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| 1 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 2 | From Redevelopment to In Situ Upgrading: Transforming Urban Village Governance in Shenzhen Through the Lens of Informality显示文摘The study on informality has experienced a shift from describing the spatial characteristics toward exploring the connotation of urban governance in recent years. This paper takes urban villages in Shenzhen, a typical informal settlement in China, as cases to analyze the two urban village governance modes of redevelopment and in situ upgrading and reveals the dynamics of the governance mode transformation. Through the lens of informality, this study focuses on the interaction among the government, the market, and former property owners on tenure legalization. The study finds that first of all, informality is the core of the transformation of urban village governance in Shenzhen. By strategically making use of informality, the government adopted different modes of urban village governance to fulfill the demands of urban development at different phases. Second, in the process of formalizing informal settlements through redevelopment, although the institutional framework is relatively complete, the boundary between informality and formality still changes continuously in property titling. While in the new governance mode of in situ upgrading in recent years, the government creates 'special areas' in informal settlements via approving their de facto tenure security, so as to attract market force to upgrade physical environment and social management. Through revealing the mechanism in the blurred area between informality and formality, this paper responds to the dualistic argument on the informality theory, deepens the idea of taking informality as a flexible urban governance strategy in developing countries, and provides new thoughts for governance of informal settlements in China and other developing countries. | Gan Xinyue Chen Yulin Bian Lanchun Qian Fang | 2019 | China City Planning Review2019，28，4： | 2 |
| 3 | Review of dynamic performance and control strategy of supercritical CO_(2) Brayton cycle显示文摘In recent years,the supercritical carbon dioxide Brayton cycle(SCBC)has been regarded as a promising next generation power conversation system,owing to its high efficiency,compact components,applicability for various kinds of heat sources and so on.This paper makes a detailed review of the dynamic performance and control strategy of SCBC.The dynamic simulation model of SCBC is overviewed in detail including different modeling methods of the main component models and validation of system model.As the most inevitable approach to evaluate the dynamic performance of SCBC in practice,existing SCBC test benches concerning SCBC are well collected and presented.Based on these,the open loop dynamic system performances by changing different manipulated variables are reviewed and then various control methods for essential state parameters by different manipulated variables are summarized.Finally,various control strategies of load following and startup/shutdown are clearly presented.With the rapid development of artificial intelligence,combining the core mechanism model and key parameters identifi-cation based on experimental data and machine learning to obtain an accurate model within a wide range of working condition is a popular trend in modeling of SCBC.Moreover,deep reinforcement learning will be a potential method for the control strategy in SCBC. | Xuan Wang Rui Wang Xingyan Bian Jinwen Cai Hua Tian Gequn Shu Xinyu Li Zheng Qin | 2021 | Energy and AI2021，5，3： | 2 |
| 4 | Auxin signaling module OsSK41-OsIAA10-OsARF regulates grain yield traits in rice显示文摘Auxin is an important phytohormone in plants, and auxin signaling pathways in rice play key roles in regulating its growth, development, and productivity. To investigate how rice grain yield traits are regulated by auxin signaling pathways and to facilitate their application in rice improvement, we validated the functional relationships among regulatory genes such as OsIAA10, OsSK41, and OsARF21 that are involved in one of the auxin(OsIAA10) signaling pathways. We assessed the phenotypic effects of these genes on several grain yield traits across two environments using knockout and/or overexpression transgenic lines.Based on the results, we constructed a model that showed how grain yield traits were regulated by OsIAA10 and OsTIR1, OsAFB2, and OsSK41 and OsmiR393 in the OsSK41-OsIAA10-OsARF module and by OsARF21 in the transcriptional regulation of downstream auxin response genes in the OsSK41-OsIAA10-OsARF module. The population genomic analyses revealed rich genetic diversity and the presence of major functional alleles at most of these loci in rice populations. The strong differentiation of many major alleles between Xian/indica and Geng/japonica subspecies and/or among modern varieties and landraces suggested that they contributed to improved productivity during evolution and breeding. We identified several important aspects associated with the genetic and molecular bases of rice grain and yield traits that were regulated by auxin signaling pathways.We also suggested rice auxin response factor(OsARF) activators as candidate target genes for improving specific target traits by overexpression and/or editing subspecies-specific alleles and by searching and pyramiding the ‘best' gene allelic combinations at multiple regulatory genes in auxin signaling pathways in rice breeding programs. | Fuying Ma Fan Zhang Yu Zhu Dengyong Lan Peiwen Yan Ying Wang Zejun Hu Xinwei Zhang Jian Hu Fuan Niu Mingyu Liu Shicong He Jinhao Cui Xinyu Yuan Ying Yan Shujun Wu Liming Cao Hongwu Bian Jinshui Yang Zhikang Li Xiaojin Luo | 2023 | Journal of Integrative Plant Biology2023，65，7： | 1 |
| 5 | Tumor-penetrating peptide fused EGFR single-domain antibody enhances cancer drug penetration into 3D multicellular spheroids and facilitates effective gastric cancer therapy显示文摘 | Huizi Sha Zhengyun Zou Kai Xin Xinyu Bian Xueting Cai Wuguang Lu Jiao Chen Gang Chen Leaf Huang Andrew M. Blair Peng Cao Baorui Liu | 2015 | Journal of Controlled Release2015，，： | 1 |
| 6 | Case report of neurofibromatosis type 1 combined with primary ciliary dyskinesia显示文摘Neurofibromatosis(NF)is a genetic disease in which the lungs are rarely involved.However,in NF cases with lung involvement,chest computed tomography may show bilateral basal reticulations,apical bullae,and cysts without bronchiectasis.Herein,we report a patient diagnosed with NF on the basis of the results of genetic testing who presented with early-onset wet cough and bronchiectasis.Considering the differential diagnosis of bronchiectasis combined with his early-onset wet cough,sinusitis,and sperm quality decline,we considered the possibility of primary ciliary dyskinesia(PCD).Further electron microscopy analysis of cilia and identification of homozygous mutations in the RSPH4A gene confirmed the diagnosis of PCD.Therefore,for patients with NF,when an image change exists in the lungs that does not correspond to NF,the possibility of other diagnoses,including PCD,must be considered. | Chun Bian Xinyue Zhao Yaping Liu Minjiang Chen Shuying Zheng Xinlun Tian Kai-Feng Xu | 2021 | Frontiers of Medicine2021，15，6： | 1 |
| 7 | Effect of Ag addition on the thermal stability and glass-forming ability of Zr_(35)Ti_(30)Cu_(7.5)Be_(27.5) bulk metallic glass显示文摘The thermal stability and glass forming ability (GFA) of Zr35-xTi30Cu7.5Be27.5Agx (x = 0-10) alloys were studied by X-ray diffraction (XRD), differential scanning calorimetry (DSC) and ultrasonic techniques. We found that the addition of 1 at.% Ag can considerably enhance the GFA as indicated by an increase in the critical glass dimension from 15 mm in the Zr35Ti30Cu7.5Be27.5 alloy to 20 mm in the Zr34Ti30Cu7.5Be27.5Ag1 alloy. However, with the addition of more Ag the supercooled liquid region (△Tx) and y parameter (defined as Tx/(Tg+Tl)) drastically decreased from 155 K and 0.436 to 76 K and 0.363, respectively, resulting in a decrease in the GFA. Additionally, the elastic constant (the ratio of shear modulus to bulk modulus or Poisson's ratio) was also used as a gauge to evaluate the GFA in Zr35-xTi30Cu7.5Be27.5Agx alloys. | ZONG HaiTao ZHANG XinYu LI LiXin BIAN LinYan LIANG ShunXing TAN ChunLin | 2012 | Chinese Science Bulletin2012，57，11： | 1 |
| 8 | Stacking monolayers at will:A scalable device optimization strategy for two-dimensional semiconductors显示文摘In comparison to monolayer(1L),multilayer(ML)two-dimensional(2D)semiconducting transition metal dichalcogenides(TMDs)exhibit more application potential for electronic and optoelectronic devices due to their improved current carrying capability,higher mobility,and broader spectral response.However,the investigation of devices based on wafer-scale ML-TMDs is still restricted by the synthesis of uniform and high-quality ML films.In this work,we propose a strategy of stacking MoS_(2) monolayers via a vacuum transfer method,by which one could obtain wafer-scale high-quality MoS_(2) films with the desired number of layers at will.The optical characteristics of these stacked ML-MoS_(2) films(>2L)indicate a weak interlayer coupling.The stacked MLMoS_(2) phototransistors show improved optoelectrical performances and a broader spectral response(approximately 300-1,000 nm)than that of 1L-MoS_(2).Additionally,the dual-gate ML-MoS_(2) transistors enable enhanced electrostatic control over the stacked ML-MoS_(2) channel,and the 3L and 4L thicknesses exhibit the optimal device performances according to the turning point of the current on/off ratio and the subthreshold swing. | Xiaojiao Guo Honglei Chen Jihong Bian Fuyou Liao Jingyi Ma Simeng Zhang Xinzhi Zhang Junqiang Zhu Chen Luo Zijian Zhang Lingyi Zong Yin Xia Chuming Sheng Zihan Xu Saifei Gou Xinyu Wang Peng Gong Liwei Liu Xixi Jiang Zhenghua An Chunxiao Cong Zhijun Qiu Xing Wu Peng Zhou Xinyu Chen Ling Tong Wenzhong Bao | 2022 | Nano Research2022，15，7： | 0 |
| 9 | 3D printedβ-sheet-reinforced natural polymer hydrogel bilayer tissue engineering scaffold显示文摘It remains a significant challenge to fabricate natural polymer(NP)hydrogels with anti-swelling ability and high strengths in the physiological environment.Herein,theβ-sheet-reinforced NP hydrogel is developed by copolymerizing methacrylated gelatin(GelMA)and methacrylated silk fibroin(SFMA)in aqueous solution,followed by ethanol treatment(named GelMA-SFMAAL).Theβ-sheets formed by SFMA can act as a stable physical crosslink to enhance the mechanical properties and prolong the degradation of the GelMA network.Importantly,the chemical crosslinking in the GelMA-SFMA hydrogel prevents excessive aggregation of hydrophobicβ-sheets,thereby avoiding the formation of brittle hydrogel.The obtained GelMA-SFMA-AL hydrogels exhibit considerably enhanced mechanical properties(Young's modulus:0.89–3.68 MPa;tensile strength:0.31–0.96 MPa;toughness:0.09–0.63 MJ/m^(3);compressive modulus:0.78–2.20 MPa;compressive strength:2.65–5.93 MPa)compared with GelMA-SFMA hydrogels(Young's modulus:0.04–0.13 MPa;tensile strength:0.04–0.07 MPa;toughness:0.01–0.02 MJ/m^(3);compressive modulus:0.03–0.09 MPa;compressive strength:0.30–0.64 MPa).A bilayer osteochondral scaffold is constructed via digital light processing(DLP)three-dimensiaonl(3D)printing technology,comprising GelMA-SFMA@diclofenac sodium(DS)-AL as the top layer and GelMA-SFMA@bioactive glass(BG)-AL as the bottom layer.The bilayer hydrogel scaffold is demonstrated to support cell attachment and spreading,and facilitate osteogenic differentiation of rat bone marrow stem cells in vitro.In vivo implantation experiment suggests this bilayer scaffold is promising to be used for osteochondral tissue regeneration. | ZHAO XinRui NIE XiongFeng ZHANG XiaoPing SUN YaGe YANG Rong BIAN XinYu ZHANG Qian WANG HongYing XU ZiYang LIU WenGuang | 2024 | Science China(Technological Sciences)2024，67，4： | 0 |
| 10 | Biliary candidiasis mimicking IgG4-related disease in a patient with normal immunity显示文摘Purpose:To report a rare case of biliary candidiasis in a host with normal immunity.Methods:Laboratory tests indicated an elevated G level of 1000 pg/ml.Microscopic examination of pathological sections demonstrated multiple,narrow base,budding yeast cells following Grocott's methenamine silver staining and periodic acid-Schiff staining.Subsequent sequence analysis supported the diagnosis of biliary candidiasis.Results:A 31-year-old previously healthy man developed obstructive jaundice under no obvious inducement.He experienced cholecystectomy and biliary drainage.Surgical specimens revealed granulomatous chronic inflammation in the gallbladder,liver,bile ducts and mesenteric lymph nodes.He was misdiagnosed with tuberculosis and received antituberculosis treatment.However,his condition did not improve.He was finally diagnosed with biliary candidiasis and administered the antifungal treatment with fluconazole.His symptoms improved after such treatment.Conclusions:We reported a case of biliary candidiasis that mimicked IgG4-RD in a host with normal immunity.Our findings highlighted the need for pathological diagnosis in patients with symptoms resembling IgG4-RD. | Wenjie Bian Yuchao Zhong Xia Zhang Hongbin Chen Ruie Feng Xinyu Zhang Danhua Shen Yanying Liu | 2022 | Rheumatology & Autoimmunity2022，2，3： | 0 |
| 11 | Traceless enzymatic protein synthesis without ligation sites constraint显示文摘Protein synthesis and semisynthesis offer immense promise for life sciences and have impacted pharmaceutical innovation.The absence of a generally applicable method for traceless peptide conjugation with a flexible choice of junction sites remains a bottleneck for accessing many important synthetic targets,however.Here we introduce the PALME(protein activation and ligation with multiple enzymes)platform designed for sequence-unconstrained synthesis and modification of biomacromolecules.The upstream activating modules accept and process easily accessible synthetic peptides and recombinant proteins,avoiding the challenges associated with preparation and manipulation of activated peptide substrates.Cooperatively,the downstream coupling module provides comprehensive solutions for sequential peptide condensation,cyclization and protein N/C-terminal or internal functionalization.The practical utility of this methodology is demonstrated by synthesizing a series of bioactive targets ranging from pharmaceutical ingredients to synthetically challenging proteins.The modular PALME platform exhibits unprecedentedly broad accessibility for traceless protein synthesis and functionalization,and holds enormous potential to extend the scope of protein chemistry and synthetic biology. | Ruifeng Li Marcel Schmidt Tong Zhu Xinyu Yang Jing Feng Yu’e Tian Yinglu Cui Timo Nuijens Bian Wu | 2022 | National Science Review2022，9，5： | 0 |
| 12 | Separation, Quantification and Structural Study of (+)-Catechin and (-)-Epicatechin by Ion Mobility Mass Spectrometry Combined with Theoretical Algorithms显示文摘Two catechin epimers and their non-covalent complexes with γ-cyclodextrin were studied by using ion mobility coupled with mass spectrometry (IM-MS). Rapid separation of complexes was achieved with the peak-to-peak resolution reaching 0.86 after optimization of IM condition. Collision cross section (CCS) was measured to explore the structural difference of complexes. A gap of 11.75 A^2 between two complexes was found. Molecular modeling and theoretical CCS calculation were adopted to explain the measurement results. Two binding ways of both complexes were found and the calculated CCS corresponds accurately to the measured CCS. Quantification of catechins in mixtures was performed and the relative error was less than 15%, indicating the effectiveness of quantification by IM-MS. | Xinyu Bian Bing Zhao Bo Pang Zhong Zheng Shu Liu Zhiqiang Liu Fengrui Song | 2019 | Chinese Journal of Chemistry2019，37，6： | 0 |
| 13 | Comparison in structure and predicted function of epiphytic bacteria on Neopyropia yezoensis and Neopyropia katadae显示文摘The economic alga Neopyropia,which holds significant value in China for its edibility and economic potential,harbors diverse epiphytic bacteria on its surface.The epiphytic bacteria on Neopyropia yezoensis and Neopyropia katadae,two nori species of Neopyropia living at the same tidal level but with distinct physiological states and living habits,were investigated to understand the differences between them and the effects of epiphytic bacteria on their differential characteristics.Analysis of 16S rRNA gene sequences and real-time quantitative PCR(qPCR)of thalli and seawater samples(n=24)revealed notable differences in microbial diversity and community structure between the two species.Bacteroidetes dominated the bacterial communities in association with N.yezoensis,whereas Proteobacteria were predominant in N.katadae.Phylogenetic Investigation of Communities by Reconstruction of Unobserved States(PICRUSt2)analysis revealed enriched genes that related to the ABC transport system,iron complex outer membrane receptor proteins,and proliferation in N.yezoensis,whereas N.katadae exhibited enrichment of genes that related to energy supply as well as cell wall and cell membrane production.The results of qPCR indicate a higher abundance of epiphytic bacteria on surface of N.yezoensis than those on surface of N.katadae.The findings indicate that differences in the living environments of N.yezoensis and N.katadae may result in distinct structural composition and abundance of epiphytic bacteria on their surfaces,thereby conferring specific biological functionalities to each microbial community,and the epiphytic bacteria may shape the living habits of hosts to some extents.This study provided a basis for understanding the close association between surface microorganisms and algal bodies,and the physiological and ecological characteristics of nori species. | Xinran WANG Junhao WANG Yunke ZHU Xinyu ZHU Hong QIN Ka BIAN Xianghai TANG | 2023 | Journal of Oceanology and Limnology2023，41，6： | 0 |
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