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| 1 | Aggregation-induced emission: a coming-of-age ceremony at the age of eighteen显示文摘Aggregation-induced emission(AIE) has drawn great attention worldwide for its unique optical phenomenon and huge potential applications. Since coined by Ben Zhong Tang et al. in 2001, AIE has been deeply investigated and widely utilized in many important areas, such as organic light-emitting diode(OLED), sensor, and bio-imaging. Herein, we highlight some important progress of AIE in these eighteen years, including the exploration of internal mechanism and potential applications. Furthermore,some other interestingly emissive behaviors, originating but distinguishing from the AIE concept, are presented. It is anticipated an overall understanding about AIE could be easily caught from this short review for scientists, no matter whether they are involved in this exciting and rising research area or not. | Jie Yang Zhenguo Chi Weihong Zhu Ben Zhong Tang Zhen Li | 2019 | Science China Chemistry2019，62，9： | 25 |
| 2 | Effect of local wound infiltration with ropivacaine on postoperative pain relief and stress response reduction after open hepatectomy显示文摘AIM To prospectively evaluate the effect of local wound infiltration with ropivacaine on postoperative pain relief and stress response reduction after open hepatectomy.METHODS A total of 56 patients undergoing open hepatectomy were randomly divided into two groups:a ropivacaine group(wound infiltration with ropivacaine solution)and a control group(infiltration with isotonic saline solution).A visual analog scale(VAS)at rest and on movement was used to measure postoperative pain for the first 48 h after surgery.Mean arterial pressure(MAP),heart rate(HR),time to bowel recovery,length of hospitalization after surgery,cumulative sufentanil consumption,and incidence of nausea and vomiting were compared between the two groups.Surgical stress hormones(epinephrine,norepinephrine,and cortisol)were detected using enzyme-linked immunosorbent assay,and the results were compared. RESULTS VAS scores both at rest and on movement at 24 h and48 h were similar between the two groups.Significantly lower VAS scores were detected at 0,6,and 12 h in the ropivacaine group compared with the control group(P<0.05 for all).MAP was significantly lower at 6,12,and 24 h(P<0.05 for all);HR was significantly lower at 0,6,12,and 24 h(P<0.05 for all);time to bowel recovery and length of hospitalization after surgery(P<0.05 for both)were significantly shortened;and cumulative sufentanil consumption was significantly lower at 6,12,24,and 36 h(P<0.05 for all)in the ropivacaine group than in the control group,although the incidence of nausea and vomiting showed no significant difference between the two groups.The levels of epinephrine,norepinephrine,and cortisol were significantly lower in the ropivacaine group than in the control group at 24 and 48 h(P<0.01 for all). CONCLUSION Local wound infiltration with ropivacaine after open hepatectomy can improve postoperative pain relief,reduce surgical stress response,and accelerate postoperative recovery. | Jing-Xian Sun Ke-Yun Bai Yan-Feng Liu Gang Du Zhi-Hao Fu Hao Zhang Jin-Huan Yang Ben Wang Xiu-Yu Wang Bin Jin | 2017 | World Journal of Gastroenterology2017，23，36： | 25 |
| 3 | An alternative therapy for drug-resistant epilepsy: transcutaneous auricular vagus nerve stimulation显示文摘 | Rong Peijing Liu Aihua Zhang Jianguo Wang Yuping Yang Anchao Li Liang Ben Hui Li Liping Liu Rupeng He Wei Liu Huanguang Huang Feng Li Xia Wu Peng Zhu Bing | 2014 | Chinese Medical Journal2014，，2： | 20 |
| 4 | Predictors to assess non-sentinel lymph node status in breast cancer patients with only one sentinel lymph node metastasis显示文摘 | YANG Ben YANG Li ZUO Wen-shu GE Wen-kai ZHENG Gang ZHENG Mei-zhu YU Zhi-yong WANG Yong-sheng | 2013 | Chinese Medical Journal2013，，3： | 17 |
| 5 | Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG显示文摘Osteoporosis is a debilitating bone disease affecting millions of people. Here, we used human urine-derived stem cells(USCs),which were noninvasively harvested from unlimited and easily available urine, as a 'factory' to obtain extracellular vesicles(USCEVs) and demonstrated that the systemic injection of USC-EVs effectively alleviates bone loss and maintains bone strength in osteoporotic mice by enhancing osteoblastic bone formation and suppressing osteoclastic bone resorption. More importantly, the anti-osteoporotic properties of USC-EVs are not notably disrupted by the age, gender, or health condition(with or without osteoporosis) of the USC donor. Mechanistic studies determined that collagen triple-helix repeat containing 1(CTHRC1) and osteoprotegerin(OPG) proteins are enriched in USC-EVs and required for USC-EV-induced pro-osteogenic and anti-osteoclastic effects. Our results suggest that autologous USC-EVs represent a promising novel therapeutic agent for osteoporosis by promoting osteogenesis and inhibiting osteoclastogenesis by transferring CTHRC1 and OPG. | Chun-Yuan Chen Shan-Shan Rao Yi-Juan Tan Ming-Jie Luo Xiong-Ke Hu Hao Yin Jie Huang Yin Hu Zhong-Wei Luo Zheng-Zhao Liu Zhen-Xing Wang Jia Cao Yi-Wei Liu Hong-Ming Li Yang Chen Wei Du Jiang-Hua Liu Yan Zhang Tuan-Hui Chen Hao-Ming Liu Ben Wu Tao Yue Yi-Yi Wang Kun Xia Peng-Fei Lei Si-Yuan Tang Hui Xie | 2019 | Bone Research2019，7，3： | 14 |
| 6 | The Change of the Inlet Geometry of a Centrifugal Compressor Stage and its Influence on the Compressor Performance显示文摘The impact on the compressor performance is important for designing the inlet pipe of the centrifugal compressor of a vehicle turbocharger with different inlet pipes. First, an experiment was performed to determine the compressor performance from three cases: a straight inlet pipe, a long bent inlet pipe and a short bent inlet pipe. Next, dynamic sensors were installed in key positions to collect the sign of the unsteady pressure of the centrifugal compressor. Combined with the results of numerical simulations, the total pressure distortion in the pipes, the pressure distributions on the blades and the pressure variability in the diffuser are studied in detail. The results can be summarized as follows: a bent pipe results in an inlet distortion to the compressor, which leads to performance degradation, and the effect is more apparent as the mass flow rate increases. The distortion induced by the bent inlet is not only influenced by the distance between the outlet of the bent section and the leading edge of the impeller but also by the impeller rotation. The flow fields in the centrifugal impeller and the diffuser are influenced by a coupling effect produced by the upstream inlet distortion and the downstream blocking effect from the volute tongue. If the inlet geometry is changed, the distributions and the fluctuation intensities of the static pressure on the main blade surface of the centrifugal impeller and in the diffuser are changed accordingly. | WANG Leilei YANG Ce ZHAO Ben LAO Dazhong MA Chaochen LI Du | 2013 | Journal of Thermal Science2013，22，3： | 13 |
| 7 | A comparative study of totally laparoscopic distal gastrectomy versus laparoscopic-assisted distal gastrectomy in gastric cancer patients: Short-term operative outcomes at a high-volume center显示文摘Objective: Laparoscopic gastrectomy has been established as a standard treatment for early gastric cancer, and its use is increasing recently. Compared with the conventional laparoscopy-assisted distal gastrectomy(LADG), totally laparoscopic distal gastrectomy(TLDG) involves intracorporeal reconstruction, which can avoid the additional incision, resulting in pain reduction and early recovery. This study aimed to compare the short-term postoperative outcomes of TLDG vs. LADG in gastric cancer in a high-volume center.Methods: A retrospective cohort study was conducted on 1,322 patients who underwent laparoscopic distal gastrectomy from June 2012 to June 2017 at the National Cancer Center, Korea. LADG was performed in the early period before July 2015, and TLDG was applied in the later period. Postoperative short-term outcomes were compared in terms of complication and clinical course between the two groups. Pain score was measured by rating the pain intensity from 0 to 10 points on postoperative day(POD) 1 and 3.Results: A total of 667 patients underwent LADG and 655 patients underwent TLDG. Clinicopathologic characteristics were not different in both groups. Intraoperative estimated blood loss(EBL) was significantly lower in the TLDG group(P<0.001). Postoperative pain scores were significantly lower in the TLDG group than in the LADG group on POD 1(5.1±1.5 vs. 4.8±1.4, P=0.015). First flatus passage after operation was significantly earlier in the TLDG group(3.4±0.8 d vs. 3.2±0.6 d, P<0.001). There were no differences in postoperative complications and hospital stay between the two groups.Conclusions: Based on the reported short-term postoperative outcomes, TLDG is safe and feasible as well as LADG. Moreover, compared with LADG, TLDG can reduce intraoperative EBL and postoperative pain and enhance the bowel motility in gastric cancer surgery. | Won Ho Han Amir Ben Yehuda Deok-Hee Kim Seung Geun Yang Bang Wool Eom Hong Man Yoon Young-Woo Kim Keun Won Ryu | 2018 | Chinese Journal of Cancer Research2018，30，5： | 11 |
| 8 | Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats显示文摘Glycine is a well-documented cytoprotective agent.However,whether it has a protective effect against myocar-dial ischemia-reperfusion injury in vivo is still unknown.By using an open-chest anesthetized rat model,we found that glycine reduced the infarct size by 21% in ischemia-reperfusion injury rats compared with that in the vehicle-treated MI/R rats.The left ventricular ejection fraction and fractional shortening were increased by 19.11% and 30.98%,respectively,in glycine-treated rats.The plasma creatine kinase levels in ischemia-reperfusion injury rats decreased following glycine treatment.Importantly,administration of glycine significantly inhibited apoptosis in post-ischemia-reperfusion myocardium,which was accompanied by suppression of phosphorylated p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase,as well as the Fas ligand.These results suggest that gly-cine attenuates myocardial ischemia-reperfusion injury in vivo by inhibiting cardiomyocytes apoptosis. | Xiaozheng Zhong Xiaoyu Li Lingling Qiana Yiming Xu Yan Lu Jing Zhang Nan Li Xudong Zhu Jingjing Ben Qing Yang Qi Chen | 2012 | The Journal of Biomedical Research2012，26，5： | 10 |
| 9 | Class A scavenger receptor activation inhibits endoplasmic reticulum stress-induced autophagy in macrophage显示文摘Macrophage death in advanced atherosclerosis promotes plaque necrosis and destabilization.Involvement of autophagy in bulk degradation of cellular components has been recognized recently as an important mechanism for cell survival under endoplasmic reticulum(ER) stress.We previously found that the engagement of class A scavenger receptor(SR-A) triggered JNK-dependent apoptosis in ER-stressed macrophages.However,pro-apoptotic mechanisms mediated by SR-A are not fully understood.Therefore,we sought to see if SR-A mediated apoptosis was associated with autophagy in macrophages.Here,we showed that fucoidan inhibited microtubule-associated protein light chain 3-phospholipid conjugates(LC3-Ⅱ) formation as well as the number of autophagosomes under ER stress.The inhibition of LC3-Ⅱ formation was paralleled by the activation of the mTOR pathway,and the inhibition of mTOR allowed LC3-Ⅱ induction in macrophages treated with thapsigargin plus fucoidan.Furthermore,apoptosis induced by fucoidan was prevented under ER stress by the mTOR inhibitor.We propose that fucoidan,a SR-A agonist,may contribute to macrophage apoptosis during ER stress by inhibiting autophagy. | Hanpeng Huang Xiaoyu Li Yan Zhuang Nan Li Xudong Zhu Jin Hu Jingjing Ben Qing Yang Hui Bai Qi Chen | 2014 | The Journal of Biomedical Research2014，28，3： | 9 |
| 10 | Nine-month angiographic and two-year clinical follow-up of polymer-free sirolimus-eluting stent versus durable-polymer sirolimus-eluting stent for coronary artery disease: the Nano randomized trial显示文摘 | Zhang Yaojun Chen Fang Takashi Muramatsu Xu Bo Li Zhanquan Ge Junbo He Qing Yang Zhijian Li Shumei Wang Lefeng Wang Haichang He Ben Li Kang Qi Guoxian Li Tianchang Zeng Hesong Peng Jianjun Jiang Tieming Zeng Qiutang Zhu Jianhua Fu Guosheng Christos V. Bourantas Patrick W. Serruys Huo Yong | 2014 | Chinese Medical Journal2014，，11： | 8 |
| 11 | Host–guest materials with room temperature phosphorescence:Tunable emission color and thermal printing patterns显示文摘The research of purely organic materials with long afterglow has drawn more and more attention,especially for those with stimulus‐response characteristic.So far,this kind of material is really very scarce and their performance is not good enough.In this study,we successfully developed an efficient heatingresponsive room‐temperature phosphorescence material with phosphorescence efficiency and lifetime up to 13.4%and 2.08 s through the simple host–guest doping strategy.Further on,by introducing the additional energy acceptor of fluorescein with concentration‐dependent emission to construct ternary doping systems,the afterglow color was extended from blue to yellow.Accordingly,the multicolor thermal printings have been easily realized,showing the great practical application prospects. | Yunsheng Wang Jie Yang Yanxiang Gong Manman Fang Zhen Li Ben Zhong Tang | 2020 | SmartMat2020，1，1： | 8 |
| 12 | Vertically Aligned Silicon Carbide Nanowires/Boron Nitride Cellulose Aerogel Networks Enhanced Thermal Conductivity and Electromagnetic Absorbing of Epoxy Composites显示文摘With the innovation of microelectronics technology, the heat dissipation problem inside the device will face a severe test. In this work, cellulose aerogel(CA) with highly enhanced thermal conductivity(TC) in vertical planes was successfully obtained by constructing a vertically aligned silicon carbide nanowires(SiC NWs)/boron nitride(BN) network via the ice template-assisted strategy. The unique network structure of SiC NWs connected to BN ensures that the TC of the composite in the vertical direction reaches 2.21 W m^(-1) K^(-1) at a low hybrid filler loading of 16.69 wt%, which was increased by 890% compared to pure epoxy(EP). In addition, relying on unique porous network structure of CA, EP-based composite also showed higher TC than other comparative samples in the horizontal direction. Meanwhile, the composite exhibits good electrically insulating with a volume electrical resistivity about 2.35 × 10^(11) Ω cm and displays excellent electromagnetic wave absorption performance with a minimum reflection loss of-21.5 dB and a wide effective absorption bandwidth(<-10 dB) from 8.8 to 11.6 GHz. Therefore, this work provides a new strategy for manufacturing polymer-based composites with excellent multifunctional performances in microelectronic packaging applications. | Duo Pan Gui Yang Hala MAbo-Dief Jingwen Dong Fengmei Su Chuntai Liu Yifan Li Ben Bin Xu Vignesh Murugadoss Nithesh Naik Salah MEl-Bahy Zeinhom MEl-Bahy Minan Huang Zhanhu Guo | 2022 | Nano-Micro Letters2022，14，7： | 7 |
| 13 | A Hybrid Deep Sea Navigation System of LBL/DR Integration Based on UKF and PSO-SVM显示文摘In order to improve the navigation accuracy of human occupied vehicle(HOV)precisely and efficiently,an innovative hybrid approach based on unscented Kalman filter(UKF)and support vector machine(SVM)is proposed to fuse integrated navigation data.HOV is generally equipped with long baseline(LBL)acoustic positioning system and dead reckoning(DR)as an integrated navigation system.UKF is adopted to estimate the state of the dynamic model because of its good performance in filtering nonlinear problems.An accurate and stable filtering result can be obtained when both LBL and DR are online.At the same time,SVM is utilized to train DR information with the result when LBL outrages,and the particle swarm optimization(PSO)algorithm is employed for SVM parameters optimization.Therefore,the integrated navigation system can maintain a good performance when the LBL is off-line.Simulation results with the real navigation data of Jiaolong HOV show that the methodology proposed here is able to meet the needs of HOV application. | LIU Ben LIU Kaizhou WANG Yanyan ZHAO Yang CUI Shengguo WANG Xiaohui | 2015 | 机器人2015，37，5： | 7 |
| 14 | An Overview of Mineral Dust Modeling over East Asia显示文摘East Asian dust(EAD) exerts considerable impacts on the energy balance and climate/climate change of the earth system through its influence on solar and terrestrial radiation, cloud properties, and precipitation efficiency. Providing an accurate description of the life cycle and climate effects of EAD is therefore critical to better understanding of climate change and socioeconomic development in East Asia and even worldwide. Dust modeling has undergone substantial development since the late 1990 s, associated with improved understanding of the role of EAD in the earth system. Here, we review the achievements and progress made in recent decades in terms of dust modeling research,including dust emissions, long-range transport, radiative forcing(RF), and climate effects of dust particles over East Asia. Numerous efforts in dust/EAD modeling have been directed towards furnishing more sophisticated physical and chemical processes into the models on higher spatial resolutions. Meanwhile, more systematic observations and more advanced retrieval methods for instruments that address EAD related science issues have made it possible to evaluate model results and quantify the role of EAD in the earth system, and to further reduce the uncertainties in EAD simulations. Though much progress has been made, large discrepancies and knowledge gaps still exist among EAD simulations. The deficiencies and limitations that pertain to the performance of the EAD simulations referred to in the present study are also discussed. | Siyu CHEN Jianping HUANG Yun QIAN Chun ZHAO Litai KANG Ben YANG Yong WANG Yuzhi LIU Tiangang YUAN Tianhe WANG Xiaojun MA Guolong ZHANG | 2017 | Journal of Meteorological Research2017，31，4： | 7 |
| 15 | Flame-retardant concentrated electrolyte enabling a Li F-rich solid electrolyte interface to improve cycle performance of wide-temperature lithium–sulfur batteries显示文摘Lithium–sulfur batteries have been regarded as the most promising high-energy electrochemical energy storage device owing to the high energy density, low cost and environmental friendliness. However, traditional lithium–sulfur batteries using ether-based electrolytes often suffer from severe safety risks(i.e. combustion). Herein, we demonstrated a novel kind of flame-retardant concentrated electrolyte(6.5 M lithium bis(trifluoromethylsulphonyl)imide/fluoroethylene carbonate) for highly-safe and widetemperature lithium–sulfur batteries. It was found that such concentrated electrolyte showed superior flame retardancy, high lithium-ion transference number(0.69) and steady lithium plating/stripping behavior(2.5 m Ah cm^(-2) over 3000 h). Moreover, lithium–sulfur batteries using this flame-retardant concentrated electrolyte delivered outstanding cycle performance in a wide range of temperatures(-10 °C, 25 °C and 90 °C). This superior battery performance is mainly attributed to the LiF-rich solid electrolyte interphase formed on lithium metal anode, which can effectively suppress the continuous growth of lithium dendrites. Above-mentioned fascinating characteristics would endow this flame-retardant concentrated electrolyte a very promising candidate for highly-safe and wide-temperature lithium–sulfur batteries. | Zhe Yu Jianjun Zhang Chao Wang Rongxiang Hu Xiaofan Du Ben Tang Hongtao Qu Han Wu Xin Liu Xinhong Zhou Xiaoyan Yang Guanglei Cui | 2020 | Journal of Energy Chemistry2020，29，12： | 7 |
| 16 | Smaller tumor size is associated with poor survival in T4b colon cancer显示文摘AIM: To hypothesize that in patients with colon cancer showing heavy intestinal wall invasion without distant metastasis(T4b N0-2M0), small tumor size would correlate with more aggressive tumor behaviors and therefore poorer cancer-specific survival(CSS).METHODS: We analyzed T4 b N0-2M0 colon cancer patients in the Surveillance, Epidemiology and End Results(SEER) database. A preliminary analysis of T4 b N0-2M0 colon cancer patients at the Fudan University Shanghai Cancer Center is also presented.RESULTS: A total of 1734 T4 b N0-2M0 colon cancer patients from the SEER database were included. Kaplan-Meier analysis revealed decreasing CSS with decreasing tumor size(P < 0.001). Subgroup analysis showed a significant association between poorer CSS with smaller tumor size in T4 b N0 patients(P = 0.024), and a trend of association in T4 b N1(P = 0.182) and T4 b N2 patients(P = 0.191). Multivariate analysis identified tumor size as an independent prognostic factor for CSS in T4 b N0-2M0 patients(P = 0.024). Preliminary analysis of Fudan University Shanghai Cancer Center samples suggested the 5-year CSS was 50.0%, 72.9% and 77.1% in patients with tumors ≤ 4.0 cm, 4.0-7.0 cm and ≥ 7.0 cm.CONCLUSION: Smaller tumor size is associated with poorer CSS in the T4 b N0-2M0 subset of colon cancer, particularly in the T4 b N0M0 subgroup. | Ben Huang Yang Feng Shao-Bo Mo San-Jun Cai Li-Yong Huang | 2016 | World Journal of Gastroenterology2016，22，29： | 7 |
| 17 | Phosphorylation switch modulates the interdigitated pattern of PIN1 localization and cell expansion in Arabidopsis leaf epidermis显示文摘在多细胞的纸巾以内,房间可以并列地形成一单个或多重的极的轴,而是它是不清楚的普通机制是否管理极的轴形成的不同类型。大头针蛋白质的 phosphorylation 地位,被 PINOID (PID ) 蛋白质 kinase 和 PP2A 蛋白质磷酸酶直接影响,被知道在根和射击顶的双极的房间调整大头针本地化的顶端基础的极性。这里,我们提供证据 phosphorylation 调停地位的大头针极性开关广泛地被用来与交错的脑叶和缩进包括多极的人行道房间(PC ) 在 Arabidopsis 调制细胞的进程。当 FYPP1 基因,编码称为联系 phytochrome 的 serine/threonine 蛋白质磷酸酶的 PP2A,被击倒时或当 PID 基因是 overexpressed (35S::PID ) 时, PC interdigitation 的度也极大地被减少。这些基因修正引起了 PIN1 本地化从脑叶切换到缩进区域。PP2A 和 PID 调停了 PIN1 本地化切换惊人地类似于他们在另外的房间的大头针蛋白质的顶端基础的极性开关的规定。我们的调查结果为 PIN1 极性形成,在织物 / 器官两个都为模式形成是关键的一个基本细胞的过程和细胞的层次的规定建议普通机制。 | Hongjiang Li Deshu Lin Pankaj Dhonukshe Shingo Nagawa Dandan Chen Jifi Friml Ben Scheres Hongwei Guo Zhenbiao Yang | 2011 | Cell Research2011，21，6： | 7 |
| 18 | Unsteady Flow Variability Driven by Rotor-stator Interaction at Rotor Exit显示文摘Numerical investigation of the unsteady flow variability driven by rotorstator interaction in a transonic axial compressor is performed. Two models with close and far axial gap between rotor and stator rows are studied in the simulation. Particular attention is attached to the analysis of mechanisms involved in driving rotor wake oscillation, rotor wake skewing and flow angle fluctuation at rotor exit. The results show that smaller axial gap is favorable to enhance the interaction in the region between two adjacent rows, and the fluctuation of the static pressure difference between two sides of rotor wake is improved by potential field from down stator, which is the driving force for rotor wake oscillation. The interaction between rotor and stator is weakened by increasing axial distance, rotor wake shifts to suction side of rotor blade with 5%-10% of rotor pitch, the absolute value of flow angle at rotor exit is less than that in the case of close interspace for every time step, and the fluctuation amplitude is also decreased. | ZHAO Ben YANG Ce CHEN Shan QI Mingxu ZHOU Mi | 2012 | Chinese Journal of Aeronautics2012，25，6： | 5 |
| 19 | The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury显示文摘Sentrin-specific protease 3(SENP3), a member of the desumoylating enzyme family, is known as a redox sensor and could regulate multiple cellular signaling pathways. However, its implication in myocardial ischemia reperfusion(MIR) injury is unclear. Here, we observed that SENP3 was expressed and upregulated in the mouse heart depending on reactive oxygen species(ROS) production in response to MIR injury. By utilizing si RNA-mediated cardiac specific gene silencing, SENP3 knockdown was demonstrated to significantly reduce MIR-induced infarct size and improve cardiac function. Mechanistic studies indicated that SENP3 silencing ameliorated myocardial apoptosis mainly via suppression of endoplasmic reticulum(ER) stress and mitochondrial-mediated apoptosis pathways. By contrast, adenovirusmediated cardiac SENP3 overexpression significantly exaggerated MIR injury. Further molecular analysis revealed that SENP3 promoted mitochondrial translocation of dynamin-related protein 1(Drp1) in reperfused myocardium. In addition, mitochondrial division inhibitor-1(Mdivi-1), a pharmacological inhibitor of Drp1, significantly attenuated the exaggerated mitochondrial abnormality and cardiac injury by SENP3 overexpression after MIR injury. Taken together, we provide the first direct evidence that SENP3 upregulation pivotally contributes to MIR injury in a Drp1-dependent manner, and suggest that SENP3 suppression may hold therapeutic promise for constraining MIR injury. | Lingchen Gao Yichao Zhao Jie He Yang Yan Longwei Xu Nan Lin Qingqi Ji Renyang Tong Yanan Fu Yu Gao Yuanyuan Su Ancai Yuan Ben He Jun Pu | 2018 | Journal of Genetics and Genomics2018，45，3： | 5 |
| 20 | Visually constructing the chemical structure of a single molecule by scanning Raman picoscopy显示文摘The strong spatial confinement of a nanocavity plasmonic field has made it possible to visualize the inner structure of a single molecule and even to distinguish its vibrational modes in real space.W ith such ever-improved spatial resolution,it is anticipated that full vibrational imaging of a molecule could be achieved to reveal molecular structural details.Here we demonstrate full Raman images of individual vibrational modes at the angstrom level for a single Mg-porphine molecule;revealing distinct characteristics of each vibrational mode in real space.Furthermore,by exploiting the underlying interference effect and Raman fingerprint database,we propose a new methodology for structural determination,which we have called'scanning Raman picoscopy',to show how such ultrahigh-resolution spectromicroscopic vibrational images can be used to visually assemble the chemical structure of a single molecule through a simple Lego-like building process. | Yao Zhang Ben Yang Atif Ghafoor Yang Zhang Yu-Fan Zhang Rui-Pu Wang Jin-Long Yang Yi Luo Zhen-Chao Dong J.G.Hou | 2019 | National Science Review2019，6，6： | 5 |
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