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| 1 | Synergistic antitumor efficiency of docetaxel and curcumin against lung cancer显示文摘Curcumin (淫液) ,主要 polyphenolic curcuminoid,从沉金根茎姜黄 longa 获得了,最近被报导在 vitro 并且在 vivo 有潜在的 antitumor 效果。Docetaxel (文档) 为非小的房间肺癌症的治疗被认为化疗同样首要。这里,我们第一次报导淫液能 synergistically 提高在里面 vitro 并且在对肺癌症的文档的 vivo antitumor 功效。在当前的学习,联合索引(CI ) 在 vitro 并且在 vivo 研究是打算的在里面决定在淫液和文档之间的相互作用。在里面在里面 vitro cytotoxicity 测试,中等效果的分析清楚地在某些集中显示了在淫液和文档之间的一个 synergistic 相互作用。而且,在 vivo,评估进一步在确定的 A549 与由静脉内的交货独自一个的文档相比表明了淫液 + 文档的优异 anticancer 功效移植异种皮移植模型。结果证明淫液 synergistically 在 4 天起始的治疗以后立即增加了文档的功效。另外,淫液和文档的同时的管理几乎没在治疗学的剂量包括骨头髓和肝显示出很少毒性到正常纸巾。因此,在 vitro 并且在 vivo,评估在传统的化疗对肺癌症和淫液的介绍表明了淫液和文档的令人满意的 synergistic antitumor 功效是阻止非小的房间肺癌症的传播的一个很有希望的方法。 | Haitao Yin Rui Guo Yong Xu Yulong Zheng Zhibo Hou Xinzheng Dai Zhengdong Zhang Donghui Zheng Hua'e Xu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，2： | 4 |
| 2 | Involvement of long non-coding RNAs in the progression of esophageal cancer显示文摘Esophageal cancer(EC)is one of the most common malignant tumors of the digestive system with high incidence and mortality rate worldwide.Therefore,exploring the pathogenesis of ECand searching for new targeted therapies are the current research hotspot for EC treatment.Long non-coding RNAs(lncRNAs)are endogenous RNAs with more than 200 nucleotides,but without proteincoding function.In recent years,lncRNAs have gradually become the focuses in the field of non-coding RNA.Some lncRNAs have been proved to be closely related to the pathogenesis of EC.Many lncRNAs are abnormally expressed in EC and participate in many biological processes including cell proliferation,apoptosis,and metastasis by inhibiting or promoting target gene expression.LncRNAs can also regulate the progression of EC through epithelial-mesenchymal transformation(EMT),which is closely related to the occurrence,development,and prognosis of EC.In this article,we review and discuss the involvement of lncRNAs in the progression of EC. | Wenhua Xue Yuanyuan Zheng Zhibo Shen Lifeng Li Zhirui Fan Wenbin Wang Zijia Zhu Yunkai Zhai Jie Zhao Quancheng Kan | 2021 | Cancer Communications2021，41，5： | 4 |
| 3 | Molecular Clump Extraction Algorithm Based on Local Density Clustering显示文摘The detection and parameterization of molecular clumps are the first step in studying them.We propose a method based on the Local Density Clustering algorithm while physical parameters of those clumps are measured using the Multiple Gaussian Model algorithm.One advantage of applying the Local Density Clustering to the clump detection and segmentation,is the high accuracy under different signal-to-noise levels.The Multiple Gaussian Model is able to deal with overlapping clumps whose parameters can reliably be derived.Using simulation and synthetic data,we have verified that the proposed algorithm could accurately characterize the morphology and flux of molecular clumps.The total flux recovery rate in 13CO(J=1-0)line of M16 is measured as 90.2%.The detection rate and the completeness limit are 81.7%and 20 K km s-1 in 13CO(J=1-0)line of M16,respectively. | Xiaoyu Luo Sheng Zheng Yao Huang Shuguang Zeng Xiangyun Zeng Zhibo Jiang Zhiwei Chen | 2022 | Research in Astronomy and Astrophysics2022，22，1： | 3 |
| 4 | RNA-Seq Study Reveals AP2-Domain-Containing Signalling Regulators Involved in Initial Imbibition of Seed Germination in Rice显示文摘A number of internal signals are required for seed germination.However,the precise signalling responses in the initial imbibition of seed germination are not yet fully understood in rice.In this study,the RNA sequencing(RNA-Seq)approach was conducted in 8 h imbibed seeds to understand the signalling responses in the initial imbibition of rice seed germination.A total of 563 differentially expressed genes(DEGs)with at least 4-fold change were identified in 8 h imbibed seeds compared to dry seeds.MapMan analysis revealed that the majority of signalling response-related DEGs were hormone-and transcription factor-related genes,in which the largest number of DEGs belong to the AP2-domain-containing regulators,and their expressions were significantly induced in the initial imbibition of seed germination in rice.Moreover,at least five AP2-domain-containing transcription factor OsDREBs were identified in the initial imbibition of rice seed germination,and the expressions of 251 DEGs were putatively regulated by OsDREBs through the dehydration-responsive element(DRE)cis-element assay.It suggested that the OsDREBs might play important roles in the regulation of initial seed imbibition in rice.The identified genes provide a valuable resource to study the signalling regulation of seed germination in the future. | HE Yongqi ZHAO Jia FENG Defeng HUANG Zhibo LIANG Jiaming ZHENG Yufei CHENG Jinping YING Jifeng WANG Zhoufei | 2020 | Rice science2020，27，4： | 2 |
| 5 | Atomistic simulation on the generation of defects in Cu/SiC composites during cooling显示文摘The coefficient of thermal expansion(CTE)mismatch between the reinforcement and the matrix results in thermal residual stresses and defects within metal-matrix composites(MMCs)upon cooling from the processing temperature to ambient temperature.The residual stresses and thermally induced defects play an important role in the mechanical properties of MMCs,it is critical to understand the mechanism of defect formation and evolution.This study provides atomistic simulations to reveal the generation of thermal residual stresses,dislocation and incomplete stacking fault tetrahedron(ISFT)during cooling in the idealized Cu/SiC composites.We found that dislocations are generated explosively in a certain temperature range during cooling,which results in a non-linear relationship between dislocation density and temperature.The combined effect of the stresses induced by CTE mismatch and the thermodynamic state of the metal leads to the rapid generation of dislocations.The Shockley partial and the highly stable stair rod are the two dominant dislocation structures.The immobile stair-rod dislocations and the highly stable ISFTs formed in the initial high temperature stage inhibit further development of plastic deformation.The present results provide new insights into the defect formation mechanism and the dislocation strengthening mechanism of MMCs caused by thermal mismatch between constituents. | Yongnan Xiong Wangyu Hu Yao Shu Xing Luo Zhibo Zhang Jiazhen He Cuicui Yin Kaihong Zheng | 2022 | Journal of Materials Science & Technology2022，，28： | 1 |
| 6 | Synthesis of switchable amphipathic molecules triggered by CO2 through carbonyl - amine condensation 显示文摘 | QIAO WEIHONG ZHENG ZHIBO PENG HUAN | 2011 | European Journal of Lipid Science and Technology2011，113，7： | 1 |
| 7 | Science with the 2.5-meter Wide Field Survey Telescope(WFST)显示文摘The Wide Field Survey Telescope(WFST) is a dedicated photometric surveying facility being built jointly by University of Science and Technology of China(USTC) and the Purple Mountain Observatory(PMO). It is equipped with a 2.5-meter diameter primary mirror, an active optics system, and a mosaic CCD camera with 0.73 gigapixels on the primary focal plane for highquality image capture over a 6.5-square-degree field of view. The installation of WFST near the summit of Saishiteng mountain in the Lenghu region is scheduled in summer of 2023, and the operation is planned to start three months later. WFST will scan the northern sky in four optical bands(u, g, r and i) at cadences from hourly/daily in the deep high-cadence survey(DHS) program, to semi-weekly in the wide field survey(WFS) program. During a photometric night, a nominal 30 s exposure in the WFS program will reach a depth of 22.27, 23.32, 22.84, and 22.31(AB magnitudes) in these four bands, respectively, allowing for the detection of a tremendous amount of transients in the low-z universe and a systematic investigation of the variability of Galactic and extragalactic objects. In the DHS program, intranight 90 s exposures as deep as 23(u) and 24 mag(g), in combination with target of opportunity follow-ups, will provide a unique opportunity to explore energetic transients in demand for high sensitivities, including the electromagnetic counterparts of gravitational wave events, supernovae within a few hours of their explosions,tidal disruption events and fast, luminous optical transients even beyond redshift of unity. In addition, the final 6-year co-added images, anticipated to reach g■25.8 mag in WFS or 1.5 mags deeper in DHS, will be of fundamental importance to general Galactic and extragalactic science. The highly uniform legacy surveys of WFST will serve as an indispensable complement to those of the Vera C. Rubin Observatory's Legacy Survey of Space and Time(LSST) that monitors the southern sky. | Tinggui Wang Guilin Liu Zhenyi Cai Jinjun Geng Min Fang Haoning He Ji-an Jiang Ning Jiang Xu Kong Bin Li Ye Li Wentao Luo Zhizheng Pan Xuefeng Wu Ji Yang Jiming Yu Xianzhong Zheng Qingfeng Zhu Yi-Fu Cai Yuanyuan Chen Zhiwei Chen Zigao Dai Lulu Fan Yizhong Fan Wenjuan Fang Zhicheng He Lei Hu Maokai Hu Zhiping Jin Zhibo Jiang Guoliang Li Fan Li Xuzhi Li Runduo Liang Zheyu Lin Qingzhong Liu Wenhao Liu Zhengyan Liu Wei Liu Yao Liu Zheng Lou Han Qu Zhenfeng Sheng Jianchun Shi Yiping Shu Zhenbo Su Tianrui Sun Hongchi Wang Huiyuan Wang Jian Wang Junxian Wang Daming Wei Junjie Wei Yongquan Xue Jingzhi Yan Chao Yang Ye Yuan Yefei Yuan Hongxin Zhang Miaomiao Zhang Haibin Zhao Wen Zhao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，10： | 1 |
| 8 | Synthesis and Properties of a Series of C02 Switchable Surfactants with Imidazoline Group显示文摘 | Weihong Qiao Zhibo Zheng Qingzhao Shi | 2012 | J Surfact Deterg2012，15，5： | 1 |
| 9 | Improved suspension quality and liquid level stability in stirred tanks with Rotor-Stator agitator based on CFD simulation显示文摘The solid-liquid mixing is an important operation unit in the preparation of composites by stirring casting.High quality composite materials need good homogeneity and stable liquid level.In this work,the performances of the Rotor-Stator agitator for solid suspension in stirred tank were investigated through CFD modeling,including the homogeneity,power consumption and liquid level stability.The Eulerian-Eulerian(E-E)multiphase model and the RNG k-εturbulence model were adopted for modeling the multiphase flow and the turbulence effects,respectively.The effect of various important parameters such as stirring speed,particle size,solid loading and the use of baffles were examined.Adding a stator structure with array holes outside the rotor can optimize the flow pattern,thereby improving the mixing uniformity and liquid level stability.The homogeneity and liquid level stability attained by the Rotor-Stator agitator were better than those for the A200(an axial-flow agitator)and the Rushton(a radial-flow agitator). | Cuicui Yin Jiazhen He Yongnan Xiong Zhibo Zhang Xing Luo Yao Shu Danfeng Long Kaihong Zheng | 2023 | Particuology2023，，11： | 0 |
| 10 | Study design of deep learning based automatic detection of cerebrovascular diseases on medical imaging: a position paper from Chinese Association of Radiologists显示文摘In recent years,with the development of artificial intelligence,especially deep learning technology,researches on automatic detection of cerebrovascular diseases on medical images have made tremendous progress and these models are gradually entering into clinical practice.However,because of the complexity and flexibility of the deep learning algorithms,these researches have great variability on model building,validation process,performance description and results interpretation.The lack of a reliable,consistent,standardized design protocol has,to a certain extent,affected the progress of clinical translation and technology development of computer aided detection systems.After reviewing a large number of literatures and extensive discussion with domestic experts,this position paper put forward recommendations of standardized design on the key steps of deep learning-based automatic image detection models for cerebrovascular diseases.With further research and application expansion,this position paper would continue to be updated and gradually extended to evaluate the generalizability and clinical application efficacy of such tools. | Longjiang Zhang Zhao Shi Min Chen Yingmin Chen Jingliang Cheng Li Fan Nan Hong Wenxiao Jia Guihua Jiang Shenghong Ju Xiaogang Li Xiuli Li Changhong Liang Weihua Liao Shiyuan Liu Zaiming Lu Lin Ma Ke Ren Pengfei Rong Bin Song Gang Sun Rongpin Wang Zhibo Wen Haibo Xu Kai Xu Fuhua Yan Yizhou Yu Yunfei Zha Fandong Zhang Minwen Zheng Zhen Zhou Wenzhen Zhu Guangming Lu Zhengyu Jin on behalf of Chinese Association of Radiologists | 2022 | Intelligent Medicine2022，2，4： | 0 |
| 11 | Phonon-assisted upconversion in twisted two-dimensional semiconductors显示文摘Phonon-assisted photon upconversion(UPC)is an anti-Stokes process in which incident photons achieve higher energy emission by absorbing phonons.This letter studies phonon-assisted UPC in twisted 2D semiconductors,in which an inverted contrast between UPC and conventional photoluminescence(PL)of WSe2 twisted bilayer is emergent.A 4-fold UPC enhancement is achieved in 5.5°twisted bilayer while PL weakens by half.Reduced interlayer exciton conversion efficiency driven by lattice relaxation,along with enhanced pump efficiency resulting from spectral redshift,lead to the rotation-angle-dependent UPC enhancement.The counterintuitive phenomenon provides a novel insight into a unique way that twisted angle affects UPC and light-matter interactions in 2D semiconductors.Furthermore,the UPC enhancement platform with various superimposable means offers an effective method for lighting bilayers and expanding the application prospect of 2D stacked van der Waals devices. | Yuchen Dai Pengfei Qi Guangyi Tao Guangjie Yao Beibei Shi Zhixin Liul Zhengchang Liu Xiao He Pu Peng Zhibo Dang Liheng Zheng Tianhao Zhang Yongji Gong Yan Guan Kaihui Liu Zheyu Fang | 2023 | Light(Science & Applications)2023，12，1： | 0 |
| 12 | Pancreatic cancer with ovarian metastasis: cases report and literature review显示文摘Background: Pancreatic cancer with ovarian metastases is rare and easily misdiagnosed. Patients with ovarian metastases are first diagnosed with ovarian cancer and may miss the opportunity to receive surgical operation. We report 7 rare cases of ovarian metastases secondary to pancreatic adenocarcinoma and review the literature to analyze clinical characteristics, diagnostic methods, and potential therapeutic strategies for the rare malignancy.Cases Summary: We retrospectively analyzed the clinical data of 7 female patients with ovarian metastases of primary pancreatic cancer who were admitted to our hospital from January 01, 1985, to April 1, 2020. These 7 patients were diagnosed with ovarian metastasis at an average age of 52.28 (38-69) years. The reason for the patient’s visit was generally a mass in the lower abdomen and/or abdominal pain. Six of them had significantly higher serum Carbohydrate antigen19-9 (CA19-9) levels, 6 patients had pancreatic tumors located in the body or tail, and 1 patient had one in the head of the pancreas. All patients underwent excision of ovarian tumors and resection or biopsy of pancreatic tumors. Five patients had pancreatic ductal adenocarcinoma (PDAC), and 2 had pancreatic cystadenocarcinoma (PCC), all of which were revealed by the pathological results. Ovarian tumors were assessed by pathology and were consistent with pancreatic metastasis. Currently, all 7 patients have died (follow-up to January 2, 2021). The median survival time for all patients was 13.7 months (2.9-27 months).Conclusions: For this rare tumor, elevated serum CA19-9 may indicate that the primary lesion is in the pancreas. Enhanced pancreatic Computed Tomography (CT) can facilitate diagnostic localization. In addition, if the pancreatic tumor cannot be removed, the ovarian tumor should still be resected to reduce the tumor load and improve the quality of life. | Zeru Li Xingtong Zhou Bangbo Zhao Zhibo Zheng Cheng Qin Xudong Liu Huadan Xue Weibin Wang | 2023 | Journal of Pancreatology2023，6，1： | 0 |
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