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| 1 | Management of digestive bleeding related to portal hypertension in cirrhotic patients:A French multicenter cross-sectional practice survey显示文摘AIM: To investigate the conformity of management practices of gastrointestinal hemorrhage in cirrhotic patients with relevant guidelines. METHODS: A questionnaire on the management of digestive bleeding was completed for all consecutive cirrhotic patients admitted to 31 French hospitals. RESULTS: One hundred and twenty-six bleeding events were recorded. It was the first bleeding episode in 79 patients (63%), of whom 40 (51%) had a prior diagnosis of cirrhosis and 25 (32%) had previously undergone an endoscopy. The bleeding episode was a recurrence in 46 patients (37%). The median time between onset and admission was 4 h, but exceeded 12 h in 42% of cases. There was an agreement between centers forearly vasoactive drug administration (87% of cases), association with ligation (42%) more often than sclerosis (21%) at initial endoscopy, and antibiotic prophylaxis (64%). By contrast, prescription of beta-blockade alone or in combination (0 to 100%, P = 0.003) for secondary prophylaxis and lactulose (26% to 86%, P = 0.04), differed among centers. CONCLUSION: In French hospitals, management of bleeding related to portal hypertension in cirrhotic patients is generally in keeping with the consensus. Broad variability still remains concerning beta-blockade use for secondary prophylaxis. Screening for esophageal varices, the use of antibiotic prophylaxis and patients information need to be improved. | Pierre Ingrand Jérme Gournay Pierre Bernard Frédéric Oberti Brigitte Bernard-Chabert Arnault Pauwels Philippe Renard Eric Bartoli Jean-Franois Cadranel Jean-Claude Barbare Isabelle Ingrand Michel Beauchant | 2006 | World Journal of Gastroenterology2006，12，48： | 4 |
| 2 | 伦理学与SARS:多伦多的教训显示文摘SARS的流行说明传染病在世界范围内流行是件多么容易的事,为了更好地应对下一次流行病,我们不仅要解决医学方面的问题,也同样需要解决伦理学方面的问题。 | Peter A Singer Solomon R Benatar Mark Bernstein Abdallah S Daar Bernard M Dickens Susan K MacRae Ross E G Upshur Linda Wright Randi Zlotnik Shaul 肖月 | 2004 | 英国医学杂志中文版2004，7，4： | 3 |
| 3 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 4 | The American-European consensus conference on acute respiratory distress syndrome:definitions,mechanisms,relevant outcomes,and clinical trial coordination显示文摘 | Bernard G R Artigas A Brigham K L | 1994 | Am J Respir Crit Care Med1994，151，： | 2 |
| 5 | Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)显示文摘 | Claudia Allemani Hannah K Weir Helena Carreira Rhea Harewood Devon Spika Xiao-Si Wang Finian Bannon Jane V Ahn Christopher J Johnson Audrey Bonaventure Rafael Marcos-Gragera Charles Stiller Gulnar Azevedo e Silva Wan-Qing Chen Olufemi J Ogunbiyi Bernard R | 2015 | The Lancet . 2015 (9972)2015，，： | 2 |
| 6 | The AmericanEuropea n consensus conference on ARDS:definitions,mechanisms,relevant outcome,and clinical trial c oordination显示文摘 | Bernard G R Artigas A Brigham K L | 1994 | Am J Respir Crit Care Med1994，149，： | 2 |
| 7 | Stable suppression of tumorigenicity by virus-mediated RNA interference显示文摘 | Thijn R Brummelkamp René Bernards Reuven Agami | 2002 | Cancer Cell2002，，3： | 2 |
| 8 | Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: A systematic review and meta-analysis显示文摘 | Bernard Uzzan Régis Cohen Patrick Nicolas Michel Cucherat Gérard-Yves Perret | 2006 | Critical Care Medicine2006，，7： | 2 |
| 9 | Acute lung injury and the acute respiratory distress syndrome: a clinical review显示文摘 | Arthur P Wheeler Gordon R Bernard | 2007 | 2007 (9572)2007，，9572： | 2 |
| 10 | Report of the AmericanEuropean consensus conference on ARDS:definitions,mechanisms,relevant ou tcomes and clinical trial coordination显示文摘 | Bernard G R | 1994 | Intensive Care Med1994，20，： | 2 |
| 11 | Prospective randomized comparison between axial- and lateral-viewing capsule endoscopy systems in patients with obscure digestive bleeding显示文摘 | Mathieu Pioche Geoffroy Vanbervliet Philippe Jacob Cloti de Duburque Rodica Gincul Bernard Filoche Jacques Daudet Jér?me Filippi Jean-Christophe Saurin | 2013 | Endoscopy2013，，： | 2 |
| 12 | B - myb rescues ras - induced premature senescence, which requires its transactivation domain 显示文摘 | Masselink H Vastenhouw N Bernards R | 2001 | Cancer Lett2001，171，1： | 1 |
| 13 | Effective tumor immunotherapy directed against an oncogene-encoded produce using a vaccinia virus vector显示文摘 | Destree A McKenzies | 1987 | Proc Natl Acad Sci USA1987，84，19： | 1 |
| 14 | GRAS Substances显示文摘 | Bernard L Oser R A Ford | 1998 | Food Technology1998，52，9： | 1 |
| 15 | Low-molecular-weight proteins as markers of organ toxicity with special reference to Clara cell protein显示文摘 | Bernard A Lauwerys R | 1995 | Toxicol Lett1995，77，： | 1 |
| 16 | Stable suppression of tumorigenicity by virus-mediated RNA interference显示文摘 | Brummelkamp TR Bernards R Agami R | 2002 | Cancer Cell2002，2，3： | 1 |
| 17 | Structure and expression of the rnurine retinoblastoma gene and characterization of its encoded protein显示文摘 | Bernards R Shackleford GM Gerber MR | 1989 | Proc Natl Acad Sci USA1989，86，： | 1 |
| 18 | Serotonin syndrome after concomitant treatment with linezolid and citalopram 显示文摘 | Bernard L Stem R Lewand D | 2003 | Clin Infect Dis2003，36，9： | 1 |
| 19 | A 10-year prospective study of ITI dental implants placed in the posterior region Ⅱ:influence of crown-to-implant ratio and different prosthetic treatment modalitles on crestal bone loss显示文摘 | BLANES R J BERNARD J P BLANES Z M | | 0，，06： | 1 |
| 20 | A system for stable expression of short interfering RNAs in mammalian cells 显示文摘 | Brummelkamp TR Bernards R Agami R | 2002 | Science2002，296，5567： | 1 |
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