineering2010，23，4： | 11 |
| 2 | Characteristics of secondary inorganic aerosol and sulfate species in size-fractionated aerosol particles in Shanghai显示文摘Sulfate, nitrate and ammonium(SNA) are the dominant species in secondary inorganic aerosol, and are considered an important factor in regional haze formation. Size-fractionated aerosol particles for a whole year were collected to study the size distribution of SNA as well as their chemical species in Shanghai. SNA mainly accumulated in fine particles and the highest average ratio of SNA to particulate matter(PM) was observed to be 47% in the fine size fraction(0.49–0.95 μm). Higher sulfur oxidation ratio and nitrogen oxidation ratio values were observed in PM of fine size less than 0.95 μm. Ion balance calculations indicated that more secondary sulfate and nitrate would be generated in PM of fine size(0.49–0.95 μm). Sulfur K-edge X-ray absorption near-edge structure(XANES) spectra of typical samples were analyzed. Results revealed that sulfur mainly existed as sulfate with a proportion(atomic basis) more than 73% in all size of PM and even higher at 90% in fine particles. Sulfate mainly existed as(NH4)2SO4 and gypsum in PM of Shanghai. Compared to non-haze days, a dramatic increase of(NH4)2SO4 content was found in fine particles on haze days only, which suggested the promoting impact of(NH4)2SO4 on haze formation. According to the result of air mass backward trajectory analysis, more(NH4)2SO4 would be generated during the periods of air mass stagnation. Based on XANES, analysis of sulfate species in size-fractionated aerosol particles can be an effective way to evaluate the impact of sulfate aerosols on regional haze formation. | Shilei Long Jianrong Zeng Yan Li Liangman Bao Lingling Cao Ke Liu Liang Xu Jun Lin Wei Liu Guanghua Wang Jian Yao Chenyan Ma Yidong Zhao | 2014 | Journal of Environmental Sciences2014，26，5： | 10 |
| 3 | Research on indoor experimentation of range SAL imaging system显示文摘By means of advantages of both SAR and lidar, the combination of the techniques of (inverse) synthetic aperture and lidar makes it possible to obtain high resolution 2-D image. In this paper, an indoor experimental system of inverse synthetic aperture lidar imaging is given and a processing approach is presented. The given system is in the mode of lidar system with separated receiver and transmitter, which can effectively eliminate the jamming from the lens or/and the intersection between two optic fibers. Based on the reference channel techniques, a method for the compensation of nonlinear frequency in the time domain is presented, which can solve the problem of nonlinear frequency efficiently. Then, with the mature inverse synthetic aperture algorithm, an image of inverse synthetic aperture lidar can be obtained, which is the first attempt in China. Finally, experimental results confirm the validity of the presented method and the feasibility of the experimental system. | GUO Liang XING MengDao ZHANG Long TANG Yu BAO Zheng | 2009 | Science China(Technological Sciences)2009，52，10： | 9 |
| 4 | Sulfur speciation and bioaccumulation in camphor tree leaves as atmospheric sulfur indicator analyzed by synchrotron radiation XRF and XANES显示文摘Analyzing and understanding the effects of ambient pollution on plants is getting more and more attention as a topic of environmental biology.A method based on synchrotron radiation X-ray fluorescence and X-ray absorption near edge structure spectroscopy was established to analyze the sulfur concentration and speciation in mature camphor tree leaves (CTLs),which were sampled from 5 local fields in Shanghai,China.Annual SO2 concentration,SO42-concentration in atmospheric particulate,SO42-and sulfur concentration in soil were also analyzed to explore the relationship between ambient sulfur sources and the sulfur nutrient cycling in CTLs.Total sulfur concentration in mature camphor tree leaves was 766-1704 mg/kg.The mainly detected sulfur states and their corresponding compounds were +6 (sulfate,include inorganic sulfate and organic sulfate),+5.2 (sulfonate),+2.2 (suloxides),+0.6 (thiols and thiothers),+0.2 (organic sulfides).Total sulfur concentration was strongly correlated with sulfate proportion with a linear correlation coefficient up to 0.977,which suggested that sulfur accumulated in CTLs as sulfate form.Reduced sulfur compounds (organic sulfides,thiols,thioethers,sulfoxide and sulfonate) assimilation was sufficed to meet the nutrient requirement for growth at a balanced level around 526 mg/kg.The sulfate accumulation mainly caused by atmospheric sulfur pollution such as SO2 and airborne sulfate particulate instead of soil contamination.From urban to suburb place,sulfate in mature CTLs decreased as the atmospheric sulfur pollution reduced,but a dramatic increase presented near the seashore,where the marine sulfate emission and maritime activity pollution were significant.The sulfur concentration and speciation in mature CTLs effectively represented the long-term biological accumulation of atmospheric sulfur pollution in local environment. | Jianrong Zeng Guilin Zhang Liangman Bao Shilei Long Mingguang Tan Yan Li Chenyan Ma Yidong Zhao | 2013 | Journal of Environmental Sciences2013，25，3： | 9 |
| 5 | Rig-I^-/- mice develop colitis associated with downregulation of Gαi2显示文摘 | Yi Wang Hong-Xin Zhang Yue-Ping Sun Zi-Xing Liu Xue-Song Liu Long Wang Shun-Yuan Lu Hui Kong Qiao-Ling Liu Xi-Hua Li Zhen-Yu Lu Sai-Juan Chen Zhu Chen Shi-San Bao Wei Dai Zhu-Gang Wang | 2007 | Cell Research2007，17，10： | 8 |
| 6 | Maize grain concentrations and above-ground shoot acquisition of micronutrients as affected by intercropping with turnip, faba bean, chickpea, and soybean显示文摘Most research on micronutrients in maize has focused on maize grown as a monocrop. The aim of this study was to determine the effects of intercropping on the concentrations of micronutrients in maize grain and their acquisition via the shoot. We conducted field experiments to investigate the effects of intercropping with turnip (Brassica campestris L.), faba bean (Vicia faba L.), chickpea (Cicer arietinum L.), and soybean (Glycine max L.) on the iron (Fe), manganese (Mn), copper (Cu) and zinc (Zn) concentrations in the grain and their acquisition via the above-ground shoots of maize (Zea mays L.). Compared with monocropped maize grain, the grain of maize intercropped with legumes showed lower concentrations of Fe, Mn, Cu, and Zn and lower values of their corresponding harvest indexes. The micronutrient concentrations and harvest indexes in grain of maize intercropped with turnip were the same as those in monocropped maize grain. Intercropping stimulated the above-ground maize shoot acquisition of Fe, Mn, Cu and Zn, when averaged over different phosphorus (P) application rates. To our knowledge, this is the first report on the effects of intercropping on micronutrient concentrations in maize grain and on micronutrients acquisition via maize shoots (straw+grain). The maize grain Fe and Cu concentrations, but not Mn and Zn concentrations, were negatively correlated with maize grain yields. The concentrations of Fe, Mn, Cu, and Zn in maize grain were positively correlated with their corresponding harvest indexes. The decreased Fe, Mn, Cu, and Zn concentrations in grain of maize intercropped with legumes were attributed to reduced translocation of Fe, Mn, Cu, and Zn from vegetative tissues to grains. This may also be related to the delayed senescence of maize plants intercropped with legumes. We conclude that turnip/maize intercropping is beneficial to obtain high maize grain yield without decreased concentrations of Fe, Mn, Cu, and Zn in the grain. Further research is required to clarify the mechanisms underlying the changes in micronutrient concentrations in grain of intercropped maize. | XIA HaiYong ZHAO JianHua SUN JianHao XUE YanFang EAGLING Tristan BAO XingGuo ZHANG FuSuo LI Long | 2013 | Science China(Life Sciences)2013，56，9： | 8 |
| 7 | Circular RNA circStag1 promotes bone regeneration by interacting with HuR显示文摘Postmenopausal osteoporosis is a common bone metabolic disorder characterized by deterioration of the bone microarchitecture,leading to an increased risk of fractures.Recently,circular RNAs(circ RNAs)have been demonstrated to play pivotal roles in regulating bone metabolism.However,the underlying functions of circ RNAs in bone metabolism in postmenopausal osteoporosis remain obscure.Here,we report that circ Stag1 is a critical osteoporosis-related circ RNA that shows significantly downregulated expression in osteoporotic bone marrow mesenchymal stem cells(BMSCs)and clinical bone tissue samples from patients with osteoporosis.Overexpression of circ Stag1 significantly promoted the osteogenic capability of BMSCs.Mechanistically,we found that circ Stag1 interacts with human antigen R(Hu R),an RNA-binding protein,and promotes the translocation of Hu R into the cytoplasm.A high cytoplasmic level of Hu R led to the activation of the Wnt signaling pathway by stabilizing and enhancing low-density lipoprotein receptor-related protein 5/6(Lrp5/6)andβ-catenin expression,thereby stimulating the osteogenic differentiation of BMSCs.Furthermore,overexpression of circ Stag1 in vivo by circ Stag1-loaded adeno-associated virus(circ Stag1-AAV)promoted new bone formation,thereby preventing bone loss in ovariectomized rats.Collectively,we show that circ Stag1 plays a pivotal role in promoting the regeneration of bone tissue via Hu R/Wnt signaling,which may provide new strategies to prevent bone metabolic disorders such as postmenopausal osteoporosis. | Gaoyang Chen Canling Long Shang Wang Zhenmin Wang Xin Chen Wanze Tang Xiaoqin He Zhiteng Bao Baoyu Tan Jin Zhao Yongheng Xie Zhizhong Li Dazhi Yang Guozhi Xiao Songlin Peng | 2022 | Bone Research2022，10，3： | 7 |
| 8 | Highly efficient Cu/anatase TiO2 {001}-nanosheets catalysts for methanol synthesis from CO2显示文摘Anatase TiO_2 nanosheets(-ns-) with dominant exposed {001} facets were used as support to load copper,and the synthesized Cu/TiO_2-ns catalysts were evaluated for CO_2 hydrogenation to methanol. Under the reaction conditions, P = 3.0 MPa, T = 260 ℃, V(N_2):V(H_2):V(CO_2) = 8:69:23 and gas hourly space velocity(GHSV) = 3600 mL g^(-1)h^(-1), the methanol yield reached an appealing high value, 5.6%. Copper-loading amount, calcination temperature and reduction atmosphere have been investigated in this work, which significantly influence the particle sizes of copper and/or the defect concentration in TiO_2, then leading to different catalytic performance. Characterizations of XRD, EPR, CO_2-TPD and FTIR demonstrate that higher specific surface area of Cu is good for the hydrogenation of CO_2 and adequate amount of Ti^(3+) plays important roles in CO_2 activation. Both of them facilitate high turnover frequency(TOF) of methanol formation. | Yunfeng Bao Chunlei Huang Limin Chen Yu dong Zhang Long Liang Jinjun Wen Mingli Fu Junliang Wu Daiqi Ye | 2018 | Journal of Energy Chemistry2018，27，2： | 7 |
| 9 | An approach to forward looking FMCW radar imaging based on two-dimensional Chirp-Z transform显示文摘Airborne forward looking radar imaging, which is an important work mode of imaging radar system, has many advantages combined with frequency modulated continuous wave (FMCW) technology. This paper studies the configuration with one central antenna element for signal transmitting and other antenna elements for signal receiving. According to its imaging geometry, the analytical expression of the received signal for forward looking imaging radar based on FMCW is given. By performing the equivalent phase center principle, the received signal is equalized to the case of system configuration with antenna both for transmitting and receiving signals. The Doppler frequency shift effect, induced by the platform’s continuous motion while radar transmits and receives signals, is analyzed in detail and the approximate compensation method is shown. Based on this, a novel method for forward looking FMCW radar imaging is developed, which adopts two-dimensional Chirp-Z transform to implement scaling operation. Also the complete derivation process of the algorithm and the expression of each compensation factor are presented. The whole algorithm only includes FFT and complex multiplication, with interpolation free, and is easy to implement in reality. Simulation results verify the correctness of the analysis and the validity of the proposed algorithm. | LIANO Yi WANG HongXian ZHANG Long BAO Zheng | 2010 | Science China(Information Sciences)2010，53，8： | 6 |
| 10 | Epigallocatechin-3-gallate Alleviates Cognitive Deficits in APP/PS1 Mice显示文摘Alzheimer's disease(AD)shows cognitive impairments in clinic,which is multifactorial with different etiopathogenic mechanisms such as A|3 deposition,neuroinflammation and neuronal dystrophy involved.Therefore,multi-targets drugs with neuroprotective,anti-amyloidogenic and anti-inflammatory properties will be effective in AD treatment.Epigallocatechin-3-gallate(EGCG)possesses a broad spectrum of pharmacological activities in the prevention and treatment of multiple neurodegenerative diseases.In the present study,we showed that oral administration of EGCG(50 mg/kg)for 4 months significantly attenuated the cognitive deficits in APP/PS1 transgenic mice,which served as AD model.Moreover,EGCG induced an improvement in dendritic integrity and expression levels of synaptic proteins in the brain of APP/PS 1 mice.And EGCG exerted obvious anti-inflammatory effects,which was manifested by alleviating microglia activation,decreasing pro-inflammatory cytokine(IL-β)and increasing anti-inflammatory cytokines(IL-10,IL-β).Furthermore,p-amyloid(AP)plaques were markedly reduced in the hippocampus of 6-month old APP/PS 1 mice after EGCG treatment.In conclusion,these findings indicate that EGCG improves AD-like cognitive impairments through neuroprotective,anti-amyloidogenic and anti-inflammatory effects,thus is a promising therapeutic can didate for AD. | Jian BAO Wei LIU Hong-yan ZHOU Yu-ran GUI You-hua YANG Meng-juan WU Yi-fan XIAO Jin-ting SHANG Gui-feng LONG Xi-ji SHU | 2020 | Current Medical Science2020，40，1： | 6 |
| 11 | Research advances in unsupported Pt-based catalysts for electrochemical methanol oxidation显示文摘Direct methanol fuel cells are one of the most promising alternative energy technologies in the foreseeable future, but its successful commercialization in large scale is still heavily hindered by several technical shortfalls, especially the undesirable activity and durability issues of electrocatalysts toward methanol oxidation reaction. In light of these challenges, the inherent advantages of unsupported Pt based nanostructures demonstrate their great potentials as durable and efficient electrocatalysts for direct methanol fuel cells. This review will summarize recent achievements of unsupported Pt-based electrocatalysts toward methanol oxidation, with highlighting the interactions between the performance and structure tailoring and composition modulating. At last, a perspective is proposed for the upcoming challenges and possible opportunities to further prompt the practical application of unsupported Pt-based electrocatalysts for direct methanol fuel cells. | Xin Long Tian Lijuan Wang Peilin Deng Yu Chen Bao Yu Xia | 2017 | Journal of Energy Chemistry2017，26，6： | 5 |
| 12 | Consensus on the digestive endoscopic tunnel technique显示文摘With the digestive endoscopic tunnel technique(DETT), many diseases that previously would have been treated by surgery are now endoscopically curable by establishing a submucosal tunnel between the mucosa and muscularis propria(MP). Through the tunnel, endoscopic diagnosis or treatment is performed for lesions in the mucosa, in the MP, and even outside the gastrointestinal(GI) tract.At present, the tunnel technique application range covers the following:(1)Treatment of lesions originating from the mucosal layer, e.g., endoscopic submucosal tunnel dissection for oesophageal large or circular early-stage cancer or precancerosis;(2) treatment of lesions from the MP layer, per-oral endoscopic myotomy, submucosal tunnelling endoscopic resection, etc.; and(3) diagnosis and treatment of lesions outside the GI tract, such as resection of lymph nodes and benign tumour excision in the mediastinum or abdominal cavity. With the increasing number of DETTs performed worldwide, endoscopic tunnel therapeutics, which is based on DETT, has been gradually developed and optimized. However, there is not yet an expert consensus on DETT to regulate its indications, contraindications, surgical procedure, and postoperative treatment.The International DETT Alliance signed up this consensus to standardize the procedures of DETT. In this consensus, we describe the definition, mechanism,and significance of DETT, prevention of infection and concepts of DETTassociated complications, methods to establish a submucosal tunnel, and application of DETT for lesions in the mucosa, in the MP and outside the GI tract(indications and contraindications, procedures, pre-and postoperative treatments, effectiveness, complications and treatments, and a comparison between DETT and other operations). | Ning-Li Chai Hui-Kai Li En-Qiang Linghu Zhao-Shen Li Shu-Tian Zhang Yu Bao Wei-Gang Chen Philip WY Chiu Tong Dang Wei Gong Shu-Tang Han Jian-Yu Hao Shui-Xiang He Bing Hu1 Bing Hu2 Xiao-Jun Huang Yong-Hui Huang Zhen-Dong Jin Mouen A Khashab James Lau Peng Li Rui Li De-Liang Liu Hai-Feng Liu Jun Liu Xiao-Gang Liu Zhi-Guo Liu Ying-Cai Ma Gui-Yong Peng Long Rong Wei-Hong Sha Pateek Sharma Jian-Qiu Sheng Shui-Sheng Shi Dong Wan Seo Si-Yu Sun Gui-Qi Wang Wen Wang Qi Wu Hong Xu Mei-Dong Xu Ai-Ming Yang Fang Yao Hong-Gang Yu Ping-Hong Zhou Bin Zhang Xiao-Feng Zhang Ya-Qi Zhai | 2019 | World Journal of Gastroenterology2019，25，7： | 5 |
| 13 | A theoretical model of semi-elliptic surface crack growth显示文摘A theoretical model of semi-elliptic surface crack growth based on the low cycle strain damage accumulation near the crack tip along the cracking direction and the Newman–Raju formula is developed. The crack is regarded as a sharp notch with a small curvature radius and the process zone is assumed to be the size of cyclic plastic zone. The modified Hutchinson, Rice and Rosengren(HRR) formulations are used in the presented study. Assuming that the shape of surface crack front is controlled by two critical points: the deepest point and the surface point.The theoretical model is applied to semi-elliptic surface cracked Al 7075-T6 alloy plate under cyclic loading, and five different initial crack shapes are discussed in present study. Good agreement between experimental and theoretical results is obtained. | Shi Kaikai Cai Lixun Chen Long Bao Chen | 2014 | Chinese Journal of Aeronautics2014，27，3： | 5 |
| 14 | Back-n white neutron source at CSNS and its applications显示文摘Back-streaming neutrons from the spallation target of the China Spallation Neutron Source(CSNS)that emit through the incoming proton channel were exploited to build a white neutron beam facility(the so-called Back-n white neutron source),which was completed in March 2018.The Back-n neutron beam is very intense,at approximately 29107 n/cm2/s at 55 m from the target,and has a nominal proton beam with a power of 100 kW in the CSNS-I phase and a kinetic energy of 1.6 GeV and a thick tungsten target in multiple slices with modest moderation from the cooling water through the slices.In addition,the excellent energy spectrum spanning from 0.5 eV to 200 MeV,and a good time resolution related tothe time-of-flight measurements make it a typical white neutron source for nuclear data measurements;its overall performance is among that of the best white neutron sources in the world.Equipped with advanced spectrometers,detectors,and application utilities,the Back-n facility can serve wide applications,with a focus on neutron-induced cross-sectional measurements.This article presents an overview of the neutron beam characteristics,the experimental setups,and the ongoing applications at Backn. | Jing-Yu Tang Qi An Jiang-Bo Bai Jie Bao Yu Bao Ping Cao Hao-Lei Chen Qi-Ping Chen Yong-Hao Chen Zhen Chen Zeng-Qi Cui Rui-Rui Fan Chang-Qing Feng Ke-Qing Gao Xiao-Long Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Xi-Ru Huang Hao-Yu Jiang Wei Jiang Zhi-Jie Jiang Han-Tao Jing Ling Kang Bo Li Chao Li Jia-Wen Li Qiang Li Xiao Li Yang Li Jie Liu Rong Liu Shu-Bin Liu Xing-Yan Liu Ze Long Guang-Yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Xin-Yi Tang Bin-Bin Tian Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Xiao-Yun Yang Yi-Wei Yang Han Yi Li Yu Tao Yu Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Zhi-Yong Zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu 无 | 2021 | Nuclear Science and Techniques2021，32，1： | 4 |
| 15 | A Teosinte-derived Allele of a MYB Transcription Repressor Confers Multiple Disease Resistance in Maize.显示文摘Natural alleles controlling multiple disease resistances (MDR) are valuable for crop breeding. However, only one MDR gene have been cloned in maize, and molecular mechanisms of MDR are not clear. By map-based cloning, we have cloned a teosinte-derived allele of a resistance gene, Mexicana lesion mimic 1 (ZmMM1), which has a lesion mimic phenotype and confers resistance to northern leaf blight (NLB), gray leaf spot (GLS) and southern corn rust (SCR). Strong MDR conferred by the teosinte allele is linked with the polymorphisms in the 3' untranslated region of the ZmMM1 gene that cause increased accumulation of ZmMM1 protein. ZmMM1 acts as a transcription repressor and negatively regulates transcription of specific target genes including ZmMM1-target gene 3 (ZmMT3), which functions as a negative regulator of plant immunity and associated cell death. The successful isolation of the ZmMM1 resistance gene will help not only in developing broad-spectrum and durable disease resistance but also in understanding the molecular mechanisms underlying MDR. | Hongze Wang Jiabao Hou Pei Ye Long Hu Junshi Huang Zhikang Dai Bao Zhang Sha Dai Jiamin Que Haoxuan Min Gengshen Chen Yanbo Wang Min Jiang Yan Liang Lin Li Xuecai Zhang Zhibing Lai | 2021 | Molecular Plant2021，14，11： | 4 |
| 16 | Detection, parameter estimation and imaging of maneuvering target in wide-band signal显示文摘The signal-to-noise ratio may be increased by the cross-range coherence integration so as to detect the moving target in low signal-to-noise ratio (SNR) condition. But, the radial velocity, acceleration and the change of acceleration due to the maneuvering motion of target may induce serious range migration and cross-range high-order phase terms leading to the unfocused cross-range image, the reduction of signal-noise ratio and the invalidation of target detection. Therefore, in order to solve these problems, this paper proposes a new method based on the adjacent correlation and scale transform methods for detection, parameters estimation and imaging of maneuvering targets in wide-band signal. This method can align the range and remove the cross-range high-order phase terms induced by the radial motion of target, enabling us to detect the target and estimate its moving parameters better. Finally, the simulated target is used to confirm that the method proposed by this paper can perfectly detect the maneuvering target in low signal-to-noise ratio condition, estimate its motion parameters and obtain an ISAR image of target. | LI YaChao XlNG MengDao ZHANG Long BAO Zheng | 2009 | Science in China(Series F)2009，52，6： | 4 |
| 17 | RACK1 modulates NF-KB activation by interfering with the interaction between TRAF2 and the IKK complex显示文摘抄写因素 NF-κ B 响应许多刺激在天生的免疫起一个枢轴的作用,并且这条小径的协调规定决定合适的主人回答到细胞外的信号。在这研究,我们作为 NF-κ 的一个新奇否定管理者识别了 RACK1; B 发信号, NF-κ调停 B 的 cytokine 正式就职和煽动性的反应。RACK1 身体上以一种被触发 TNF 的方式与 IKK 建筑群联系。这个相互作用防碍 IKK 建筑群的招募到 TRAF2,它是为 TNF 触发的 IKK phosphorylation 和随后的激活的关键步。由 modulating 在 TRAF2 和 IKK 之间的相互作用, RACK1 调整 NF-κ 的层次;响应刺激的不同紧张的 B 激活。我们的调查结果建议 RACK1 在控制被触发 TNF 的 NF-κ 的敏感起一个重要作用; B 由调整 IKK 激活发信号并且提供新卓见进煽动性的反应的否定规定。 | Fan Yao Ling-Yun Long Yue-Zhen Deng Yuan-Yuan Feng Guo-Yuan Ying Wen-Dai Bao Guo Li Dong-Xian Guan Yin-Qiu Zhu Jing-Jing Li Dong Xie | 2014 | Cell Research2014，24，3： | 4 |
| 18 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 19 | Au nanocomposite enhanced electret film for triboelectric nanogenerator显示文摘 | Bao Dong Chen Wei Tang Chi Zhang Liang Xu Lai Pan Zhu Lei Jing Yang Chuan He Jian Chen Long Liu Tao Zhou Zhong Lin Wang | 2018 | Nano Research2018，11，6： | 4 |
| 20 | Interferon-induced Transmembrane Protein 3 Prevents Acute Influenza Pathogenesis in Mice显示文摘Objective Interferon-induced transmembrane protein 3(IFITM3)is an important member of the IFITM family.However,the molecular mechanisms underlying its antiviral action have not been completely elucidated.Recent studies on IFITM3,particularly those focused on innate antiviral defense mechanisms,have shown that IFITM3 affects the body’s adaptive immune response.The aim of this study was to determine the contribution of IFITM3 proteins to immune control of influenza infection in vivo.Methods We performed proteomics,flow cytometry,and immunohistochemistry analysis and used bioinformatics tools to systematically compare and analyze the differences in natural killer(NK)cell numbers,their activation,and their immune function in the lungs of Ifitm3-/-and wild-type mice.Results Ifitm3-/-mice developed more severe inflammation and apoptotic responses compared to wild-type mice.Moreover,the NK cell activation was higher in the lungs of Ifitm3-/-mice during acute influenza infection.Conclusions Based on our results,we speculate that the NK cells are more readily activated in the absence of IFITM3,increasing mortality in Ifitm3-/-mice. | SUN Qiang LEI Na LU Jian GAO Rong Bao LI Zi LIU Li Qi SUN Ying GUO Jun Feng WANG Da Yan SHU Yue Long | 2020 | Biomedical and Environmental Sciences2020，33，5： | 4 |
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