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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | Neurons secrete miR-132.containing exosomes to regulate brain vascular integrity显示文摘脉管的完整帮助维持大脑微型环境动态平衡,它为中央神经系统的正常开发和函数是批评的。神经房间能调整大脑,这被知道脉管的正直。由于包含的神经与血管的相互作用的高复杂性,不管多么大脑的神经规定理解脉管的正直仍然是原始的。用未经触动的 zebrafish 幼虫和有教养的啮齿类动物大脑房间,我们发现神经原转移 miR-132,一高度保存了并且充实神经原的 microRNA,经由到 endothelial 房间(EC ) 到的 secreting exosomes 维持大脑脉管的正直。后面的 translocation 到通过 exosome 成为主观的 EC, miR-132 调整脉管的 endothelial cadherin (VE-cadherin ) 的表示,重要 adherens 连接蛋白质,由直接指向真核细胞的延伸因素 2 kinase (eef2k ) 。neuronal miR-132 表示或 exosome 分泌物的混乱,或脉管的 eef2k 的 overexpression 损害 VE-cadherin 表示和大脑脉管的正直。我们的学习显示 miR-132 作为调停的一个细胞间的信号扮演大脑的神经规定脉管的完整并且建议 neuronal exosome 是为神经与血管的通讯的一条新奇大街。 | Bing Xu Yu Zhang Xu-Fei Du Jia Li Hua-Xing Zi Ji-Wen Bu Yong Yan Hua Han Jiu-Lin Du | 2017 | Cell Research2017，27，7： | 46 |
| 3 | Major element,trace element,and Sr,Nd and Pb iso-tope studies of Cenozoic basalts from the South China Sea显示文摘The whole rock K-Ar ages of basalts from the South China Sea basin vary from 3.8 to 7.9 Ma, which suggest that intra-plate volcanism after the cessation of spreading of the South China Sea (SCS) is comparable to that in adjacent regions around the SCS, i.e., Leiqiong Peninsula, northern margin of the SCS, Indochina block, and so on. Based on detailed petrographic studies, we selected many fresh ba-saltic rocks and measured their major element, trace element, and Sr-Nd-Pb isotope compositions. Geochemical characteristics of major element and trace element show that these basaltic rocks belong to alkali basalt magma series, and are similar to OIB-type basalt. The extent of partial melting of mantle rock in source region is very low, and magma may experience crystallization differentiation and cu-mulation during the ascent to or storing in the high-level magma chamber. Sr-Nd-Pb isotopic data of these basaltic rocks imply an inhomogeneous mantle below the South China Sea. The nature of magma origin has a two end-member mixing model, one is EM2 (Enriched Mantle 2) which may be originated from mantle plume, the other is DMM (Depleted MORB Mantle). Pb isotopic characteristics show the Dupal anomaly in the South China Sea, and combined with newly found Dupal anomaly at Gakkel ridge in Arctic Ocean, this implies that Dupal anomaly is not only limited to South Hemisphere. In variation diagrams among Sr, Nd and Pb, the origin nature of mantle below the SCS is similar to those below Leiqiong peninsula, northern margin of the SCS and Indochina peninsula, and is different from those below north and northeast China. This study provides geochemical constraints on Hainan mantle plume. | YAN QuanShu SHI XueFa WANG KunShan BU WenRui XIAO Long | 2008 | Science China Earth Sciences2008，51，4： | 33 |
| 4 | Experimental study of an aircraft fuel tank inerting system显示文摘In this work, a simulated aircraft fuel tank inerting system has been successfully established based on a model tank. Experiments were conducted to investigate the influences of different operating parameters on the inerting effectiveness of the system, including flow rate of the inert gas(nitrogen-enriched air), inert gas concentration, fuel load of the tank and different inerting approaches. The experimental results show that under the same operating conditions, the time span of a complete inerting process decreased as the flow rate of inert gas was increased; the time span using the inert gas with 5% oxygen concentration was much longer than that using pure nitrogen;when the fuel tank was inerted using the ullage washing approach, the time span increased as the fuel load was decreased; the ullage washing approach showed the best inerting performance when the time span of a complete inerting process was the evaluation criterion, but when the decrease of dissolved oxygen concentration in the fuel was also considered to characterize the inerting effectiveness, the approach of ullage washing and fuel scrubbing at the same time was the most effective. | Cai Yan Bu Xueqin Lin Guiping Sun Bing Zeng Yu Li Zixuan | 2015 | Chinese Journal of Aeronautics2015，28，2： | 15 |
| 5 | Balancing Effect of Biejiajian Oral Liquid(鳖甲煎口服液)on ACE-AngⅡ-AT1R Axis and ACE2-Ang-(1–7)-Mas Axis in Rats with CCl_4-Induced Hepatic Fibrosis显示文摘Objective: To explore the effect of Biejiajian Oral Liquid(鳖甲煎口服液, BOL) on CCl4-induced hepatic fibrosis in rats by detecting the changes in the levels of angiotensinⅡ(AngⅡ), angiotensin-(1–7) [Ang-(1–7)], angiotensin-converting enzyme(ACE), ACE2, angiotensinⅡ type 1 receptor(AT1 R), Mas, etc. Methods: A total of 180 Wistar rats were randomly divided into two groups by random digital table method: prevention experiment and treatment experiment. Each group was further subdivided into the fol owing 6 subgroups: normal control group, model group, vitamin E [100 mg/(kg·d), VE] group, enalapril [10 mg/(kg·g), Ena] group, high-dosage [20 g/(kg·d)] BOL group, and low-dosage [10 g/(kg·d)] BOL group. The hepatic fibrosis rat model was established by subcutaneous injection of CCl4 for 6 weeks. Prevention experiment and treatment experiment were administered with specific drugs at different times. At the end of treatment experiment, the pathological changes of liver were observed after hematoxylin-eosin staining. The expressions of ingredients in renin-angiotensin-aldosterone system(RAAS) such as AngⅡ, Ang-(1–7), ACE, ACE2, AT1 R, Mas, renin, CYP11 B2 and angen in liver were detected by enzyme linked immunosorbent assay, immunohistochemistry method or reverse transcription-polymerase chain reaction, respectively. Results: The levels of AngⅡ and Ang-(1–7) at the 6 th week increased by 496.10% and 73.64%, respectively, compared with those at the 2 nd week in the model group(P<0.01). With prevention or treatment with high-dosage BOL, there was an evident reduction of AngⅡ level but an improvement of Ang-(1–7) level. Specifically, AngⅡ level of high-dosage group decreased by 77.50% in prevention experiment(P=0.000) and by 76.93% in treatment experiment(P=0.002) compared with that in the model group. Ang-(1–7) level increased by 91.69% in prevention experiment(P=0.006) and by 70.77% in the treatment experiment(P=0.010) compared with that in the model group. The expression levels of m RNA of renin, ACE, CYP11 B2, angen and AT1 R decreased by 58.15%, 99.90%, 99.84%, 99.99% and 99.99%(al P<0.01), respectively. Conclusions: BOL could help resist liver fibrosis in rats by enhancing the level of each ingredient in ACE2-Ang-(1–7)-Mas axis, while decreasing the level of each ingredient in ACE-AngⅡ-AT1 R axis. To some extent, BOL could enhance the regulation of RAAS in rats with CCl4-induced hepatic fibrosis. | LI Xiao-ya PENG Yan BU Xia-wei YAO Jia YAO Li | 2018 | Chinese Journal of Integrative Medicine2018，24，11： | 14 |
| 6 | Molecular Typing of Brucella Suis Collected from 1960s to 2010s in China by MLVA and PFGE显示文摘Brucellosis is a bacterial anthropozoonosis usually caused by Brucella abortus, Brucella melitensis, Brucella suis and Brucella canis. Brucella suis, the causative agent of swine brucellosis, is classified into five biovars and preferentially infects different animal hosts [1] . | LI Zhen Jun CUI Bu Yun CHEN Hai CHEN Jing Diao ZHAO Hong Yan PIAO Dong Ri JIANG Hai ZHANG Li TANG Xu KE Chang Wen YAO zhen TIAN Guo Zhong | 2013 | Biomedical and Environmental Sciences2013，26，6： | 13 |
| 7 | Oxaliplatin plus S-1 or capecitabine as neoadjuvant or adjuvant chemotherapy for locally advanced gastric cancer with D2lymphadenectomy: 5-year follow-up results of a phase II-III randomized trial显示文摘Objective: To compare the effect of neoadjuvant chemotherapy(NACT) with adjuvant chemotherapy(ACT)using oxaliplatin plus S-1(SOX) or capecitabine(CapeOX) on gastric cancer patients with D2 lymphadenectomy.Methods: This was a two-by-two factorial randomized phase II-III trial, and registered on ISRCTN registry(No. ISRCTN12206108). Locally advanced gastric cancer patients were randomized to neoadjuvant SOX,neoadjuvant CapeOX, adjuvant SOX, or adjuvant CapeOX arms. Primary analysis was performed on an intentionto-treat(ITT) basis using overall survival(OS) as primary endpoint.Results: This trial started in September 2011 and closed in December 2012 with 100 patients enrolled.Treatment completion rate was 56%, 52%, 38% and 30% in the four arms, respectively. NACT group had fewer dropouts due to unacceptable toxicity(P=0.042). Surgical complication rate did not differ by the four groups(P=0.986). No survival significant difference was found comparing NACT with ACT(P=0.664; 5-year-OS: 70% vs.74% respectively), nor between the SOX and CapeOX groups(P=0.252; 5-year-OS: 78% vs. 66% respectively).Subgroup analysis showed SOX significantly improved survival in patients with diffuse type(P=0.048).Conclusions: No significant survival difference was found between NACT and ACT. SOX and CapeOX had good safety and efficacy as neoadjuvant regimens. Diffuse type patients may survive longer due to SOX. | Kan Xue Xiangji Ying Zhaode Bu Aiwen Wu Zhongwu Li Lei Tang Lianhai Zhang Yan Zhang Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 10 |
| 8 | Remote Sensing Monitoring of Gullies on a Regional Scale: A Case Study of Kebai Region in Heilongjiang Province, China显示文摘Gully erosion is one of the major causes of land degradation in most areas and attracts increasing attention from researchers. We monitored gullies in the Kebai region in Heilongjiang Province of China by using remote sensing data and found that gully density increased with the increase in slope when the slope was less than 3°. Gully density in sunny slopes or windward slopes was greater than in shady slopes or leeward slopes because of the impacts of freezing and thawing, wind and solar radiation. Specifically, the gully density in northeast slope was the greatest and in southwest was the smallest. Gully density was reduced with increasing slope length and the longer the slope length, the less the gully density changed between 1965 and 2005. Affected by runoff, gullies most easily to occur in concave slopes and the critical elevation for gully erosion was 250–275 m. Moreover, hilly regions had the greatest gully density, followed by tableland regions, whereas the gully density in flatlands was the lowest. However, the gully density of these three types of landforms all increased between 1945 and 2000, and the portion of increase was 57.45%(hill), 52.91%(mesa) and 25.32%(plain), respectively. | ZHANG Shuwen LI Fei LI Tianqi YANG Jiuchun BU Kun CHANG Liping WANG Wenjuan YAN Yechao | 2015 | Chinese Geographical Science2015，25，5： | 10 |
| 9 | Characteristics of the HIV/AIDS Epidemic in Women Aged 15-49 Years from 2005 to 2012 in China显示文摘Objective To describe the characteristics of the HIV/AIDS epidemic in women aged 15-49 years in China. Methods HIV/AIDS cases from 2005 to 2012 that fulfilled the inclusion and exclusion criteria were identified on the Chinese HIV/AIDS case reporting system. Descriptive and spatial analyses were performed. Results A total of 103,559 female HIV/AIDS cases were included in our study. Based on the descriptive analysis, between 2005 and 2012, the proportion of heterosexually acquired HIV infection among women(15-49 years) increased rapidly from 35.8% to 87.4%. Approximately 60% of these cases were infected through non-marital heterosexual contact. Among older women(40-49 years), a slightly increasing trend was identified. The spatial analysis detected ‘hot spots' in the Xinjiang, Yunnan, Sichuan, Guangxi, and Chongqing provinces. The epidemic trends in these areas were predominately driven by heterosexual transmission. Conclusion Non-marital heterosexual contact is a very important factor in the HIV/AIDS epidemic in women aged 15-49 years, and the HIV infection rate in older women is increasing. Several epidemic hot spots were detected in northwestern and southwestern China. Efficient interventions are needed to control the spread of HIV/AIDS among women living in these areas. | ZHANG Xia Yan HUANG Tao FENG Yi Bing LI Meng CHEN Fang Fang LI Yin Ge JIN Shan Shan BU Kai WANG Lu | 2015 | Biomedical and Environmental Sciences2015，28，10： | 10 |
| 10 | Comorbidity Burden of Dementia:A Hospital-Based Retrospective Study from 2003 to 2012 in Seven Cities in China显示文摘Dementia is increasing dramatically and imposes a huge burden on society. To date, there is a lack of data on the health status of patients with dementia in China. In an attempt to investigate the comorbidity burden of dementia patients in China at the national level, we enrolled 2,938 patients with Alzheimer's disease(AD), vascular dementia(Va D), or other types of dementia, who were admitted to tertiary hospitals in seven regions of China from January2003 to December 2012. The Charlson Comorbidity Index(CCI) was used to evaluate the comorbidity burden of the patients with dementia. Among these patients, 53.4% had AD, 26.3% had Va D, and 20.3% had other types of dementia. The CCI was 3.0 ± 1.9 for all patients,3.4 ± 1.8 for those with Va D, and 3.0 ± 2.1 for those with AD. The CCI increased with age in all patients, andthe length of hospital stay and daily expenses rose with age and CCI. Males had a higher CCI and a longer stay than females. Moreover, patients admitted in the last 5 years of the study had a higher CCI than those admitted in the first 5 years. We found that the comorbidity burden of patients with dementia is heavy. These findings provide a better understanding of the overall health status of dementia patients, and help to increase the awareness of clinicians and policy-makers to improve medical care for patients. | Qing-Hua Wang Xin Wang Xian-Le Bu Yan Lian Yang Xiang Hong-Bo Luo Hai-Qiang Zou Jie Pu Zhong-He Zhou Xiao-Ping Cui Qing-Song Wang Xiang-Qun Shi Wei Han Qiang Wu Hui-Sheng Chen Hang Lin Chang-Yue Gao Li-Li Zhang Zhi-Qiang Xu Meng Zhang Hua-Dong Zhou Yan-Jiang Wang | 2017 | Neuroscience Bulletin2017，33，6： | 10 |
| 11 | Efficacy and Safety of Teriflunomide in Chinese Patients with Relapsing Forms of Multiple Sclerosis: A Subgroup Analysis of the Phase 3 TOWER Study显示文摘Background:Disease-modifying therapy is the standard treatment for patients with multiple sclerosis (MS)in remission.The primary objective of the current analysis was to assess the efficacy and safety of two teriflunomide doses (7mg and 14mg)in the subgroup of Chinese patients with relapsing MS included in the TOWER study. Methods:TOWER was a multicenter,multinational,randomized, double-blind,parallel-group (three groups),placebo-controlled study.This subgroup analysis includes 148 Chinese patients randomized to receive either teriflunomide 7mg (n =51), teriflunomide 14mg (n=43),or placebo (n=54). Results:Of the 148patients in the intent-to-treat population, adjusted annualized-relapse rates were 0.63(95% confidence interval [CI]:0.44,0.92)in the placebo group,0.48(95%CI:0.33, 0.70)in the teriflunomide 7mg group,and 0.18(95%CI:0.09,0.36)in the terifltmomide 14mg group;this corresponded to a significant relative risk reduction in the teriflunomide 14mg group versus placebo (-71.2%,P =0.0012).Terifiunomide 14mg also tended to reduce 12-week confirmed disability worsening by 68.1% compared with placebo (hazard ratio:0.319,P =0.1194).There were no differences across all treatment groups in the proportion of patients with treatment-emergent adverse events (TEAEs;72.2% in the placebo group,74.5%in the teriflunomide 7mg group,and 69.8% in the teriflunomide 14mg group);corresponding proportions for serious adverse events were 11.1%,3.9%,and 11.6%,respectively.The most frequently reported TEAEs with teriflunomide versus placebo were neutropenia,increased alanine aminotransferase,and hair thinning. Conclusions:Teriflunomide was as effective and safe in the Chinese subpopulation as it was in the overall population of patients in the TOWER trial.Teriflunomide has the potential to meet unmet medical needs for MS patients in China. | Wei Qiu De-Hui Huang Shi-Fang Hou Mei-Ni Zhang Tao Jin Hui-Qing Dong Hua Peng Chao-Dong Zhang Gang Zhao Yi-Ning Huang Dong Zhou Wei-Ping Wu Bao-Jun Wang Ji-Mei Li Xing-Hu Zhang Yan Cheng Hai-Feng Li Ling Li Chuan-Zhen Lu Xu Zhang Bi-Tao Bu Wan-Li Dong Dong-Sheng Fan Xue-Qiang Hu Xian-Hao Xu | 2018 | Chinese Medical Journal2018，，23： | 10 |
| 12 | A novel role of hematopoietic CCL5 in promoting triple-negative mammary tumor progression by regulating generation of myeloid-derived suppressor cells显示文摘CCL5 是响应压力信号在有免疫力、非有免疫力的房间的一个宽数组表示的 CC chemokine 家庭的一个成员。有先进人的乳癌的 CCL5 表示相互关联。然而,它行动的功能的意义和模式没被建立。这里,我们证明 CCL5 缺乏的老鼠对高度好攻击的、三元组否定的乳房的肿瘤生长抵抗。造血的 CCL5 在这显型是主导的。造血的 CCL5 的缺席由积累 Ly6C +/Gr-1+, 的异常产生导出 myeloid 的 suppressor 房间(MDSC )> 嗨有损害能力到的 和 Ly6G + MDSC 压制 CD8 + T 房间的 cytotoxicity。CCL5 的这些性质在 orthotopic 和自发的乳房的肿瘤被观察。CCL5 的调停抗体的全身的封锁禁止肿瘤前进并且对非产生免疫性的肿瘤提高治疗学的种痘的功效。CCL5 也帮助维持人的 MDSC 的抑制免疫力的能力。我们的学习揭开经由与导出肿瘤的刺激殖民地的因素在合作在骨头髓产生 MDSC 支持乳房的肿瘤前进的造血地导出的 CCL5 的一项新奇、 chemokine 独立的活动。学习在在造血的分隔空间和肿瘤壁龛之间的相互影响上打开可观的灯。因为在正常生理学的这个分子的明显的非必需的性质, CCL5 可以象有 MDSC 渗入的重要数量的大量稳固的肿瘤一样为乳癌在免疫疗法代表一个优秀治疗学的目标。 | Yan Zhang Dandan Lv Ha-Jeong Kim Robert A Kurt Wen Bu Yi Li Xiaojing Ma | 2013 | Cell Research2013，23，3： | 9 |
| 13 | Ground-based observation of aerosol optical properties in Lanzhou, China显示文摘Aerosol optical properties from August 2006 to July 2007 were obtained from ground-based and sky radiance measurements in Semi- Arid Climate and Environment Observatory of Lanzhou University (SACOL), China. High aerosol optical thickness (AOT) associated with low ngstrm exponent (α) was mainly observed in spring, which was consistent with the seasonal dust production from Hexi Corridor. The maximum monthly average value of AOT 0.56 occurred in March of 2007, which was two times larger than the minimum value of 0.28 in October of 2006. Approximately 60% of the AOT ranged between 0.3 and 0.5, and nearly 93% of α value varied from 0.1 to 0.8, which occurred in spring. The significant correlation between aerosol properties and water vapor content was not observed. The aerosol volume size distribution can be characterized by the bimodal logarithm normal structure: fine mode (r < 0.6 μm) and coarse mode (r > 0.6 μm). Aerosols in spring of SACOL were dominated by large particles with the volume concentration ratio of coarse to fine modes being 7.85. The average values of asymmetry factor (g) in the wavelength range 440-1020 nm were found to be 0.71, 0.67, 0.67 and 0.69 in spring, summer, autumn and winter, respectively. | YU Xingna ZHU Bin FAN Shuxian YIN Yan BU Xiaoli | 2009 | Journal of Environmental Sciences2009，21，11： | 7 |
| 14 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 15 | DeST 3.0:A new-generation building performance simulation platform显示文摘Buildings contribute to almost 30%of total energy consumption worldwide.Developing building energy modeling programs is of great significance for lifecycle building performance assessment and optimization.Advances in novel building technologies,the requirements of high-performance computation,and the demands for multi-objective models have brought new challenges for building energy modeling software and platforms.To meet the increasing simulation demands,DeST 3.0,a new-generation building performance simulation platform,was developed and released.The structure of DeST 3.0 incorporates four simulation engines,including building analysis and simulation(BAS)engine,HVAC system engine,combined plant simulation(CPS)engine,and energy system(ES)engine,connected by air loop and water loop balancing iterations.DeST 3.0 offers numerous new simulation features,such as advanced simulation modules for building envelopes,occupant behavior and energy systems,cross-platform and compatible simulation kernel,FMI/FMU-based co-simulation functionalities,and high-performance parallel simulation architecture.DeST 3.0 has been thoroughly evaluated and validated using code verification,inter-program comparison,and case-study calibration.DeST 3.0 has been applied in various aspects throughout the building lifecycle,supporting building design,operation,retrofit analysis,code appliance,technology adaptability evaluation as well as research and education.The new generation building simulation platform DeST 3.0 provides an efficient tool and comprehensive simulation platform for lifecycle building performance analysis and optimization. | Da Yan Xin Zhou Jingjing An Xuyuan Kang Fan Bu Youming Chen Yiqun Pan Yan Gao Qunli Zhang Hui Zhou Kuining Qiu Jing Liu Yan Liu Honglian Li Lei Zhang Hong Dong Lixin Sun Song Pan Xiang Zhou Zhe Tian Wenjie Zhang Ruhong Wu Hongsan Sun Yu Huang Xiaohong Su Yongwei Zhang Rui Shen Diankun Chen Guangyuan Wei Yixing Chen Jinqing Peng | 2022 | Building Simulation2022，15，11： | 5 |
| 16 | Structure and electrochemical properties of LaMgNi4-xCox(x=0-0.8)hydrogen storage electrode alloys显示文摘LaMgNi_(4-x)Co_x(x = 0-0.8) electrode alloys used for MH/Ni batteries were prepared by induction melting. The structures and electrochemical hydrogen storage properties of the alloys were investigated in detail.X-ray diffraction(XRD) and scanning electron microscopy(SEM) analysis show that LaMgNi4 phase and LaNi5 phase are obtained. The lattice parameters of the two phases increase first and then decrease with Co content increasing.The electrochemical properties of the alloy electrodes were measured by means of simulated battery tests. Results show that the addition of Co does not change the discharge voltage plateau of the alloy electrodes. However, the maximum discharge capacity increases from 319.9 mAh·g^(-1)(x = 0)to 347.5 mAh·g^(-1)(x = 0.4) and then decreases to331.7 mAh·g^(-1)(x = 0.8). The effects of Co content on electrochemical kinetics of the alloy electrodes were also performed. The high rate dischargeability(HRD) first increases and then decreases with Co content increasing and reaches the maximum value(95.0 %) when x = 0.4. Test results of the electrochemical impedance spectra(EIS),potentiodynamic polarization curves and constant potential step measurements of the alloy electrodes all demonstrate that when Co content is 0.4 at%, the alloy exhibits the best comprehensive electrochemical properties. | Tai Yang Ting-Ting Zhai Ze-Ming Yuan Wen-Gang Bu Yan Qi Yang-Huan Zhang | 2018 | Rare Metals2018，37，3： | 5 |
| 17 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 18 | China organic-rich shale geologic features and special shale gas production issues显示文摘The depositional environment of organic-rich shale and the related tectonic evolution in China are rather different from those in North America.In China,organic-rich shale is not only deposited in marine environment,but also in non-marine environment:marine-continental transitional environment and lacustrine environment.Through analyzing large amount of outcrops and well cores,the geologic features of organic-rich shale,including mineral composition,organic matter richness and type,and lithology stratigraphy,were analyzed,indicating very special characteristics.Meanwhile,the more complex and active tectonic movements in China lead to strong deformation and erosion of organic-rich shale,well-development of fractures and faults,and higher thermal maturity and serious heterogeneity.Co-existence of shale gas,tight sand gas,and coal bed methane(CBM)proposes a new topic:whether it is possible to co-produce these gases to reduce cost.Based on the geologic features,the primary production issues of shale gas in China were discussed with suggestions. | Yiwen Ju Guochang Wang Hongling Bu Qingguang Li Zhifeng Yan | 2014 | Journal of Rock Mechanics and Geotechnical Engineering2014，6，3： | 5 |
| 19 | SDG714 Regulates Specific Gene Expression and Consequently Affects Plant Growth via H3K9 Dimethylation显示文摘Histone lysine methylation is known to be involved in the epigenetic regulation of gene expression in all eukaryotes including plants. Here we show that the rice SDG714 is primarily responsible for dimethylation but not trimethylation on histone H3K9 in vivo. Overexpression of YFP-SDG714 in Arabidopsis significantly inhibits plant growth and this inhibition is associated with an enhanced level of H3K9 dimethylation. Our microarray results show that many genes essential for the plant growth and development were downregulated in transgenic Arabidopsis plants overexpressing YFP-SDG714. By chromatin immunoprecipitation analysis, we show that YFP-SDG714 is targeted to specific chromatin regions and dimethylate the H3K9, which is linked with heterochromatinization and the downregulation of genes. Most interestingly, when YFP-SDG714 production is stopped, the inhibited plants can partially restore their growth, suggesting that the perturbation of gene expression caused by YFP-SDG714 is revertible. Taken together, our results point to an important role of SDG714 in H3K9 dimethylation, suppression of gene expression and plant growth, and provide a potential method to regulate gene expression and plant development by an on-off switch of SDG714 expression. | Bo Ding Yan Zhu Zhong-Yuan Bu Wen-Hui Shen Yu Yu Ai-Wu Dong | 2010 | Journal of Integrative Plant Biology2010，52，4： | 5 |
| 20 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
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