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| 1 | 2018 update of expert consensus statement on antiplatelet therapy in East Asian patients with ACS or undergoing PCI显示文摘East Asians are the most populous race in the world and their health status is an important global issue.Compared with Caucasian populations, East Asian patients have a different benefit/risk ratio when using antithrombotic treatment. Despite this observation, treatment strategies in East Asian patients are mostly based on the American and European guidelines. Despite a lower platelet inhibitory response to clopidogrel, East Asian patients show a similar or even a lower rate of ischemic event occurrence and higher bleeding risk compared with Caucasian patients. For potent P2Y_(12) inhibitors(ticagrelor and prasugrel),East Asian patients have shown less favorable net clinical benefits compared with Caucasian patients,which may be related to differences in pharmacokinetic/pharmacodynamic profiles and therapeutic zone of antiplatelet effect. This updated consensus mainly focuses on state-of-the-art and current controversies in the East Asian population. In addition, when East Asian patients are administered potent P2Y_(12) receptor inhibitors, the strategies and ongoing trials to overcome the related hurdles are discussed. | Yong Huo Young-Hoon Jeong Yanjun Gong Daowen Wang Ben He Jiyan Chen Guosheng Fu Yundai Chen Jianping Li Yi Li Shinya Goto Udaya S.Tantry Paul A.Gurbel Jong-Hwa Ahn Hyo-Soo Kim Myung Ho Jeong Yaling Han Sidney C.Smith Jr. Junbo Ge | 2019 | Science Bulletin2019，64，3： | 12 |
| 2 | Nine-month angiographic and two-year clinical follow-up of polymer-free sirolimus-eluting stent versus durable-polymer sirolimus-eluting stent for coronary artery disease: the Nano randomized trial显示文摘 | Zhang Yaojun Chen Fang Takashi Muramatsu Xu Bo Li Zhanquan Ge Junbo He Qing Yang Zhijian Li Shumei Wang Lefeng Wang Haichang He Ben Li Kang Qi Guoxian Li Tianchang Zeng Hesong Peng Jianjun Jiang Tieming Zeng Qiutang Zhu Jianhua Fu Guosheng Christos V. Bourantas Patrick W. Serruys Huo Yong | 2014 | Chinese Medical Journal2014，，11： | 8 |
| 3 | Recent Advances and Perspectives in Transition Metal-Catalyzed 1,4-Functionalizations of Unactivated 1,3-Enynes for the Synthesis of Allenes显示文摘Classic methods for the synthesis of allenes usually introduce only one functional group into products.In this review,we highlight the recent advances and perspectives in the synthesis of allenes by transition metal-catalyzed 1,4-functionalization of unactivated 1,3-enynes. | Liang Fu Steffen GreВies Pinhong Chen Guosheng Liu | 2020 | Chinese Journal of Chemistry2020，38，1： | 7 |
| 4 | Grid-cell Aerosol Direct Shortwave Radiative Forcing Calculated Using the SBDART Model with MODIS and AERONET Observations:An Application in Winter and Summer in Eastern China显示文摘Taking winter and summer in eastern China as an example application, a grid-cell method of aerosol direct radiative forcing(ADRF) calculation is examined using the Santa Barbara DISORT Atmospheric Radiative Transfer(SBDART) model with inputs from MODIS and AERONET observations and reanalysis data. Results show that there are significant seasonal and regional differences in climatological mean aerosol optical parameters and ADRF. Higher aerosol optical depth(AOD)occurs in summer and two prominent high aerosol loading centers are observed. Higher single scattering albedo(SSA) in summer is likely associated with the weak absorbing secondary aerosols. SSA is higher in North China during summer but higher in South China during winter. Aerosols induce negative forcing at the top of the atmosphere(TOA) and surface during both winter and summer, which may be responsible for the decrease in temperature and the increase in relative humidity.Values of ADRF at the surface are four times stronger than those at the TOA. Both AOD and ADRF present strong interannual variations; however, their amplitudes are larger in summer. Moreover, patterns and trends of ADRF do not always correspond well to those of AOD. Differences in the spatial distributions of ADRF between strong and weak monsoon years are captured effectively. Generally, the present results justify that to calculate grid-cell ADRF at a large scale using the SBDART model with observational aerosol optical properties and reanalysis data is an effective approach. | Yunfei FU Jiachen ZHU Yuanjian YANG Renmin YUAN Guosheng LIU Tao XIAN Peng LIU | 2017 | Advances in Atmospheric Sciences2017，34，8： | 6 |
| 5 | Shexiang Tongxin dropping pill(麝香通心滴丸)protects against sodium laurate-induced coronary microcirculatory dysfunction in rats显示文摘OBJECTIVE:To investigate the protective effects of Shexiang Tongxin dropping pill(麝香通心滴丸,STDP)in a rat model of coronary microcirculatory dysfunction(CMD).METHODS:Sprague-Dawley rats were allocated randomly into four groups:sham,CMD model,STDP,and nicorandil.After 4 weeks of treatment,CMD was induced by injection of sodium laurate(0.2 m L,2 g/L)into the left ventricle while obstructing the ascending aorta.Rats in the sham group underwent an identical surgical procedure but were administered physiological(0.9%)saline(0.2 m L).Twenty-four hours after surgery,blood samples were collected for biochemical analyses and enzyme-linked immunosorbent assays.Heart tissues were removed for histopathology staining;apoptosis and inflammatory cytokines were examined by Western blotting.RESULTS:The STDP group had a lower level of creatine kinase-myocardial band,lactate dehydrogenase,and cardiac troponin-I than that in the CMD model group.Infiltration of inflammatory cells,myocardial ischaemia,and microthrombosis were relieved in the STDP group compared with CMD model group.Levels of endothelin-1,nuclear factor-kappa B,tumour necrosis factor-α,interleukin-6,interleukin-1β,malondialdehyde,B-cell lymphoma(Bcl)-2-associated X protein,and caspase-3 were lower,and levels of nitric oxide,Bcl-2,and superoxide dismutase were higher,in the STDP group in comparison with the CMD model group.CONCLUSION:STDP pretreatment improved the CMD induced by sodium laurate via anti-inflammatory,anti-apoptosis,and anti-oxidant mechanisms. | LIU Huahua ZHAO Jingjing ZHU Yeke TANG Weiliang PENG Fang PAN Sunlei FU Guosheng | 2021 | Journal of Traditional Chinese Medicine2021，41，1： | 6 |
| 6 | Ozone vertical variations during a typhoon derived from the OMI observations and reanalysis data显示文摘Typhoon is considered to play a key role in the dynamical exchange processes taking place between the troposphere and stratosphere.In this paper,the impact of typhoon on the ozone distribution in the upper troposphere and middle stratosphere is investigated using ozone profiles measured by Aura’s Ozone Monitoring Instrument and meteorological fields from reanalysis data.During the passage of Typhoon Hai-Tang in 2005 over the western North Pacific,low values of ozone column above 200 hPa and ozone mixing ratio between the upper troposphere and the middle stratosphere(from 200 to 50 hPa)are observed right above the typhoon’s track,a result due to the strong upward propagation of air associated with overshooting convection in typhoon.A comparative analysis of different stages of Hai-Tang suggests that in the region where typhoon has higher intensity the troposphere-to-stratosphere transport is enhanced.These results indicated that the typhoon has a significant impact on the ozone variation in the upper troposphere and the middle stratosphere. | FU YunFei XIAN Tao Lü DaRen LIU GuoSheng HENG ZhiWei SUN Liang LIU Qi WANG Yu YANG YuanJian | 2013 | Chinese Science Bulletin2013，58，32： | 5 |
| 7 | Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis显示文摘在有丝分裂的染色体分离被和锭子微导管的 thekinetochore 的相互作用安排。我们的最近的学习证明 NEK2A 在 thekinetochore 与 MAD1 交往并且可能作为锭子检查点发信号的一个新奇综合者工作。然而, NEK2A 怎么在有丝分裂调整 kinetochore 微导管附件,是不清楚的。这里,我们证明 thatNEK2A phosphorylates 人 Sgo1 和如此的磷酸化为在有丝分裂的忠诚 chromosomecongression 是必要的。NEK2A 直接绑在 HsSgo1 试管内并且与 HsSgo1 共同散布到有丝分裂的房间的 kinetochore。我们的试管内磷酸化实验表明了那 HsSgo1is NEK2A 和磷酸化地点的底层是由加入判定了被印射到重量的单位(14 ) 和重量的单位(507 )(32 ) P。尽管如此的磷酸化没为 HsSgo1to 的汇编被要求 kinetochore, non-phosphorylatable 异种 HsSgo1 的表示使不安 chromosomecongression 并且导致了微导管附件错误的戏剧的增加,包括 syntelicand monotelic 附件。这些调查结果在安排动态 kinetochore 微导管为调停 NEK2A 的 phosphorylationof HsSgo1 揭示一个关键角色相互作用。我们建议人的 Sgo1 的调停 thatNEK2A 的磷酸化在 kinetochores 提供在 centromeric 结合和锭子微导管附件之间的一个连接。 | Guosheng Fu Xia Ding Kai Yuan Felix Aikhionbare Jianhui Yao Xin Cai Kai Jiang Xuebiao Yao | 2007 | Cell Research2007，17，7： | 4 |
| 8 | Recent Advances and Perspectives of Transition Metal- Catalyzed Asymmetric Fluorination Reactions显示文摘然而,包含氟的符号的分子的合成由于氟化物的大价值在最近的年里收到了集中的注意转变 CF 契约的催化金属的不对称的建设更不被开发。这评论介绍转变的最近的前进催化金属的不对称的氟化作用反应,最后的 CF 契约从有机金属的建筑群的减少的消除在是。另外,这块地的观点也被为不对称的氟化作用和相关转变的未来研究提供,例如 trifluoromethylation, trifluoromethylthiolation 和 trifluoromethoxylation。 | Chaohuang Chen Liang Fu Pinhong Chen Guosheng Liu | 2017 | Chinese Journal of Chemistry2017，35，12： | 4 |
| 9 | QT DISPERSION: A RISK INDICATOR FOR SEVERE VENTRICULAR ARRHYTHMIA IN PATIENTS WITH ISCHEMIC AND IDIOPATHIC CARDIOMYOPATHY显示文摘Increased QT dispersion in the surface ECG (QTd = QTmax minus QTmin) is considered as an indicator of electrical inhomogeneitv and a useful predictor for severe ventricular arrhythmia and sudden cardiac death in patients with different heart diseases. Patients with ischemic and idiopathic cardiomyopathy have a very high incidence of severe ventricular arrhythmia and sudden cardiac death. We compared QT, QTc. JT and JTc dispersion in ischemic (ICMP) and idopathic (CCMP) cardiomyopathy patients with and without severe ventricular arrhythmia and normal controls. | Fu Guosheng Achim MeiBner Rudiger Simon | 1995 | Chinese Medical Journal1995，，3： | 2 |
| 10 | Vibration Effect and Damage Evolution Characteristics of Tunnel Surrounding Rock Under Cyclic Blasting Loading显示文摘Model test studies based on the similarity theory were conducted to investigate vibration effect and damage evolution characteristics of tunnel surrounding rock under push-type cyclic blasting excavation.The model was constructed with a ratio of 1∶15.By simulating the tunnel excavation of push-type cyclic blasting,the influence of the blasting parameter change on vibration effect was explored.The damage degree of tunnel surrounding rock was evaluated by the change of the acoustic wave velocity at the same measuring point after blasting.The relationship between the damage evolution of surrounding rock and blasting times was established.The research results show that:(1)In the same geological environment,the number of delay initiation is larger,the main vibration frequency of blasting seismic wave is higher,and the attenuation of high frequency signal in the rock and soil is faster.The influence of number of delay initiation on blasting vibration effect cannot be ignored;(2)Under push-type cyclic blasting excavation,there were great differences in the decreasing rates of acoustic wave velocity of the measuring points which have the same distance to the blasting region at the same depth,and the blasting damage ranges of surrounding rock were typically anisotropic at both depth and breadth;(3)When blasting parameters were basically kept as the same,the growth trend of the cumulative acoustic wave velocity decreasing rate at the measuring point was nonlinear under different cycle blasting excavations;(4)There were nonlinear evolution characteristics between the blasting cumulative damage(D)of surrounding rock and blasting times(n)under push-type cyclic blasting loading,and different measuring points had corresponding blasting cumulative damage propagation models,respectively.The closer the measuring point was away from the explosion source,the faster the cumulative damage extension.Blasting cumulative damage effect of surrounding rock had typically nonlinear evolution properties and anisotropic characteristics. | Guosheng Zhong Yongzhong Lou Yuhua Fu | 2017 | Journal of Beijing Institute of Technology2017，26，3： | 1 |
| 11 | Error estimation of perturbations under CRI显示文摘 | Cheng Guosheng Fu Yuxi | 2006 | IEEE Transac- tions on Fuzzy Systems2006，14，6： | 1 |
| 12 | Possible Misidetifical of rain type by TRMM PR over Tibetan Plateau 显示文摘 | Fu Yunfei Liu Guosheng | 2007 | J of Applied Meteorology and Climatology2007，46，5： | 1 |
| 13 | Thymosin β4 reduces senescence of endothelial progenitor cells via thePI3K/Akt/eNOS signal transduction pathway显示文摘 | Juan Li Fuyu Qiu Lu Yu Yanbo Zhao Guosheng Fu Binquan Zhou | 2013 | Molecular Medicine Reports2013，，2： | 1 |
| 14 | SDF-1α/CXCR4 decreases endothelial progenitor cells apoptosis under serum deprivation by PI3K/Akt/eNOS pathway显示文摘 | Hao Zheng Tao Dai Binquan Zhou Junhui Zhu He Huang Min Wang Guosheng Fu | 2008 | Atherosclerosis2008，，1： | 1 |
| 15 | Correlation between Structure and resistivityvariations of the live human skull 显示文摘 | Chi Tang Fusheng You Guang Cheng Dakuan Gao Feng Fu Guosheng Yang Xiuzhen Dong | 2008 | IEEE Trans On Biomedical Engineering2008，55，： | 1 |
| 16 | Possible misidentification of raintype by TRMM PR over Tibetan Plateau显示文摘 | Fu Yunfei Liu Guosheng | 2007 | Appl Meteor2007，46，5： | 1 |
| 17 | Tower mast of pre-cipitation over the central Tibetan Plateau summer显示文摘 | Fu Yunfei Liu Guosheng Wu Guoxiong | 2006 | Geo-phys Res Lett2006，33，05： | 1 |
| 18 | A highly efficient method of epoxidation of olefins with hydrogen peroxide catalyzed by changeable hexadentate 8-quinolinolato manganese(III) complexes显示文摘 | Sheng Zhong Yueming Tan Zaihui Fu Qingji Xie Fang Xie Xiaoping Zhou Zhengpei Ye Guosheng Peng Dulin Yin | 2008 | Journal of Catalysis2008，，1： | 1 |
| 19 | Prevention and Reversal of Atrial Fibrillation Inducibility and Autonomic Remodeling by Low-Level Vagosympathetic Nerve Stimulation显示文摘 | Xia Sheng Benjamin J. Scherlag Lilei Yu Shuyan Li Reza Ali Ying Zhang Guosheng Fu Hiroshi Nakagawa Warren M. Jackman Ralph Lazzara Sunny S. Po | 2011 | Journal of the American College of Cardiology2011，，5： | 1 |
| 20 | A Study of the Distribution and Variability of Cloud Water Using ISCCP, SSM/I Cloud Product, and Reanalysis Datasets显示文摘 | Heng Zhiwei Fu Yunfei Liu Guosheng Zhou Renjun Wang Yu Yuan Renmin Guo Jingchao Dong Xue | 2014 | Journal of Climate2014，，9： | 1 |
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