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| 1 | Characteristics and outcomes of patients with autoimmune pancreatitis after pancreatectomy:a retrospective study显示文摘Objective:Autoimmune pancreatitis(AIP)is a rare and special type of pancreatitis,which is often difficult to distinguish from pancreatic cancer.We aimed to discuss the clinical characteristics,operation characteristics,and therapeutic effects of AIP pa-tients who received surgical treatment based on retrospective analysis.Methods:The medical records of patients who underwent surgery at Peking Union Medical College Hospital from January 2012 to July 2021 and whose postoperative pathology was AIP were collected.Clinical symptoms,laboratory examinations,imaging features,surgical information,and prognostic data were analyzed.Results:Nineteen patients with AIP(median age 60 years old,14 males)underwent surgery,whose main indication for surgery was suspected of a malignant lesion(n=18,94.7%).Ten patients underwent pancreaticoduodenectomy,8 underwent distal pancreatectomy,and 1 underwent total pancreatectomy,the pathological result of whom were all AIP.The main postoperative complication was pancreatic fistula(n=11,57.9%),and one patient(5.3%)underwent a second operation due to gastrointestinal anastomotic bleeding.One patient(5.6%)had a recurrence of AIP,3 patients(16.7%)were treated with glucocorticoid after sur-gery,and one patient(5.6%)was treated with immunosuppressors.Conclusions:Differential diagnosis of AIP from pancreatic cancer is complex.Operation difficulty and complication incidence for patients with AIP were similar to pancreatic cancer patients.Although glucocorticoid is the first-line treatment for AIP,surgery may still be necessary for patients who are strongly suspected of a malignant lesion. | Bangbo Zhao Cheng Qin Tianyu Li Zeru Li Yuanyang Wang Weibin Wang | 2023 | Journal of Pancreatology2023，6，2： | 0 |
| 2 | Exosome-mediated cell-cell communication within pancreatic cancer tumor microenvironment: a narrative review显示文摘The significance of exosomes has emerged in a variety of physiological processes and diseases.Pancreatic cancer remains one of the most lethal diseases at present.Recently,increasing evidence has suggested that exosomes are vital for mediating the elaborate interaction of highly heterogeneous cell clusters within the pancreatic tumor microenvironment,contributing to activating pancreatic stellate cells and cancer-associated fibroblasts,compromising immune cells,and enhancing angiogenesis.Besides their natural and intrinsic roles,exosomes may provide a novel potential way for pancreatic cancer management and therapy as well.Thus,exosomes not only mediate cellular communication during pancreatic cancer progression but also serve as a promising player in precise pancreatic cancer management and treatment.To comprehensively summarize the role of exosomes in pancreatic cancer,we searched the PubMed database and reviewed all relevant original studies. | Cheng Qin Bangbo Zhao Yuanyang Wang Tianhao Li Zeru Li Tianyu Li Yutong Zhao Weibin Wang | 2022 | Journal of Pancreatology2022，5，3： | 0 |
| 3 | Exosome-mediated cell-cell communication within pancreatic cancer tumor microenvironment:a narrative review显示文摘The significance of exosomes has emerged in a variety of physiological processes and diseases.Pancreatic cancer remains one of the most lethal diseases at present.Recently,increasing evidence has suggested that exosomes are vital for mediating the elaborate interaction of highly heterogeneous cell clusters within the pancreatic tumor microenvironment,contributing to activating pancreatic stellate cells and cancer-associated fibroblasts,compromising immune cells,and enhancing angiogenesis.Besides their natural and intrinsic roles,exosomes may provide a novel potential way for pancreatic cancer management and therapy as well.Thus,exosomes not only mediate cellular communication during pancreatic cancer progression but also serve as a promising player in precise pancreatic cancer management and treatment.To comprehensively summarize the role of exosomes in pancreatic cancer,we searched the PubMed database and reviewed all relevant original studies. | Cheng Qin Bangbo Zhao Yuanyang Wang Tianhao Li Zeru Li Tianyu Li Yutong Zhao Weibin Wang | 2023 | Journal of Pancreatology2023，6，1： | 0 |
| 4 | Pancreatic cancer with ovarian metastasis: cases report and literature review显示文摘Background: Pancreatic cancer with ovarian metastases is rare and easily misdiagnosed. Patients with ovarian metastases are first diagnosed with ovarian cancer and may miss the opportunity to receive surgical operation. We report 7 rare cases of ovarian metastases secondary to pancreatic adenocarcinoma and review the literature to analyze clinical characteristics, diagnostic methods, and potential therapeutic strategies for the rare malignancy.Cases Summary: We retrospectively analyzed the clinical data of 7 female patients with ovarian metastases of primary pancreatic cancer who were admitted to our hospital from January 01, 1985, to April 1, 2020. These 7 patients were diagnosed with ovarian metastasis at an average age of 52.28 (38-69) years. The reason for the patient’s visit was generally a mass in the lower abdomen and/or abdominal pain. Six of them had significantly higher serum Carbohydrate antigen19-9 (CA19-9) levels, 6 patients had pancreatic tumors located in the body or tail, and 1 patient had one in the head of the pancreas. All patients underwent excision of ovarian tumors and resection or biopsy of pancreatic tumors. Five patients had pancreatic ductal adenocarcinoma (PDAC), and 2 had pancreatic cystadenocarcinoma (PCC), all of which were revealed by the pathological results. Ovarian tumors were assessed by pathology and were consistent with pancreatic metastasis. Currently, all 7 patients have died (follow-up to January 2, 2021). The median survival time for all patients was 13.7 months (2.9-27 months).Conclusions: For this rare tumor, elevated serum CA19-9 may indicate that the primary lesion is in the pancreas. Enhanced pancreatic Computed Tomography (CT) can facilitate diagnostic localization. In addition, if the pancreatic tumor cannot be removed, the ovarian tumor should still be resected to reduce the tumor load and improve the quality of life. | Zeru Li Xingtong Zhou Bangbo Zhao Zhibo Zheng Cheng Qin Xudong Liu Huadan Xue Weibin Wang | 2023 | Journal of Pancreatology2023，6，1： | 0 |
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