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| 1 | Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer显示文摘5-methylcytosine (5mC ) 和它的氧化形式 5-hydroxymethylcytosine (5hmC ) 被建议了涉及 tumorigenesis。因为印射方法的广泛地使用的 5mC 的读出,定序的重亚硫酸盐(BS-seq ) ,是 5mC 的和, 5hmC 层次, 5mC/5hmC 模式和这二修正的关系仍然保持糟糕理解。由介绍真实 5mC (BS-seq 由帮助 Tet 的 BS-seq 改正了, TAB-seq ) 并且 5hmC (TAB-seq ) 在单个核苷酸的分辨率同时铺平,我们这里证明与匹配的正常纸巾相比没有在肾肿瘤的 5mC 的全球损失。相反地, 5hmC 全球性被失去在几乎所有肾肿瘤纸巾。在肿瘤纸巾的 5hmC 水平是为肾癌症的一个独立预示的标记,与与更短的全面幸存联系的 5hmC 的底层。而且,我们证明 5hmC 的损失与匹配的正常纸巾相比在肿瘤被连接到 hypermethylation,特别地在基因身体区域。惊人地,基因身体 hypermethylation 显著地与肿瘤相关的基因的 silencing 被联系。IDH1 的 Downregulation 作为在肾癌症位于 5hmC 损失下面的机制被识别。恢复 5hmC 层次稀释了肿瘤房间的侵略能力并且在一个异种皮移植模型压制了肿瘤生长。一起,我们的结果证明 5hmC 的损失在由改变 DNA methylation 模式的肾癌症是一个预示的标记和一个 oncogenic 事件。 | Ke Chen Jing Zhang Zhongqiang Guo Qin Ma Zhengzheng Xu Yuanyuan Zhou Ziying Xu Zhongwu Li Xiongjun- Ye Xuesong Li Bifeng Yuan Yuwen Ke Chuan He Liqun Zhou Jiang Liu WeiminCi | 2016 | Cell Research2016，26，1： | 10 |
| 2 | Exploring Optimum Power Unit of Propulsion System for High Altitude Airship 显示文摘 | Chen Shengqi Song Bifeng Wang Haifeng | 2015 | Journal of Aerospace Engineering2015，229，2： | 1 |
| 3 | Study in the design and manufacture process of the elastic cable anchor box in steel box girder of Taizhou Bridge显示文摘Taizhou Yangtze River Highway Bridge is a large span suspension bridge with three pylons. The elastic cables are installed to connect the steel tower and the steel box girder. The constraints can increase the safety coefficient of the middle saddle, and improve the stress conditions of the middle pylon and decrease the deflection in the middle of the main girder, as well as the longitudinal displacement of the main girder caused by live loads. The anchorage boxes of the elastic cable are installed in the wind fairing outside the vertical web plate of the box girder. Two anchor boxes form a pair and are arranged parallelly. Eight anchor boxes are installed in the bridge. In this paper, the design scheme and the technical difficulties in manufacturing are briefly discussed with the precision control techniques. | Gu Bifeng Chen Ce Ding Lei | 2011 | Engineering Sciences2011，9，2： | 1 |
| 4 | Modeling and flapping vibration suppression of a novel tailless flapping wing micro air vehicle显示文摘This paper establishes and analyzes a high-fidelity nonlinear time-periodic dynamic model and the corresponding state observer for flapping vibration suppression of a novel tailless Flapping Wing Micro Air Vehicle(FWMAV),named NPU-Tinybird.Firstly,a complete modeling of NPU-Tinybird is determined,including the aerodynamic model based on the quasi-steady method,the kinematic and dynamic model about the mechanism of flapping and attitude control,combined with the single rigid body dynamic model.Based on this,a linearized longitudinal pitch dynamic cycle-averaged model is obtained and analyzed through the methods of neural network fitting and system identification,preparing for the design of flapping vibration suppression observer.Flapping vibration is an inherent property of the tailless FWMAV,which arises from the influence of time-periodic aerodynamic forces and moments.It can be captured by attitude and position sensors on the plane,which impairs the flight performance and efficiency of flight controller and actuators.To deal with this problem,a novel state observer for flapping vibration suppression is designed.A robust optimal controller based on the linear quadratic theory is also designed to stabilize the closed-loop system.Simulation results are given to verify the performance of the observer,including the closed loop responses combined with robust optimal controller,the comparison of different parameters of observer and the comparison with several classic methods,such as Kalman filter,H-infinity filter and low-pass filter,which prove that the novel observer owns a fairly good suppression effect on flapping vibration and benefits for the improvement of flight performance and control efficiency. | Siqi WANG Bifeng SONG Ang CHEN Qiang FU Jin CUI | 2022 | Chinese Journal of Aeronautics2022，35，3： | 1 |
| 5 | Preparation and characterization of methacrylate-based monolith for ca- pillary hydrophilic interaction chromatography显示文摘 | Chen Mingluan Li Liman Yuan Bifeng | 2012 | J Chro- matogr A2012，1230，23： | 1 |
| 6 | Concise synthesis of xanthones by the tandem etherification——Acylation of diaryliodonium salts with salicylates显示文摘An efficient synthetic method for multi-substituted xanthones was developed. The reaction of diaryliodonium salts and salicylates was employed for the preparation of the xanthones. This method proceeded through an intermolecular etherification-acylation to give target heterocycles in good yields(up to 91%). Multi-substituted xanthones were gained by shifting the substituent of salicylates or diaryliodonium | Gaoxiaozheng Liu Chao Wu Bifeng Chen Ru He Chao Chen | 2018 | Chinese Chemical Letters2018，29，6： | 0 |
| 7 | The Astrometric Performance Test of 80 cm Telescope at Yaoan Station and Precise CCD Positions of Apophis显示文摘The 80 cm azimuthal telescope has newly been mounted at Yaoan Station,Purple Mountain Observatory since2018.The astrometric performance of the telescope is tested in the following three aspects.(a)The geometric distortion of its CCD attached.It is stable in both a single epoch and multi epochs.Eight distortion solutions are derived over about one year.The maximum values range from 0.75 to 0.79 pixel and the median values range from 0.14 to 0.16 pixel.(b)The limit magnitude of stars.About 20.5 mag(Gaia-G)stars can be detected with Johnson-V filter exposured in 300 s.The astrometric error of about 20.5 mag stars is estimated at O'.14 using the fitted sigmoidal function.(c)The astrometric accuracy and the precision of stacked fast-moving faint object.24 stacked frames of the potentially hazardous asteroid(99942)Apophis were derived on 2021 April 14 and 15(fainter than18 mag)based on the ephemeris shifts.During data reduction,the newest Gaia EDR3 Catalog and Jet Propulsion Laboratory Horizons ephemeris are referenced as theoretical positions of stars and Apophis,respectively.Our results show that the mean(O-C)s(observed minus computed)of Apophis are-O'.018 and O'.020 in R.A.and decl.,and the dispersions are estimated at O'.094 and O'.085,respectively,which show the consistency of the stacked results by Astrometrica. | Bifeng Guo Qingyu Peng Ying Chen Zhongjie Zheng Yijia Shang Dan Li Xiao Chen | 2022 | Research in Astronomy and Astrophysics2022，22，5： | 0 |
| 8 | Quantifying the agreement and accuracy characteristics of four satellite-based LULC products for cropland classification in China显示文摘Various land use and land cover(LULC)products have been produced over the past decade with the development of remote sensing technology.Despite the differences in LULC classification schemes,there is a lack of research on assessing the accuracy of their application to croplands in a unified framework.Thus,this study evaluated the spatial and area accuracies of cropland classification for four commonly used global LULC products(i.e.,MCD12Q1V6,GlobCover2009,FROM-GLC and GlobeLand30)based on the harmonised FAO criterion,and quantified the relationships between four factors(i.e.,slope,elevation,field size and crop system)and cropland classification agreement.The validation results indicated that MCD12Q1 and GlobeLand30 performed well in cropland classification regarding spatial consistency,with overall accuracies of 94.90 and 93.52%,respectively.The FROMGLC showed the worst performance,with an overall accuracy of 83.17%.Overlaying the cropland generated by the four global LULC products,we found the proportions of complete agreement and disagreement were 15.51 and 44.72% for the cropland classification,respectively.High consistency was mainly observed in the Northeast China Plain,the Huang-Huai-Hai Plain and the northern part of the Middle-lower Yangtze Plain,China.In contrast,low consistency was detected primarily on the eastern edge of the northern and semiarid region,the Yunnan-Guizhou Plateau and southern China.Field size was the most important factor for mapping cropland.For area accuracy,compared with China Statistical Yearbook data at the provincial scale,the accuracies of different products in descending order were:GlobeLand30,FROM-GLC,MCD12Q1,and GlobCover2009.The cropland classification schemes mainly caused large area deviations among the four products,and they also resulted in the different ranks of spatial accuracy and area accuracy among the four products.Our results can provide valuable suggestions for selecting cropland products at the national or provincial scale and help cropland mapping and reconstruction,which is essential for food security and crop management,so they can also contribute to achieving the Sustainable Development Goals issued by the United Nations. | Jie Xue Xianglin Zhang Songchao Chen Bifeng Hu Nan Wang Zhou Shi | 2024 | Journal of Integrative Agriculture2024，23，1： | 0 |
| 9 | Experimental Study on the Effect of Increased Downstroke Duration for an FWAV with Morphing-coupled Wing Flapping Configuration显示文摘This paper is based on a previously developed bio-inspired Flapping Wing Aerial Vehicle(FWAV),RoboFalcon,which can fly with a morphing-coupled flapping pattern.In this paper,a simple flapping stroke control system based on Hall effect sensors is designed and applied,which is capable of assigning different up-and down-stroke speeds for the RoboFalcon platform to achieve an adjustable downstroke ratio.The aerodynamic and power characteristics of the morphing-coupled flapping pattern and the conventional flapping pattern with varying downstroke ratios are measured through a wind tunnel experiment,and the corresponding aerodynamic models are developed and analyzed by the nonlinear least squares method.The relatively low power consumption of the slow-downstroke mode of this vehicle is verified through outdoor flight tests.The results of wind tunnel experiments and flight tests indicate that increased downstroke duration can improve aerodynamic and power performance for the RoboFalcon platform. | Ang Chen Bifeng Song ZhiheWang Kang Liu Dong Xue Xiaojun Yang | 2024 | Journal of Bionic Engineering2024，21，1： | 0 |
| 10 | Consensus statement on research and application of Chinese herbal medicine derived extracellular vesicles-like particles(2023 edition)显示文摘To promote the development of extracellular vesicles of herbal medicine especially the establishment of standardization,led by the National Expert Committee on Research and Application of Chinese Herbal Vesicles,research experts in the field of herbal medicine and extracellular vesicles were invited nationwide with the support of the Expert Committee on Research and Application of Chinese Herbal Vesicles,Professional Committee on Extracellular Vesicle Research and Application,Chinese Society of Research Hospitals and the Guangdong Engineering Research Center of Chinese Herbal Vesicles.Based on the collation of relevant literature,we have adopted the Delphi method,the consensus meeting method combined with the nominal group method to form a discussion draft of“Consensus statement on research and application of Chinese herbal medicine derived extracellular vesicles-like particles(2023)”.The first draft was discussed in online and offline meetings on October 12,14,November 2,2022 and April and May 2023 on the current status of research,nomenclature,isolation methods,quality standards and research applications of extracellular vesicles of Chinese herbal medicines,and 13 consensus opinions were finally formed.At the Third Academic Conference on Research and Application of Chinese Herbal Vesicles,held on May 26,2023,Kewei Zhao,convenor of the consensus,presented and read the consensus to the experts of the Expert Committee on Research and Application of Chinese Herbal Vesicles.The consensus highlights the characteristics and advantages of Chinese medicine,inherits the essence,and keeps the righteousness and innovation,aiming to provide a reference for colleagues engaged in research and application of Chinese herbal vesicles at home and abroad,decode the mystery behind Chinese herbal vesicles together,establish a safe,effective and controllable accurate Chinese herbal vesicle prevention and treatment system,and build a bridge for Chinese medicine to the world. | Qing Zhao Tong Wang Hongbin Wang Peng Cao Chengyu Jiang Hongzhi Qiao Lihua Peng Xingdong Lin Yunyao Jiang Honglei Jin Huantian Zhang Shengpeng Wang Yang Wang Ying Wang Xi Chen Junbing Fan Bo Li Geng Li Bifeng Liu Zhiyang Li Suhua Qi Mingzhen Zhang Jianjian Zheng Jiuyao Zhou Lei Zheng Kewei Zhao | 2024 | Chinese Herbal Medicines2024，16，1： | 0 |
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