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| 1 | The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation显示文摘 | Vidisha Tripathi Jonathan D. Ellis Zhen Shen David Y. Song Qun Pan Andrew T. Watt Susan M. Freier C. Frank Bennett Alok Sharma Paula A. Bubulya Benjamin J. Blencowe Supriya G. Prasanth Kannanganattu V. Prasanth | 2010 | Molecular Cell2010，，6： | 4 |
| 2 | Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair显示文摘Macrophage plasticity is critical for normal tissue repair following injury.In pathologic states such as diabetes,macrophage plasticity is impaired,and macrophages remain in a persistent proinflammatory state;however,the reasons for this are unknown.Here,using single-cell RNA sequencing of human diabetic wounds,we identified increased JMJD3 in diabetic wound macrophages,resulting in increased inflammatory gene expression.Mechanistically,we report that in wound healing,JMJD3 directs early macrophage-mediated inflammation via JAK1,3/STAT3 signaling.However,in the diabetic state,we found that IL-6,a cytokine increased in diabetic wound tissue at later time points post-injury,regulates JMJD3 expression in diabetic wound macrophages via the JAK1,3/STAT3 pathway and that this late increase in JMJD3 induces NFκB-mediated inflammatory gene transcription in wound macrophages via an H3K27me3 mechanism.Interestingly,RNA sequencing of wound macrophages isolated from mice with JMJD3-deficient myeloid cells(Jmjd3f/fLyz2Cre+)identified that the STING gene(Tmem173)is regulated by JMJD3 in wound macrophages.STING limits inflammatory cytokine production by wound macrophages during healing.However,in diabetic mice,its role changes to limit wound repair and enhance inflammation.This finding is important since STING is associated with chronic inflammation,and we found STING to be elevated in human and murine diabetic wound macrophages at late time points.Finally,we demonstrate that macrophage-specific,nanoparticle inhibition of JMJD3 in diabetic wounds significantly improves diabetic wound repair by decreasing inflammatory cytokines and STING.Taken together,this work highlights the central role of JMJD3 in tissue repair and identifies cell-specific targeting as a viable therapeutic strategy for nonhealing diabetic wounds. | Christopher O.Audu William J.Melvin Amrita D.Joshi Sonya J.Wolf Jadie Y.Moon Frank M.Davis Emily C.Barrett Kevin D.Mangum Hongping Deng Xianying Xing Rachel Wasikowski Lam C.Tsoi Sriganesh B.Sharma Tyler M.Bauer James Shadiow Matthew A.Corriere Andrea TObi Steven LKunkel Benjamin Levi Bethany BMoore Johann EGudjonsson Andrew MSmith Katherine A.Gallagher | 2022 | Cellular & Molecular Immunology2022，19，11： | 2 |
| 3 | Regulation of Enterocyte Apoptosis by Acyl-CoA Synthetase 5 Splicing显示文摘 | Nikolaus Gassler Wilfried Roth Benjamin Funke Armin Schneider Frank Herzog Jens J.W. Tischendorf Kerstin Grund Roland Penzel Ignacio G. Bravo John Mariadason Volker Ehemann Jaromir Sykora Tobias L. Haas Henning Walczak Tom Ganten Hanswalter Zentgraf Peter | 2007 | Gastroenterology2007，，2： | 2 |
| 4 | Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair显示文摘AIM To determine endothelin-1(ET-1)concentration before and after surgical coarctectomy and evaluate its association with left ventricular geometric change.METHODSA prospective,cohort study of 24 patients aged 2 d to 10years with coarctation of the aorta undergoing surgical repair.A sub-cohort of patients with age<1 mo was classified as'neonates'.Echocardiograms were performed just prior to surgery and in the immediate post-op period to assess left ventricle mass index and relative wall thickness(RWT).Plasma ET-1 levels were assessed at both time points.Association between ET-1 levels and ventricular remodeling was assessed.RESULTSPatients<1 year demonstrated higher pre-op ET-1 than post-op(2.8 pg/m L vs 1.9 pg/m L,P=0.02).Conversely,patients>1 year had no change in ET-1 concentration before and after surgery(1.1 vs 1.4,NS).Pre-op,patients<1 year demonstrated significantly higher ET-1 than older children(2.8 vs 1.1,P=0.001).Post-op there was no difference between the age groups(1.9 vs 1.4,NS).Neither RWT nor left ventricle mass index(LVMI)varied from pre-op to post-op.The subset of neonates showed a strong positive correlation between pre-op ET-1 and RWT(r=0.92,P=0.001).Patients with ET-1>2 pg/m L preop demonstrated higher LVMI(65.7 g/m^(2.7) vs 38.5 g/m^(2.7),P=0.004)and a trend towards higher RWT(45%vs39%,P=0.07)prior to repair than those with lower ET-1concentration.CONCLUSIONET-1 concentration is significantly variable in the perioperative period surrounding coarctectomy.Older children and infants have different responses to surgical repair suggesting different mechanisms of activation. | Benjamin Steven Frank Tracy T Urban Suhong Tong Courtney Cassidy Max B Mitchell Christopher S Nichols Jesse A Davidson | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 5 | Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial显示文摘 | Ajay K Kakkar Benjamin Brenner Ola E Dahl Bengt I Eriksson Patrick Mouret Jim Muntz Andrea G Soglian ákos F Pap Frank Misselwitz Sylvia Haas | 2008 | The Lancet2008，，9632： | 1 |
| 6 | The role of the circadian system in fractal neurophysiological control显示文摘 | Benjamin R. Pittman‐Polletta Frank A. J. L. Scheer Matthew P. Butler Steven A. Shea Kun Hu | 2013 | Biol Rev2013，，4： | 1 |
| 7 | The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients显示文摘 | Hans Dieter Nischalke Cordula Berger Carolin Luda Tobias Müller Thomas Berg Martin Coenen Benjamin Kr?mer Christian K?rner Jonel Trebicka Frank Grünhage Frank Lammert Jacob Nattermann Tilman Sauerbruch Ulrich Spengler | 2011 | Journal of Hepatology2011，，4： | 1 |
| 8 | Selective management of blunt hepatic injuries including nonoperative management is a safe and effective strategy显示文摘 | Ashley Britton Christmas Ashley K. Wilson Benjamin Manning Glen A. Franklin Frank B. Miller J. David Richardson Jorge L. Rodriguez | 2005 | Surgery2005，，4： | 1 |
| 9 | High-Mobility Group Box-1 in Ischemia-Reperfusion Injury of the Heart显示文摘 | Martin Andrassy Hans C. Volz John C. Igwe Benjamin Funke Sebastian N. Eichberger Ziya Kaya Sebastian Buss Frank Autschbach Sven T. Pleger Ivan K. Lukic Florian Bea Stefan E. Hardt Per M. Humpert Marco E. Bianchi Heimo Mairb?url Peter P. Nawroth Andrew Rem | 2008 | Circulation2008，，25： | 1 |
| 10 | Echelle calibration and wavelength calculation 显示文摘 | Frank L Moore J R Benjamin F | 1972 | Journal of Optical Society of America1972，62，6： | 1 |
| 11 | Resin-derived hierarchical porous carbon spheres with high catalytic performance in the oxidative dehydrogenation of ethylbenzene显示文摘 | Wang Lifeng Juan J Delgado Benjamin Frank | 2012 | Chem Sus Chem2012，5，4： | 1 |
| 12 | HEVC complexity and implementation analysis显示文摘 | Frank Bossen Benjamin Bross Karsten Suhring | 2012 | IEEETransactions on Circuits and Systems for Video Technol-ogy2012，22，12： | 1 |
| 13 | Adult spinal deformity-postoperative standing imbalance:how much can you tolerate?An overview of key parameter in assessing alignment and planning corrective surgery显示文摘 | Frank S Ashish P Benjamin U | 2010 | Spine2010，35，25： | 1 |
| 14 | Effects of nitrogen fertilization and irrigation on N2O emissions from a sandy soil in Germany显示文摘 | Benjamin Trost Annette Prochnow Michael Baumecker Andreas Meyer-Aurich Katrin Drastig Frank Ellmer | 2015 | Archives of Agronomy and Soil Science2015，，5： | 1 |
| 15 | Principles of carbon nanotube dielectrophoresis显示文摘Dielectrophoresis(DEP)describes the motion of suspended objects when exposed to an inhomogeneous electric field.It has been successful as a method for parallel and site-selective assembling of nanotubes from a dispersion into a sophisticated device architecture.Researchers have conducted extensive works to understand the DEP of nanotubes in aqueous ionic surfactant solutions.However,only recently,DEP was applied to polymer-wrapped single-walled carbon nanotubes(SWCNTs)in organic solvents due to the availability of ultra-pure SWCNT content.In this paper,the focus is on the difference between the DEP in aqueous and organic solutions.It starts with an introduction into the DEP of carbon nanotubes(CNT-DEP)to provide a comprehensive,in-depth theoretical background before discussing in detail the experimental procedures and conditions.For academic interests,this work focuses on the CNT-DEP deposition scheme,discusses the importance of the electrical double layer,and employs finite element simulations to optimize CNT-DEP deposition condition with respect to the experimental observation.An important outcome is an understanding of why DEP in organic solvents allows for the deposition and alignment of SWCNTs in low-frequency and even static electric fields,and why the response of semiconducting SWCNTs(s-SWCNTs)is strongly enhanced in non-conducting,weakly polarizable media.Strategies to further improve CNT-DEP for s-SWCNT-relevant applications are given as well.Overall,this work should serve as a practical guideline to select the appropriate setting for effective CNT DEPs. | Wenshan Li Frank Hennrich Benjamin S.Flavel Simone Dehm Manfred Kappes Ralph Krupke | 2021 | Nano Research2021，14，7： | 1 |
| 16 | Monitoring the influence of different weathering conditions on polyethylene pipes by IR-microscopy显示文摘 | Raquel Maria Karsten Rode Robert Brüll Frank Dorbath Benjamin Baudrit Martin Bastian Emmanuelle Brendlé | 2011 | Polymer Degradation and Stability2011，，10： | 1 |
| 17 | Content-aware traffic engineering显示文摘 | Benjamin Frank Ingmar Poese Georgios Smaragdakis Steve Uhlig Anja Feldmann | 2012 | ACM SIGMETRICS Performance Evaluation Review2012，，： | 1 |
| 18 | EAES recommendations for the management of gastroesophageal reflux disease显示文摘 | Karl Hermann Fuchs Benjamin Babic Wolfram Breithaupt Bernard Dallemagne Abe Fingerhut Edgar Furnee Frank Granderath Peter Horvath Peter Kardos Rudolph Pointner Edoardo Savarino Maud Herwaarden-Lindeboom Giovanni Zaninotto | 2014 | Surgical Endoscopy2014，，： | 1 |
| 19 | Pushing CDN-ISP collaboration to the limit显示文摘 | Benjamin Frank Ingmar Poese Yin Lin Georgios Smaragdakis Anja Feldmann Bruce Maggs Jannis Rake Steve Uhlig Rick Weber | 2013 | ACM SIGCOMM Computer Communication Review2013，，： | 1 |
| 20 | Pathology of the large intestine in patients with vascular type Ehlers-Danlos syndrome显示文摘 | Hendrik Bl?ker Benjamin Funke Ingrid Hausser Thilo Hackert Peter Schirmacher Frank Autschbach | 2007 | Virchows Archiv2007，，6： | 1 |
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